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MOLECULAR CHARACTERIZATION OF CRISPROFF EPIGENETIC EDITOR ACTIVITY REVEALS MUTANT ALLELE-SPECIFICTERT REPRESSION IN GLIOBLASTOMA CRISPR-OFF 表观遗传编辑活性的分子表征揭示了胶质母细胞瘤中突变等位基因特异性的 TERT 抑制 Hubbard, Akane; Ma, Zerong; Stevers, Nicholas O.; Zou, Christopher; Lin, Katie; Raval, Krish; Sharma, Rohit; Goudy, Laine; Gilbert, Luke A.; Murthy, Niren; Berger, Mitchel S.; Costello, Joseph F.; Liu, S. John 分享 收藏
Role of LRRC25 in local and systemic immunosuppression and its reversal LRRC25在局部和系统性免疫抑制及其逆转中的作用 Zamler, Daniel B.; Lakshmanachetty, Senthilnath; Stevers, Nicholas O.; Chan, Gary K. L.; Liu, Jerry; Chen, Lee; Lerman, Ben; Kwok, Darwin W.; Hong, Chibo; Cove, Maggie Colton; Gallus, Marco; Mathur, Radhika; Dabaco, Cristina; Rodino, Jessica; Schupp, Patrick G.; Shai, Anny; Phillips, Joanna J.; Okada, Hideho; Oldham, Michael C.; Costello, Joseph F. 分享 收藏
Spatially Resolved Antigenic Landscapes In Low-grade Glioma Reveal Targets For Personalized Immunotherapy 低级别胶质瘤的空间分辨抗原景观揭示个性化免疫治疗靶点 Kwok, Darwin; Zhang, Michael; Wang, Cliff; Cove, Maggie Colton; Hong, Chibo; Stevers, Nicholas; Lerman, Benjamin; Lakshmanachetty, Senthilnath; Borrman, Tyler; Pan, Zheng; Yuen, Benjamin; Peng, Songming; Nguyen, Diana; Martin, Michael; Hilz, Stephanie; Phillips, Joanna; Shai, Anny; Bush, Nancy Ann Oberheim; Hervey-Jumper, Shawn; Mcdermott, Michael; Mandl, Stefanie; Okada, Hideho; Costello, Joseph 分享 收藏
An AI-engineered bioPROTAC reverses immortality ofTERT promoter mutant tumors 一种人工智能设计的生物PROTAC逆转了TERT启动子突变肿瘤的永生性 Stevers, Nicholas; Chen, Ellen; Wu, Joshua; Patel, Trishna; Collins, Sara; Montoya, Megan; Wu, Samuel; Batsios, Georgios; Gillespie, Anne; Hong, Chibo; Kasahara, Noriyuki; Viswanath, Pavithra; Costello, Joseph 分享 收藏
TARGETING TELOMERE MAINTENANCE SENSITIZES GROUP 3 MEDULLOBLASTOMAS TO IONIZING RADIATION 靶向端粒维持使第3组髓母细胞瘤对电离辐射更敏感 Jung, Jangham; Yu, Bohyeon; Stevers, Nicholas; Jain, Abhinav; Rosatti, Emanuele; Costello, Joseph; Gallus, Marco; Okada, Hideho; Nguyen, James; Ho, Winson; Lu, Rongze; Diaz, Aaron 分享 收藏
3D spatial sampling to quantify morphologic heterogeneity in isocitrate dehydrogenase-wildtype glioblastoma 3D空间采样用于量化异柠檬酸脱氢酶野生型胶质母细胞瘤的形态学异质性 Voong, Viva; Beccari, Sol; Hashemi, Elaheh; Kriener, Birgit; Mathur, Radhika; Lafontaine, Marisa; Shai, Anny; Lupo, Janine M.; Chang, Edward F.; Hervey-Jumper, Shawn L.; Berger, Mitchel S.; Waszak, Sebastian M.; Costello, Joseph F.; Phillips, Joanna J. 分享 收藏
Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival IDH突变型星形细胞瘤的纵向分析揭示了与生存率低下相关的获得性ras-mapk通路突变 Almaraz, Eduardo Rodriguez; Guerra, Geno A.; Al-Adli, Nadeem N.; Young, Jacob S.; Dada, Abraham; Quintana, Daniel; Taylor, Jennie W.; Bush, Nancy Ann Oberheim; Clarke, Jennifer L.; Butowski, Nicholas A.; de Groot, John; Pekmezci, Melike; Perry, Arie; Bollen, Andrew W.; Scheffler, Aaron W.; Glidden, David, V; Phillips, Joanna J.; Costello, Joseph F.; Chang, Edward F.; Hervey-Jumper, Shawn; Berger, Mitchel S.; Francis, Stephen S.; Chang, Susan M.; Solomon, David A. 分享 收藏
Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses Lucas, Calixto-Hope G.; Al-Adli, Nadeem N.; Young, Jacob S.; Gupta, Rohit; Morshed, Ramin A.; Wu, Jasper; Ravindranathan, Ajay; Shai, Anny; Oberheim Bush, Nancy Ann; Taylor, Jennie W.; de Groot, John; Villanueva-Meyer, Javier E.; Pekmezci, Melike; Perry, Arie; Bollen, Andrew W.; Theodosopoulos, Philip, V; Aghi, Manish K.; Chang, Edward F.; Hervey-Jumper, Shawn L.; Raleigh, David R.; Molinaro, Annette M.; Costello, Joseph F.; Diaz, Aaron A.; Clarke, Jennifer L.; Butowski, Nicholas A.; Phillips, Joanna J.; Chang, Susan M.; Berger, Mitchel S.; Solomon, David A. 分享 收藏
TUMOR-WIDE RNA SPLICING ABERRATIONS GENERATE IMMUNOGENIC PUBLIC NEOANTIGENS IN GLIOBLASTOMAS AND OTHER CANCER TYPES Kwok, Darwin; Stevers, Nicholas; Etxeberria, Inaki; Nejo, Takahide; Cove, Maggie Colton; Chen, Lee; Jung, Jangham; Okada, Kaori; Lakshmanachetty, Senthilnath; Gallus, Marco; Barpanda, Abhilash; Hong, Chibo; Chan, Gary; Liu, Jerry; Wu, Samuel; Ramos, Emilio; Yamamichi, Akane; Watchmaker, Payal; Ogino, Hirokazu; Saijo, Atsuro; Du, Aidan; Grishanina, Nadia; Woo, James; Diaz, Aaron; Chang, Susan; Phillips, Joanna; Wiita, Arun; Klebanoff, Christopher; Costello, Joseph; Okada, Hideho 分享 收藏
CLINICAL OUTCOMES AND PREDICTIVE BIOMARKERS FOR IDH-WILDTYPE GLIOBLASTOMAS DEVELOPING HYPERMUTATION FOLLOWING TEMOZOLOMIDE TREATMENT Young, Jacob; Lucas, Calixto-Hope; Al-Adli, Nadeem; Gupta, Rohit; Morshed, Ramin; Wu, Jasper; Ravindranathan, Ajay; Shai, Anny; Oberheim-Bush, Nancy Ann; Taylor, Jennie; de Groot, John; Villanueva-Meyer, Javier; Pekmezci, Melike; Perry, Arie; Bollen, Andy; Theodosopoulos, Philip; Aghi, Manish; Chang, Edward; Hervey-Jumper, Shawn; Raleigh, David; Diaz, Aaron; Costello, Joseph; Clarke, Jennifer; Butowski, Nicholas; Phillips, Joanna; Chang, Susan; Berger, Mitchel; Solomon, David 分享 收藏
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LONGITUDINAL EPIGENOMIC EVOLUTION OF IDH-WILDTYPE GLIOBLASTOMA Al-Adli, Nadeem N.; Young, Jacob S.; Lucas, Calixto-Hope G.; Gupta, Rohit; Morshed, Ramin A.; Wu, Jasper; Ravindranathan, Ajay; Shai, Anny; Bush, Nancy Ann Oberheim; Taylor, Jennie W.; de Groot, John; Villanueva-Meyer, Javier; Pekmezci, Melike; Perry, Arie; Bollen, Andrew W.; Theodosopoulos, Philip, V; Aghi, Manish K.; Chang, Edward F.; Hervey-Jumper, Shawn L.; Raleigh, David R.; Diaz, Aaron A.; Costello, Joseph F.; Clarke, Jennifer L.; Butowski, Nicholas; Phillips, Joanna J.; Chang, Susan M.; Berger, Mitchel S.; Solomon, David A. 分享 收藏
