Tim Holland‐Letz - Publications, H-index & Citations

Tim Holland‐Letz

german cancer research center

53H指数

203论文数

1.5W被引数

收录论文 88

发表时间

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models 全球小鼠甲基化图谱的研究揭示了小儿癌症模型中的亚型特异性拷贝数改变

Nature Genetics

IF29

2025-12-11

OAAI

Melanie Schoof; Tuyu Zheng; Martin Sill; Roland Imle; Alessia Cais; Lea Altendorf; Alicia Fürst; Nina Hofmann; Kati Ernst; Dominik Vonficht; Kenneth Chun-Ho Chan; Tim Holland-Letz; Andreas Postlmayr; Ryo Shiraishi; Wanchen Wang; Alaide Morcavallo; Michael Spohn; Carolin Göbel; Judith Niesen; Levke-Sophie Peter; Franck Bourdeaut; Zhi-Yan Han; Yanxin Pei; Najiba Murad; Fredrik J. Swartling; Jessica Taylor; Monika Yadav; Garrett R. Gibson; Richard J. Gilbertson; Matthias Dottermusch; Rajanya Roy; Kornelius Kerl; Rainer Glass; Jiying Cheng; Martin A. Horstmann; Gerrit Wolters-Eisfeld; Haotian Zhao; Dominik Sturm; Viveka Nand Yadav; Louis Chesler; Simon Haas; William A. Weiss; Paul A. Northcott; Lena M. Kutscher; Ana Guerreiro Stucklin; Olivier Ayrault; Julia E. Neumann; Daisuke Kawauchi; David T. W. Jones; Kristian Pajtler; Ana Banito; Stefan M. Pfister; Ulrich Schüller; Marc Zuckermann

Early-detection and prevention effects of screening sigmoidoscopy: evidence from randomized trials revisited 筛查性乙状结肠镜检查的早期检测和预防效果：来自随机试验的证据再回顾

JNCI: Journal of the National Cancer Institute

IF0

2025-10-30

OAAI

Hermann Brenner, MD, MPH; Tim Holland-Letz, PhD; Annette Kopp-Schneider, PhD; Thomas Heisser, PhD; Michael Hoffmeister, PhD

Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer 病理学家式可解释AI用于前列腺癌可解释的Gleason分级

Nature Communications

IF15.7

2025-10-08

OAAI

Gesa Mittmann; Sara Laiouar-Pedari; Hendrik A. Mehrtens; Sarah Haggenmüller; Tabea-Clara Bucher; Tirtha Chanda; Nadine T. Gaisa; Mathias Wagner; Gilbert Georg Klamminger; Tilman T. Rau; Christina Neppl; Eva Maria Compérat; Andreas Gocht; Monika Haemmerle; Niels J. Rupp; Jula Westhoff; Irene Krücken; Maximilian Seidl; Christian M. Schürch; Marcus Bauer; Wiebke Solass; Yu Chun Tam; Florian Weber; Rainer Grobholz; Jaroslaw Augustyniak; Thomas Kalinski; Christian Hörner; Kirsten D. Mertz; Constanze Döring; Andreas Erbersdobler; Gabriele Deubler; Felix Bremmer; Ulrich Sommer; Michael Brodhun; Jon Griffin; Maria Sarah L. Lenon; Kiril Trpkov; Liang Cheng; Fei Chen; Angelique Levi; Guoping Cai; Tri Q. Nguyen; Ali Amin; Alessia Cimadamore; Ahmed Shabaik; Varsha Manucha; Nazeel Ahmad; Nidia Messias; Francesca Sanguedolce; Diana Taheri; Ezra Baraban; Liwei Jia; Rajal B. Shah; Farshid Siadat; Nicole Swarbrick; Kyung Park; Oudai Hassan; Siamak Sakhaie; Michelle R. Downes; Hiroshi Miyamoto; Sean R. Williamson; Tim Holland-Letz; Christoph Wies; Carolin V. Schneider; Jakob Nikolas Kather; Yuri Tolkach; Titus J. Brinker

Evaluating interactions of patients with large language models for medical information 使用大型语言模型评估患者在医学信息中的交互作用

BJU INTERNATIONAL

IF4.4

2025-02-18

OAAI

Carl, Nicolas; Haggenmueller, Sarah; Wies, Christoph; Nguyen, Lisa; Winterstein, Jana Theres; Hetz, Martin Joachim; Mangold, Maurin Helen; Hartung, Friedrich Otto; Gruene, Britta; Holland-Letz, Tim; Michel, Maurice Stephan; Brinker, Titus Josef; Wessels, Frederik

