Luigi Grasso - Publications, H-index & Citations

Luigi Grasso

eisai co ltd

28H指数

120论文数

2.7K被引数

收录论文 44

发表时间

ICAM-1 Is Overexpressed by Cancers and Negatively Impacts Antibody-Based Therapies Including Antibody-Drug Conjugates ICAM-1在癌症中过度表达，并负向影响包括抗体药物偶联物在内的抗体疗法

EUROPEAN JOURNAL OF IMMUNOLOGY

IF3.7

2025-03-20

PREAI

Kline, J. Bradford; Grasso, Luigi; Nicolaides, Nicholas C.

NAV-201, an orally bioavailable small molecule NK cell activator enhancing antibody-mediated cancer therapies

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Nicolaides, Nicholas C.; Grasso, Luigi; Kline, J. Brad

NAV-006: A next-generation rituximab targeting CD20 for the treatment of B-cell lymphomas immunosuppressed by MUC16/CA125

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Grasso, Luigi; Kline, J. Bradford; Nicolaides, Nicholas C.

Engineering of ICAM-1 refractory antibodies for the development of therapeutic antibodies and antibody drug conjugates (ADCs) in ICAM-1 over-expressing cancers

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Kline, Brad; Grasso, Luigi; Nicolaides, Nicolas

NAV-001, a high-efficacy antibody-drug conjugate targeting mesothelin with improved delivery of potent payload by counteracting MUC16/CA125 effects

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Grasso, Luigi; Kline, J. Bradford; Nicolaides, Nicholas C.

NAV-003, a full-length IgG1 bispecific antibody targeting a unique mesothelin epitope and CD3 to improve cytotoxicity against humoral immunosuppressed tumors

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Grasso, Luigi; Jiang, Qun; Hassan, Raffit; Nicolaides, Nicholas C.; Kline, J. Bradford

Gene expression analysis of tumor spheroids reveals a role for suppressed DNA mismatch repair in multicellular resistance to alkylating agents

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Francia, G; Man, S; Teicher, B; Grasso, L; Kerbel, RS

Synergistic effect of carboplatin on farletuzumab (FAR) tumor cell killing via downregulation of the humoral immunosuppressive CA125 protein and enhanced antibody dependent cellular cytotoxicity (ADCC)

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Kline, J. Bradford; Furuuchi, Keiji; Fulmer, James; McDonough, Jennifer; Grasso, Luigi; Nicolaides, Nicholas C.

IORT and stray radiation: comparison of 2 commercial linacs

RADIOTHERAPY AND ONCOLOGY

IF5.3

2019-04-01

OAAI

Stevens, P.; Van Hoof, F.; Holvoet, M.; Messens, E.; Grasso, L.; De Stefano, S.; Felici, G.; Verellen, D.

MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-12-03

OAAI

Cheng, Xin; Li, Jing; Tanaka, Keigo; Majumder, Utpal; Milinichik, Andrew Z.; Verdi, Arielle C.; Maddage, Christopher J.; Rybinski, Katherine A.; Fernando, Shawn; Fernando, Danielle; Kuc, Megan; Furuuchi, Keiji; Fang, Frank; Uenaka, Toshimitsu; Grasso, Luigi; Albone, Earl F.

Farletuzumab, a monoclonal antibody directed against folate receptor alpha, shows no evidence of teratogenicity in cynomolgus monkeys

REPRODUCTIVE TOXICOLOGY

IF2.8

2018-08-01

PREAI

Moriyama, Tomoyuki; Kakiuchi, Dai; Grasso, Luigi; Hutto, David L.; Fernando, Danielle; Schweizer, Charles

MORAb-202, a folate receptor-alpha (FRA)-targeting antibody-eribulin drug conjugate (ADC), exhibits durable antitumor activity and payload-mediated bystander effects on the tumor microenvironment in triple-negative breast cancer

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Furuuchi, Keiji; Cheng, Xin; Rybinski, Katherine; Moriyama, Tomoyuki; Fulmer, James; Maddage, Chris; Milinichik, Andrew; Tanaka, Keigo; Lai, George; Dula, Mary Lou; Fernando, Danielle; Grasso, Luigi; Albone, Earl; Uenaka, Toshimitsu

CA125 suppresses amatuximab immune-effector function and elevated serum levels are associated with reduced clinical response in first line mesothelioma patients

CANCER BIOLOGY & THERAPY

IF4.6

2018-04-25

OAAI

Nicolaides, Nicholas C.; Schweizer, Charles; Somers, Elizabeth B.; Wang, Wenquan; Fernando, Shawn; Ross, Erin N.; Grasso, Luigi; Hassan, Raffit; Kline, J. Bradford

MORAb-202: a folate receptor alpha (FRA)-targeting antibody-drug conjugate, exhibiting targeted antitumor activity and bystander elimination of cancer-associated fibroblasts

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-01-01

PREAI

Rybinski, Katherine A.; Maddage, Christopher; Cheng, Xin; Albone, Earl; Grasso, Luigi; Furuuchi, Keiji; Uenaka, Toshimitsu

Use of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Finnberg, Niklas K.; Gokare, Prashanth; Lev, Avital; MacFarlane, Alexander W.; Campbell, Kerry S.; Kaputa, Karen; Farma, Jeffrey; Grasso, Luigi; Nicolaides, Nicholas C.; El-Deiry, Wafik

RESPECT (REsidue-SPEcific Conjugation Technology): A platform technology utilizing native cysteine and lysine residues for the generation of homogeneous antibody-drug conjugates

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Albone, Earl; Spidel, Jared; Cheng, Xin; Park, Young Chul; Jacob, Sara; Verdi, Arielle; Milinichik, Andrew; Vaessen, Ben; Kline, J. Bradford; Grasso, Luigi

Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer

GENOMICS

IF3

2017-07-01

PREAI

O'Shannessy, Daniel J.; Bendas, Katie; Schweizer, Charles; Wang, Wenquan; Albone, Earl; Somers, Elizabeth B.; Weil, Susan; Meredith, Rhonda K.; Wustner, Jason; Grasso, Luigi; Landers, Mark; Nicolaides, Nicholas C.

CA125/MUC16 suppresses antibody-dependent cellular cytotoxicity of IgG1-based therapies via perturbation of antibody Fc-Receptor engagement on immune effector cells

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Kline, J. Bradford; Kennedy, Rina; Fernando, Shawn; McDonough, Jennifer; Albone, Earl; Somers, Elizabeth B.; Wang, Wenquan; Schweizer, Charles; Grasso, Luigi; Nicolaides, Nicholas C.

Engineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins

MABS

IF7.3

2017-05-25

OAAI

Spidel, Jared L.; Albone, Earl F.; Cheng, Xin; Vaessen, Benjamin; Jacob, Sara; Milinichik, Andrew Z.; Verdi, Arielle; Kline, J. Bradford; Grasso, Luigi

Multicenter validation of ion chambers in reference dosimetry of two IORT-dedicated electron linacs

RADIOTHERAPY AND ONCOLOGY

IF5.3

2017-05-01

OAAI

Scalchi, P.; Felici, G.; Ciccotelli, A.; Petrucci, A.; Piazzi, V.; Romeo, N.; Pentiricci, A.; Cavagnetto, F.; Andreoli, S.; Cattani, F.; Fabbri, S.; de Fatis, P. Tabarelli; Romagnoli, R.; Soriani, A.; Augelli, B.; Paolucci, M.; D'Avenia, P.; Bertolini, M.; Massafra, R.; Moretti, E.; De Stefano, S.; Grasso, L.; Baiocchi, C.; Francescon, P.

研究方向