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收藏分享 收藏 TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation (vol 5, pg 1834, 2024)TIGIT和PD-L1协同阻断通过促进共刺激作用，促进多能、非耗竭抗肿瘤T细胞的克隆扩增（vol 5, pg 1834, 2024）
Nutsch, Katherine; Banta, Karl L.; Wu, Thomas D.; Tran, Charles W.; Mittman, Stephanie; Duong, Ellen; Nabet, Barzin Y.; Qu, Yan; Muller, Soren; Patil, Namrata S.; Chiang, Eugene Y.; Mellman, Ira 分享 收藏 Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentationGuttman, Ofer; Le Thomas, Adrien; Marsters, Scot; Lawrence, David A.; Gutgesell, Lauren; Zuazo-Gaztelu, Iratxe; Harnoss, Jonathan M.; Haag, Simone M.; Murthy, Aditya; Strasser, Geraldine; Modrusan, Zora; Wu, Thomas; Mellman, Ira; Ashkenazi, Avi 分享 收藏 Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responsesBanta, Karl L.; Xu, Xiaozheng; Chitre, Avantika S.; Au-Yeung, Amelia; Takahashi, Chikara; O'Gorman, William E.; Wu, Thomas D.; Mittman, Stephanie; Cubas, Rafael; Comps-Agrar, Laetitia; Fulzele, Amit; Bennett, Eric J.; Grogan, Jane L.; Hui, Enfu; Chiang, Eugene Y.; Mellman, Ira 分享 收藏 Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1αLe Thomas, Adrien; Ferri, Elena; Marsters, Scot; Harnoss, Jonathan M.; Lawrence, David A.; Zuazo-Gaztelu, Iratxe; Modrusan, Zora; Chan, Sara; Solon, Margaret; Chalouni, Cecile; Li, Weihan; Koeppen, Hartmut; Rudolph, Joachim; Wang, Weiru; Wu, Thomas D.; Walter, Peter; Ashkenazi, Avi 分享 收藏 Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapiesLo, Amy A.; Wallace, Andrew; Oreper, Daniel; Lounsbury, Nicolas; Havnar, Charles; Pechuan-Jorge, Ximo; Wu, Thomas D.; Bourgon, Richard; Jones, Ryan; Krogh, Katrina; Yang, Guang-Yu; Zill, Oliver A. 分享 收藏 IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor MicroenvironmentHarnoss, Jonathan M.; Le Thomas, Adrien; Reichelt, Mike; Guttman, Ofer; Wu, Thomas D.; Marsters, Scot A.; Shemorry, Anna; Lawrence, David A.; Kan, David; Segal, Ehud; Merchant, Mark; Totpal, Klara; Crocker, Lisa M.; Mesh, Kathryn; Dohse, Monika; Solon, Margaret; Modrusan, Zora; Rudolph, Joachim; Koeppen, Hartmut; Walter, Peter; Ashkenazi, Avi 分享 收藏 CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1Du, Xiangnan; de Almeida, Patricia; Manieri, Nick; Nagata, Denise de Almeida; Wu, Thomas D.; Bowles, Kristin Harden; Arumugam, Vidhyalakshmi; Schartner, Jill; Cubas, Rafael; Mittman, Stephanie; Javinal, Vincent; Anderson, Keith R.; Warming, Soren; Grogan, Jane L.; Chiang, Eugene Y. 分享 收藏 Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding AntibodyChai, Ning; Swem, Lee R.; Reichelt, Mike; Chen-Harris, Haiyin; Luis, Elizabeth; Park, Summer; Fouts, Ashley; Lupardus, Patrick; Wu, Thomas D.; Li, Olga; McBride, Jacqueline; Lawrence, Michael; Xu, Min; Tan, Man-Wah 分享 收藏 Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterationsBueno, Raphael; Stawiski, Eric W.; Goldstein, Leonard D.; Durinck, Steffen; De Rienzo, Assunta; Modrusan, Zora; Gnad, Florian; Nguyen, Thong T.; Jaiswal, Bijay S.; Chirieac, Lucian R.; Sciaranghella, Daniele; Dao, Nhien; Gustafson, Corinne E.; Munir, Kiara J.; Hackney, Jason A.; Chaudhuri, Amitabha; Gupta, Ravi; Guillory, Joseph; Toy, Karen; Ha, Connie; Chen, Ying-Jiun; Stinson, Jeremy; Chaudhuri, Subhra; Zhang, Na; Wu, Thomas D.; Sugarbaker, David J.; de Sauvage, Frederic J.; Richards, William G.; Seshagiri, Somasekar 分享 收藏 A comprehensive transcriptional portrait of human cancer cell lines人类癌细胞系的全面转录肖像Klijn, Christiaan; Durinck, Steffen; Stawiski, Eric W.; Haverty, Peter M.; Jiang, Zhaoshi; Liu, Hanbin; Degenhardt, Jeremiah; Mayba, Oleg; Gnad, Florian; Liu, Jinfeng; Pau, Gregoire; Reeder, Jens; Cao, Yi; Mukhyala, Kiran; Selvaraj, Suresh K.; Yu, Mamie; Zynda, Gregory J.; Brauer, Matthew J.; Wu, Thomas D.; Gentleman, Robert C.; Manning, Gerard; Yauch, Robert L.; Bourgon, Richard; Stokoe, David; Modrusan, Zora; Neve, Richard