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Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases Blomgren, Peter; Chandrasekhar, Jayaraman; Di Paolo, Julie A.; Fung, Wanchi; Geng, Guoju; Ip, Carmen; Jones, Randall; Kropf, Jeffrey E.; Lansdon, Eric B.; Lee, Seung; Lo, Jennifer R.; Mitchell, Scott A.; Murray, Bernard; Pohlmeyer, Chris; Schmitt, Aaron; Suekawa-Pirrone, Kimberly; Wise, Sarah; Xiong, Jin-Ming; Xu, Jianjun; Yu, Helen; Zhao, Zhongdong; Currie, Kevin S. 分享 收藏
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Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties 发现具有改善的药物样特性的布鲁顿酪氨酸激酶的有效和选择性三环抑制剂 Wang, Xiaojing; Barbosa, James; Blomgren, Peter; Bremer, Meire C.; Chen, Jacob; Crawford, James J.; Deng, Wei; Dong, Liming; Eigenbrot, Charles; Gallion, Steve; Hau, Jonathon; Hu, Huiyong; Johnson, Adam R.; Katewa, Arna; Kropf, Jeffrey E.; Lee, Seung H.; Liu, Lichuan; Lubach, Joseph W.; Macaluso, Jen; Maciejewski, Pat; Mitchell, Scott A.; Ortwine, Daniel F.; DiPaolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Zhao, Zhongdong; Zhou, Fusheng; Currie, Kevin S.; Young, Wendy B. 分享 收藏
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PRECLINICAL CHARACTERIZATION OF GS-9876, A NOVEL, ORAL SYK INHIBITOR THAT SHOWS EFFICACY IN MULTIPLE ESTABLISHED RAT MODELS OF COLLAGEN-INDUCED ARTHRITIS Di Paolo, J.; Blomgren, P.; Dolton, M.; Jones, R.; Kropf, J.; Lee, T.; Mitchell, S.; Murray, B.; Suekawa-Pirrone, K.; Wise, S.; Xu, J.; Zhao, Z.; Currie, K. 分享 收藏
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Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase Currie, Kevin S.; Kropf, Jeffrey E.; Lee, Tony; Blomgren, Peter; Xu, Jianjun; Zhao, Zhongdong; Gallion, Steve; Whitney, J. Andrew; Maclin, Deborah; Lansdon, Eric B.; Maciejewski, Patricia; Rossi, Ann Marie; Rong, Hong; Macaluso, Jennifer; Barbosa, James; Di Paolo, Julie A.; Mitchell, Scott A. 分享 收藏
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