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Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter's transformation Hing, Zachary A.; Walker, Janek S.; Whipp, Ethan C.; Brinton, Lindsey; Cannon, Matthew; Zhang, Pu; Sher, Steven; Cempre, Casey B.; Brown, Fiona; Smith, Porsha L.; Agostinelli, Claudio; Pileri, Stefano A.; Skinner, Jordan N.; Williams, Katie; Phillips, Hannah; Shaffer, Jami; Beaver, Larry P.; Pan, Alexander; Shin, Kyle; Gregory, Charles T.; Ozer, Gulcin H.; Yilmaz, Selen A.; Harrington, Bonnie K.; Lehman, Amy M.; Yu, Lianbo; Coppola, Vincenzo; Yan, Pearlly; Scherle, Peggy; Wang, Min; Pitis, Philip; Xu, Chaoyi; Vaddi, Kris; Chen-Kiang, Selina; Woyach, Jennifer; Blachly, James S.; Alinari, Lapo; Yang, Yiping; Byrd, John C.; Baiocchi, Robert A.; Blaser, Bradley W.; Lapalombella, Rosa 分享 收藏
VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia Sher, Steven; Whipp, Ethan; Walker, Janek; Zhang, Pu; Beaver, Larry; Williams, Katie; Orwick, Shelley; Ravikrishnan, Janani; Walker, Brandi; Perry, Elizabeth; Gregory, Charles; Purcell, Matthew; Pan, Alexander; Yan, Pearlly; Alinari, Lapo; Johnson, Amy J.; Frigault, Melanie M.; Greer, Joy M.; Hamdy, Ahmed; Izumi, Raquel; Mo, Xiaokui; Sampath, Deepa; Woyach, Jennifer; Blachly, James; Byrd, John C.; Lapalombella, Rosa 分享 收藏
Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions Zhang, Pu; Brinton, Lindsey T.; Gharghabi, Mehdi; Sher, Steven; Williams, Katie; Cannon, Matthew; Walker, Janek S.; Canfield, Daniel; Beaver, Larry; Cempre, Casey B.; Phillips, Hannah; Chen, Xuyong; Yan, Pearlly; Lehman, Amy; Scherle, Peggy; Wang, Min; Vaddi, Kris; Baiocchi, Robert; Wang, Ruoning; Sampath, Deepa; Alinari, Lapo; Blachly, James S.; Lapalombella, Rosa 分享 收藏
A Large Cluster of New Onset Autoimmune Myositis in the Yorkshire Region Following SARS-CoV-2 Vaccination De Marco, Gabriele; Giryes, Sami; Williams, Katie; Alcorn, Nicola; Slade, Maria; Fitton, John; Nizam, Sharmin; Smithson, Gayle; Iqbal, Khizer; Tran, Gui; Pekarska, Katrina; Keen, Mansoor Ul Haq; Solaiman, Mohammad; Middleton, Edward; Wood, Samuel; Buss, Rihards; Devine, Kirsty; Marzo-Ortega, Helena; Green, Mike; McGonagle, Dennis 分享 收藏
Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia Walker, Janek S.; Hing, Zachary A.; Sher, Steven; Cronin, James; Williams, Katie; Harrington, Bonnie; Skinner, Jordan N.; Cempre, Casey B.; Gregory, Charles T.; Pan, Alexander; Yano, Max; Beaver, Larry P.; Walker, Brandi R.; Labanowska, Jadwiga M.; Heerema, Nyla A.; Mrozek, Krzysztof; Woyach, Jennifer A.; Ruppert, Amy S.; Lehman, Amy; Ozer, Hatice Gulcin; Coppola, Vincenzo; Yan, Pearlly; Byrd, John C.; Blachly, James S.; Lapalombella, Rosa 分享 收藏
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress Sharma, Pratibha; Xu, Jihong; Williams, Katie; Easley, Michelle; Elder, J. Brad; Lonser, Russell; Lang, Frederick F.; Lapalombella, Rosa; Sampath, Deepa; Puduvalli, Vinay K. 分享 收藏
Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia 复发性XPO1突变改变慢性淋巴细胞白血病的发病机制 Walker, Janek S.; Hing, Zachary A.; Harrington, Bonnie; Baumhardt, Jordan; Ozer, Hatice Gulcin; Lehman, Amy; Giacopelli, Brian; Beaver, Larry; Williams, Katie; Skinner, Jordan N.; Cempre, Casey B.; Sun, Qingxiang; Shacham, Sharon; Stromberg, Benjamin R.; Summers, Matthew K.; Abruzzo, Lynne, V; Rassenti, Laura; Kipps, Thomas J.; Parikh, Sameer; Kay, Neil E.; Rogers, Kerry A.; Woyach, Jennifer A.; Coppola, Vincenzo; Chook, Yuh Min; Oakes, Christopher; Byrd, John C.; Lapalombella, Rosa 分享 收藏
Large-Scale Drug Screen Identifies FDA-Approved Drugs for Repurposing in Sickle-Cell Disease Cannon, Matthew; Phillips, Hannah; Smith, Sidney; Williams, Katie; Brinton, Lindsey; Gregory, Charles; Landes, Kristina; Desai, Payal; Byrd, John; Lapalombella, Rosa 分享 收藏
Synthetic lethal and resistance pathways in midostaurin-treated AML Brinton, Lindsey T.; Williams, Katie; Orwick, Shelley; Beaver, Larry; Canfield, Daniel; Cempre, Casey; Skinner, Jordan; Wasmuth, Ronni; Hassan, Quais; Byrd, John C.; Lapalombella, Rosa; Blachly, James S. 分享 收藏
Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia Mitchel, Shaneice R.; Larkin, Karilyn; Grieselhuber, Nicole R.; Lai, Tzung-Huei; Cannon, Matthew; Orwick, Shelley; Sharma, Pratibha; Asemelash, Yerdanose; Zhang, Pu; Goettl, Virginia M.; Beaver, Larry; Mims, Alice; Puduvalli, Vinay K.; Blachly, James S.; Lehman, Amy; Harrington, Bonnie; Henderson, Sally; Breitbach, Justin T.; Williams, Katie E.; Dong, Shuai; Baloglu, Erkan; Senapedis, William; Kirschner, Karl; Sampath, Deepa; Lapalombella, Rosa; Byrd, John C. 分享 收藏
BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor Ozer, Hatice Gulcin; El-Gamal, Dalia; Powell, Ben; Hing, Zachary A.; Blachly, James S.; Harrington, Bonnie; Mitchell, Shaneice; Grieselhuber, Nicole R.; Williams, Katie; Lai, Tzung-Huei; Alinari, Lapo; Baiocchi, Robert A.; Brinton, Lindsey; Baskin, Elizabeth; Cannon, Matthew; Beaver, Larry; Goettl, Virginia M.; Lucas, David M.; Woyach, Jennifer A.; Sampath, Deepa; Lehmann, Amy M.; Yu, Lianbo; Zhang, Jiazhong; Ma, Yan; Zhang, Ying; Spevak, Wayne; Shi, Songyuan; Severson, Paul; Shellooe, Rafe; Carias, Heidi; Tsang, Garson; Dong, Ken; Ewing, Todd; Marimuthu, Adhirai; Tantoy, Christina; Walters, Jason; Sanftner, Laura; Rezaei, Hamid; Nespi, Marika; Matusow, Bernice; Habets, Gaston; Ibrahim, Prabha; Zhang, Chao; Mathe, Ewy A.; Bollag, Gideon; Byrd, John C.; Lapalombella, Rosa 分享 收藏
Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies Hing, Z. A.; Fung, H. Y. J.; Ranganathan, P.; Mitchell, S.; El-Gamal, D.; Woyach, J. A.; Williams, K.; Goettl, V. M.; Smith, J.; Yu, X.; Meng, X.; Sun, Q.; Cagatay, T.; Lehman, A. M.; Lucas, D. M.; Baloglu, E.; Shacham, S.; Kauffman, M. G.; Byrd, J. C.; Chook, Y. M.; Garzon, R.; Lapalombella, R. 分享 收藏
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Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia Chen, Shih-Shih; Raval, Aparna; Johnson, Amy J.; Hertlein, Erin; Liu, Te-Hui; Jin, Victor X.; Sherman, Mara H.; Liu, Shu-Jun; Dawson, David W.; Williams, Katie E.; Lanasa, Mark; Liyanarachchi, Sandya; Lin, Thomas S.; Marcucci, Guido; Pekarsky, Yuri; Davuluri, Ramana; Croce, Carlo M.; Guttridge, Denis C.; Teitell, Michael A.; Byrd, John C.; Plass, Christoph 分享 收藏
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