M.; de Sauvage, Frederic J.; Settleman, Jeffrey; Seshagiri, Somasekar; Zhang, Zemin 分享 收藏 Diverse modes of genomic alteration in hepatocellular carcinomaJhunjhunwala, Suchit; Jiang, Zhaoshi; Stawiski, Eric W.; Gnad, Florian; Liu, Jinfeng; Mayba, Oleg; Du, Pan; Diao, Jingyu; Johnson, Stephanie; Wong, Kwong-Fai; Gao, Zhibo; Li, Yingrui; Wu, Thomas D.; Kapadia, Sharookh B.; Modrusan, Zora; French, Dorothy M.; Luk, John M.; Seshagiri, Somasekar; Zhang, Zemin 分享 收藏 Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancerLiu, Jinfeng; McCleland, Mark; Stawiski, Eric W.; Gnad, Florian; Mayba, Oleg; Haverty, Peter M.; Durinck, Steffen; Chen, Ying-Jiun; Klijn, Christiaan; Jhunjhunwala, Suchit; Lawrence, Michael; Liu, Hanbin; Wan, Yinan; Chopra, Vivek; Yaylaoglu, Murat B.; Yuan, Wenlin; Ha, Connie; Gilbert, Houston N.; Reeder, Jens; Pau, Gregoire; Stinson, Jeremy; Stern, Howard M.; Manning, Gerard; Wu, Thomas D.; Neve, Richard M.; de Sauvage, Frederic J.; Modrusan, Zora; Seshagiri, Somasekar; Firestein, Ron; Zhang, Zemin 分享 收藏 Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancersParikh, Chaitali; Janakiraman, Vasantharajan; Wu, Wen-I; Foo, Catherine K.; Kljavin, Noelyn M.; Chaudhuri, Subhra; Stawiski, Eric; Lee, Brian; Lin, Jie; Li, Hong; Lorenzo, Maria N.; Yuan, Wenlin; Guillory, Joseph; Jackson, Marlena; Rondon, Jesus; Franke, Yvonne; Bowman, Krista K.; Sagolla, Meredith; Stinson, Jeremy; Wu, Thomas D.; Wu, Jiansheng; Stokoe, David; Stern, Howard M.; Brandhuber, Barbara J.; Lin, Kui; Skelton, Nicholas J.; Seshagiri, Somasekar 分享 收藏 Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing eventsLiu, Jinfeng; Lee, William; Jiang, Zhaoshi; Chen, Zhongqiang; Jhunjhunwala, Suchit; Haverty, Peter M.; Gnad, Florian; Guan, Yinghui; Gilbert, Houston N.; Stinson, Jeremy; Klijn, Christiaan; Guillory, Joseph; Bhatt, Deepali; Vartanian, Steffan; Walter, Kimberly; Chan, Jocelyn; Holcomb, Thomas; Dijkgraaf, Peter; Johnson, Stephanie; Koeman, Julie; Minna, John D.; Gazdar, Adi F.; Stern, Howard M.; Hoeflich, Klaus P.; Wu, Thomas D.; Settleman, Jeff; de Sauvage, Frederic J.; Gentleman, Robert C.; Neve, Richard M.; Stokoe, David; Modrusan, Zora; Seshagiri, Somasekar; Shames, David S.; Zhang, Zemin 分享 收藏 Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancerRudin, Charles M.; Durinck, Steffen; Stawiski, Eric W.; Poirier, John T.; Modrusan, Zora; Shames, David S.; Bergbower, Emily A.; Guan, Yinghui; Shin, James; Guillory, Joseph; Rivers, Celina Sanchez; Foo, Catherine K.; Bhatt, Deepali; Stinson, Jeremy; Gnad, Florian; Haverty, Peter M.; Gentleman, Robert; Chaudhuri, Subhra; Janakiraman, Vasantharajan; Jaiswal, Bijay S.; Parikh, Chaitali; Yuan, Wenlin; Zhang, Zemin; Koeppen, Hartmut; Wu, Thomas D.; Stern, Howard M.; Yauch, Robert L.; Huffman, Kenneth E.; Paskulin, Diego D.; Illei, Peter B.; Varella-Garcia, Marileila; Gazdar, Adi F.; de Sauvage, Frederic J.; Bourgon, Richard; Minna, John D.; Brock, Malcolm V.; Seshagiri, Somasekar 分享 收藏 The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patientsJiang, Zhaoshi; Jhunjhunwala, Suchit; Liu, Jinfeng; Haverty, Peter M.; Kennemer, Michael I.; Guan, Yinghui; Lee, William; Carnevali, Paolo; Stinson, Jeremy; Johnson, Stephanie; Diao, Jingyu; Yeung, Stacy; Jubb, Adrian; Ye, Weilan; Wu, Thomas D.; Kapadia, Sharookh B.; de Sauvage, Frederic J.; Gentleman, Robert C.; Stern, Howard M.; Seshagiri, Somasekar; Pant, Krishna P.; Modrusan, Zora; Ballinger, Dennis G.; Zhang, Zemin 分享 收藏 分享 收藏 Differential aberrant DNA methylation predicts for Tarceva response in NSCLCShames, David S.; Januario, Tom; Holcomb, Thomas; Soriano, Robert; Wu, Thomas; Modrusan, Zora; Seshagiri, Somasekar; Egan, Brian; Hampton, Garret M.; Amler, Lukas C.; Yauch, Robert L. 分享 收藏 
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