未登录 Synthesis, relative configuration and CB1 receptor affinity studies for a set of 1,2,3-triazole derivatives Szafranski, Przemyslaw W.; Siwek, Agata; Smaga-Maslanka, Irena; Pomierny-Chamiolo, Lucyna; Ilnicki, Piotr; Zuchowski, Grzegorz; Nevalainen, Tapio; Filip, Malgorzata; Zajdel, Pawel; Cegla, Marek T. 分享 收藏
Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells Singha, Prosanta K.; Maklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio J.; Patil, Mahadeo R.; Tonduru, Arun K.; Poso, Antti; Laitinen, Jarmo T.; Savinainen, Juha R. 分享 收藏
CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells Hytti, M.; Andjelic, S.; Josifovska, N.; Piippo, N.; Korhonen, E.; Hawlina, M.; Kaarniranta, K.; Nevalainen, T. J.; Petrovski, G.; Parkkari, T.; Kauppinen, A. 分享 收藏
Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors 自分泌运动因子抑制剂2，4-二氢吡喃并 [2，3-c] 吡唑衍生物的设计、合成及生物学评价 Pantsar, Tatu; Singha, Prosanta; Nevalainen, Tapio J.; Koshevoy, Igor; Leppanen, Jukka; Poso, Antti; Niskanen, Juha M. A.; Pasonen-Seppanen, Sanna; Savinainen, Juha R.; Laitinen, Tuomo; Laitinen, Jarmo T. 分享 收藏
In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048) Aaltonen, Niina; Kedzierska, Ewa; Orzelska-Gorka, Jolanta; Lehtonen, Marko; Navia-Paldanius, Dina; Jakupovic, Hermina; Savinainen, Juha R.; Nevalainen, Tapio; Laitinen, Jarmo T.; Parkkari, Teija; Gynther, Mikko 分享 收藏
Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α/β-hydrolase domain containing 11 (ABHD11) Navia-Paldanius, Dina; Patel, Jayendra Z.; Navarro, Miriam Lopez; Jakupovic, Hermina; Goffart, Steffi; Pasonen-Seppanen, Sanna; Nevalainen, Tapio J.; Jaaskelainen, Tiina; Laitinen, Tuomo; Laitinen, Jarmo T.; Savinainen, Juha R. 分享 收藏
Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists Yrjola, Sari; Parkkari, Teija; Navia-Paldanius, Dina; Laitinen, Tuomo; Kaczor, Agnieszka A.; Kokkola, Tarja; Adusei-Mensah, Frank; Savinainen, Juha R.; Laitinen, Jarmo T.; Poso, Antti; Alexander, Amy; Penman, June; Stott, Lisa; Anskat, Marie; Irving, Andrew J.; Nevalainen, Tapio J. 分享 收藏
Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors Patel, Jayendra Z.; van Bruchem, John; Laitinen, Tuomo; Kaczor, Agnieszka A.; Navia-Paldanius, Dina; Parkkari, Teija; Savinainen, Juha R.; Laitinen, Jarmo T.; Nevalainen, Tapio J. 分享 收藏
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists Yrjola, Sari; Sarparanta, Mirkka; Airaksinen, Anu J.; Hytti, Maria; Kauppinen, Anu; Pasonen-Seppanen, Sanna; Adinolfi, Barbara; Nieri, Paola; Manera, Clementina; Keinanen, Outi; Poso, Antti; Nevalainen, Tapio J.; Parkkari, Teija 分享 收藏
Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors 1,2，5-噻二唑氨基甲酸酯作为有效和选择性ABHD6抑制剂的优化 Patel, Jayendra Z.; Nevalainen, Tapio J.; Savinainen, Juha R.; Adams, Yahaya; Laitinen, Tuomo; Runyon, Robert S.; Vaara, Miia; Ahenkorah, Stephen; Kaczor, Agnieszka A.; Navia-Paldanius, Dina; Gynther, Mikko; Aaltonen, Niina; Joharapurkar, Amit A.; Jain, Mukul R.; Haka, Abigail S.; Maxfield, Frederick R.; Laitinen, Jarmo T.; Parkkari, Teija 分享 收藏
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) Korhonen, Jani; Kuusisto, Anne; van Bruchem, John; Patel, Jayendra Z.; Laitinen, Tuomo; Navia-Paldanius, Dina; Laitinen, Jarmo T.; Savinainen, Juha R.; Parkkari, Teija; Nevalainen, Tapio J. 分享 收藏
Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) 人单酰基甘油脂肪酶 (MAGL) 对前列腺素甘油酯的强力水解 Savinainen, Juha R.; Kansanen, Emilia; Pantsar, Tatu; Navia-Paldanius, Dina; Parkkari, Teija; Lehtonen, Marko; Laitinen, Tuomo; Nevalainen, Tapio; Poso, Antti; Levonen, Anna-Liisa; Laitinen, Jarmo T. 分享 收藏
Chiral 1,3,4-Oxadiazol-2-ones as Highly Selective FAAH Inhibitors Patel, Jayendra Z.; Parkkari, Teija; Laitinen, Tuomo; Kaczor, Agnieszka A.; Saario, Susanna M.; Savinainen, Juha R.; Navia-Padanius, Dina; Cipriano, Mariateresa; Leppanen, Jukka; Koshevoy, Igor O.; Poso, Antti; Fowler, Christopher J.; Laitinen, Jarmo T.; Nevalainen, Tapio 分享 收藏
1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling Kasnanen, Heikki; Minkkila, Anna; Taupila, Susanna; Patel, Jayendra Z.; Parkkari, Teija; Lahtela-Kakkonen, Maija; Saario, Susanna M.; Nevalainen, Tapio; Poso, Antti 分享 收藏
Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists Yrjola, Sari; Kalliokoski, Tuomo; Laitinen, Tuomo; Poso, Antti; Parkkari, Teija; Nevalainen, Tapio 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
