David M. MacAlpine - Publications, H-index & Citations

David M. MacAlpine

duke university

41H指数

92论文数

9.9K被引数

收录论文 45

发表时间

Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation 牟永, K.; 李, Y.; 麦克阿尔平, H.K.; 哈特曼, A.J.; 麦克阿尔平, D.M. 全基因组核小体和转录因子对遗传扰动的响应揭示了染色质介导的转录调控机制. 基因组研究. 2026, 36, 115–128. [Google Scholar] [CrossRef] [PubMed]

Genome Research

IF5.5

2026-01-01

PREAI

Moyung, Kevin; Li, Yulong; MacAlpine, Heather K.; Hartemink, Alexander J.; MacAlpine, David M.

DNA mutagenesis driven by transcription factor competition with mismatch repair 由转录因子竞争与错配修复驱动的DNA诱变作用

Cell

IF42.5

2025-07-29

PREAI

Wei Zhu; Yuning Zhang; Harshit Sahay; Hana Wasserman; Ariel Afek; Jonathan Williams; Samantha Shaltz; Caitlin Johnson; Kyle Pinheiro; David M. MacAlpine; Keith R. Weninger; Dorothy A. Erie; Sue Jinks-Robertson; Raluca Gordân

Spt6-Spn1 interaction is required for RNA polymerase II association and precise nucleosome positioning along transcribed genes Spt6-Spn1相互作用对于RNA聚合酶II的结合以及转录基因上精确核小体定位是必需的。

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2025-05-01

OAAI

Chen, Boning; Dronamraju, Raghuvar; Smith-Kinnaman, Whitney R.; Justice, Sarah A. Peck; Hepperla, Austin J.; Macalpine, Heather K.; Simon, Jeremy M.; Mosley, Amber L.; MacAlpine, David M.; Strahl, Brian D.

Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase

GENOME RESEARCH

IF5.5

2023-12-11

OAAI

Chen, Boning; MacAlpine, Heather K.; Hartemink, Alexander J.; MacAlpine, David M.

Developmental regulation of DNA replication: Replication fork barriers and programmed gene amplification in Tetrahymena thermophila

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

OAAI

Zhang, Z; MacAlpine, DM; Kapler, GM

Type I elements mediate replication fork pausing at conserved upstream sites in the Tetrahymena thermophila ribosomal DNA minichromosome

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

OAAI

MacAlpine, DM; Zhang, Z; Kapler, GM

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Tsai, Feng-Ling; Vijayraghavan, Sriram; Prinz, Joseph; MacAlpine, Heather K.; MacAlpine, David M.; Schwacha, Anthony

Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-17

OAAI

Feng, Jianxun; Gan, Haiyun; Eaton, Matthew L.; Zhou, Hui; Li, Shuqi; Belsky, Jason A.; MacAlpine, David M.; Zhang, Zhiguo; Li, Qing

RoboCOP: jointly computing chromatin occupancy profiles for numerous factors from chromatin accessibility data

NUCLEIC ACIDS RESEARCH

IF13.1

2021-07-13

OAAI

Mitra, Sneha; Zhong, Jianling; Tran, Trung Q.; MacAlpine, David M.; Hartemink, Alexander J.

Stochastic initiation of DNA replication across the human genome

MOLECULAR CELL

IF16.6

2021-07-01

OAAI

MacAlpine, David M.

Linking the dynamics of chromatin occupancy and transcription with predictive models

GENOME RESEARCH

IF5.5

2021-04-23

OAAI

Tran, Trung Q.; MacAlpine, Heather K.; Tripuraneni, Vinay; Mitra, Sneha; MacAlpine, David M.; Hartemink, Alexander J.

Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication

GENOME RESEARCH

IF5.5

2021-04-02

OAAI

Tripuraneni, Vinay; Memisoglu, Gonen; MacAlpine, Heather K.; Tran, Trung Q.; Zhu, Wei; Hartemink, Alexander J.; Haber, James E.; MacAlpine, David M.

Capturing the primordial Kras mutation initiating urethane carcinogenesis

NATURE COMMUNICATIONS

IF15.7

2020-04-14

OAAI

Li, Siqi; MacAlpine, David M.; Counter, Christopher M.

Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork

GENOME RESEARCH

IF5.5

2019-06-19

OAAI

Gutierrez, Monica P.; MacAlpine, Heather K.; MacAlpine, David M.

Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats

PLOS GENETICS

IF3.7

2019-05-13

OAAI

Foss, Eric J.; Gatbonton-Schwager, Tonibelle; Thiesen, Adam H.; Taylor, Erin; Soriano, Rafael; Lao, Uyen; MacAlpine, David M.; Bedalov, Antonio

DNA copy number evolution in Drosophila cell lines (vol 15, R70, 2014)

GENOME BIOLOGY

IF9.4

2019-03-11

OAAI

Lee, Hangnoh; McManus, C. Joel; Cho, Dong-Yeon; Eaton, Matthew; Renda, Fioranna; Somma, Maria Patrizia; Cherbas, Lucy; May, Gemma; Powell, Sara; Zhang, Dayu; Zhan, Lijun; Resch, Alissa; Andrews, Justen; Celniker, Susan E.; Cherbas, Peter; Przytycka, Teresa M.; Gatti, Maurizio; Oliver, Brian; Graveley, Brenton; MacAlpine, David

Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila

GENOME RESEARCH

IF5.5

2018-10-02

OAAI

Armstrong, Robin L.; Penke, Taylor J. R.; Strahl, Brian D.; Matera, A. Gregory; McKay, Daniel J.; MacAlpine, David M.; Duronio, Robert J.

Nucleosomes influence multiple steps during replication initiation

ELIFE

IF0

2017-03-21

OAAI

Azmi, Ishara F.; Watanabe, Shinya; Maloney, Michael F.; Kang, Sukhyun; Belsky, Jason A.; MacAlpine, David M.; Peterson, Craig L.; Bell, Stephen P.

Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization

NUCLEIC ACIDS RESEARCH

IF13.1

2016-12-06

OAAI

Wang, Yating; Khan, Abid; Marks, Anna B.; Smith, Owen K.; Giri, Sumanprava; Lin, Yo-Chuen; Creager, Rachel; MacAlpine, David M.; Prasanth, Kannanganattu V.; Aladjem, Mirit I.; Prasanth, Supriya G.

ORChestrating the human DNA replication program

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-08-05

OAAI

MacAlpine, David M.

研究方向