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Loss-of-function and gain-of-function genetic screens identify potential biomarkers and combination partners for the highly selective allosteric PI3Kd inhibitor roginolisib (IOA-244) Tarantelli, C.; Sartori, G.; Spriano, F.; Civanelli, E.; Cascione, L.; Rinaldi, A.; Niewola-Staszkowska, K.; Lahn, M.; Napoli, S.; Di Conza, G.; Bertoni, F. 分享 收藏
A pharmacologic screen identifies drugs to be combined with the non-ATP competitive PI3Kδ inhibitor roginolisib (IOA-244) for an improved anti-tumor activity in lymphoma models Tarantelli, Chiara; Civanelli, Elisa; Cannas, Eleonora; Spriano, Filippo; Mensah, Afua A.; Cascione, Luciano; Arribas, Alberto J.; Stathis, Anastasios; Niewola-Staszkowska, Karolina; Di Conza, Giusy; Lahn, Michael; Bertoni, Francesco 分享 收藏
Translating a novel autotaxin inhibitor from preclinical proof of concept in pancreatic cancer to a biomarker response in human subjects Milleri, S.; Deken, M.; Medhi, R.; Carruthers, A.; Tagliavini, A.; Nizzardo, A.; Pergher, M.; Niewola-Staszkowska, K.; Cheasty, A.; Fraser, A.; Shah, P.; van der Veen, L.; Ziviani, L.; Lahn, M.; Johnson, Z. 分享 收藏
Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2 Riggi, Margot; Niewola-Staszkowska, Karolina; Chiaruttini, Nicolas; Colom, Adai; Kusmider, Beata; Mercier, Vincent; Soleimanpour, Saeideh; Stahl, Michael; Matile, Stefan; Roux, Aurelien; Loewith, Robbie 分享 收藏
Dual action antifungal small molecule modulates multidrug efflux and TOR signaling 双重作用抗真菌小分子调节多药外排和TOR信号 Shekhar-Guturja, Tanvi; Gunaherath, G. M. Kamal B.; Wijeratne, E. M. Kithsiri; Lambert, Jean-Philippe; Averette, Anna F.; Lee, Soo Chan; Kim, Taeyup; Bahn, Yong-Sun; Tripodi, Farida; Ammar, Ron; Doehl, Katja; Niewola-Staszkowska, Karolina; Schmitt, Lutz; Loewith, Robbie J.; Roth, Frederick P.; Sanglard, Dominique; Andes, David; Nislow, Corey; Coccetti, Paola; Gingras, Anne-Claude; Heitman, Joseph; Gunatilaka, A. A. Leslie; Cowen, Leah E. 分享 收藏
A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction Kennedy, Michael A.; Moffat, Tia C.; Gable, Kenneth; Ganesan, Suriakarthiga; Niewola-Staszkowska, Karolina; Johnston, Anne; Nislow, Corey; Giaever, Guri; Harris, Linda J.; Loewith, Robbie; Zaremberg, Vanina; Harper, Mary-Ellen; Dunn, Teresa; Bennett, Steffany A. L.; Baetz, Kristin 分享 收藏
A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast Kennedy, Michael A.; Gable, Kenneth; Niewola-Staszkowska, Karolina; Abreu, Susana; Johnston, Anne; Harris, Linda J.; Reggiori, Fulvio; Loewith, Robbie; Dunn, Teresa; Bennett, Steffany A. L.; Baetz, Kristin 分享 收藏
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