Andrew C. Good - Publications, H-index & Citations

Andrew C. Good

c4 therapeutics, inc., 490 arsenal way, suite 120, watertown, massachusetts 02472, united states

29H指数

85论文数

3.1K被引数

收录论文 28

发表时间

Discovery of CFT8634; a Potent; Selective; and Orally Bioavailable Heterobifunctional Degrader of BRD9 CFT8634的发现；一种强效、选择性且口服生物利用的异双功能BRD9降解剂

Journal of Medicinal Chemistry

IF6.8

2025-11-24

PREAI

Katrina L. Jackson; Ning Yin; Roman V. Agafonov; Prasoon Chaturvedi; Kyle Cole; Scott J. Eron; Andrew C. Good; June A. Hart; Minsheng He; Christina S. Henderson; Hongwei Huang; R. Jason Kirby; Linda Lee; Moses Moustakim; Christopher G. Nasveschuk; Andrew J. Phillips; Roy M. Pollock; Laura L. Poling; Gesine K. Veits; Jeremy Yap; Rhamy Zeid; Amro Ali; Adam S. Crystal; Eunju Hurh; Huan Liu; Riadh Lobbardi; Leonard Reyno; Stewart L. Fisher

Discovery of an orally bioavailable; CNS active pan-mutant RET kinase heterobifunctional degrader 口服生物利用型、具有中枢神经系统活性的泛突变RET激酶杂双功能降解剂的发现

RSC Med. Chem.

IF3.6

2025-08-14

PREAI

Douglas L. Orsi; Kiel E. Lazarski ‡; Reina Improgo §; R. V. Agafonov; Jae Young Ahn ¶; Joelle Baddour §; Katelyn Cassidy; Prasoon Chaturvedi; Kyle S. Cole ||; Richard W. Deibler ¶; W. Austin Elam **; Mark E. Fitzgerald ††; Victoria J. Garza ‡‡; Andrew Good §§; Christopher H. Hulton ¶¶; Marta Isasa ||||; Katrina L. Jackson; Ping Li; Yanke Liang ***; Ryan E. Michael; Morgan Welzel O'Shea †††; Moses Moustakim ¶; Samantha Perino ‡‡‡; Fazlur Rahman §§§; Matthew J. Schnaderbeck ¶¶¶; Nicholas P. Stone ||||||; Bonnie Tillotson; Gesine K. Veits ****; Abigail Vogelaar; Jeremy L. Yap ††††; Robert T. Yu ‡‡‡‡; Hongwei Huang ****; James A. Henderson

Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-11-04

OAAI

Vu, Binh T.; Dominique, Romyr; Fahr, Bruce J.; Li, Hongju H.; Fry, David C.; Xu, Lizhong; Yang, Hong; Puzio-Kuter, Anna; Good, Andrew; Liu, Binbin; Huang, Kuo-Sen; Tanaka, Naoko; Davis, Thomas W.; Dumble, Melissa L.

The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Liang, Yanke; Sowa, Mathew E.; Jackson, Katrina L.; Simard, Jeffrey R.; Kreger, Bridget; Li, Ping; Poling, Laura; Baddour, Joelle; Good, Andrew; Huang, Hongwei; Eron, Scott; Nasveschuk, Christopher G.; Yu, Robert; Fitzgerald, Mark; Garza, Victoria; O'Shea, Morgan W.; Veits, Gesine; Yap, Jeremy Y.; Moustakim, Moses; Hart, Ashley; Agafonov, Roman V.; Sarkissian, Grace; Patel, Joe S.; Deibler, Richard; Cole, Kyle S.; Cocozziello, David; Rahman, Fazlur; Phillips, Andrew J.; Norton, Elizabeth; Crystal, Adam S.; Pollock, Roy M.; Fisher, Stewart L.

