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E

Eric S. Lander

broad institute
H指数:271
被引数:52.2万

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Quantitative changes in 3D contact predict changes in enhancer-promoter regulation upon cohesin depletion

3D接触的定量变化可预测cohesin耗竭后增强子-启动子调控的变化

Nature Communications
IF15.7
2026-09-290
OAAI
Philine Guckelberger; Benjamin R. Doughty; Suhas S. P. Rao; Glen Munson; Yingxuan Tan; Xiangmeng Shawn Cai; Charles P. Fulco; Joseph Nasser; Drew T. Bergman; Judhajeet Ray; Evelyn Jagoda; Andreas R. Gschwind; Maya U. Sheth; Chad J. Munger; Anthony S. Tan; Kristy S. Mualim; Saul Godinez Pulido; Namita Mitra; David Weisz; Muhammad Saad Shamim; Neva C. Durand; Ragini Mahajan; Ruqayya Khan; Lars M. Steinmetz; Masato T. Kanemaki; Eric S. Lander; Erez Lieberman Aiden; Jesse M. Engreitz
Functional dissection of complex trait variants at single-nucleotide resolution

在单核苷酸分辨率下对复杂性状变异的功能解析

Nature
IF48.5
2026-02-250
OAAI
Layla Siraj; Rodrigo I. Castro; Hannah B. Dewey; Susan Kales; John C. Butts; Thanh Thanh L. Nguyen; Masahiro Kanai; Daniel Berenzy; Kousuke Mouri; Qingbo S. Wang; Petko P. Fiziev; Kristin Tsuo; Zachary R. McCaw; Sager J. Gosai; François Aguet; Ran Cui; Irfahan Kassam; Jeremy McRae; Christopher M. Vockley; Caleb A. Lareau; Sergey Abramov; Alexandr Boystov; Jeff Vierstra; Yukinori Okada; Alexander Gusev; Thouis R. Jones; Eric S. Lander; Pardis C. Sabeti; Hilary K. Finucane; Steven K. Reilly; Jacob C. Ulirsch; Ryan Tewhey
Dissecting and quantifying pancreatic cancer plasticity using single-cell multiomics, lineage tracing and functional genomics reveals novel mediators of therapy resistance
CANCER RESEARCH
IF16.6
2024-04-050
PRE
Mehta, Arnav; Bi, Lynn; Yeramosu, Deepika; Bogaev, Michael; Jankowiak, Martin; Collins, Abigail; Al'Khafaji, Aziz; Parikh, Milan; Babadi, Mehrtash; Evans, Kyle; Bloemendal, Alex; Kunnes, Russell; Schwartz, Marc; Munson, Glen; Donnard, Elisa; Jones, Thouis R.; Stanger, Ben Z.; Shendure, Jay; Weissman, Jonathan; Ting, David T.; Aguirre, Andrew; Hacohen, Nir; Pe'er, Dana; Lander, Eric S.
Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

利用基因特征的多基因富集来预测复杂性状和疾病背后的基因

NATURE GENETICS
IF31.8
2023-07-1355
OA
Weeks, Elle M. M.; Ulirsch, Jacob C. C.; Cheng, Nathan Y. Y.; Trippe, Brian L. L.; Fine, Rebecca S. S.; Miao, Jenkai; Patwardhan, Tejal A. A.; Kanai, Masahiro; Nasser, Joseph; Fulco, Charles P. P.; Tashman, Katherine C. C.; Aguet, Francois; Li, Taibo; Ordovas-Montanes, Jose; Smillie, Christopher S. S.; Biton, Moshe; Shalek, Alex K. K.; Ananthakrishnan, Ashwin N. N.; Xavier, Ramnik J. J.; Regev, Aviv; Gupta, Rajat M. M.; Lage, Kasper; Ardlie, Kristin G. G.; Hirschhorn, Joel N. N.; Lander, Eric S. S.; Engreitz, Jesse M. M.; Finucane, Hilary K. K.
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease
CIRCULATION-GENOMIC AND PRECISION MEDICINE
IF5.5
2022-12-019
OA
Khera, Amit, V; Wang, Minxian; Chaffin, Mark; Emdin, Connor A.; Samani, Nilesh J.; Schunkert, Heribert; Watkins, Hugh; McPherson, Ruth; Erdmann, Jeanette; Elosua, Roberto; Boerwinkle, Eric; Ardissino, Diego; Butterworth, Adam S.; Di Angelantonio, Emanuele; Naheed, Aliya; Danesh, John; Chowdhury, Rajiv; Krumholz, Harlan M.; Sheu, Wayne H-H; Rich, Stephen S.; Rotter, Jerome, I; Chen, Yii-der Ida; Gabriel, Stacey; Lander, Eric S.; Saleheen, Danish; Kathiresan, Sekar
A patient-driven clinicogenomic partnership for metastatic prostate cancer

