未登录 Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study Lasater, Elisabeth A.; Amin, Dhara N.; Bannerji, Rajat; Mali, Raghuveer Singh; Barrett, Kathy; Rys, Ryan N.; Oeh, Jason; Lin, Eva; Sterne-Weiler, Tim; Ingalla, Ellen Rei; Go, MaryAnn; Yu, Shang-Fan; Krem, Maxwell M.; Arthur, Chris; Hahn, Uwe; Johnston, Anna; Karur, Vinit; Khan, Nadia; Marlton, Paula; Phillips, Tycel; Gritti, Giuseppe; Seymour, John F.; Tani, Monica; Yuen, Sam; Martin, Scott; Chang, Matthew T.; Rose, Christopher M.; Pham, Victoria C.; Polson, Andrew G.; Chang, YiMeng; Wever, Claudia; Johnson, Nathalie A.; Jiang, Yanwen; Hirata, Jamie; Sampath, Deepak; Musick, Lisa; Flowers, Christopher R.; Wertz, Ingrid E. 分享 收藏
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα Hanan, Emily J.; Braun, Marie-Gabrielle; Heald, Robert A.; MacLeod, Calum; Chan, Connie; Clausen, Saundra; Edgar, Kyle A.; Eigenbrot, Charles; Elliott, Richard; Endres, Nicholas; Friedman, Lori S.; Gogol, Emily; Gu, Xiao-Hui; Thibodeau, Rebecca Hong; Jackson, Philip S.; Kiefer, James R.; Knight, Jamie D.; Nannini, Michelle; Narukulla, Raman; Pace, Amanda; Pang, Jodie; Purkey, Hans E.; Salphati, Laurent; Sampath, Deepak; Schmidt, Stephen; Sideris, Steve; Song, Kyung; Sujatha-Bhaskar, Swathi; Ultsch, Mark; Wallweber, Heidi; Xin, Jianfeng; Yeap, SiewKuen; Young, Amy; Zhong, Yu; Staben, Steven T. 分享 收藏
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors Savill, Kristin M. Zimmerman; Lee, Brian B.; Oeh, Jason; Lin, Jie; Lin, Eva; Chung, Wei-Jen; Young, Amy; Chen, Wennie; Mis, Monika; Mesh, Kathryn; Eastham, Jeffrey; Gnad, Florian; Jiang, Zhaoshi; Stawiski, Eric W.; Haley, Benjamin; Daemen, Anneleen; Wang, Xiaojing; Koeppen, Hartmut; Modrusan, Zora; Martin, Scott E.; Sampath, Deepak; Lin, Kui 分享 收藏
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer Liang, Jun; Zbieg, Jason R.; Blake, Robert A.; Chang, Jae H.; Daly, Stephen; DiPasquale, Antonio G.; Friedman, Lori S.; Gelzleichter, Thomas; Gill, Matthew; Giltnane, Jennifer M.; Goodacre, Simon; Guan, Jane; Hartman, Steven J.; Ingalla, Ellen Rei; Kategaya, Lorn; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada S.; Lai, Tommy; Li, Jun; Liao, Jiangpeng; Liu, Zhiguo; Mody, Vidhi; McLean, Neville; Metcalfe, Ciara; Nannini, Michelle A.; Oeh, Jason; O'Rourke, Martin G.; Ortwine, Daniel F.; Ran, Yingqing; Ray, Nicholas C.; Roussel, Fabien; Sambrone, Amy; Sampath, Deepak; Schutt, Leah K.; Vinogradova, Maia; Wai, John; Wang, Tao; Wertz, Ingrid E.; White, Jonathan R.; Yeap, Siew Kuen; Young, Amy; Zhang, Birong; Zheng, Xiaoping; Zhou, Wei; Zhong, Yu; Wang, Xiaojing 分享 收藏
Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways Pham, Trang H.; Hagenbeek, Thijs J.; Lee, Ho-June; Li, Jason; Rose, Christopher M.; Lin, Eva; Yu, Mamie; Martin, Scott E.; Piskol, Robert; Lacap, Jennifer A.; Sampath, Deepak; Pham, Victoria C.; Modrusan, Zora; Lill, Jennie R.; Klijn, Christiaan; Malek, Shiva; Chang, Matthew T.; Dey, Anwesha 分享 收藏
Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade Kohlhapp, Frederick J.; Haribhai, Dipica; Mathew, Rebecca; Duggan, Ryan; Ellis, Paul A.; Wang, Rui; Lasater, Elisabeth A.; Shi, Yan; Dave, Nimita; Riehm, Jacob J.; Robinson, Valerie A.; Do, An D.; Li, Yijin; Orr, Christine J.; Sampath, Deepak; Raval, Aparna; Merchant, Mark; Bhathena, Anahita; Salem, Ahmed Hamed; Hamel, Keith M.; Leverson, Joel D.; Donawho, Cherrie; Pappano, William N.; Uziel, Tamar 分享 收藏
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER plus Breast Cancer Liang, Jun; Blake, Robert; Chang, Jae; Friedman, Lori S.; Goodacre, Simon; Hartman, Steven; Ingalla, Ellen Rei; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada; Li, Jun; Lai, Kwong Wah; Liao, Jiangpeng; Mody, Vidhi; McLean, Neville; Metcalfe, Ciara; Nannini, Michelle; Ortwine, Daniel; Ran, Yingqing; Ray, Nick; Roussel, Fabien; Sambrone, Amy; Sampath, Deepak; Vinogradova, Maia; Wai, John; Wang, Tao; Yeap, Kuen; Young, Amy; Zbieg, Jason; Zhang, Birong; Zheng, Xiaoping; Zhong, Yu; Wang, Xiaojing 分享 收藏
Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models Mali, Raghuveer Singh; Zhang, Qi; DeFilippis, Rosa Anna; Cavazos, Antonio; Kuruvilla, Vinitha Mary; Raman, Jayant; Mody, Vidhi; Choo, Edna F.; Dail, Monique; Shah, Neil P.; Konopleva, Marina; Sampath, Deepak; Lasater, Elisabeth A. 分享 收藏
Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors ipatasertib联合化疗的抗肿瘤活性: 实体瘤Ib期研究的结果 Isakoff, S. J.; Tabernero, J.; Molife, L. R.; Soria, J. -C.; Cervantes, A.; Vogelzang, N. J.; Patel, M. R.; Hussain, M.; Baron, A.; Argiles, G.; Conkling, R.; Sampath, D.; Maslyar, D.; Patel, P.; Chan, W.; Gendreau, S.; Musib, L.; Xu, N.; Ma, H.; Lin, K.; Bendell, J. 分享 收藏
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor Wang, Le; Doherty, George A.; Judd, Andrew S.; Tao, Zhi-Fu; Hansen, T. Matthew; Frey, Robin R.; Song, Xiaohong; Bruncko, Milan; Kunzer, Aaron R.; Wang, Xilu; Wendt, Michael D.; Flygare, John A.; Catron, Nathaniel D.; Judge, Russell A.; Park, Chang H.; Shekhar, Shashank; Phillips, Darren C.; Nimmer, Paul; Smith, Morey L.; Tahir, Stephen K.; Xiao, Yu; Xue, John; Zhang, Haichao; Le, Phuong N.; Mitten, Michael J.; Boghaert, Erwin R.; Gao, Wenqing; Kovar, Peter; Choo, Edna F.; Diaz, Dolores; Fairbrother, Wayne J.; Elmore, Steven W.; Sampath, Deepak; Leverson, Joel D.; Souers, Andrew James 分享 收藏
Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia Wandler, Anica M.; Huang, Benjamin J.; Craig, Jeffrey W.; Hayes, Kathryn; Yan, Hannah; Meyer, Lauren K.; Scacchetti, Alessandro; Monsalve, Gabriela; Dail, Monique; Li, Qing; Wong, Jasmine C.; Weinberg, Olga; Hasserjian, Robert P.; Kogan, Scott C.; Jonsson, Philip; Yamamoto, Keith; Sampath, Deepak; Nakitandwe, Joy; Downing, James R.; Zhang, Jinghui; Aster, Jon C.; Taylor, Barry S.; Shannon, Kevin 分享 收藏
GDC-0077 is a selective PI3K alpha inhibitor with robust efficacy in PIK3CA mutant hormone-positive breast cancer models Edgar, Kyle; Hong, Rebecca; Song, Kyung; Schmidt, Steven; Hafner, Marc; Arrazate, Alfonso; Williams, Erin; De La Cruz, Cecile; Oeh, Jason; Sampath, Deepak; Staben, Steve; Friedman, Lori 分享 收藏