Unraveling the effects of screening colonoscopy on colorectal cancer early detection and prevention: the NordICC trial revisited

CANCER COMMUNICATIONS

IF24.9

2024-12-16

OAAI

Brenner, Hermann; Holland-Letz, Tim; Kopp-Schneider, Annette; Heisser, Thomas; Hoffmeister, Michael

Comparing Patient's Confidence in Clinical Capabilities in Urology: Large Language Models Versus Urologists 比较患者对泌尿科临床能力的信心: 大型语言模型与泌尿科医师

EUROPEAN UROLOGY OPEN SCIENCE

IF4.5

2024-12-01

OAAI

Carl, Nicolas; Nguyen, Lisa; Haggenmueller, Sarah; Hetz, Martin Joachim; Winterstein, Jana Theres; Hartung, Friedrich Otto; Gruene, Britta; Kather, Jakob Nikolas; Holland-Letz, Tim; Michel, Maurice Stephan; Wessels, Frederik; Brinker, Titus Josef

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours

BRITISH JOURNAL OF CANCER

IF6.8

2024-06-28

OAAI

Seiboldt, Till; Zeiser, Constantia; Nguyen, Duy; Celikyuerekli, Simay; Herter, Sonja; Najafi, Sara; Stroh-Dege, Alexandra; Meulenbroeks, Chris; Mack, Norman; Salem-Altintas, Rabia; Westermann, Frank; Schlesner, Matthias; Milde, Till; Kool, Marcel; Holland-Letz, Tim; Vogler, Meike; Peterziel, Heike; Witt, Olaf; Oehme, Ina

SOLID PEDIATRIC TUMORS IN MICE REVEAL MODEL-SPECIFIC GLOBAL DNA METHYLATION AND CNV PROFILES CORRESPONDING TO HUMAN COUNTERPARTS

NEURO-ONCOLOGY

IF13.4

2024-06-18

OAAI

Schoof, Melanie; Zheng, Tuyu; Sill, Martin; Imle, Roland; Hofmann, Nina; Ernst, Kati; Vonficht, Dominik; Chan, Chun Ho; Cais, Alessia; Holland-Letz, Tim; Postlmayr, Andreas; Shiraishi, Ryo; Wang, Wanchen; Morcavallo, Alaide; Spohn, Michael; Goebel, Carolin; Niesen, Judith; Peter, Levke-Sophie; Eckhardt, Alicia; Bourdeaut, Franck; Han, Zhi-Yan; Pei, Yanxin; Murad, Najiba; Swartling, Fredrik J.; Taylor, Jessica; Gilbertson, Richard J.; Dottermusch, Matthias; Kerl, Kornelius; Glass, Rainer; Cheng, Jiying; Horstmann, Martin A.; Nollau, Peter; Wolters-Eisfeld, Gerrit; Zhao, Haotian; Sturm, Dominik; Chesler, Louis; Haas, Simon; Weiss, William A.; Northcott, Paul A.; Kutscher, Lena M.; Stuecklin, Ana Guerreiro; Ayrault, Olivier; Neumann, Julia E.; Kawauchi, Daisuke; Jones, David; Pfister, Stefan M.; Pajtler, Kristian; Banito, Ana; Schueller, Ulrich; Zuckermann, Marc

Colorectal cancer risk stratification on histological slides based on survival curves predicted by deep learning

NPJ PRECISION ONCOLOGY

IF8

2023-09-26

OAAI

Hoehn, Julia; Krieghoff-Henning, Eva; Wies, Christoph; Kiehl, Lennard; Hetz, Martin J.; Bucher, Tabea-Clara; Jonnagaddala, Jitendra; Zatloukal, Kurt; Mueller, Heimo; Plass, Markus; Jungwirth, Emilian; Gaiser, Timo; Steeg, Matthias; Holland-Letz, Tim; Brenner, Hermann; Hoffmeister, Michael; Brinker, Titus J.

