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P

Philippe N. Bolduc

biogen inc
H指数:10
被引数:820

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Discovery and Optimization of Thienopyrazine RNA-Splicing Modulators for the Treatment of Huntington’s Disease

发现和优化噻吩吡嗪类RNA剪接调节剂以治疗亨廷顿病

Journal of Medicinal Chemistry
IF6.8
2026-03-170
PRE
Chaofan Xu; Neeta Abraham; Nupur Bansal; Philippe N. Bolduc; Patrick Cullen; Thomas M. Carlile; Yirui Chen; Colin K. Choi; Rachelle Driscoll; Eric Stefan; Christina M. Gallo; Zhen Gao; Catherine L. Guardado; Guilherme Guimaraes; James Harvey; Sarah Huff; Dann Huh; Jessica Hurt; Melissa M. Kemp; Kwang Soo Lee; Joon Lee; Mukesh Lulla; Soumya Negi; Marta Nevalainen; Emily A. Peterson; Thomas J. Purgett; Joseph C. Santoro; Daniel R. Smith; Andreas Weihofen; Zain Yousaf; Magnus Pfaffenbach
Triply convergent Ni-electrocatalytic assembly of 1,1-diaryl cyclobutanes, azetidines and oxetanes

三重汇聚的Ni电催化组装1,1-二芳基环丁烷、氮杂环丁烷和氧杂环丁烷

Nature Chemistry
IF20.2
2025-11-110
PRE
Luca Massaro; Philipp Neigenfind; Andrew Feng; Gannon Kuehn; Flynn C. Attard; Ava DeSanti; Michael R. Collins; Martin Bravo; Raymond K. Twumasi; Doris Chen; Philippe N. Bolduc; Michael Nicastri; Megan A. Emmanuel; Martins S. Oderinde; Maximilian D. Palkowitz; Xiaofan Zheng; Arianne C. Hunter; Kaid C. Harper; Chet C. Tyrol; Pavel K. Mykhailiuk; Yu Kawamata; Phil S. Baran
Accelerating Medicinal Chemistry: A C(sp3)-Rich Fragment Toolbox for Redox-Neutral Cross-Coupling

加速药物化学: 用于氧化还原中性交叉耦合的富含C(sp3) 的片段工具箱

Angewandte Chemie International Edition
IF16.9
2025-11-100
PRE
Dr. Jet Tsien; Dr. Áron Péter; Dr. Xin Zeng; Dr. Shuanghu Wang; Dr. Baiyang Jiang; Dr. Megan A. Emmanuel; Dr. Martins S. Oderinde; Dr. Philippe N. Bolduc; Dr. Michael C. Nicastri; Shalini Dey; Dr. Michael R. Collins; Dr. Johnny W. Lee; Martin Bravo; Dr. Paul F. Richardson; Neal W. Sach; Louise Bernier; Dr. Maximilian D. Palkowitz; Dr. Jennifer X. Qiao; Prof. Yu Kawamata; Prof. Phil S. Baran
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-03-129
PRE
Evans, Ryan; Bolduc, Philippe N.; Pfaffenbach, Magnus; Gao, Fang; May-Dracka, Tricia; Fang, Terry; Hopkins, Brian T.; Chodaparambil, Jayanth, V; Henry, Kate L.; Li, Pei; Metrick, Claire; Nelson, Ashley; Trapa, Patrick; Thomas, Ankur; Burkly, Linda; Peterson, Emily A.
Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers

