Gideon Bollag - Publications, H-index & Citations

Gideon Bollag

1 bolivar drive

67H指数

360论文数

3.1W被引数

收录论文 101

发表时间

RAF inhibitors activate the integrated stress response by direct activation of GCN2 RAF抑制剂通过直接激活GCN2来激活整合应激反应

Nature Communications

IF15.7

2025-11-17

OAAI

Rebecca Gilley; Andrew M. Kidger; Graham Neill; Eve Morrison; Paul Severson; Dominic P. Byrne; Niall S. Kenneth; Gideon Bollag; Chao Zhang; Taiana Maia de Oliveira; Patrick A. Eyers; Richard Bayliss; Glenn R. Masson; Simon J. Cook

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models 靶向TAZ-TEAD在微小残留病灶中增强了黑色素瘤模型中靶向治疗的持续时间

Nature Communications

IF15.7

2025-11-05

OAAI

Connor A. Ott; Timothy J. Purwin; Pan-Yu Chen; Somenath Chowdhury; George L. Mellor; Kristine Luo; Glenn L. Mersky; Manoela Tiago; William D. Madden; Scott D. Varney; Dan A. Erkes; John Lamar; Claudia Capparelli; Gideon Bollag; Andrew E. Aplin

OPN-6602, an Orally Bioavailable EP300/CBP Bromodomain Inhibitor, Targets Multiple Myeloma through Suppression of IRF4 and MYC OPN-6602，一种口服生物利用的EP300/CBP溴区结构域抑制剂，通过抑制IRF4和MYC靶向多发性骨髓瘤

BLOOD

IF23.1

2024-11-05

PREAI

Matusow, Bernice; Saghafinia, Sadegh; Li, Pei Pei; Kohler, Amanda; Chen, Pan-Yu; Nichols, Christine; Singh, Parmveer; Inokuchi, Kerry; Walling, Jackie M.; Bollag, Gideon

A Phase 1b, Dose Escalation/Dose Expansion, Multicenter, Open-Label Study to Assess the Safety and Tolerability of OPN-6602 Monotherapy and in Combination with Dexamethasone in Subjects with Relapsed and/or Refractory Multiple Myeloma 一项1b期、剂量递增/剂量扩展、多中心、开放标签研究，旨在评估OPN-6602单药治疗以及与地塞米松联合治疗在复发和/或难治性多发性骨髓瘤受试者中的安全性与耐受性。

BLOOD

IF23.1

2024-11-05

PREAI

Walling, Jackie M.; Matusow, Bernice; Nichols, Christine; Singh, Parmveer; Inokuchi, Kerry; Bollag, Gideon

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Ott, Connor A.; Purwin, Timothy; Tiago, Manoela; Lou, Kristine; Chen, Pan-Yu; Chowdhury, Somaneth; Mersky, Glenn; Hacohen, Nir; Lamar, John; Capparelli, Claudia; Bollag, Gideon; Aplin, Andrew

OPN-6602, a potent dual EP300/ CBP bromodomain inhibitor, targets multiple myeloma through concomitant suppression of IRF4 and c-MYC

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Matusow, Bernice; Spevak, Wayne; Zhang, Chao; Ma, Yan; Shellooe, Rafe; Tsai, James; Li, Pei Pei; Chen, Pan Yu; Habets, Gaston; Nichols, Christine; Singh, Parmveer; Inokuchi, Kerry; Walling, Jackie; Halladay, Jason; Bollag, Gideon

OPN-9840, a non-covalent potent pan-TEAD inhibitor, exhibits single agent efficacy in preclinical malignant mesothelioma models

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Chen, Pan-Yu; Matusow, Bernice; Tsai, James; Li, Peipei; Hoa Nguyen; Habets, Gaston; Bollag, Gideon; Chowdhury, Somenath

OPN-6602, a dual EP300/CBP bromodomain inhibitor modulates androgen-driven transcription, including MYC, in mCRPC

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Matusow, Bernice; Spevak, Wayne; Zhang, Chao; Ma, Yan; Shellooe, Rafe; Li, Peipei; Tsai, James; Chen, Pan-Yu; Singh, Parmveer; Walling, Jackie; Nichols, Christine; Halladay, Jason; Inokuchi, Kerry; Habets, Gaston; Bollag, Gideon

Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

JCI INSIGHT

IF6.1

2023-09-08

OAAI

Chen, Pan-Yu; Huang, Benjamin J.; Harris, Max; Boone, Christopher; Wang, Weijie; Carias, Heidi; Mesiona, Brian; Mavrici, Daniela; Kohler, Amanda C.; Bollag, Gideon; Zhang, Chao; Zhang, Ying; Shannon, Kevin

BET inhibition alleviates T-cell dysfunction in chronic lymphocytic leukemia

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Smith, Audrey L.; Eiken, Alexandria P.; Skupa, Sydney A.; D'Angelo, Christopher R.; Kallam, Avyakta; Lunning, Matthew A.; Bociek, Gregory; Vose, Julie M.; Ben Powell; Dalia, Gideon Bollag

Biochemical and functional characterization of germ line KRAS mutations

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

123

OAAI

Schubbert, Suzanne; Bollag, Gideon; Lyubynska, Natalya; Nguyen, Hoa; Kratz, Christian P.; Zenker, Martin; Niemeyer, Charlotte M.; Molven, Anders; Shannon, Kevin

MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus 1型神经纤维瘤病表现的MEK抑制剂: 临床证据和共识