DEVELOPMENT OF A FUNCTIONAL PLATFORM FOR REAL-TIME PERSONALIZED DRUG SENSITIVITY PROFILING OF PATIENT-DERIVED 3D FRESH TUMOR TISSUE CULTURES IN THE PEDIATRIC PRECISION ONCOLOGY PROGRAM INFORM

NEURO-ONCOLOGY

IF13.4

2023-06-12

OAAI

Peterziel, Heike; Jamaladdin, Nora; El Harouni, Dina; Gerloff, Xenia F.; Herter, Sonja; Fiesel, Petra; Berker, Yannick; Blattner-Johnson, Mirjam; Schramm, Kathrin; Jones, Barbara C.; Reuss, David; Turunen, Laura; Friedenauer, Aileen; Holland-Letz, Tim; Sill, Martin; Weiser, Lena; Previti, Christopher; Ubramanian, Gnanaprakash Balas; Gerber, Nicolas U.; Gojo, Johannes; Hutter, Caroline; Ora, Ingrid; Lohi, Olli; Kattamis, Antonis; De Wilde, Bram; Termann, Frank Wes; Tippelt, Stephan; Graf, Norbert; Nathrath, Michaela; Sparber-Sauer, Monika; Sehested, Astrid; Kramm, Christof M.; Dirksen, Uta; Kallioniemi, Olli; Pfister, Stefan M.; Van Tilburg, Cornelis M.; Jones, David T. W.; Saarela, Jani; Pietiainen, Vilja; Jager, Natalie; Schlesner, Matthias; Kopp-Schneider, Annette; Oppermann, Sina; Milde, Till; Witt, Olaf; Oehme, Ina

Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM 儿科精确肿瘤学计划中3D肿瘤组织培养物的药物敏感性分析INFORM

NPJ PRECISION ONCOLOGY

IF8

2022-12-27

OAAI

Peterziel, Heike; Jamaladdin, Nora; ElHarouni, Dina; Gerloff, Xenia F.; Herter, Sonja; Fiesel, Petra; Berker, Yannick; Blattner-Johnson, Mirjam; Schramm, Kathrin; Jones, Barbara C.; Reuss, David; Turunen, Laura; Friedenauer, Aileen; Holland-Letz, Tim; Sill, Martin; Weiser, Lena; Previti, Christopher; Balasubramanian, Gnanaprakash; Gerber, Nicolas U.; Gojo, Johannes; Hutter, Caroline; Ora, Ingrid; Lohi, Olli; Kattamis, Antonis; de Wilde, Bram; Westermann, Frank; Tippelt, Stephan; Graf, Norbert; Nathrath, Michaela; Sparber-Sauer, Monika; Sehested, Astrid; Kramm, Christof M.; Dirksen, Uta; Kallioniemi, Olli; Pfister, Stefan M.; van Tilburg, Cornelis M.; Jones, David T. W.; Saarela, Jani; Pietiaeinen, Vilja; Jaeger, Natalie; Schlesner, Matthias; Kopp-Schneider, Annette; Oppermann, Sina; Milde, Till; Witt, Olaf; Oehme, Ina

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

CELL REPORTS

IF6.9

2022-10-01

OAAI

Rommel, Marcel G. E.; Walz, Lisa; Fotopoulou, Foteini; Kohlscheen, Saskia; Schenk, Franziska; Miskey, Csaba; Botezatu, Lacramioara; Krebs, Yvonne; Voelker, Iris M.; Wittwer, Kevin; Holland-Letz, Tim; Ivics, Zoltan; von Messling, Veronika; Essers, Marieke A. G.; Milsom, Michael D.; Pfaller, Christian K.; Modlich, Ute

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging 炎症暴露导致造血干细胞自我更新活动的长期损害和加速衰老

CELL STEM CELL

IF20.4

2022-08-01

102

OAAI

Bogeska, Ruzhica; Mikecin, Ana-Matea; Kaschutnig, Paul; Fawaz, Malak; Buechler-Schaeff, Marleen; Le, Duy; Ganuza, Miguel; Vollmer, Angelika; Paffenholz, Stella, V; Asada, Noboru; Rodriguez-Correa, Esther; Frauhammer, Felix; Buettner, Florian; Ball, Melanie; Knoch, Julia; Staeble, Sina; Walter, Dagmar; Petri, Amelie; Carreno-Gonzalez, Martha J.; Wagner, Vinona; Brors, Benedikt; Haas, Simon; Lipka, Daniel B.; Essers, Marieke A. G.; Weru, Vivienn; Holland-Letz, Tim; Mallm, Jan-Philipp; Rippe, Karsten; Kraemer, Stephan; Schlesner, Matthias; Freeman, Shannon McKinney; Florian, Maria Carolina; King, Katherine Y.; Frenette, Paul S.; Rieger, Michael A.; Milsom, Michael D.

Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma

NEURO-ONCOLOGY ADVANCES

IF4.1

2022-03-13

OAAI

Krausert, Sonja; Brabetz, Sebastian; Mack, Norman L.; Schmitt-Hoffner, Felix; Schwalm, Benjamin; Peterziel, Heike; Mangang, Aileen; Holland-Letz, Tim; Sieber, Laura; Korshunov, Andrey; Oehme, Ina; Jager, Natalie; Witt, Olaf; Pfister, Stefan M.; Kool, Marcel

Diagnostic performance of artificial intelligence for histologic melanoma recognition compared to 18 international expert pathologists

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

IF11.8

2022-03-01

PREAI

Brinker, Titus J.; Schmitt, Max; Krieghoff-Henning, Eva I.; Barnhill, Raymond; Beltraminelli, Helmut; Braun, Stephan A.; Carr, Richard; Fernandez-Figueras, Maria-Teresa; Ferrara, Gerardo; Fraitag, Sylvie; Gianotti, Raffaele; Llamas-Velasco, Mar; Mueller, Cornelia S. L.; Perasole, Antonio; Requena, Luis; Sangueza, Omar P.; Santonja, Carlos; Starz, Hans; Vale, Esmeralda; Weyers, Wolfgang; Hekler, Achim; Kather, Jakob N.; Froebling, Stefan; Krahl, Dieter; Holland-Letz, Tim; Utikal, Jochen S.; Saggini, Andrea; Kutzner, Heinz

Biosensor for deconvolution of individual cell fate in response to ion beam irradiation

CELL REPORTS METHODS

IF4.5

2022-02-01

OAAI

Niklas, Martin; Schlegel, Julian; Liew, Hans; Zimmermann, Ferdinand; Rein, Katrin; Walsh, Dietrich W. M.; Dzyubachyk, Oleh; Holland-Letz, Tim; Rahmanian, Shirin; Greilich, Steffen; Runz, Armin; Jaekel, Oliver; Debus, Juergen; Abdollahi, Amir

Deep learning can predict lymph node status directly from histology in colorectal cancer 深度学习可以直接从结直肠癌组织学中预测淋巴结状态

EUROPEAN JOURNAL OF CANCER

IF7.1

2021-11-01

OAAI

Kiehl, Lennard; Kuntz, Sara; Hoehn, Julia; Jutzi, Tanja; Krieghoff-Henning, Eva; Kather, Jakob N.; Holland-Letz, Tim; Kopp-Schneider, Annette; Chang-Claude, Jenny; Brobeil, Alexander; von Kalle, Christof; Froehling, Stefan; Alwers, Elizabeth; Brenner, Hermann; Hoffmeister, Michael; Brinker, Titus J.

Performance of [68Ga]Ga-PSMA-11 PET/CT in patients with recurrent prostate cancer after prostatectomy-a multi-centre evaluation of 2533 patients 前列腺切除术后复发性前列腺癌患者的 [68Ga]Ga-PSMA-11 PET/CT表现-2533例患者的多中心评估

European Journal of Nuclear Medicine and Molecular Imaging

IF7.6

2021-02-04

OAAI

Afshar-Oromieh, Ali; da Cunha, Marcelo Livorsi; Wagner, Jairo; Haberkorn, Uwe; Debus, Nils; Weber, Wolfgang; Eiber, Matthias; Holland-Letz, Tim; Rauscher, Isabel

Potential therapeutic effect of low-dose paclitaxel in melanoma patients resistant to immune checkpoint blockade: A pilot study 低剂量紫杉醇对免疫检查点阻断耐药的黑色素瘤患者的潜在治疗作用: 一项初步研究

CELLULAR IMMUNOLOGY

IF2.9

2021-02-01

PREAI

Gebhardt, Christoffer; Simon, Sonja C. S.; Weber, Rebekka; Gries, Mirko; Mun, Dong Hun; Reinhard, Raphael; Holland-Letz, Tim; Umansky, Viktor; Utikal, Jochen

Drawing statistical conclusions from experiments with multiple quantitative measurements per subject 从每个受试者多次定量测量的实验中得出统计结论

RADIOTHERAPY AND ONCOLOGY

IF5.3

2020-11-01

PREAI

Holland-Letz, Tim; Kopp-Schneider, Annette

研究方向