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收藏The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury
Lee, Hakjoo; Lee, Tae Jin; Galloway, Chad A.; Zhi, Wenbo; Xiao, Wei; Bentley, Karen L. de Mesy; Sharma, Ashok; Teng, Yong; Sesaki, Hiromi; Yoon, Yisang
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收藏Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents通过高通量筛选鉴定ERK5转录活性的激活因子以及内皮细胞ERK5在他汀类药物和抗疟药诱导的血管保护作用中的作用
Nhat-Tu Le; Takei, Yuichiro; Izawa-Ishizawa, Yuki; Heo, Kyung-Sun; Lee, Hakjoo; Smrcka, Alan V.; Miller, Benjamin L.; Ko, Kyung Ae; Ture, Sara; Morrell, Craig; Fujiwara, Keigi; Akaike, Masashi; Abe, Jun-ichi
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收藏A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis
Nhat-Tu Le; Heo, Kyung-Sun; Takei, Yuichiro; Lee, Hakjoo; Woo, Chang-Hoon; Chang, Eugene; McClain, Carolyn; Hurley, Cheryl; Wang, Xin; Li, Faqian; Xu, Haodong; Morrell, Craig; Sullivan, Mark A.; Cohen, Michael S.; Serafimova, Iana M.; Taunton, Jack; Fujiwara, Keigi; Abe, Jun-ichi
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收藏Phosphorylation of Adaptor Protein Containing Pleckstrin Homology Domain, Phosphotyrosine Binding Domain, and Leucine Zipper Motif 1 (APPL1) at Ser430 Mediates Endoplasmic Reticulum (ER) Stress-induced Insulin Resistance in Hepatocytes
Liu, Meilian; Zhou, Lijun; Wei, Li; Villarreal, Ricardo; Yang, Xin; Hu, Derong; Riojas, Ramon A.; Holmes, Bekke M.; Langlais, Paul R.; Lee, Hakjoo; Dong, Lily Q.
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