未登录 Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines Elrick, Hillary; Peterson, Kevin A.; Willis, Brandon J.; Lanza, Denise G.; Acar, Elif F.; Ryder, Edward J.; Teboul, Lydia; Kasparek, Petr; Birling, Marie-Christine; Adams, David J.; Bradley, Allan; Braun, Robert E.; Brown, Steve D.; Caulder, Adam; Codner, Gemma F.; Demayo, Francesco J.; Dickinson, Mary E.; Doe, Brendan; Duddy, Graham; Gertsenstein, Marina; Goodwin, Leslie O.; Herault, Yann; Lintott, Lauri G.; Lloyd, K. C. Kent; Lorenzo, Isabel; Mackenzie, Matthew; Mallon, Ann-Marie; Mckerlie, Colin; Parkinson, Helen; Ramirez-Solis, Ramiro; Seavitt, John R.; Sedlacek, Radislav; Skarnes, William C.; Smedley, Damien; Wells, Sara; White, Jacqueline K.; Wood, Joshua A.; Akhtar, Shaheen; Allan, Alasdair J.; Allen, Susan; Andre, Philippe; Archer, Daniel; Atkins, Sarah; Avery, Ruth; Ayadi, Abdel; Barrett, Daniel; Beyetinova, Tanya; Bell, Toni; Berry, Melissa; Boroviak, Katharina; Bottomley, Joanna; Brendler-Spaeth, Tim; Brown, Ellen; Burvill, Jonathan; Bussell, James; Cardeno, Charis; Carter, Rebecca V.; Castellanos-Penton, Patricia; Christou, Skevoulla; Clark, Greg; Clarke, Shannon; Cleak, James; Crawford, Ronnie; Creighton, Amie; Cruz, Maribelle; Danisment, Ozge; Davis, Charlotte; Doran, Joanne; Erbs, Valerie; Fan-Lan, Qing; Fell, Rachel; Feng, He; Fougerolle, Jean-Victor; Fower, Alex; Frake, Gemma; Fray, Martin D.; Galli, Antonella; Gannon, David; Gardiner, Wendy J.; Gaspero, Angelina; Gleeson, Diane; Godbehere, Chris; Grau, Evelyn; Griffiths, Mark; Griggs, Nicola; Grimsrud, Kristin; Hazeltine, Sarah; Hutchison, Marie; Ingle, Catherine; Iyer, Vivek; Jager, Kayla; Joeng, Joanna; Kales, Susan; Kaur, Perminder; Kenyon, Janet; Kopkanova, Jana; Kujath, Christelle; Kundi, Helen; Kutny, Peter; Laurin, Valerie; Lejeay, Sandrine; Lelliott, Christopher; Loeffler, Jorik; Lorentz, Romain; Mccabe, Christopher V.; Malzer, Elke; Matthews, Peter; Maswood, Ryea; Mckay, Matthew; Meehan, Terrence; Melvin, David; Murphy, Alison; Nakhuda, Asif; Patel, Amit; Paulavets, Ilya; Pavlovic, Guillaume; Pawelka, Ashley; Pike, Fran J.; Platte, Radka; Price, Peter D.; Rajaya, Kiran; Reddy, Shalini; Rich, Whitney; Rosen, Barry; Ross, Victoria; Ruhe, Mark; Santos, Luis; Schaeffer, Laurence; Schwiening, Alix; Selloum, Mohammed; Sethi, Debarati; Sidiangco, Jan R.; Sinclair, Caroline; Sins, Elodie; Sleep, Gillian; Sorg, Tania; Starbuck, Becky; Stewart, Michelle; Swash, Holly; Thomas, Mark; Tondat, Sandra; Urban, Rachel; Urbanova, Jana; Varley, Susan; Von Schiller, Dominque; Wardle-Jones, Hannah; Weavers, Lauren; Woods, Michael; Murray, Stephen A.; Heaney, Jason D.; Nutter, Lauryl M. J. 分享 收藏
Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models Dumont, Beth L.; Gatti, Daniel M.; Ballinger, Mallory A.; Lin, Dana; Phifer-Rixey, Megan; Sheehan, Michael J.; Suzuki, Taichi A.; Wooldridge, Lydia K.; Frempong, Hilda Opoku; Lawal, Raman Akinyanju; Churchill, Gary A.; Lutz, Cathleen; Rosenthal, Nadia; White, Jacqueline K.; Nachman, Michael W. 分享 收藏
Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity Peterson, Kevin A.; Khalouei, Sam; Hanafi, Nour; Wood, Joshua A.; Lanza, Denise G.; Lintott, Lauri G.; Willis, Brandon J.; Seavitt, John R.; Braun, Robert E.; Dickinson, Mary E.; White, Jacqueline K.; Lloyd, K. C. Kent; Heaney, Jason D.; Murray, Stephen A.; Ramani, Arun; Nutter, Lauryl M. J. 分享 收藏