SARCOMATOUS TRANSFORMATION OF GLIOBLASTOMA IS ASSOCIATED WITH A DISTINCT MOLECULAR SIGNATURE Lucas, Calixto-Hope; Al-Adli, Nadeem; Young, Jacob; Gupta, Rohit; Morshed, Ramin; Wu, Jasper; Ravindranathan, Ajay; Shai, Anny; Bush, Nancy Ann Oberheim; Taylor, Jennie; de Groot, John; Villanueva-Meyer, Javier; Pekmezci, Melike; Perry, Arie; Bollen, Andrew; Theodosopoulos, Philip; Aghi, Manish; Chang, Edward; Hervey-Jumper, Shawn; Raleigh, David; Diaz, Aaron; Costello, Joseph; Clarke, Jennifer; Butowski, Nicholas; Phillips, Joanna; Berger, Mitchel; Chang, Susan; Solomon, David 分享 收藏
LONGITUDINAL TUMOR-WIDE SAMPLING OF GLIOBLASTOMA REVEALS EARLY EVOLUTIONARY DIVERGENCE OF RECURRENCE AND CLUES TOWARDS IDENTIFYING THE BIOLOGICAL TUMOR CENTER Lerman, Benjamin; Hong, Chibo; Schupp, Patrick; Chen, Lee; Zamler, Daniel; Smirnov, Ivan; Phillips, Joanna; Shai, Anny; Lupo, Janine; Oldham, Michael; Costello, Joseph 分享 收藏
EPIGENETIC EDITING BY MRNA-BASED CRISPROFF ENABLES FLEXIBLE AND DURABLE TARGETING OF GLIOBLASTOMA DRIVERS MGMT AND TERT Lin, Katie; Zou, Christopher; Goudy, Laine; Sharma, Rohit; Stevers, Nicholas O.; Pak, Joanna; Foster, Kyla; Payne, Emily; Shai, Anny; Ozawa, Tomoko; de Groot, John F.; Vasudevan, Harish; Phillips, Joanna J.; Raleigh, David R.; Costello, Joseph F.; Murthy, Niren; Gilbert, Luke A.; Berger, Mitchel; Liu, S. John 分享 收藏
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Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma Beccari, Sol; Mohamed, Esraa; Voong, Viva; Hilz, Stephanie; Lafontaine, Marisa; Shai, Anny; Lim, Yunita; Martinez, Jerry; Switzman, Benjamin; Yu, Ryon L.; Lupo, Janine M.; Chang, Edward F.; Hervey-Jumper, Shawn L.; Berger, Mitchel S.; Costello, Joseph F.; Phillips, Joanna J. 分享 收藏
Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples Wang, Qixuan; Wang, Juan; Mathur, Radhika; Youngblood, Mark W.; Jin, Qiushi; Hou, Ye; Stasiak, Lena A.; Luan, Yu; Costello, Joseph F.; Yue, Feng 分享 收藏
Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types Kwok, Darwin; Stevers, Nicholas O.; Nejo, Takahide; Chen, Lee H.; Etxeberria, Inaki; Jung, Jangham; Okada, Kaori; Cove, Maggie Colton; Lakshmanachetty, Senthilnath; Gallus, Marco; Barpanda, Abhilash; Hong, Chibo; Chan, Gary Kl; Wu, Samuel H.; Ramos, Emilio; Yamamichi, Akane; Liu, Jerry Yz; Watchmaker, Payal; Ogino, Hirokazu; Saijo, Atsuro; Du, Aidan; Grishanina, Nadia; Woo, James; Diaz, Aaron; Chang, Susan M.; Phillips, Joanna J.; Wiita, Arun P.; Klebanoff, Christopher A.; Costello, Joseph F.; Okada, Hideho 分享 收藏
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