未登录DCC-3084, a brain penetrant RAF dimer inhibitor, broadly inhibits BRAF class I, II, and III alterations leading to growth inhibition of intracranially implanted tumors in preclinical models
Al-Ani, Gada; Bulfer, Stacie L.; Zwicker, Jefferey D.; Crawley, Chase K.; Elliot, Kristin M.; Javed, Salim; Groer, Qi; Hood, Molly M.; Large, Joshua W.; Luther, Kylie; Romero, Yeni K.; Stanley, Forrest A.; Tanner, Daniel C.; Telikepalli, Hanumaiah; Le Bourdonnec, Bertrand; Smith, Bryan D.; Flynn, Daniel L. .png)
分享.png)
收藏Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacyYu, Yasmin; Bogdan, Madhumita; Noman, Muhammad Zaeem; Parpal, Santiago; Bartolini, Elisabetta; Van Moer, Kris; Kleinendorst, Simone Caroline; Saether, Kristine Bilgrav; Tresaugues, Lionel; Silvander, Camilla; Lindstroem, Johan; Simeon, Jodi; Timson, Mary Jane; Al-Hashimi, Hikmat; Smith, Bryan D.; Flynn, Daniel L.; Alexeyenko, Andrey; Viklund, Jenny; Andersson, Martin; Martinsson, Jessica; Tamm, Katja Pokrovskaja; De Milito, Angelo; Janji, Bassam 分享 收藏 分享 收藏 分享 收藏 DCC-3084, a RAF dimer inhibitor, broadly inhibits BRAF class I, II, III, BRAF fusions, and RAS-driven solid tumors leading to tumor regression in preclinical modelsBulfer, Stacie L.; Le Bourdonnec, Bertrand; Zwicker, Jeffery D.; Ahn, Yu Mi; Al-Ani, Gada; Al-Hashimi, Hikmat; Crawley, Chase; Elliott, Kristin M.; Faisal, Saqib; Harned, Andrew M.; Heiniger, Cale L.; Hood, Molly M.; Javed, Salim; Kennedy, Michael; Large, Joshua W.; Leary, Cynthia B.; Lu, Wei-Ping; Luther, Kylie; Petty, Max D.; Picard, Hunter R.; Proto, Justin T.; Romero, Yeni K.; Stanley, Forrest A.; Stoltz, Kristen L.; Tanner, Daniel C.; Telikepalli, Hanumaiah; Timson, Mary J.; Vogeti, Lakshminarayana; Vogeti, Subha; Yang, Sihyung; Zhong, Lexy H.; Smith, Bryan D.; Flynn, Daniel L. 分享 收藏 分享 收藏 DP-9024, an investigational small molecule modulator of the integrated stress response kinase GCN2, synergizes with asparaginase therapy in leukemic tumorsAl-Ani, Gada; Elliott, Kristin M.; Groer, Qi; Rudeen, Aaron J.; Kearney, Patrick C.; Zwicker, Jeffery D.; Ahn, Yu Mi; Bulfer, Stacie L.; Heiniger, Cale L.; Hood, Molly M.; Javed, Salim; Large, Joshua W.; Petty, Max D.; Stoltz, Kristen L.; Le Bourdonnec, Bertrand; Smith, Bryan D.; Flynn, Daniel L. 分享 收藏 分享 收藏 Pan-exon mutant KIT inhibitor DCC-3009 demonstrates tumor regressions in preclinical gastrointestinal stromal tumor modelsSmith, Bryan D.; Vogeti, Subha; Caldwell, Timothy M.; Telikepalli, Hanumaiah; Ahn, Yu Mi; Al-Ani, Gada; Bulfer, Stacie L.; Greenwood, Andrew; Heiniger, Cale L.; Large, Joshua W.; Leary, Cynthia B.; Lu, Wei-Ping; Luther, Kylie; Patt, William C.; Petty, Max D.; Romero, Yeni K.; Stanley, Forrest A.; Stoltz, Kristen L.; Tanner, Daniel C.; Yang, Sihyung; Zhan, Yu; Le Bourdonnec, Bertrand; Flynn, Daniel L. 分享 收藏 DP-9149, an investigational small molecule modulator of the Integrated Stress Response kinase GCN2, pre-clinically causes solid tumor growth inhibition as a single agent and regression in combination with standard of care agentsAl-Ani, Gada; Groer, Qi; Elliott, Kristin M.; Rudeen, Aaron J.; Kearney, Patrick C.; Zwicker, Jeffery D.; Ahn, Yu Mi; Bulfer, Stacie L.; Heiniger, Cale L.; Hood, Molly M.; Javid, Salim; Large, Joshua W.; Petty, Max D.; Stoltz, Kristen L.; Le Bourdonnec, Bertrand; Smith, Bryan D.; Flynn, Daniel L. 