未登录 The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk Valdecantos, M. Pilar; Ruiz, Laura; Folgueira, Cintia; Rada, Patricia; Gomez-Santos, Beatriz; Solas, Maite; Hitos, Ana B.; Field, Joss; Francisco, Vera; Escalona-Garrido, Carmen; Zagmutt, Sebastian; Calderon-Dominguez, Maria; Mera, Paula; Garcia-Martinez, Irma; Maymo-Masip, Elsa; Grajales, Diana; Alen, Rosa; Mora, Alfonso; Sainz, Neira; Vides-Urrestarazu, Irene; Vilarrasa, Nuria; Arbones-Mainar, Jose M.; Zaragoza, Carlos; Moreno-Aliaga, Maria J.; Aspichueta, Patricia; Fernandez-Veledo, Sonia; Vendrell, Joan; Serra, Dolors; Herrero, Laura; Schreiber, Renate; Zechner, Rudolf; Sabio, Guadalupe; Hornigold, David; Rondinone, Cristina M.; Jermutus, Lutz; Grimsby, Joseph; Valverde, angela M. 分享 收藏
Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation Tyagi, Puneet; Patel, Chandresh; Gibson, Kimberly; Macdougall, Fiona; Pechenov, Sergei Y.; Will, Sarah; Revell, Jefferson; Huang, Yue; Rosenbaum, Anton I.; Balic, Kemal; Maharoof, Umar; Grimsby, Joseph; Subramony, J. Anand 分享 收藏
Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity Andersen, Mette K.; Angquist, Lars; Bork-Jensen, Jette; Jonsson, Anna E.; Stinson, Sara E.; Sandholt, Camilla H.; Thodberg, Malte; Pikkupeura, Laura Maarit; Ongstad, Emily L.; Grarup, Niels; Astrup, Arne; Pedersen, Oluf; Williams, Kristine; Barres, Romain; Sorensen, Thorkild I. A.; Linneberg, Allan; Grimsby, Joseph; Rhodes, Christopher J.; Hansen, Torben 分享 收藏
High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity Stinson, Sara E.; Jonsson, Anna E.; Andersen, Mette K.; Lund, Morten A. V.; Holm, Louise Aas; Fonvig, Cilius E.; Huang, Yun; Stankevic, Evelina; Juel, Helene Baek; aengquist, Lars; Sorensen, Thorkild I. A.; Ongstad, Emily L.; Gaddipati, Ranjitha; Grimsby, Joseph; Rhodes, Christopher J.; Pedersen, Oluf; Christiansen, Michael; Holm, Jens-Christian; Hansen, Torben 分享 收藏
Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries Boland, Brandon B.; Laker, Rhianna C.; O'Brien, Siobhan; Sitaula, Sadichha; Sermadiras, Isabelle; Nielsen, Jens Christian; Barkholt, Pernille; Roostalu, Urmas; Hecksher-Sorensen, Jacob; Sejthen, Sara Rubek; Thorbek, Ditte Dencker; Suckow, Arthur; Burmeister, Nicole; Oldham, Stephanie; Will, Sarah; Howard, Victor G.; Gill, Benji M.; Newton, Philip; Naylor, Jacqueline; Hornigold, David C.; Austin, Jotham; Lantier, Louise; McGuinness, Owen P.; Trevaskis, James L.; Grimsby, Joseph S.; Rhodes, Christopher J. 分享 收藏
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control Dreyfuss, Jonathan M.; Yuchi, Yixing; Dong, Xuehong; Efthymiou, Vissarion; Pan, Hui; Simonson, Donald C.; Vernon, Ashley; Halperin, Florencia; Aryal, Pratik; Konkar, Anish; Sebastian, Yinong; Higgs, Brandon W.; Grimsby, Joseph; Rondinone, Cristina M.; Kasif, Simon; Kahn, Barbara B.; Foster, Kathleen; Seeley, Randy; Goldfine, Allison; Djordjilovic, Vera; Patti, Mary Elizabeth 分享 收藏
Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease Pechenov, Sergei; Revell, Jefferson; Will, Sarah; Naylor, Jacqueline; Tyagi, Puneet; Patel, Chandresh; Liang, Lihuan; Tseng, Leo; Huang, Yue; Rosenbaum, Anton, I; Balic, Kemal; Konkar, Anish; Grimsby, Joseph; Subramony, J. Anand 分享 收藏
Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial Le Lay, John E.; Du, Qun; Mehta, Minal B.; Bhagroo, Nicholas; Hummer, B. Timothy; Falloon, Judith; Carlson, Glenn; Rosenbaum, Anton, I; Jin, ChaoYu; Kimko, Holly; Tsai, Lan-Feng; Novick, Steven; Cook, Bill; Han, David; Han, Chang Yeop; Vaisar, Tomas; Chait, Alan; Karathanasis, Sotirios K.; Rhodes, Christopher J.; Hirshberg, Boaz; Damschroder, Melissa M.; Hsia, Judith; Grimsby, Joseph S. 分享 收藏
