未登录 Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition 抗菌大环肽揭示了一种独特的BamA抑制模式 Walker, Morgan E.; Zhu, Wei; Peterson, Janine H.; Wang, Hao; Patteson, Jon; Soriano, Aileen; Zhang, Han; Mayhood, Todd; Hou, Yan; Mesbahi-Vasey, Samaneh; Gu, Meigang; Frost, John; Lu, Jun; Johnston, Jennifer; Hipolito, Christopher; Lin, Songnian; Painter, Ronald E.; Klein, Daniel; Walji, Abbas; Weinglass, Adam; Kelly, Terri M.; Saldanha, Adrian; Schubert, Jeffrey; Bernstein, Harris D.; Walker, Scott S. 分享 收藏
Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy Skudlarek, Jason W.; Cooke, Andrew J.; Mitchell, Helen J.; Babaoglu, Kerim; Shaw, Anthony W.; Tong, Ling; Nomland, Ashley B.; Labroli, Marc; Sha, Deyou; Mulhearn, James J.; Wu, Chengwei; Li, Sarah W.; Beshore, Douglas C.; Hughes, Jonathan M. E.; Jouffroy, Matthieu; Wang, Hao; Balibar, Carl J.; Painter, Ronald E.; Shen, Pamela; Lange, Henry S.; Ishchenko, Andrii; Chen, Yun-Ting; Klein, Daniel J.; Tracy, Rodger W.; Miller, Randy R.; Cabalu, Tamara D.; Wu, Zhe; Leithead, Andrew; Scapin, Giovanna; Hruza, Alan W.; Dzhekieva, Liudmila; Bukhtiyarova, Marina; Homsher, Michelle F.; Xu, Min; Bahnck-Teets, Carolyn; McKenney, David; Buevich, Alexei V.; Liu, Jian; Zhang, Li-Kang; Meng, Tao; Kelly, Terri; Dinunzio, Edward; Soisson, Stephen; Cheng, Robert K. Y.; Hennig, Michael; Raheem, Izzat; Walker, Scott S. 分享 收藏
Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics Leus, Inga V.; Adamiak, Justyna; Chandar, Brinda; Bonifay, Vincent; Zhao, Shibin; Walker, Scott S.; Squadroni, Brian; Balibar, Carl J.; Kinarivala, Nihar; Standke, Lisa C.; Voss, Henning U.; Tan, Derek S.; Rybenkov, Valentin V.; Zgurskaya, Helen I. 分享 收藏
分享 收藏
A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier Hart, Elizabeth M.; Mitchell, Angela M.; Konovalova, Anna; Grabowicz, Marcin; Sheng, Jessica; Han, Xiaoqing; Rodriguez-Rivera, Frances P.; Schwaid, Adam G.; Malinverni, Juliana C.; Balibar, Carl J.; Bodea, Smaranda; Si, Qian; Wang, Hao; Homsher, Michelle F.; Painter, Ronald E.; Ogawa, Anthony K.; Sutterlin, Holly; Roemer, Terry; Black, Todd A.; Rothman, Deborah M.; Walker, Scott S.; Silhavy, Thomas J. 分享 收藏
Inhibitor of intramembrane protease RseP blocks the σE response causing lethal accumulation of unfolded outer membrane proteins 膜内蛋白酶抑制剂RseP阻断 σ e反应，导致未折叠外膜蛋白的致死积累 Konovalova, Anna; Grabowicz, Marcin; Balibar, Carl J.; Malinverni, Juliana C.; Painter, Ronald E.; Riley, Daniel; Mann, Paul A.; Wang, Hao; Garlisi, Charles G.; Sherborne, Brad; Rigel, Nathan W.; Ricci, Dante P.; Black, Todd A.; Roemer, Terry; Silhavy, Thomas J.; Walker, Scott S. 分享 收藏
Discovery of Selective RNA-Binding Small Molecules by Affinity Selection Mass Spectrometry Rizvi, Noreen F.; Howe, John A.; Nahvi, Ali; Klein, Daniel J.; Fischmann, Thierry O.; Kim, Hai-Young; McCoy, Mark A.; Walker, Scott S.; Hruza, Alan; Richards, Matthew P.; Chamberlin, Chad; Saradjian, Peter; Butko, Margaret T.; Mercado, Gabriel; Burchard, Julja; Strickland, Corey; Dandliker, Peter J.; Smith, Graham F.; Nickbarg, Elliott B. 分享 收藏
Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor Walker, Scott S.; Degen, David; Nickbarg, Elliott; Carr, Donna; Soriano, Aileen; Mandal, Mihir; Painter, Ronald E.; Sheth, Payal; Xiao, Li; Sher, Xinwei; Murgolo, Nicholas; Su, Jing; Olsen, David B.; Ebright, Richard H.; Young, Katherine 分享 收藏
Development of Novel Benzomorpholine Class of Diacylglycerol Acyltransferase I Inhibitors Zhou, Gang; Zorn, Nicolas; Ting, Pauline; Aslanian, Robert; Lin, Mingxiang; Cook, John; Lachowicz, Jean; Lin, Albert; Smith, Michelle; Hwa, Joyce; van Heek, Margaret; Walker, Scott 分享 收藏
Discovery of a Novel Class of Orally Active Antifungal β-1,3-D-Glucan Synthase Inhibitors Walker, Scott S.; Xu, Yiming; Triantafyllou, Ilias; Waldman, Michelle F.; Mendrick, Cara; Brown, Nathaniel; Mann, Paul; Chau, Andrew; Patel, Reena; Bauman, Nicholas; Norris, Christine; Antonacci, Barry; Gurnani, Maya; Cacciapuoti, Anthony; McNicholas, Paul M.; Wainhaus, Samuel; Herr, R. Jason; Kuang, Rongze; Aslanian, Robert G.; Ting, Pauline C.; Black, Todd A. 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome p450 14α-demethylase Mann, PA; Parmegiani, RM; Wei, SQ; Mendrick, CA; Li, X; Loebenberg, D; DiDomenico, B; Hare, RS; Walker, SS; McNicholas, PA 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