转移性前列腺癌的患者驱动的临床基因组合作关系

CELL GENOMICS
IF9
2022-09-011
OAAI
Crowdis, Jett; Balch, Sara; Sterlin, Lauren; Thomas, Beena S.; Camp, Sabrina Y.; Dunphy, Michael; Anastasio, Elana; Shah, Shahrayz; Damon, Alyssa L.; Ramos, Rafael; Sosa, Delia M.; Small, Ilan K.; Tomson, Brett N.; Nguyen, Colleen M.; Mcgillicuddy, Mary; Chastain, Parker S.; He, Meng Xiao; Cheung, Alexander T. M.; Wankowicz, Stephanie; Tewari, Alok K.; Kim, Dewey; Aldubayan, Saud H.; Dowdye, Ayanah; Zola, Benjamin; Nowak, Joel; Manarite, Jan; Gunn, Idola Henry; Olson, Bryce; Lander, Eric S.; Painter, Corrie A.; Wagle, Nikhil; Van Allen, Eliezer M.
Inferring gene regulation from stochastic transcriptional variation across single cells at steady state

从稳态下单细胞的随机转录变异推断基因调控

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2022-08-1517
OAAI
Gupta, Anika; Martin-Rufino, Jorge D.; Jones, Thouis R.; Subramanian, Vidya; Qiu, Xiaojie; Grody, Emanuelle, I; Bloemendal, Alex; Weng, Chen; Niu, Sheng-Yong; Min, Kyung Hoi; Mehta, Arnav; Zhang, Kaite; Siraj, Layla; Khafaji, Aziz Al'; Sankaran, Vijay G.; Raychaudhuri, Soumya; Cleary, Brian; Grossman, Sharon; Lander, Eric S.
Compatibility rules of human enhancer and promoter sequences
Nature
IF48.5
2022-05-200
PRE
Drew T. Bergman; Thouis R. Jones; Vincent Liu; Judhajeet Ray; Evelyn Jagoda; Layla Siraj; Helen Y. Kang; Joseph Nasser; Michael Kane; Antonio Rios; Tung H. Nguyen; Sharon R. Grossman; Charles P. Fulco; Eric S. Lander; Jesse M. Engreitz
Genome-wide enhancer maps link risk variants to disease genes

全基因组增强子图谱将风险变异与疾病基因联系起来

Nature
IF48.5
2021-04-070
PRE
Joseph Nasser; Drew T. Bergman; Charles P. Fulco; Philine Guckelberger; Benjamin R. Doughty; Tejal A. Patwardhan; Thouis R. Jones; Tung H. Nguyen; Jacob C. Ulirsch; Fritz Lekschas; Kristy Mualim; Heini M. Natri; Elle M. Weeks; Glen Munson; Michael Kane; Helen Y. Kang; Ang Cui; John P. Ray; Thomas M. Eisenhaure; Ryan L. Collins; Kushal Dey; Hanspeter Pfister; Alkes L. Price; Charles B. Epstein; Anshul Kundaje; Ramnik J. Xavier; Mark J. Daly; Hailiang Huang; Hilary K. Finucane; Nir Hacohen; Eric S. Lander; Jesse M. Engreitz
A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

3 q21-1的一个调节变体导致高血糖和骨矿物质密度改变的多效性风险增加

CELL METABOLISM
IF30.9
2021-03-0125
OAAI
Sinnott-Armstrong, Nasa; Sousa, Isabel S.; Laber, Samantha; Rendina-Ruedy, Elizabeth; Dankel, Simon E. Nitter; Ferreira, Teresa; Mellgren, Gunnar; Karasik, David; Rivas, Manuel; Pritchard, Jonathan; Guntur, Anyonya R.; Cox, Roger D.; Lindgren, Cecilia M.; Hauner, Hans; Sallari, Richard; Rosen, Clifford J.; Hsu, Yi-Hsiang; Lander, Eric S.; Kiel, Douglas P.; Claussnitzer, Melina
HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-12-2119
OA
Marshall, Jamie L.; Doughty, Benjamin R.; Subramanian, Vidya; Guckelberger, Philine; Wang, Qingbo; Chen, Linlin M.; Rodriques, Samuel G.; Zhang, Kaite; Fulco, Charles P.; Nasser, Joseph; Grinkevich, Elizabeth J.; Noel, Teia; Mangiameli, Sarah; Bergman, Drew T.; Greka, Anna; Lander, Eric S.; Chen, Fei; Engreitz, Jesse M.

研究方向

暂未获取到该数据
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Gad Getz
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Todd R. Golub
H 指数:176论文数:757被引数:26.7万
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Mark J. Daly
H 指数:224论文数:1,263被引数:40.9万
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Matthew Meyerson
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Michael S. Lawrence
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C
Carrie Sougnez
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J
John D. Rioux
H 指数:99论文数:394被引数:7.2万
T
Thomas J. Hudson
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