Artefacts in Volume Data Generated with High Resolution Episcopic Microscopy (HREM) Reissig, Lukas F.; Geyer, Stefan H.; Rose, Julia; Prin, Fabrice; Wilson, Robert; Szumska, Dorota; Galli, Antonella; Tudor, Catherine; White, Jacqueline K.; Mohun, Tim J.; Weninger, Wolfgang J. 分享 收藏
Accelerating functional gene discovery in osteoarthritis (vol 12, 467, 2021) Butterfield, Natalie C.; Curry, Katherine F.; Steinberg, Julia; Dewhurst, Hannah; Komla-Ebri, Davide; Mannan, Naila S.; Adoum, Anne-Tounsia; Leitch, Victoria D.; Logan, John G.; Waung, Julian A.; Ghirardello, Elena; Southam, Lorraine; Youlten, Scott E.; Wilkinson, J. Mark; McAninch, Elizabeth A.; Vancollie, Valerie E.; Kussy, Fiona; White, Jacqueline K.; Lelliott, Christopher J.; Adams, David J.; Jacques, Richard; Bianco, Antonio C.; Boyde, Alan; Zeggini, Eleftheria; Croucher, Peter I.; Williams, Graham R.; Bassett, J. H. Duncan 分享 收藏
Accelerating functional gene discovery in osteoarthritis 加速骨关节炎的功能基因发现 Butterfield, Natalie C.; Curry, Katherine F.; Steinberg, Julia; Dewhurst, Hannah; Komla-Ebri, Davide; Mannan, Naila S.; Adoum, Anne-Tounsia; Leitch, Victoria D.; Logan, John G.; Waung, Julian A.; Ghirardello, Elena; Southam, Lorraine; Youlten, Scott E.; Wilkinson, J. Mark; McAninch, Elizabeth A.; Vancollie, Valerie E.; Kussy, Fiona; White, Jacqueline K.; Lelliott, Christopher J.; Adams, David J.; Jacques, Richard; Bianco, Antonio C.; Boyde, Alan; Zeggini, Eleftheria; Croucher, Peter I.; Williams, Graham R.; Bassett, J. H. Duncan 分享 收藏
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density Swan, Anna L.; Schuett, Christine; Rozman, Jan; Moreno, Maria del Mar Muniz; Brandmaier, Stefan; Simon, Michelle; Leuchtenberger, Stefanie; Griffiths, Mark; Brommage, Robert; Keskivali-Bond, Piia; Grallert, Harald; Werner, Thomas; Teperino, Raffaele; Becker, Lore; Miller, Gregor; Moshiri, Ala; Seavitt, John R.; Cissell, Derek D.; Meehan, Terrence F.; Acar, Elif F.; Lelliott, Christopher J.; Flenniken, Ann M.; Champy, Marie-France; Sorg, Tania; Ayadi, Abdel; Braun, Robert E.; Cater, Heather; Dickinson, Mary E.; Flicek, Paul; Gallegos, Juan; Ghirardello, Elena J.; Heaney, Jason D.; Jacquot, Sylvie; Lally, Connor; Logan, John G.; Teboul, Lydia; Mason, Jeremy; Spielmann, Nadine; McKerlie, Colin; Murray, Stephen A.; Nutter, Lauryl M. J.; Odfalk, Kristian F.; Parkinson, Helen; Prochazka, Jan; Reynolds, Corey L.; Selloum, Mohammed; Spoutil, Frantisek; Svenson, Karen L.; Vales, Taylor S.; Wells, Sara E.; White, Jacqueline K.; Sedlacek, Radislav; Wurst, Wolfgang; Lloyd, Kent K. C.; Croucher, Peter, I; Fuchs, Helmut; Williams, Graham R.; Bassett, Duncan; Gailus-Durner, Valerie; Herault, Yann; Mallon, Ann-Marie; Brown, Steve D. M.; Mayer-Kuckuk, Philipp; de Angelis, Martin Hrabe 分享 收藏
T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue Racine, Jeremy J.; Chapman, Harold D.; Doty, Rosalinda; Cairns, Brynn M.; Hines, Timothy J.; Tadenev, Abigail L. D.; Anderson, Laura C.; Green, Torrian; Dyer, Meaghan E.; Wotton, Janine M.; Bichler, Zoe; White, Jacqueline K.; Ettinger, Rachel; Burgess, Robert W.; Serreze, David, V 分享 收藏