NEURO-ONCOLOGY

IF13.4

2022-07-05

OAAI

de Blank, Peter M. K.; Gross, Andrea M.; Akshintala, Srivandana; Blakeley, Jaishri O.; Bollag, Gideon; Cannon, Ashley; Dombi, Eva; Fangusaro, Jason; Gelb, Bruce D.; Hargrave, Darren; Kim, AeRang; Klesse, Laura J.; Loh, Mignon; Martin, Staci; Moertel, Christopher; Packer, Roger; Payne, Jonathan M.; Rauen, Katherine A.; Rios, Jonathan J.; Robison, Nathan; Schorry, Elizabeth K.; Shannon, Kevin; Stevenson, David A.; Stieglitz, Elliot; Ullrich, Nicole J.; Walsh, Karin S.; Weiss, Brian D.; Wolters, Pamela L.; Yohay, Kaleb; Yohe, Marielle E.; Widemann, Brigitte C.; Fisher, Michael J.

Inhibition of Bromodomain and Extra Terminal (BET) Domain Activity Modulates the IL-23R/IL-17 Axis and Suppresses Acute Graft-Versus-Host Disease

FRONTIERS IN ONCOLOGY

IF3.3

2021-10-15

OAAI

Snyder, Katiri J.; Choe, Hannah K.; Gao, Yandi; Sell, Natalie E.; Braunreiter, Kara M.; Zitzer, Nina C.; Neidemire-Colley, Lotus; Kalyan, Sonu; Dorrance, Adrienne M.; Keller, Andrea; Mihaylova, Maria M.; Singh, Satishkumar; Sehgal, Lalit; Bollag, Gideon; Ma, Yan; Powell, Ben; Devine, Steven M.; Ranganathan, Parvathi

A novel combination regimen of BET and FLT3 inhibition for FLT3-ITD acute myeloid leukemia

HAEMATOLOGICA

IF7.9

2021-01-28

OAAI

Lee, Lauren; Hizukuri, Yoshiyuki; Severson, Paul; Powell, Benjamin; Zhang, Chao; Ma, Yan; Narahara, Maiko; Sumi, Hiroyuki; Hernandez, Daniela; Rajkhowa, Trivikram; Bollag, Gideon; Levis, Mark

Activity, safety and circulating tumour DNA (ctDNA) dynamics of paradox breaker BRAF inhibitor PLX8394 in patients with advanced cancer

ANNALS OF ONCOLOGY

IF65.4

2020-09-01

OAAI

Gouda, M. A.; Sherman, E. J.; Gilcrease, G. W.; Vaishampayan, U. N.; Parikh, A.; Feun, L.; Kummar, S.; Huang, H.; Zhang, C.; Severson, P.; Inokuchi, K.; Silverman, M.; Bollag, G.; Janku, F.

A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia 口服FLT3抑制剂pexidartinib治疗复发/难治性FLT3-ITD-mutant急性髓系白血病的1/2期研究

BLOOD ADVANCES

IF7.1

2020-04-24

OAAI

Smith, Catherine C.; Levis, Mark J.; Frankfurt, Olga; Pagel, John M.; Roboz, Gail J.; Stone, Richard M.; Wang, Eunice S.; Severson, Paul L.; West, Brian L.; Le, Mai H.; Kayser, Sabine; Lam, Bao; Hsu, Henry H.; Zhang, Chao; Bollag, Gideon; Perl, Alexander E.

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

NATURE COMMUNICATIONS

IF15.7

2019-08-21

574

OAAI

Spangenberg, Elizabeth; Severson, Paul L.; Hohsfield, Lindsay A.; Crapser, Joshua; Zhang, Jiazhong; Burton, Elizabeth A.; Zhang, Ying; Spevak, Wayne; Line, Jack; Phan, Nicole Y.; Habets, Gaston; Rymar, Andrey; Tsang, Garson; Walters, Jason; Nespi, Marika; Singh, Parmveer; Broome, Stephanie; Ibrahim, Prabha; Zhang, Chao; Bollag, Gideon; West, Brian L.; Green, Kim N.

Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer

ENDOCRINE-RELATED CANCER

IF4.6

2019-01-01

OAAI

Guan, Wei; Hu, Junhui; Yang, Lu; Tan, Ping; Tang, Zhuang; West, Brian L.; Bollag, Gideon; Xu, Hua; Wu, Lily

RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling RAF抑制剂PLX8394选择性破坏BRAF二聚体和RAS非依赖性BRAF突变体驱动的信号传导

NATURE MEDICINE

IF50

2018-12-17

146

OAAI

Yao, Zhan; Gao, Yijun; Su, Wenjing; Yaeger, Rona; Tao, Jessica; Na, Na; Zhang, Ying; Zhang, Chao; Rymar, Andrey; Tao, Anthony; Timaul, Neilawattie M.; Mcgriskin, Rory; Outmezguine, Nathaniel A.; Zhao, HuiYong; Chang, Qing; Qeriqi, Besnik; Barbacid, Mariano; de Stanchina, Elisa; Hyman, David M.; Bollag, Gideon; Rosen, Neal

PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors

CLINICAL AND EXPERIMENTAL MEDICINE

IF3.5

2018-12-06

PREAI

Gebreyohannes, Yemarshet K.; Burton, Elizabeth A.; Wozniak, Agnieszka; Matusow, Bernice; Habets, Gaston; Wellens, Jasmien; Cornillie, Jasmien; Lin, Jack; Nespi, Marika; Wu, Guoxian; Zhang, Chao; Bollag, Gideon; Debiec-Rychter, Maria; Sciot, Raf; Schoffski, Patrick

研究方向