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-08-05

PREAI

Taylor, Alexander M.; Bailey, Chris; Belmont, Lisa D.; Campbell, Robert; Cantone, Nico; Cote, Alexandre; Crawford, Terry D.; Cummings, Richard; DeMent, Kevin; Duplessis, Martin; Flynn, Megan; Good, Andrew C.; Huang, Hon-Ren; Joshi, Shivangi; Leblanc, Yves; Murray, Jeremy; Nasveschuk, Christopher G.; Neiss, Adrianne; Poy, Florence; Romero, F. Anthony; Sandy, Peter; Tang, Yong; Tsui, Vickie; Zawadzke, Laura; Sims, Robert J., III; Audia, James E.; Bellon, Steven F.; Magnuson, Steven R.; Albrecht, Brian K.; Cochran, Andrea G.

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

ACS CHEMICAL BIOLOGY

IF3.8

2021-09-28

OAAI

Eron, Scott J.; Huang, Hongwei; Agafonov, Roman, V; Fitzgerald, Mark E.; Patel, Joe; Michael, Ryan E.; Lee, Tobie D.; Hart, Ashley A.; Shaulsky, Jodi; Nasveschuk, Christopher G.; Phillips, Andrew J.; Fisher, Stewart L.; Good, Andrew

Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-05-06

OAAI

Gehling, Victor S.; Mcgrath, John P.; Duplessis, Martin; Khanna, Avinash; Brucelle, Francois; Vaswani, Rishi G.; Cote, Alexandre; Stuckey, Jacob; Watson, Venita; Cummings, Richard T.; Balasubramanian, Srividya; Iyer, Priya; Sawant, Priyanka; Good, Andrew C.; Albrecht, Brian K.; Harmange, Jean-Christophe; Audia, James E.; Bellon, Steven F.; Trojer, Patrick; Levell, Julian R.

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-03-27

PREAI

de Araujo, Aline D.; Lim, Junxian; Wu, Kai-Chen; Xiang, Yibin; Good, Andrew C.; Skerlj, Renato; Fairlie, David P.

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor 丙型肝炎病毒NS3蛋白酶的有效抑制剂: 使用二氟甲基作为氢键供体

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-01-24

OAAI

Zheng, Barbara; D'Andrea, Stanley V.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Yan; Hrnciar, Peter; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Yu, Fei; Sheaffer, Amy K.; Knipe, Jay O.; Mosure, Kathy; Rajamani, Ramkumar; Good, Andrew C.; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Paruchuri, Manjula; Ng, Alicia; Gao, Qi; Rampulla, Richard A.; Mathur, Arvind; Meanwell, Nicholas A.; McPhee, Fiona; Scola, Paul M.

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2016-11-17

OAAI

de Araujo, Aline Dantas; Lim, Junxian; Good, Andrew C.; Skerlj, Renato T.; Fairlie, David P.

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-10-28

186

OAAI

Vaswani, Rishi G.; Gehling, Victor S.; Dakin, Les A.; Cook, Andrew S.; Nasveschuk, Christopher G.; Duplessis, Martin; Iyer, Priyadarshini; Balasubramanian, Srividya; Zhao, Feng; Good, Andrew C.; Campbell, Robert; Lee, Christina; Cantone, Nico; Cummings, Richard T.; Normant, Emmanuel; Bellon, Steven F.; Albrecht, Brian K.; Harmange, Jean-Christophe; Trojer, Patrick; Audia, James E.; Zhang, Ying; Justin, Neil; Chen, Shuyang; Wilson, Jon R.; Gamblin, Steven J.

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-05-31

OAAI

Crawford, Terry D.; Tsui, Vickie; Flynn, E. Megan; Wang, Shumei; Taylor, Alexander M.; Cote, Alexandre; Audia, James E.; Beresini, Maureen H.; Burdick, Daniel J.; Cummings, Richard; Dakin, Les A.; Duplessis, Martin; Good, Andrew C.; Hewitt, Michael C.; Huang, Hon-Ren; Jayaram, Hariharan; Kiefer, James R.; Jiang, Ying; Murray, Jeremy; Nasveschuk, Christopher G.; Pardo, Eneida; Poy, Florence; Romero, F. Anthony; Tang, Yong; Wang, Jian; Xu, Zhaowu; Zawadzke, Laura E.; Zhu, Xiaoyu; Albrecht, Brian K.; Magnuson, Steven R.; Bellon, Steve; Cochran, Andrea G.

