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Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency Castiello, Maria Carmina; Brandas, Chiara; Ferrari, Samuele; Porcellini, Simona; Sacchetti, Nicolo; Canarutto, Daniele; Draghici, Elena; Merelli, Ivan; Barcella, Matteo; Pelosi, Gabriele; Vavassori, Valentina; Varesi, Angelica; Jacob, Aurelien; Scala, Serena; Basso Ricci, Luca; Paulis, Marianna; Strina, Dario; Di Verniere, Martina; Sergi Sergi, Lucia; Serafini, Marta; Holland, Steven M.; Bergerson, Jenna R. E.; De Ravin, Suk See; Malech, Harry L.; Pala, Francesca; Bosticardo, Marita; Brombin, Chiara; Cugnata, Federica; Calzoni, Enrica; Crooks, Gay M.; Notarangelo, Luigi D.; Genovese, Pietro; Naldini, Luigi; Villa, Anna 分享 收藏
Generation of antigen-specific mature T cells from RAG1-/-RAG2-/-B2M-/- stem cells by engineering their microenvironment Chang, Patrick C.; Yuan, Xuegang; Zampieri, Alexandre; Towns, Chloe; Yoo, Sang Pil; Engstrom, Claire; Tsai, Steven; Robles, Christopher R.; Zhu, Yuhua; Lopez, Shawn; Montel-Hagen, Amelie; Seet, Christopher S.; Crooks, Gay M. 分享 收藏
IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing IRIS: 发现前mRNA选择性剪接引起的癌症免疫治疗靶点 Pan, Yang; Phillips, John W.; Zhang, Beatrice D.; Noguchi, Miyako; Kutschera, Eric; McLaughlin, Jami; Nesterenko, Pavlo A.; Mao, Zhiyuan; Bangayan, Nathanael J.; Wang, Robert; Tran, Wendy; Yang, Harry T.; Wang, Yuanyuan; Xu, Yang; Obusan, Matthew B.; Cheng, Donghui; Lee, Alex H.; Kadash-Edmondson, Kathryn E.; Champhekar, Ameya; Puig-Saus, Cristina; Ribas, Antoni; Prins, Robert M.; Seet, Christopher S.; Crooks, Gay M.; Witte, Owen N.; Xing, Yi 分享 收藏
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Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells Li, Suwen; Wang, Chloe S.; Montel-Hagen, Amelie; Chen, Ho-Chung; Lopez, Shawn; Zhou, Olivia; Dai, Kristy; Tsai, Steven; Satyadi, William; Botero, Carlos; Wong, Claudia; Casero, David; Crooks, Gay M.; Seet, Christopher S. 分享 收藏
Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity Abt, Evan R.; Rashid, Khalid; Le, Thuc M.; Li, Suwen; Lee, Hailey R.; Lok, Vincent; Li, Luyi; Creech, Amanda L.; Labora, Amanda N.; Mandl, Hanna K.; Lam, Alex K.; Cho, Arthur; Rezek, Valerie; Wu, Nanping; Abril-Rodriguez, Gabriel; Rosser, Ethan W.; Mittelman, Steven D.; Hugo, Willy; Mehrling, Thomas; Bantia, Shanta; Ribas, Antoni; Donahue, Timothy R.; Crooks, Gay M.; Wu, Ting-Ting; Radu, Caius G. 分享 收藏
Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation Mao, Zhiyuan; Nesterenko, Pavlo A.; McLaughlin, Jami; Deng, Weixian; Sojo, Giselle Burton; Cheng, Donghui; Noguchi, Miyako; Chour, William; DeLucia, Diana C.; Finton, Kathryn A.; Qin, Yu; Obusan, Matthew B.; Tran, Wendy; Wang, Liang; Bangayan, Nathanael J.; Ta, Lisa; Chen, Chia-Chun; Seet, Christopher S.; Crooks, Gay M.; Phillips, John W.; Heath, James R.; Strong, Roland K.; Lee, John K.; Wohlschlegel, James A.; Witte, Owen N. 分享 收藏
Strength of CAR signaling reveals bifurcation of T and ILC2 lineage differentiation from pluripotent stem cells Li, Suwen; Wang, Chloe S.; Montel-Hagen, Amelie; Casero, David; Lopez, Shawn; Chen, Ho-Chung; Zhou, Olivia; Botero, Carlos; Tsai, Steven C.; Wong, Claudia; Crooks, Gay M.; Seet, Christopher S. 分享 收藏
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells 3d类器官培养支持人类CAR ipsc分化为高功能CAR T细胞 Wang, Zhiqiang; McWilliams-Koeppen, Helen P.; Reza, Hernan; Ostberg, Julie R.; Chen, Wuyang; Wang, Xiuli; Huynh, Christian; Vyas, Vibhuti; Chang, Wen-Chung; Starr, Renate; Wagner, Jamie R.; Aguilar, Brenda; Yang, Xin; Wu, Xiwei; Wang, Jinhui; Chen, Wei; Koelker-Wolfe, Ellery; Seet, Christopher S.; Montel-Hagen, Amelie; Crooks, Gay M.; Forman, Stephen J.; Brown, Christine E. 分享 收藏
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells (vol 29, 515.e1, 2022) Wang, Zhiqiang; McWilliams-Koeppen, Helen P.; Reza, Hernan; Ostberg, Julie R.; Chen, Wuyang; Wang, Xiuli; Huynh, Christian; Vyas, Vibhuti; Chang, Wen-Chung; Starr, Renate; Wagner, Jamie R.; Aguilar, Brenda; Yang, Xin; Wu, Xiwei; Wang, Jinhui; Chen, Wei; Koelker-Wolfe, Ellery; Seet, Christopher S.; Montel-Hagen, Amelie; Crooks, Gay M.; Forman, Stephen J.; Brown, Christine E. 分享 收藏
