未登录 Gemcitabine, carboplatin, and Epstein-Barr virus-specific autologous cytotoxic T lymphocytes for recurrent or metastatic nasopharyngeal carcinoma: VANCE, an international randomized phase III trial Toh, H. C.; Yang, M. -h.; Wang, H. -m.; Hsieh, C. Y.; Chitapanarux, I.; Ho, K. F.; Hong, R. -l.; Ang, M. K.; Colevas, A. D.; Sirachainan, E.; Lertbutsayanukul, C.; Ho, G. F.; Nadler, E.; Algazi, A.; Lulla, P.; Wirth, L. J.; Wirasorn, K.; Liu, Y. C.; Ang, S. F.; Low, S. H. J.; Tho, L. M.; Hasbullah, H. H.; Brenner, M. K.; Wang, W. -w.; Ong, W. S.; Tan, S. H.; Horak, I.; Ding, C.; Myo, A.; Samol, J. 分享 收藏
Novel OX40 and 4-1BB derived spacers enhance CD30 CAR activity and safety in CD30 positive lymphoma models Kua, Lindsay; Ng, Chee Hoe; Tan, Jin Wei; Tan, Hwee Ching; Seh, Cheah Chen; Wong, Fiona; Ong, Richard; Rooney, Cliona M.; Tan, Joel; Chen, Qingfeng; Horak, Ivan D.; Tan, Kar Wai; Low, Lionel 分享 收藏
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Off-The-Shelf Epstein Barr Virus Specific T Cells Armored with B7-H3-Targeting Chimeric Antigen Receptors Is an Effective and Safe Tumor- Agnostic Therapy For B7-H3 Positive Solid Malignancies Yeo, Siok Ping; Kua, Lindsay; Tan, Jin Wei; Lim, Joanna Kristyn; Wong, Fiona; Delos Santos, May; Poh, Chek Meng; Xh, Angeline Goh; Koh, Xin Yu; Zhou, Xiao Hua; Rajarethinam, R.; Chen, Qing Feng; Her, Zhisheng; Horak, Ivan D.; Low, Lionel; Tan, Kar Wai 分享 收藏
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Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo Niendorf, Sandra; Oksche, Alexander; Kisser, Agnes; Loehler, Juergen; Prinz, Marco; Schorle, Hubert; Feller, Stephan; Lewitzky, Marc; Horak, Ivan; Knobeloch, Klaus-Peter 分享 收藏
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Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-Glucose cotransport in small intestine and develop obesity Osswald, C; Baumgarten, K; Stümpel, F; Gorboulev, V; Akimjanova, M; Knobeloch, KP; Horak, I; Kluge, R; Joost, HG; Koepsell, H 分享 收藏
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First-in-human trial exploring safety, antitumor activity, and pharmacokinetics of Sym013, a recombinant pan-HER antibody mixture, in advanced epithelial malignancies Berlin, Jordan; Tolcher, Anthony W.; Ding, Cliff; Whisenant, Jennifer G.; Horak, Ivan D.; Wood, Debra L.; Nadler, Paul, I; Hansen, Ulla Holm; Lantto, Johan; Skartved, Niels Jorgen O.; Pedersen, Mikkel W.; Patnaik, Amita 分享 收藏
Paediatric Strategy Forum for medicinal product development of chimeric antigen receptor T-cells in children and adolescents with cancer ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration 儿童和青少年癌症患者嵌合抗原受体T细胞药物产品开发儿科战略论坛与欧洲药品管理局合作，食品和药物管理局参与加速 Pearson, Andrew D. J.; Rossig, Claudia; Mackall, Crystal; Shah, Nirali N.; Baruchel, Andre; Reaman, Gregory; Ricafort, Rosanna; Heenen, Delphine; Bassan, Abraham; Berntgen, Michael; Bird, Nick; Bleickardt, Eric; Bouchkouj, Najat; Bross, Peter; Brownstein, Carrie; Cohen, Sarah Beaussant; de Rojas, Teresa; Ehrlich, Lori; Fox, Elizabeth; Gottschalk, Stephen; Hanssens, Linda; Hawkins, Douglas S.; Horak, Ivan D.; Taylor, Danielle H.; Johnson, Courtney; Karres, Dominik; Ligas, Franca; Ludwinski, Donna; Mamonkin, Maksim; Marshall, Lynley; Masouleh, Behzad K.; Matloub, Yousif; Maude, Shannon; McDonough, Joe; Minard-Colin, Veronique; Norga, Koen; Nysom, Karsten; Pappo, Alberto; Pearce, Laura; Pieters, Rob; Pule, Martin; Quintas-Cardama, Alfonso; Richardson, Nick; Schuessler-Lenz, Martina; Scobie, Nicole; Sersch, Martina A.; Smith, Malcolm A.; Sterba, Jaroslav; Tasian, Sarah K.; Weigel, Brenda; Weiner, Susan L.; Zwaan, Christian Michel; Lesa, Giovanni; Vassal, Gilles 分享 收藏
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Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Elez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio 分享 收藏
Simultaneous targeting of HER family pro-survival signaling with Pan-HER antibody mixture is highly effective in TNBC: a preclinical trial with PDXs Reddy, Tejaswini P.; Choi, Dong S.; Anselme, Ann C.; Qian, Wei; Chen, Wen; Lantto, Johan; Horak, Ivan D.; Kragh, Michael; Chang, Jenny C.; Rosato, Roberto R. 分享 收藏
Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts Rosato, Roberto R.; Choi, Don S.; Qian, Wei; Chen, Wen; Lantto, Johan; Horak, Ivan D.; Kragh, Michael; Chang, Jenny C. 分享 收藏
Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform Gjetting, Torben; Gad, Monika; Frohlich, Camilla; Lindsted, Trine; Melander, Maria C.; Bhatia, Vikram K.; Grandal, Michael M.; Dietrich, Nikolaj; Uhlenbrock, Franziska; Galler, Gunther R.; Strandh, Magnus; Lantto, Johan; Bouquin, Thomas; Horak, Ivan D.; Kragh, Michael; Pedersen, Mikkel W.; Koefoed, Klaus 分享 收藏
CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models Kristensen, Lotte K.; Frohlich, Camilla; Christensen, Camilla; Melander, Maria C.; Poulsen, Thomas T.; Galler, Gunther R.; Lantto, Johan; Horak, Ivan D.; Kragh, Michael; Nielsen, Carsten H.; Kjaer, Andreas 分享 收藏
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Preclinical characterization of Sym022, a novel anti-LAG3 antibody Grandal, Michael M.; Melander, Maria C.; Bhatia, Vikram K.; Gjetting, Torben; Lindsted, Trine; Frohlich, Camilla; Lantto, Johan; Horak, Ivan D.; Kragh, Michael; Kofoed, Klaus; Pedersen, Mikkel W. 分享 收藏
Characterization of the first chicken-derived anti-PD-1 clinical stage antibody with a unique epitope and promising anticancer activity Gjetting, Torben; Gad, Monika; Frohlich, Camilla; Melander, Maria C.; Galler, Gunther; Lantto, Johan; Bouquin, Thomas; Horak, Ivan D.; Kragh, Michael; Pedersen, Mikkel W.; Koefoed, Klaus 分享 收藏
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