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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis GLP-1R和GCGR双激动剂可通过调节线粒体功能和脂肪生成来解决NASH和肝纤维化 Boland, Michelle L.; Laker, Rhianna C.; Mather, Karly; Nawrocki, Arkadiusz; Oldham, Stephanie; Boland, Brandon B.; Lewis, Hilary; Conway, James; Naylor, Jacqueline; Guionaud, Silvia; Feigh, Michael; Veidal, Sanne S.; Lantier, Louise; McGuinness, Owen P.; Grimsby, Joseph; Rondinone, Cristina M.; Jermutus, Lutz; Larsen, Martin R.; Trevaskis, James L.; Rhodes, Christopher J. 分享 收藏
Effects of intramyocardial injection of human neonatal cardiac progenitor cells on cardiac function, circulating biomarkers and scar size post myocardial infarction in nude rats Bao, Weike; Mishra, Rachana; Gill, Benji; Bhagroo, Nicholas; Hess, Sonja; Walker, Jill; Grimsby, Joseph; Rhodes, Christopher; Kaushal, Sunjay; Karathanasis, Sotirios; Ongstad, Emily 分享 收藏
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Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis Marchetti, Gabriela M.; Burwell, Timothy J.; Peterson, Norman C.; Cann, Jennifer A.; Hanna, Richard N.; Li, Qing; Ongstad, Emily L.; Boyd, Jonathan T.; Kennedy, Maureen A.; Zhao, Weiguang; Rickert, Keith W.; Grimsby, Joseph S.; Dall'Acqua, William F.; Wu, Herren; Tsui, Ping; Borrok, M. Jack; Gupta, Ruchi 分享 收藏
Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment Chodorge, Matthieu; Celeste, Anthony J.; Grimsby, Joseph; Konkar, Anish; Davidsson, Pia; Fairman, David; Jenkinson, Lesley; Naylor, Jacqueline; White, Nicholas; Seaman, Jonathan C.; Dickson, Karen; Kemp, Benjamin; Spooner, Jennifer; Rossy, Emmanuel; Hornigold, David C.; Trevaskis, James L.; Bond, Nicholas J.; London, Timothy B.; Buchanan, Andrew; Vaughan, Tristan; Rondinone, Cristina M.; Osbourn, Jane K. 分享 收藏
Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy Pilar Valdecantos, M.; Ruiz, Laura; Pardo, Virginia; Castro-Sanchez, Luis; Garcia-Monzon, Carmelo; Lanzon, Borja; Ruperez, Javier; Barbas, Coral; Naylor, Jaqueline; Trevaskis, James L.; Grimsby, Joseph; Rondinone, Cristina M.; Valverde, Angela M. 分享 收藏
Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes Boland, Brandon B.; Brown, Charles, Jr.; Boland, Michelle L.; Cann, Jennifer; Sulikowski, Michal; Hansen, Gitte; Gronlund, Rikke V.; King, Wanda; Rondinone, Cristina; Trevaskis, James; Rhodes, Christopher J.; Grimsby, Joseph S. 分享 收藏
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats Trevaskis, James L.; Sacramento, Chester Bittencourt; Jouihan, Hani; Ali, Safina; Le Lay, John; Oldham, Stephanie; Bhagroo, Nicholas; Boland, Brandon B.; Cann, Jennifer; Chang, Yuan; O'Day, Terrence; Howard, Victor; Reers, Christina; Winzell, Maria Sorhede; Smith, David M.; Feigh, Michael; Barkholt, Pernille; Schreiter, Kay; Austen, Matthias; Andag, Uwe; Thompson, Simon; Jermutus, Lutz; Coghlan, Matthew P.; Grimsby, Joseph; Dohrmann, Cord; Rhodes, Christopher J.; Rondinone, Cristina M.; Sharma, Arun 分享 收藏
Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling Galon-Tilleman, Hadas; Yang, Hong; Bednarek, Maria A.; Spurlock, Sandra M.; Paavola, Kevin J.; Ko, Brian; To, Carmen; Luo, Jian; Tian, Hui; Jermutus, Lutz; Grimsby, Joseph; Rondinone, Cristina M.; Konkar, Anish; Kaplan, Daniel D. 分享 收藏
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