The Deep Genome Project Lloyd, K. C. Kent; Adams, David J.; Baynam, Gareth; Beaudet, Arthur L.; Bosch, Fatima; Boycott, Kym M.; Braun, Robert E.; Caulfield, Mark; Cohn, Ronald; Dickinson, Mary E.; Dobbie, Michael S.; Flenniken, Ann M.; Flicek, Paul; Galande, Sanjeev; Gao, Xiang; Grobler, Anne; Heaney, Jason D.; Herault, Yann; De Angelis, Martin Hrabe; Lupski, James R.; Lyonnet, Stanislas; Mallon, Ann-Marie; Mammano, Fabio; MacRae, Calum A.; McInnes, Roderick; McKerlie, Colin; Meehan, Terrence F.; Murray, Stephen A.; Nutter, Lauryl M. J.; Obata, Yuichi; Parkinson, Helen; Pepper, Michael S.; Sedlacek, Radislav; Seong, Je Kyung; Shiroishi, Toshihiko; Smedley, Damian; Tocchini-Valentini, Glauco; Valle, David; Wang, Chi-Kuang Leo; Wells, Sara; White, Jacqueline; Wurst, Wolfgang; Xu, Ying; Brown, Steve D. M. 分享 收藏
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation Abeler-Dorner, Lucie; Laing, Adam G.; Lorenc, Anna; Ushakov, Dmitry S.; Clare, Simon; Speak, Anneliese O.; Duque-Correa, Maria A.; White, Jacqueline K.; Ramirez-Solis, Ramiro; Saran, Namita; Bull, Katherine R.; Moron, Belen; Iwasaki, Jua; Barton, Philippa R.; Caetano, Susana; Hng, Keng I.; Cambridge, Emma; Forman, Simon; Crockford, Tanya L.; Griffiths, Mark; Kane, Leanne; Harcourt, Katherine; Brandt, Cordelia; Notley, George; Babalola, Kolawole O.; Warren, Jonathan; Mason, Jeremy C.; Meeniga, Amrutha; Karp, Natasha A.; Melvin, David; Cawthorne, Eleanor; Weinrick, Brian; Rahim, Albina; Drissler, Sibyl; Meskas, Justin; Yue, Alice; Lux, Markus; Song-Zhao, George X.; Chan, Anna; Reviriego, Carmen Ballesteros; Abeler, Johannes; Wilson, Heather; Przemska-Kosicka, Agnieszka; Edmans, Matthew; Strevens, Natasha; Pasztorek, Markus; Meehan, Terrence F.; Powrie, Fiona; Brinkman, Ryan; Dougan, Gordon; Jacobs, William, Jr.; Lloyd, Clare M.; Cornall, Richard J.; Maloy, Kevin J.; Grencis, Richard K.; Griffiths, Gillian M.; Adams, David J.; Hayday, Adrian C. 分享 收藏
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis Collins, Stephan C.; Mikhaleva, Anna; Vrcelj, Katarina; Vancollie, Valerie E.; Wagner, Christel; Demeure, Nestor; Whitley, Helen; Kannan, Meghna; Balz, Rebecca; Anthony, Lauren F. E.; Edwards, Andrew; Moine, Herve; White, Jacqueline K.; Adams, David J.; Reymond, Alexandre; Lelliott, Christopher J.; Webber, Caleb; Yalcin, Binnaz 分享 收藏
Common and distinct transcriptional signatures of mammalian embryonic lethality Collins, John E.; White, Richard J.; Staudt, Nicole; Sealy, Ian M.; Packham, Ian; Wali, Neha; Tudor, Catherine; Mazzeo, Cecilia; Green, Angela; Siragher, Emma; Ryder, Edward; White, Jacqueline K.; Papatheodoru, Irene; Tang, Amy; Fullgrabe, Anja; Bills, Konstantinos; Geyer, Stefan H.; Weninger, Wolfgang J.; Galli, Antonella; Hemberger, Myriam; Stemple, Derek L.; Robertson, Elizabeth; Smith, James C.; Mohun, Timothy; Adams, David J.; Busch-Nentwich, Elisabeth M. 分享 收藏
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Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis Goodwin, Leslie O.; Splinter, Erik; Davis, Tiffany L.; Urban, Rachel; He, Hao; Braun, Robert E.; Chesler, Elissa J.; Kumar, Vivek; van Min, Max; Ndukum, Juliet; Philip, Vivek M.; Reinholdt, Laura G.; Svenson, Karen; White, Jacqueline K.; Sasner, Michael; Lutz, Cathleen; Murray, Stephen A. 分享 收藏
