未登录 分享 收藏
Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma Stevenson, Leanne; Cairns, Lauren; Li, Xiaodun; Jammula, Sriganesh; Taylor, Harriet; Douglas, Rosalie; MCabe, Niamh; Gavory, Gerald; Jacq, Xavier; Fitzgerald, Rebecca C.; Kennedy, Richard D.; Harrison, Timothy; Turkington, Richard C. 分享 收藏
Immune microenvironment modulation following neoadjuvant therapy for oesophageal adenocarcinoma: a translational analysis of the DEBIOC clinical trial Scanlon, E.; Lavery, A.; Albraikat, M.; Stevenson, L.; Kennedy, C.; Byrne, R.; Walker, A.; Mullan-Young, B.; McManus, D. T.; Virdee, P. S.; Elhussein, L.; Turbitt, J.; Collinson, D.; Miedzybrodzka, Z.; Van Schaeybroeck, S.; McQuaid, S.; James, J. A.; Craig, S. G.; Blayney, J. K.; Petty, R. D.; Harkin, D. P.; Kennedy, R. D.; Eatock, M. M.; Middleton, M. R.; Thomas, A.; Turkington, R. C. 分享 收藏
Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation Griffin, Daryl; Carson, Robbie; Moss, Debbie; Sessler, Tamas; Lavin, Deborah; Tiwari, Vijay K.; Karelia, Shivaali; Kennedy, Richard; Savage, Kienan I.; Mcdade, Simon; Carie, Adam; Pankovich, Jim; Bazett, Mark; Van Schaeybroeck, Sandra 分享 收藏
An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma Baxter, M. A.; Spender, L. C.; Cairns, D.; Walsh, S.; Oparka, R.; Porter, R. J.; Bray, S.; Skinner, G.; King, S.; Turbitt, J.; Collinson, D.; Miedzybrodzka, Z. H.; Jellema, G.; Logan, G.; Kennedy, R. D.; Turkington, R. C.; Mclean, M. H.; Swinson, D.; Grabsch, H. I.; Lord, S.; Seymour, M. J.; Hall, P. S.; Petty, R. D. 分享 收藏
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF Jurisic, Anamarija; Sung, Pei-Ju; Wappett, Mark; Daubriac, Julien; Lobb, Ian T.; Kung, Wei-Wei; Crawford, Nyree; Page, Natalie; Cassidy, Eamon; Feutren-Burton, Stephanie; Rountree, J. S. Shane; Helm, Matthew D.; O'Dowd, Colin R.; Kennedy, Richard D.; Gavory, Gerald; Cranston, Aaron N.; Longley, Daniel B.; Jacq, Xavier; Harrison, Timothy 分享 收藏
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway STAT3/LKB1通过调控mTORC1/CREB通路调控转移性前列腺癌 Pencik, Jan; Philippe, Cecile; Schlederer, Michaela; Atas, Emine; Pecoraro, Matteo; Grund-Groeschke, Sandra; Li, Wen (Jess); Tracz, Amanda; Heidegger, Isabel; Lagger, Sabine; Trachtova, Karolina; Oberhuber, Monika; Heitzer, Ellen; Aksoy, Osman; Neubauer, Heidi A.; Wingelhofer, Bettina; Orlova, Anna; Witzeneder, Nadine; Dillinger, Thomas; Redl, Elisa; Greiner, Georg; D'Andrea, David; Ostman, Johnny R.; Tangermann, Simone; Hermanova, Ivana; Schaefer, Georg; Sternberg, Felix; Pohl, Elena E.; Sternberg, Christina; Varady, Adam; Horvath, Jaqueline; Stoiber, Dagmar; Malcolm, Tim I.; Turner, Suzanne D.; Parkes, Eileen E.; Hantusch, Brigitte; Egger, Gerda; Rose-John, Stefan; Poli, Valeria; Jain, Suneil; Armstrong, Chris W. D.; Hoermann, Gregor; Goffin, Vincent; Aberger, Fritz; Moriggl, Richard; Carracedo, Arkaitz; McKinney, Cathal; Kennedy, Richard D.; Klocker, Helmut; Speicher, Michael R.; Tang, Dean G.; Moazzami, Ali A.; Heery, David M.; Hacker, Marcus; Kenner, Lukas 分享 收藏