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer (vol 17, pg 638, 2018) Bhakta, Sunil; Crocker, Lisa M.; Chen, Yvonne; Hazen, Meredith; Schutten, Melissa M.; Li, Dongwei; Kuijl, Coenraad; Ohri, Rachana; Zhong, Fiona; Poon, Kirsten A.; Go, Mary Ann T.; Cheng, Eric; Piskol, Robert; Firestein, Ron; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Raab, Helga; Hongo, Jo-Anne; Sampath, Deepak; Dennis, Mark S.; Scheller, Richard H.; Polakis, Paul; Junutula, Jagath R. 分享 收藏
VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models Riegler, Johannes; Gill, Herman; Ogasawara, Annie; Hedehus, Maj; Javinal, Vincent; Oeh, Jason; Feri, Gregory Z.; Marik, Jan; Williams, Simon; Sampath, Deepak; Schartner, Jill; Carano, Richard A. D. 分享 收藏
Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias Huang, Benjamin J.; Wandler, Anica M.; Meyer, Lauren K.; Dail, Monique; Daemen, Anneleen; Sampath, Deepak; Li, Qing; Wang, Xinyue; Wong, Jasmine C.; Nakitandwe, Joy; Downing, James R.; Zhang, Jinghui; Taylor, Barry S.; Shannon, Kevin 分享 收藏
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo Zoeller, Jason J.; Vagodny, Aleksandr; Taneja, Krishan; Tan, Benjamin Y.; O'Brien, Neil; Slamon, Dennis J.; Sampath, Deepak; Leverson, Joel D.; Bronson, Roderick T.; Dillon, Deborah A.; Brugge, Joan S. 分享 收藏
Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models Han, Lina; Zhang, Qi; Dail, Monique; Shi, Ce; Cavazos, Antonio; Ruvolo, Vivian R.; Zhao, Yang; Kim, Eugene; Rahmani, Mohamed; Mak, Duncan H.; Jin, Sha S.; Chen, Jun; Phillips, Darren C.; Koller, Paul Bottecelli; Jacamo, Rodrigo; Burks, Jared K.; DiNardo, Courtney; Daver, Naval; Jabbour, Elias; Wang, Jing; Kantarjian, Hagop M.; Andreeff, Michael; Grant, Steven; Leverson, Joel D.; Sampath, Deepak; Konopleva, Marina 分享 收藏
Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness MEK和BCL-2/XL联合抑制在高级别浆液性卵巢癌患者来源的异种移植模型中有效，BIM水平可预测反应性 Iavarone, Claudia; Zervantonakis, Ioannis K.; Selfors, Laura M.; Palakurthi, Sangeetha; Liu, Joyce F.; Drapkin, Ronny; Matulonis, Ursula A.; Hallbergs, Dorothy; Velculescu, Victor E.; Leverson, Joel D.; Sampath, Deepak; Mills, Gordon B.; Brugge, Joan S. 分享 收藏
GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes Metcalfe, C.; Ingalla, E.; Blake, R. A.; Chang, J.; Daemen, A.; De Bruyn, T.; Giltnane, J. M.; Guan, J.; Hafner, M.; Hartman, S.; Kategaya, L.; Kleinheinz, T.; Liang, J.; Mody, V.; Nannini, M.; Oeh, J.; Ubhayakar, S.; Wertz, I.; Young, A.; Zbieg, J.; Zhou, W.; Sampath, D.; Friedman, L. S.; Wang, X. 分享 收藏
Prospective optimization of estrogen receptor degradation yields ER ligands with variable capacities for ER transcriptional suppression Metcalfe, C.; Zhou, W.; Guan, J.; Daemen, A.; Hafner, M.; Blake, R. A.; Ingalla, E.; Young, A.; Oeh, J.; De Bruyn, T.; Ubhayakar, S.; Chen, I.; Giltnane, J. M.; Li, J.; Wang, X.; Sampath, D.; Hager, J. H.; Friedman, L. S. 分享 收藏
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