High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry Yiu, Gloria; Rasmussen, Tue Kruse; Tsai, Brandon L.; Diep, Vivian K.; Haddon, David J.; Tsoi, Jennifer; Miller, Gopika D.; Comin-Anduix, Begona; Deleuran, Bent; Crooks, Gay M.; Utz, Paul J. 分享 收藏
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy 开发用于现成的癌症免疫治疗的同种异体HSC工程iNKT细胞 Li, Yan-Ruid; Zhou, Yang; Kim, Yu Jeong; Zhu, Yanni; Ma, Feiyang; Yu, Jiaji; Wang, Yu-Chen; Chen, Xianhui; Li, Zhe; Zeng, Samuel; Wang, Xi; Lee, Derek; Ku, Josh; Tsao, Tasha; Hardoy, Christian; Huang, Jie; Cheng, Donghui; Montel-Hagen, Amelie; Seet, Christopher S.; Crooks, Gay M.; Larson, Sarah M.; Sasine, Joshua P.; Wang, Xiaoyan; Pellegrini, Matteo; Ribas, Anton; Kohn, Donald B.; Wirtte, Owen; Wang, Pin; Yang, Lili 分享 收藏
The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro Sun, Victoria; Sharpley, Mark; Kaczor-Urbanowicz, Karolina E.; Chang, Patrick; Montel-Hagen, Amelie; Lopez, Shawn; Zampieri, Alexandre; Zhu, Yuhua; de Barros, Stephanie C.; Parekh, Chintan; Casero, David; Banerjee, Utpal; Crooks, Gay M. 分享 收藏
Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency 自体慢病毒基因治疗腺苷脱氨酶缺乏症 Kohn, D. B.; Booth, C.; Shaw, K. L.; Xu-Bayford, J.; Garabedian, E.; Trevisan, V.; Carbonaro-Sarracino, D. A.; Soni, K.; Terrazas, D.; Snell, K.; Ikeda, A.; Leon-Rico, D.; Moore, T. B.; Buckland, K. F.; Shah, A. J.; Gilmour, K. C.; De Oliveira, S.; Rivat, C.; Crooks, G. M.; Izotova, N.; Tse, J.; Adams, S.; Shupien, S.; Ricketts, H.; Davila, A.; Uzowuru, C.; Icreverzi, A.; Barman, P.; Fernandez, B. Campo; Hollis, R. P.; Coronel, M.; Yu, A.; Chun, K. M.; Casas, C. E.; Zhang, R.; Arduini, S.; Lynn, F.; Kudari, M.; Spezzi, A.; Zahn, M.; Heimke, R.; Labik, I.; Parrott, R.; Buckley, R. H.; Reeves, L.; Cornetta, K.; Sokolic, R.; Hershfield, M.; Schmidt, M.; Candotti, F.; Malech, H. L.; Thrasher, A. J.; Gaspar, H. B. 分享 收藏
Gene Editing Rescues in Vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System (Mar, 10.1007/s10875-021-00989-6, 2021) Gardner, Cameron L.; Pavel-Dinu, Mara; Dobbs, Kerry; Bosticardo, Marita; Reardon, Paul K.; Lack, Justin; DeRavin, Suk See; Le, Kent; Bello, Ezekiel; Pala, Francesca; Delmonte, Ottavia M.; Malech, Harry; Montel-Hagen, Amelie; Crooks, Gay; Acuto, Oreste; Porteus, Matthew H.; Notarangelo, Luigi D. 分享 收藏
Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System 基因编辑拯救人工胸腺类器官系统中RAG2-Deficient诱导多能干细胞的体外T细胞发育 Gardner, Cameron L.; Pavel-Dinu, Mara; Dobbs, Kerry; Bosticardo, Marita; Reardon, Paul K.; Lack, Justin; DeRavin, Suk See; Le, Kent; Bello, Ezekiel; Pala, Francesca; Delmonte, Ottavia M.; Malech, Harry; Montel-Hagan, Amelie; Crooks, Gay; Acuto, Oreste; Porteus, Matthew H.; Notarangelo, Luigi D. 分享 收藏
Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration Zbinden, Aline; Layland, Shannon L.; Urbanczyk, Max; Carvajal Berrio, Daniel A.; Marzi, Julia; Zauner, Monika; Hammerschmidt, Anne; Brauchle, Eva M.; Sudrow, Katrin; Fink, Simon; Templin, Markus; Liebscher, Simone; Klein, Gerd; Deb, Arjun; Duffy, Garry P.; Crooks, Gay M.; Eble, Johannes A.; Mikkola, Hanna K. A.; Nsair, Ali; Seifert, Martina; Schenke-Layland, Katja 分享 收藏
Pleiotropic Roles of VEGF in the Microenvironment of the Developing Thymus VEGF在发育中的胸腺微环境中的多效性作用 de Barros, Stephanie C.; Suterwala, Batul T.; He, Chongbin; Ge, Shundi; Chick, Brent; Blumberg, Garrett K.; Kim, Kenneth; Klein, Sam; Zhu, Yuhua; Wang, Xiaoyan; Casero, David; Crooks, Gay M. 分享 收藏
In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells Montel-Hagen, Amelie; Sun, Victoria; Casero, David; Tsai, Steven; Zampieri, Alexandre; Jackson, Nicholas; Li, Suwen; Lopez, Shawn; Zhu, Yuhua; Chick, Brent; He, Chongbin; de Barros, Stephanie C.; Seet, Christopher S.; Crooks, Gay M. 分享 收藏
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