未登录The discovery and structural basis of two distinct state-dependent inhibitors of BamA
Sun, Dawei; Storek, Kelly M.; Tegunov, Dimitry; Yang, Ying; Arthur, Christopher P.; Johnson, Matthew; Quinn, John G.; Liu, Weijing; Han, Guanghui; Girgis, Hany S.; Alexander, Mary Kate; Murchison, Austin K.; Shriver, Stephanie; Tam, Christine; Ijiri, Hiroshi; Inaba, Hiroko; Sano, Tatsuya; Yanagida, Hayato; Nishikawa, Junichi; Heise, Christopher E.; Fairbrother, Wayne J.; Tan, Man-Wah; Skelton, Nicholas; Sandoval, Wendy; Sellers, Benjamin D.; Ciferri, Claudio; Smith, Peter A.; Reid, Patrick C.; Cunningham, Christian N.; Rutherford, Steven T.; Payandeh, Jian .png)
分享.png)
收藏分享 收藏 Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte FormationDorel, Ruth; Sun, Dawei; Carruthers, Nicholas; Castanedo, Georgette M.; Ung, Peter M. U.; Factor, Daniel C.; Li, Tianbo; Baumann, Hannah; Janota, Danielle; Pang, Jodie; Salphati, Laurent; Meklemburg, Robert; Korman, Allison J.; Harper, Halie E.; Stubblefield, Samantha; Payandeh, Jian; Mchugh, Daniel; Lang, Bradley T.; Tesar, Paul J.; Dere, Edward; Masureel, Matthieu; Adams, Drew J.; Volgraf, Matthew; Braun, Marie-Gabrielle 分享 收藏 Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developabilityLiang, Wei-Ching; Xi, Hongkang; Sun, Dawei; D'Ascenzo, Luigi; Zarzar, Jonathan; Stephens, Nicole; Cook, Ryan; Li, Yinyin; Ye, Zhengmao; Matsumoto, Marissa; Payandeh, Jian; Masureel, Matthieu; Wu, Yan 分享 收藏 Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8Sun, Dawei; Sun, Yonglian; Janezic, Eric; Zhou, Tricia; Johnson, Matthew; Azumaya, Caleigh; Noreng, Sigrid; Chiu, Cecilia; Seki, Akiko; Arenzana, Teresita L.; Nicoludis, John M.; Shi, Yongchang; Wang, Baomei; Ho, Hoangdung; Joshi, Prajakta; Tam, Christine; Payandeh, Jian; Comps-Agrar, Laetitia; Wang, Jianyong; Rutz, Sascha; Koerber, James T.; Masureel, Matthieu 分享 收藏 Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitorsKschonsak, Marc; Jao, Christine C.; Arthur, Christopher P.; Rohou, Alexis L.; Bergeron, Philippe; Ortwine, Daniel F.; McKerrall, Steven J.; Hackos, David H.; Deng, Lunbin; Chen, Jun; Li, Tianbo; Dragovich, Peter S.; Volgraf, Matthew; Wright, Matthew R.; Payandeh, Jian; Ciferri, Claudio; Tellis, John C. 分享 收藏 Structure of the core human NADPH oxidase NOX2核心人类NADPH氧化酶NOX2的结构Noreng, Sigrid; Ota, Naruhisa; Sun, Yonglian; Ho, Hoangdung; Johnson, Matthew; Arthur, Christopher P.; Schneider, Kellen; Lehoux, Isabelle; Davies, Christopher W.; Mortara, Kyle; Wong, Kit; Seshasayee, Dhaya; Masureel, Matthieu; Payandeh, Jian; Yi, Tangsheng; Koerber, James T. 分享 收藏 分享 收藏 Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channelNoland, Cameron L.; Chua, Han Chow; Kschonsak, Marc; Heusser, Stephanie Andrea; Braun, Nina; Chang, Timothy; Tam, Christine; Tang, Jia; Arthur, Christopher P.; Ciferri, Claudio; Pless, Stephan Alexander; Payandeh, Jian 分享 收藏 Structural basis for HCMV Pentamer receptor recognition and antibody neutralizationHCMV五聚体受体识别和抗体中和的结构基础Kschonsak, Marc; Johnson, Matthew C.; Schelling, Rachel; Green, Evan M.; Rouge, Lionel; Ho, Hoangdung; Patel, Nidhi; Kilic, Cem; Kraft, Edward; Arthur, Christopher P.; Rohou, Alexis L.; Comps-Agrar, Laetitia; Martinez-Martin, Nadia; Perez, Laurent; Payandeh, Jian; Ciferri, Claudio 分享 收藏 Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative ActivityVerma, Vishal A.; Wang, Lan; Labadie, Sharada S.; Liang, Jun; Sellers, Benjamin D.; Wang, Jian; Dong, Liting; Wang, Qiuyue; Zhang, Shuang; Xu, Zhongya; Zhang, Yexia; Niu, Yanan; Wang, Xinxin; Wai, John; Koehler, Michael F. T.; Hu, Huiyong; Alexander, Mary Kate; Nishiyama, Mireille; Miu, Anh; Xu, Yiming; Pang, Jodie; Katakam, Anand K.; Reichelt, Michael; Austin, Cary D.; Ho, Hoangdung; Payandeh, Jian; Koth, Christopher M. 