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis Kemp, John P.; Morris, John A.; Medina-Gomez, Carolina; Forgetta, Vincenzo; Warrington, Nicole M.; Youlten, Scott E.; Zheng, Jie; Gregson, Celia L.; Grundberg, Elin; Trajanoska, Katerina; Logan, John G.; Pollard, Andrea S.; Sparkes, Penny C.; Ghirardello, Elena J.; Allen, Rebecca; Leitch, Victoria D.; Butterfield, Natalie C.; Komla-Ebri, Davide; Adoum, Anne-Tounsia; Curry, Katharine F.; White, Jacqueline K.; Kussy, Fiona; Greenlaw, Keelin M.; Xu, Changjiang; Harvey, Nicholas C.; Cooper, Cyrus; Adams, David J.; Greenwood, Celia M. T.; Maurano, Matthew T.; Kaptoge, Stephen; Rivadeneira, Fernando; Tobias, Jonathan H.; Croucher, Peter I.; Ackert-Bicknell, Cheryl L.; Bassett, J. H. Duncan; Williams, Graham R.; Richards, J. Brent; Evans, David M. 分享 收藏
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium Meehan, Terrence F.; Conte, Nathalie; West, David B.; Jacobsen, Julius O.; Mason, Jeremy; Warren, Jonathan; Chen, Chao-Kung; Tudose, Ilinca; Relac, Mike; Matthews, Peter; Karp, Natasha; Santos, Luis; Fiegel, Tanja; Ring, Natalie; Westerberg, Henrik; Greenaway, Simon; Sneddon, Duncan; Morgan, Hugh; Codner, Gemma F.; Stewart, Michelle E.; Brown, James; Horner, Neil; Haendel, Melissa; Washington, Nicole; Mungall, Christopher J.; Reynolds, Corey L.; Gallegos, Juan; Gailus-Durner, Valerie; Sorg, Tania; Pavlovic, Guillaume; Bower, Lynette R.; Moore, Mark; Morse, Iva; Gao, Xiang; Tocchini-Valentini, Glauco P.; Obata, Yuichi; Cho, Soo Young; Seong, Je Kyung; Seavitt, John; Beaudet, Arthur L.; Dickinson, Mary E.; Herault, Yann; Wurst, Wolfgang; de Angelis, Martin Hrabe; Lloyd, K. C. Kent; Flenniken, Ann M.; Nutter, Lauryl M. J.; Newbigging, Susan; McKerlie, Colin; Justice, Monica J.; Murray, Stephen A.; Svenson, Karen L.; Braun, Robert E.; White, Jacqueline K.; Bradley, Allan; Flicek, Paul; Wells, Sara; Skarnes, William C.; Adams, David J.; Parkinson, Helen; Mallon, Ann-Marie; Brown, Steve D. M.; Smedley, Damian 分享 收藏
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S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse Ingham, Neil J.; Carlisle, Francesca; Pearson, Selina; Lewis, Morag A.; Buniello, Annalisa; Chen, Jing; Isaacson, Rivka L.; Pass, Johanna; White, Jacqueline K.; Dawson, Sally J.; Steel, Karen P. 分享 收藏
Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing Buniello, Annalisa; Ingham, Neil J.; Lewis, Morag A.; Huma, Andreea C.; Martinez-Vega, Raquel; Varela-Nieto, Isabel; Vizcay-Barrena, Gema; Fleck, Roland A.; Houston, Oliver; Bardhan, Tanaya; Johnson, Stuart L.; White, Jacqueline K.; Yuan, Huijun; Marcotti, Walter; Steel, Karen P. 分享 收藏
Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration 锌指蛋白ZFP106的缺乏导致运动和感觉神经变性 Joyce, Peter I.; Fratta, Pietro; Landman, Allison S.; Mcgoldrick, Philip; Wackerhage, Henning; Groves, Michael; Busam, Bharani Shiva; Galino, Jorge; Corrochano, Silvia; Beskina, Olga A.; Esapa, Christopher; Ryder, Edward; Carter, Sarah; Stewart, Michelle; Codner, Gemma; Hilton, Helen; Teboul, Lydia; Tucker, Jennifer; Lionikas, Arimantas; Estabel, Jeanne; Ramirez-Solis, Ramiro; White, Jacqueline K.; Brandner, Sebastian; Plagnol, Vincent; Bennet, David L. H.; Abramov, Andrey Y.; Greensmith, Linda; Fisher, Elizabeth M. C.; Acevedo-Arozena, Abraham 分享 收藏
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