陈蕾｜Lei Chen

Department of Physiology教授邮箱:chenc11236@163.com

H指数:26

被引数:2,125

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个人简介

"陈蕾作者：基础医学院日期：2016-03-17 点击：11602 陈蕾教授，博士，博士生导师科学研究方向神经生理通讯：江苏省南京市江宁区龙眠大道101号南京医科大学生理学系，邮编211166电话：025-86869351电邮：chenl@njmu.edu.cn简介近年来一直从事有关TRPV4受体调控神经系统功能方面的研究工作，主持国家自然基金面上项目三项、国家自然基金青年基金项目、江苏省科学计划项目和江苏省高校自然科学研究课题各一项；参与主持中加国际合作项目一项。近年作为通讯作者/共同通讯发表SCI论文20余篇，累计影响因子超过100分，研究成果得到国内外学术界的广泛认可。先后被评为江苏省高校“青蓝工程”优秀青年骨干教师和中青年学术带头人，江苏省“六大人才高峰”高层次人才项目C类培养对象，江苏省第五期“333工程”第三层次培养对象。学术兼职1. 江苏省生理科学学会常务理事2. 江苏省卒中学会专业委员会委员承担科研课题1. 国家自然科学基金面上项目，TRPV4在抑郁症发病中的作用及其机制研究（81971274），2020-2023，55万，主持2. 国家自然科学基金面上项目，TRPV4在颞叶癫痫发病中的作用及其分子机制研究（81571270），2016-2019，68.4万，主持3. 国家自然科学基金面上项目，阻断TRPV4受体对脑缺血再灌注损伤的作用及其分子机制（31271206），2012-2015，74万，主持4. 国家自然科学基金青年基金项目，TRPV4受体介导低渗透压致痛的机制研究 (30900577)， 2010-2012；21万，主持5. 江苏省“六大人才高峰”高层次人才项目，TRPV4受体介导癫痫发病的机制研究（JY-049），2016-2019，4万，主持6. 江苏省科技计划项目，新型镇痛药的靶点TRPV4受体介导低渗透压致痛的机制研究(BK2009416)，2009-2011，8万，主持7. 江苏省高校自然科学研究课题，围生期双酚A暴露阻碍突触可塑性发育成熟的分子制 (08KJB310007)，2008-2010；3万，主持8. 国家自然科学基金-中加国际合作项目，辛伐他汀改善阿尔茨海默病脑供血和认知功能细胞机制的探讨（81361120247），2013-2015，100万，共同主持代表性论文1. Qi, XT#, Chen X, Luo Q, Liu LH, An D, Sha S, Du YM, Wu CF*, Chen L*. TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus. Mol Neurobiol, 2024, 10.1007/s12035-024-04504-x2. An D#, Qi XT, Li KP, Xu WX, Wang Y, Chen X, Sha S, Wu CF, Du YM*, Chen L*. Blockage of TRPV4 downregulates the nuclear factor‑kappa B signaling pathway to inhibit inflammatory responses and neuronal death in mice with pilocarpine‑induced status epilepticus. Cell Mol Neurobiol. 2023, 43(3): 1283-1300.3. Wu YW#, Lu K#, Lu Y, Liao J, Zhang SS, Yang ST, Zhao N, Dong Q, Chen L, Wu QF*, Du YM*. Transient receptor potential vanilloid 4 (TRPV4) in neutrophils enhances myocardial ischemia/reperfusion injury. J Leukoc Biol. 2023, 114(3): 266–279.4. Xu WX#, Wang Y, Qi XT, Li KP, Zhou L, Sha S, Wang XL, Wu CF, Du YM*, Chen L*. Involvement of TRPV4 in changes in rapidly inactivating potassium channels in the early stage of pilocarpine-induced status epilepticus in mice. J Cell Physiol., 2022, 237(1): 856-867.5. Yang ST#, Zhao ZY#, Zhao N#, Liao J, Lu Y, Zhang SS, Lu K, Wu YW, Wu QF, Dong Q, Chen L*, Du YM*. Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice. Cell Calcium, 2022, 104: 102590.6. Qin YY#, Xu WX, Li KP, Luo Q, Chen X, Wang Y, Chen L*, Sha S*. Repeated inhibition of sigma-1 receptor suppresses GABAA receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors. Front Mol Neurosci, 2022, 15: 959224.7. Zhou L#, Xu WX#, An D, Sha S, Men C, Li YC, Wang XL, Du YM, Chen L*.Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine-induced status epilepticus. J Neurosci Res., 2021 99(3): 914-926.8. Zhang SS#, Lu K, Yang ST, Wu YW, Liao J, Lu Y, Wu QF, Zhao N, Dong Q, Chen L*, Du YM*. Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts. Cell Calcium, 2021, 100: 102483.9. Liao J#, Wu QF#, Qian C#, Zhao N#, Zhao AY, Lu K, Zhang SS, Dong Q, Chen L, Li QC, Du YM*. TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats.JCI Insight., 2020, 5(23): e137528.10.Tang CF#, Zhang J, Liu PY, Zhou Y, Hu QY, Zhong Y, Wang XL*, Chen L*. Chronic exposure to low dose of bisphenol A causes follicular atresia by inhibiting kisspeptin neurons in anteroventral periventricular nucleus in female mice. Neurotoxicology, 2020,79:164-176.11.Qin YY#, An D, Xu WX, Qi XT, Wang XL, Chen L, Chen L*, Sha S*. Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice. Front Aging Neurosci, 2020, 12:240.12.Wang ZQ#, Zhou L#, An D, Xu WX, Wu CF, Sha S, Li YC, Zhu YC, Chen AD, Du YM, Chen L*, Chen L. TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice. Cell Death Dis., 2019, 10: 386.13.Men C#, Wang ZQ#, Zhou L#, Qi MW, An D, Xu WX, Zhan YY*, Chen L*. Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice. Brain Res Bull., 2019, 152: 128-133.14.Qi MW#, Wu CF#, Wang ZQ, Zhou L, Men C, Du YM, Huang SM*, Chen L*, Chen L. Transient receptor potential vanilloid 4 activation-induced increase in glycine-activated current in mouse hippocampal pyramidal neurons. Cell Physiol Biochem., 2018, 45(3): 1084-1096.15.Tian YJ#, Qi MW#, Wang ZQ, Wu CF, Sun Z, Li YC, Sha S, Du YM, Chen L*, Chen L. Activation of transient receptor potential vanilloid 4 impairs the dendritic arborization of newborn neurons in the hippocampal dentate gyrus through the AMPK and Akt signaling pathways. Front Mol Neurosci., 2017, 10: 190.16.Tian YJ#, Qi MW, Hong ZW, Li YC, Yuan YB, Du YM, Chen L*, Chen L. Activation of transient receptor potential vanilloid 4 promotes the proliferation of stem cells in the adult hippocampal dentate gyrus. Mol Neurobiol., 2017, 54(8): 5768-5779.17.Wu QF#, Qian C#, Zhao N#, Dong Q, Li J, Wang BB, Chen L, Yu L, Han B, Du YM*, Liao YH. Activation of transient receptor potential vanilloid 4 involves in hypoxia/reoxygenation injury in cardiomyocytes. Cell Death Dis., 2017, 8: e2828.18.Dong Q#, Li J#, Wu QF#, Zhao N, Qian C, Ding D, Wang BB, Chen L, Guo KF, Fu D, Han B, Liao YH, Du YM*. Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. Sci Rep., 2017, 7: 42678.19.Hong ZW#, Tian YJ#, Qi MW, Li YC, Du YM, Chen L*, Liu WT*, Chen L. Transient receptor potential vanilloid 4 inhibits γ-aminobutyric acid-activated current in hippocampal pyramidal neurons. Front Mol Neurosci., 2016, 9: 77.20.Hong ZW#, Jie PH, Tian YJ, Chen TT, Chen L*, Chen L. Transi"