Discovery and Optimization of Thienopyrazine RNA-Splicing Modulators for the Treatment of Huntington’s Disease发现和优化噻吩吡嗪类RNA剪接调节剂以治疗亨廷顿病Journal of Medicinal ChemistryIF6.82026-03-170PRE
Discovery of BIO-8169-A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of NeuroinflammationJOURNAL OF MEDICINAL CHEMISTRYIF6.82024-05-022PRE
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 InhibitorsACS MEDICINAL CHEMISTRY LETTERSIF42024-04-262PRE
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic StrokeJOURNAL OF MEDICINAL CHEMISTRYIF6.82024-03-129PRE
Cxcl10 Chemokine Induces Migration of ING4-Deficient Breast Cancer Cells via a Novel Cross Talk Mechanism between the Cxcr3 and Egfr ReceptorsMOLECULAR AND CELLULAR BIOLOGYIF2.72023-02-2714OA
Discovery of Phospholipase D Inhibitors with Improved Drug-likeProperties and Central Nervous System PenetranceACS MEDICINAL CHEMISTRY LETTERSIF42022-03-035OA
Proteomic Characterization of the Dynamics of Ischemic Stroke in MiceJOURNAL OF PROTEOME RESEARCHIF3.62021-06-0413OAAI
Human PLD structures enable drug design and characterization of isoenzyme selectivityNATURE CHEMICAL BIOLOGYIF13.72020-02-1027PREAI
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic LiabilitiesJOURNAL OF MEDICINAL CHEMISTRYIF6.82017-04-2047PREAI
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo ActivityJOURNAL OF MEDICINAL CHEMISTRYIF6.82017-04-2057PREAI
Sulfonamides as Selective Nav1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement (vol 7, pg 1062, 2016)ACS MEDICINAL CHEMISTRY LETTERSIF42017-02-280OAAI
Sulfonamides as Selective Nav1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target EngagementACS MEDICINAL CHEMISTRY LETTERSIF42016-09-2839OAAI
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor ActivityJOURNAL OF MEDICINAL CHEMISTRYIF6.82016-02-1131PREAI
Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors (vol 58, pg 2417, 2015)JOURNAL OF MEDICINAL CHEMISTRYIF6.82015-04-220OAAI
Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met InhibitorsJOURNAL OF MEDICINAL CHEMISTRYIF6.82015-03-0332PREAI
Sustainable Practices in Medicinal Chemistry: Current State and Future DirectionsJOURNAL OF MEDICINAL CHEMISTRYIF6.82013-05-09186PREAI
A convenient guide to help select replacement solvents for dichloromethane in chromatographyGREEN CHEMISTRYIF9.22012-01-0181PRE
Plastic Surgeon Compliance with National Safety Initiatives: Clinical Outcomes and Never EventsPLASTIC AND RECONSTRUCTIVE SURGERYIF3.42010-08-0125PREAI
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