The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-03-05

PREAI

Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona

Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-02-20

120

PREAI

Scola, Paul M.; Wang, Alan Xiangdong; Good, Andrew C.; Sun, Li-Qiang; Combrink, Keith D.; Campbell, Jeffrey A.; Chen, Jie; Tu, Yong; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley; Zheng, Barbara; Hewawasam, Piyasena; Ding, Min; Thuring, Jan; Li, Jianqing; Hernandez, Dennis; Yu, Fei; Falk, Paul; Zhai, Guangzhi; Sheaffer, Amy K.; Chen, Chaoqun; Lee, Min S.; Barry, Diana; Knipe, Jay O.; Li, Wenying; Han, Yong-Hae; Jenkins, Susan; Gesenberg, Christoph; Gao, Qi; Sinz, Michael W.; Santone, Kenneth S.; Zvyaga, Tatyana; Rajamani, Ramkumar; Klei, Herbert E.; Colonno, Richard J.; Grasela, Dennis M.; Hughes, Eric; Chien, Caly; Adams, Stephen; Levesque, Paul C.; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-01-17

PREAI

Belema, Makonen; Nguyen, Van N.; Romine, Jeffrey L.; St Laurent, Denis R.; Lopez, Omar D.; Goodrich, Jason T.; Nower, Peter T.; O'Boyle, Donald R., II; Lemm, Julie A.; Fridell, Robert A.; Gao, Min; Fang, Hua; Krause, Rudolph G.; Wang, Ying-Kai; Oliver, A. Jayne; Good, Andrew C.; Knipe, Jay O.; Meanwell, Nicholas A.; Snyder, Lawrence B.

Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-10-02

PREAI

Gerritz, Samuel W.; Zhai, Weixu; Shi, Shuhao; Zhu, Shirong; Toyn, Jeremy H.; Meredith, Jere E., Jr.; Iben, Lawrence G.; Burton, Catherine R.; Albright, Charles F.; Good, Andrew C.; Tebben, Andrew J.; Muckelbauer, Jodi K.; Camac, Daniel M.; Metzler, William; Cook, Lynda S.; Padmanabha, Ramesh; Lentz, Kimberley A.; Sofia, Michael J.; Poss, Michael A.; Macor, John E.; Thompson, Lorin A., III

Implications of Promiscuous Pim-1 Kinase Fragment Inhibitor Hydrophobic Interactions for Fragment-Based Drug Design

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-03-05

PREAI

Good, Andrew C.; Liu, Jinyu; Hirth, Bradford; Asmussen, Gary; Xiang, Yibin; Biemann, Hans-Peter; Bishop, Kimberly A.; Frerngen, Trisha; Fitzgerald, Maria; Gladysheva, Tatiana; Jain, Annuradha; Jancsics, Katherine; Metz, Markus; Papoulis, Andrew; Skerlj, Renato; Stepp, J. David; Wei, Ronnie R.

Molecular Shape and Medicinal Chemistry: A Perspective

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-05-27

281

OAAI

Nicholls, Anthony; McGaughey, Georgia B.; Sheridan, Robert P.; Good, Andrew C.; Warren, Gregory; Mathieu, Magali; Muchmore, Steven W.; Brown, Scott P.; Grant, J. Andrew; Haigh, James A.; Nevins, Neysa; Jain, Ajay N.; Kelley, Brian

Optimization of CAMD techniques 3. Virtual screening enrichment studies: a help or hindrance in tool selection?

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2008-01-09

168

PREAI

Good, Andrew C.; Oprea, Tudor I.

Measuring CAMD technique performance. 2. How druglike are drugs? Implications of random test set selection exemplified using druglikeness classification models

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2006-12-06

PREAI

Good, Andrew C.; Hermsmeier, Mark A.

研究方向