镍-电催化脱羧芳基化以进入四元中心

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-01-187
PRE
Laudadio, Gabriele; Neigenfind, Philipp; Peter, Aron; Rubel, Camille Z.; Emmanuel, Megan A.; Oderinde, Martins S.; Ewing, Tamara El-Hayek; Palkowitz, Maximilian D.; Sloane, Jack L.; Gillman, Kevin W.; Ridge, Daniel; Mandler, Michael D.; Bolduc, Philippe N.; Nicastri, Michael C.; Zhang, Benxiang; Clementson, Sebastian; Petersen, Nadia Nasser; Martin-Gago, Pablo; Mykhailiuk, Pavel; Engle, Keary M.; Baran, Phil S.
Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling
Nature
IF48.5
2023-10-030
PRE
Benxiang Zhang; Jiayan He; Yang Gao; Laura Levy; Martins S. Oderinde; Maximilian D. Palkowitz; T. G. Murali Dhar; Michael D. Mandler; Michael R. Collins; Daniel C. Schmitt; Philippe N. Bolduc; TeYu Chen; Sebastian Clementson; Nadia Nasser Petersen; Gabriele Laudadio; Cheng Bi; Yu Kawamata; Phil S. Baran
Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2022-09-1573
OA
Palkowitz, Maximilian D.; Laudadio, Gabriele; Kolb, Simon; Choi, Jin; Oderinde, Martins S.; Ewing, Tamara El-Hayek; Bolduc, Philippe N.; Chen, TeYu; Zhang, Hao; Cheng, Peter T. W.; Zhang, Benxiang; Mandler, Michael D.; Blasczak, Vanna D.; Richter, Jeremy M.; Collins, Michael R.; Schioldager, Ryan L.; Bravo, Martin; Dhar, T. G. Murali; Vokits, Benjamin; Zhu, Yeheng; Echeverria, Pierre-Georges; Poss, Michael A.; Shaw, Scott A.; Clementson, Sebastian; Petersen, Nadia Nasser; Mykhailiuk, Pavel K.; Baran, Phil S.
A small-molecule inhibitor of C5 complement protein
NATURE CHEMICAL BIOLOGY
IF13.7
2019-06-1714
PREAI
Jendza, Keith; Kato, Mitsunori; Salcius, Michael; Srinivas, Honnappa; De Erkenez, Andrea; Nguyen, Anh; McLaughlin, Doug; Be, Celine; Wiesmann, Christian; Murphy, Jason; Bolduc, Philippe; Mogi, Muneto; Duca, Jose; Namil, Abdel; Capparelli, Michael; Darsigny, Veronique; Meredith, Erik; Tichkule, Ritesh; Ferrara, Luciana; Heyder, Jessica; Liu, Fang; Horton, Patricia A.; Romanowski, Michael J.; Schirle, Markus; Mainolfi, Nello; Anderson, Karen; Michaud, Gregory A.
The Discovery of (S)-1-(6-(34(4-(1-(Cyclopropanecarbonyl)piperidin-4-y1)-2-methylphenypamino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-03-029
PREAI
Ehara, Takeru; Adams, Christopher M.; Bevan, Doug; Ji, Nan; Meredith, Erik L.; Belanger, David B.; Powers, James; Kato, Mitsunori; Solovay, Catherine; Liu, Donglei; Capparelli, Michael; Bolduc, Philippe; Grob, Jonathan E.; Daniels, Matthew H.; Ferrara, Luciana; Yang, Louis; Li, Byron; Towler, Christopher S.; Stacy, Rebecca C.; Prasanna, Ganesh; Mogi, Muneto

研究方向

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P
Phil S. Baran
H 指数:127论文数:1,065被引数:5.8万
M
Maximilian D. Palkowitz
H 指数:13论文数:53被引数:1,590
M
Michael C. Nicastri
H 指数:14论文数:58被引数:1,698
Y
Yu Kawamata
H 指数:32论文数:176被引数:9,907
M
Martins S. Oderinde
H 指数:27论文数:117被引数:3,062
G
Gabriele Laudadio
H 指数:25论文数:78被引数:3,553
M
Magnus Pfaffenbach
H 指数:4论文数:6被引数:45
M
Michael R. Collins
H 指数:30论文数:108被引数:6,192
E
Emily A. Peterson
H 指数:23论文数:67被引数:2,404
M
Megan A. Emmanuel
H 指数:12论文数:38被引数:1,280