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Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927 Kahraman, Mehmet; Govek, Steven P.; Nagasawa, Johnny Y.; Lai, Andiliy; Bonnefous, Celine; Douglas, Karensa; Sensintaffar, John; Liu, Nhin; Lee, KyoungJin; Aparicio, Anna; Kaufman, Josh; Qian, Jing; Slaw, Gang; Prudente, Rene; Joseph, James D.; Darimont, Beatrice; Brigham, Daniel; Heyman, Richard; Rix, Peter J.; Hager, Jeffrey H.; Smith, Nicholas D. 分享 收藏
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Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer Nagasawa, Johnny; Govek, Steven; Kahraman, Mehmet; Lai, Andiliy; Bonnefous, Celine; Douglas, Karensa; Sensintaffar, John; Lu, Nhin; Lee, KyoungJin; Aparicio, Anna; Kaufman, Josh; Qian, Jing; Shao, Gang; Prudente, Rene; Joseph, James D.; Darimont, Beatrice; Brigham, Daniel; Maheu, Kate; Heyman, Richard; Rix, Peter J.; Hager, Jeffrey H.; Smith, Nicholas D. 分享 收藏
Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER plus breast cancer: From GDC-0810 to GDC-0927 Kahraman, Mehmet; Govek, Steven P.; Nagasawa, Johnny Y.; Lai, Andiliy; Bonnefous, Celine; Douglas, Karensa; Sensintaffar, John; Lu, Nhin; Lee, KyoungJin; Aparicio, Anna; Kaufman, Josh; Qian, Jing; Shao, Gang; Prudente, Rene; Joseph, James D.; Darimont, Beatrice; Brigham, Daniel; Heyman, Richard; Rix, Peter J.; Hager, Jeffrey H.; Smith, Nicholas D.; Blake, Robert A.; Chang, Jae; Choo, Edna; Daemen, Anneleen; Friedman, Lori S.; Guan, Jane; Hartman, Steven; Ingalla, Ellen; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada; Metcalfe, Ciara; Mody, Vidhi; Nannini, Michelle; Sampath, Deepak; Young, Amy; Vinogradova, Maia; Zhou, Wei; Liang, Jun; Wang, Xiaojing 分享 收藏
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The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER plus breast cancer Joseph, James D.; Darimont, Beatrice; Zhou, Wei; Arrazate, Alfonso; Young, Amy; Ingalla, Ellen; Walter, Kimberly; Blake, Robert A.; Nonomiya, Jim; Guan, Zhengyu; Kategaya, Lorna; Govek, Steven P.; Lai, Andiliy G.; Kahraman, Mehmet; Brigham, Dan; Sensintaffar, John; Lui, Nhin; Sheo, Gang; Qian, Jing; Grillot, Kate; Moon, Michael; Prudente, Rene; Bischoff, Eric; Lee, Kyoung-Jin; Bonnefous, Celine; Douglas, Karensa L.; Julien, Jackaline D.; Nagasawa, Johnny Y.; Aparicio, Anna; Kaufman, Josh; Haley, Benjamin; Giltnane, Jennifer M.; Wertz, Ingrid E.; Lackner, Mark R.; Nannini, Michelle A.; Sampath, Deepak; Schwarz, Luis; Manning, Henry Charles; Tantawy, Mohammed Noor; Arteaga, Carlos L.; Heyman, Richard A.; Rix, Peter J.; Friedman, Lori; Smith, Nicholas D.; Metcalfe, Ciara; Hager, Jeffrey H. 分享 收藏
Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancer Joseph, James; Govek, Steven; Darimont, Beatrice; Brigham, Daniel; Aparicio, Anna; Bischoff, Eric; Kahraman, Mehmet; Nannini, Michelle; Kaufman, Joshua; Lai, Andily; Lee, Kyoung-Jin; Oeh, Jason; Lu, Nhin; Zhou, Wei; Moon, Michael; Qian, Jing; Sensintaffar, John; Shao, Gang; Sampath, Deepak; Friedman, Lori S.; Rix, Peter; Heyman, Richard A.; Smith, Nicholas; Hager, Jeffrey H. 分享 收藏