分享 收藏 DP-9024, an investigational small molecule modulator of the Integrated Stress Response kinase PERK, causes B-cell cancer growth inhibition as single agent and in combination with standard-of-care agentsAl-Ani, Gada; Groer, Qi; Rudeen, Aaron J.; Elliott, Kristin M.; Kearney, Patrick C.; Zwicker, Jeffery D.; Ahn, Yu Mi; Bulfer, Stacie L.; Heiniger, Cale L.; Hood, Molly M.; Javed, Salim; Large, Joshua W.; Petty, Max D.; Stoltz, Kristen L.; Le Bourdonnec, Bertrand; Smith, Bryan D.; Flynn, Daniel L. 分享 收藏 Dimerization-induced activation of the integrated stress response kinase PERK by an investigational small molecule modulator, DP-9024Al-Ani, Gada; Rudeen, Aaron J.; Groer, Qi; Elliott, Kristin M.; Kearney, Patrick C.; Zwicker, Jeffery D.; Ahn, Yu Mi; Bulfer, Stacie L.; Heiniger, Cale L.; Hood, Molly M.; Javid, Salim; Large, Joshua W.; Petty, Max D.; Stoltz, Kristen L.; Le Bourdonnec, Bertrand; Smith, Bryan D.; Flynn, Daniel L. 分享 收藏 分享 收藏 Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by MacrophagesSmith, Bryan D.; Kaufman, Michael D.; Wise, Scott C.; Ahn, Yu Mi; Caldwell, Timothy M.; Leary, Cynthia B.; Lu, Wei-Ping; Tan, Gege; Vogeti, Lakshminarayana; Vogeti, Subha; Wilky, Breelyn A.; Davis, Lara E.; Sharma, Maitreyi; Ruiz-Soto, Rodrigo; Flynn, Daniel L. 分享 收藏 分享 收藏 NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitorsSomwar, Romel; Hofmann, Nicolle E.; Smith, Bryan; Odintsov, Igor; Vojnic, Morana; Linkov, Irina; Tam, Ashley; Khodos, Inna; Mattar, Marissa S.; de Stanchina, Elisa; Flynn, Daniel; Ladanyi, Marc; Drilon, Alexander; Shinde, Ujwal; Davare, Monika A. 分享 收藏 A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic CancerSullivan, Ryan J.; Hollebecque, Antoine; Flaherty, Keith T.; Shapiro, Geoffrey I.; Ahnert, Jordi Rodon; Millward, Michael J.; Zhang, Wei; Gao, Ling; Sykes, Amanda; Willard, Melinda D.; Yu, Danni; Schade, Andrew E.; Crowe, KrisAnne; Flynn, Daniel L.; Kaufman, Michael D.; Henry, James R.; Peng, Sheng-Bin; Benhadji, Karim A.; Conti, Ilaria; Gordon, Michael S.; Tiu, Ramon V.; Hong, David S. 分享 收藏 Preclinical studies with DCC-3116, an ULK kinase inhibitor designed to inhibit autophagy as a potential strategy to address mutant RAS cancersSmith, Bryan D.; Vogeti, Lakshminarayana; Gupta, Anu; Singh, Jarnail; Al-Ani, Gada; Bulfer, Stacie L.; Caldwell, Timothy M.; Timson, Mary J.; Vogeti, Subha; Yu Mi Ahn; Al-Hashimi, Hikmat; Crawley, Chase K.; Heiniger, Cale L.; Leary, Cynthia B.; Proto, Justin T.; Shen, Quanrong; Telikepalli, Hanumaiah; Yates, Karen; Lu, Wei-Ping; Flynn, Daniel L. 分享 收藏 Inhibition of oncogenic and drug-resistant PDGFRA and KIT alterations by DCC-2618Smith, Bryan D.; Kaufman, Michael D.; Gupta, Anu; Leary, Cynthia B.; Lu, Wei-ping; Bulfer, Stacie L.; Al-Ani, Gada; Singh, Jarnail; Vogeti, Subha; Heinrich, Michael C.; Flynn, Daniel L. 分享 收藏 Neoadjuvant chemotherapy promotes macrophage-induced MenaINV-dependent pro-metastatic changes in breast tumorsKaragiannis, George S.; Sharma, Ved P.; Brizio, Sara; Burt, Joseph; Wang, Yarong; Entenberg, David; Smith, Bryan; Flynn, Daniel; Oktay, Maja H.; Condeelis, John 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