分享 收藏
Histopathological and molecular immune landscape and DNA damage response signatures to predict response to carboplatin and docetaxel in TNT trial TNBC cohort Tovey, Holly; Sipos, Orsolya; Hoadley, Katherine A.; Parker, Joel S.; Quist, Jelmar; Kernaghan, Sarah; Kilburn, Lucy; Salgado, Roberto; Loi, Sherene; Kennedy, Richard D.; Roxanis, Ioannis; Gazinska, Patrycja; Pinder, Sarah E.; Bliss, Judith; Perou, Charles M.; Haider, Syed; Tutt, Andrew; Grigoriadis, Anita; Cheang, Maggie Chon U. 分享 收藏
分享 收藏
A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours El Helali, Aya; Plummer, Ruth; Jayson, Gordon C.; Coyle, Vicky M.; Drew, Yvette; Mescallado, Nerissa; Harris, Noor; Clamp, Andrew R.; McCann, Janine; Swaisland, Helen; Kennedy, Richard D.; Cranston, Aaron N.; Wilson, Richard H. 分享 收藏
A comprehensive systematic review and network meta-analysis: the role of anti-angiogenic agents in advanced epithelial ovarian cancer El Helali, Aya; Wong, Charlene H. L.; Choi, Horace C. W.; Chan, Wendy W. L.; Dickson, Naomi; Siu, Steven W. K.; Chan, Karen K.; Ngan, Hextan Y. S.; Ngan, Roger K. C.; Kennedy, Richard D. 分享 收藏
分享 收藏
The clinical and molecular significance associated with STING signaling in breast cancer Parkes, Eileen E.; Humphries, Matthew P.; Gilmore, Elaine; Sidi, Fatima A.; Bingham, Victoria; Phyu, Su M.; Craig, Stephanie; Graham, Catherine; Miller, Joseph; Griffin, Daryl; Salto-Tellez, Manuel; Madden, Stephen F.; Kennedy, Richard D.; Bakhoum, Samuel F.; McQuaid, Stephen; Buckley, Niamh E. 分享 收藏
分享 收藏
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer Khawaja, Hajrah; Campbell, Andrew; Roberts, Jamie Z.; Javadi, Arman; O'Reilly, Paul; McArt, Darragh; Allen, Wendy L.; Majkut, Joanna; Rehm, Markus; Bardelli, Alberto; Di Nicolantonio, Federica; Scott, Christopher J.; Kennedy, Richard; Vitale, Nicolas; Harrison, Timothy; Sansom, Owen J.; Longley, Daniel B.; Evergren, Emma; Van Schaeybroeck, Sandra 分享 收藏
分享 收藏
分享 收藏
cGAS-STING driven immune activation predicts response to neoadjuvant chemotherapy and suggests rational IO combination therapies: Results of the Neo-DDIR study McIntosh, Stuart A.; Savage, Kienan I.; James, Colin; Lioe, Tong; Walker, Steven; Lowry, Keith; Knight, Laura; McGavigan, Andrena; Logan, Gemma; Hurwitz, Jane; Kirk, Stephen J.; Harkin, Paul; Kennedy, Richard D.; Parkes, Eileen E. 分享 收藏
Results of a phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumours Roberts, Corran; Strauss, Victoria Y.; Kopijasz, Sylwia; Gourley, Charlie; Hall, Marcia; Montes, Ana; Abraham, Jacinta; Clamp, Andrew; Kennedy, Richard; Banerjee, Susana; Folkes, Lisa K.; Stratford, Michael; Nicum, Shibani 分享 收藏
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