分享 收藏 分享 收藏 Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic ConjugateKajihara, Kimberly K.; Pantua, Homer; Hernandez-Barry, Hilda; Hazen, Meredith; Deshmukh, Kiran; Chiang, Nancy; Ohri, Rachana; Castellanos, Erick R.; Martin, Lynn; Matsumoto, Marissa L.; Payandeh, Jian; Storek, Kelly M.; Schneider, Kellen; Smith, Peter A.; Koehler, Michael F. T.; Tsai, Siao Ping; Vandlen, Richard; Loyet, Kelly M.; Nakamura, Gerald; Pillow, Thomas; Seshasayee, Dhaya; Kapadia, Sharookh B.; Hazenbos, Wouter L. W. 分享 收藏 Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome functionDavies, Christopher W.; Stowe, Irma; Phung, Qui T.; Ho, Hoangdung; Bakalarski, Corey E.; Gupta, Aaron; Zhang, Yingnan; Lill, Jennie R.; Payandeh, Jian; Kayagaki, Nobuhiko; Koerber, James T. 分享 收藏 A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatmentBalestrini, Alessia; Joseph, Victory; Dourado, Michelle; Reese, Rebecca M.; Shields, Shannon D.; Rouge, Lionel; Bravo, Daniel D.; Chernov-Rogan, Tania; Austin, Cary D.; Chen, Huifen; Wang, Lan; Villemure, Elisia; Shore, Daniel G. M.; Verma, Vishal A.; Hu, Baihua; Chen, Yong; Leong, Laurie; Bjornson, Chris; Hotel, Kathy; Gogineni, Alvin; Lee, Wyne P.; Suto, Eric; Wu, Xiumin; Liu, John; Zhang, Juan; Gandham, Vineela; Wang, Jianyong; Payandeh, Jian; Ciferri, Claudio; Estevez, Alberto; Arthur, Christopher P.; Kortmann, Jens; Wong, Ryan L.; Heredia, Jose E.; Doerr, Jonas; Jung, Min; Vander Heiden, Jason A.; Roose-Girma, Merone; Tam, Lucinda; Barck, Kai H.; Carano, Richard A. D.; Ding, Han Ting; Brillantes, Bobby; Tam, Christine; Yang, Xiaoying; Gao, Simon S.; Ly, Justin Q.; Liu, Liling; Chen, Liuxi; Liederer, Bianca M.; Lin, Joseph H.; Magnuson, Steven; Chen, Jun; Hackos, David H.; Elstrott, Justin; Rohou, Alexis; Safina, Brian S.; Volgraf, Matthew; Bauer, Rebecca N.; Riol-Blanco, Lorena 分享 收藏 Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian CancerLo, Amy A.; Johnston, Jennifer; Li, Ji; Mandikian, Danielle; Hristopoulos, Maria; Clark, Robyn; Nickles, Dorothee; Liang, Wei-Ching; Hotzel, Kathy; Dunlap, Debra; Thinh Pham; Cai, Hao; Ovacik, Meric; Bravo-Perez, Daniel; Mai, Elaine; Slaga, Dionysos; Ellerman, Diego; Ziai, James; Totpal, Klara; Lee, Genee; Boswell, C. Andrew; Payandeh, Jian; Wu, Yan; Junttila, Teemu T. 分享 收藏 A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion ChannelLiu, Chang; Reese, Rebecca; Vu, Simon; Rouge, Lionel; Shields, Shannon D.; Kakiuchi-Kiyota, Satoko; Chen, Huifen; Johnson, Kevin; Shi, Yu Patrick; Chernov-Rogan, Tania; Greiner, Demi Maria Zabala; Kohli, Pawan Bir; Hackos, David; Brillantes, Bobby; Tam, Christine; Li, Tianbo; Wang, Jianyong; Safina, Brian; Magnuson, Steve; Volgraf, Matthew; Payandeh, Jian; Zheng, Jie; Rohou, Alexis; Chen, Jun 分享 收藏 分享 收藏 Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptDStorek, Kelly M.; Chan, Joyce; Vij, Rajesh; Chiang, Nancy; Lin, Zhonghua; Bevers, Jack, III; Koth, Christopher M.; Vernes, Jean-Michel; Meng, Y. Gloria; Yin, JianPing; Wallweber, Heidi; Dalmas, Olivier; Shriver, Stephanie; Tam, Christine; Schneider, Kellen; Seshasayee, Dhaya; Nakamura, Gerald; Smith, Peter A.; Payandeh, Jian; Koerber, James T.; Comps-Agrae, Laetitia; Rutherford, Steven T. 分享 收藏 Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic PainMcKerrall, Steven J.; Nguyen, Teresa; Lai, Kwong Wah; Bergeron, Philippe; Deng, Lunbin; DiPasquale, Antonio; Chang, Jae H.; Chen, Jun; Chernov-Rogan, Tania; Hackos, David H.; Maher, Jonathan; Ortwine, Daniel F.; Pang, Jodie; Payandeh, Jian; Proctor, William R.; Shields, Shannon D.; Vogt, Jennifer; Ji, Pengfei; Liu, Wenfeng; Ballini, Elisa; Schumann, Lilia; Tarozzo, Glauco; Bankar, Girish; Chowdhury, Sultan; Hasan, Abid; Johnson, J. P., Jr.; Khakh, Kuldip; Lin, Sophia; Cohen, Charles J.; Dehnhardt, Christoph M.; Safina, Brian S.; Sutherlin, Daniel P. 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}