Thorsten R. Mempel - Publications, H-index & Citations

Thorsten R. Mempel

Massachusetts General Hospital and Harvard Medical School

56H指数

135论文数

1.8W被引数

收录论文 64

发表时间

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer CRISPR筛选识别恢复癌症中年龄相关T细胞功能障碍的靶点

Cell

IF42.5

2026-07-29

PREAI

Alex C.Y. Chen; Keely Y. Ji; Cansu Yerinde; Nelson H. Knudsen; Kevin Bi; Shumeng Hao; Vasyl Zhabotynsky; Daniela Martinez; Thomas J. Carmona-LaSalle; Kazuhiro Taguchi; Katherine H. Xu; Elizabeth M. Seider; Marc A. Schwartz; Maria Zschummel; Linda T. Nieman; Kathleen B. Yates; Francesca S. Gazzaniga; Brian C. Miller; Thorsten R. Mempel; Robert T. Manguso

Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity 瘤内递送4-1BBL可增强IL-12触发的抗胶质瘤免疫反应

Molecular Therapy

IF12

2025-08-20

OAAI

Taral R. Lunavat; Lisa Nieland; Sanne M. van de Looij; Alexandra J.E.M. de Reus; Charles P. Couturier; Chadi A. El Farran; Tyler E. Miller; Julia K. Lill; Maryam Schübel; Tianhe Xiao; Emilio Di Ianni; Elliot C. Woods; Yi Sun; David Rufino-Ramos; Thomas S. van Solinge; Shadi Mahjoum; Emily Grandell; Mao Li; Vamsi Mangena; Gavin P. Dunn; Russell W. Jenkins; Thorsten R. Mempel; Xandra O. Breakefield; Koen Breyne

Chemokines that govern T cell activity in tumors

CURRENT OPINION IN IMMUNOLOGY

IF5.8

2025-02-01

PREAI

Mempel, Thorsten R.; Malehmir, Mohsen

Epigenetic therapy modulates the tumor microenvironment to sensitize anti-PD-1 refractory head and neck cancers to immunotherapy 表观遗传疗法通过调节肿瘤微环境，使对PD-1耐药的头颈癌对免疫治疗更敏感。

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

Pai, S.; Qin, T.; Mattox, A.; Campbell, J.; Park, J. C.; Shin, K-Y.; Sadow, P.; Faquin, W.; Haddad, R.; Pittet, M.; Garris, C.; Mempel, T.; Oneill, A.; Sartor, M.

The aged tumor microenvironment limits T cell control of cancer 老年肿瘤微环境限制了T细胞对癌症的控制

NATURE IMMUNOLOGY

IF27.6

2024-05-14

OAAI

Chen, Alex C. Y.; Jaiswal, Sneha; Martinez, Daniela; Yerinde, Cansu; Ji, Keely; Miranda, Velita; Fung, Megan E.; Weiss, Sarah A.; Zschummel, Maria; Taguchi, Kazuhiro; Garris, Christopher S.; Mempel, Thorsten R.; Hacohen, Nir; Sen, Debattama R.

The aged tumor microenvironment limits CD8+T cell control of cancer

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

How chemokines organize the tumour microenvironment 趋化因子如何组织肿瘤微环境

NATURE REVIEWS CANCER

IF66.8

2023-12-08

PREAI

Mempel, Thorsten R.; Lill, Julia K.; Altenburger, Lukas M.

Review Dendritic cells as shepherds of T cell immunity in cancer 树突状细胞作为癌症T细胞免疫的牧羊人

IMMUNITY

IF26.3

2023-10-01

OAAI

Pittet, Mikael J.; Di Pilato, Mauro; Garris, Christopher; Mempel, Thorsten R.

Combining precision oncology and immunotherapy by targeting the MALT1 protease

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2022-10-21

OAAI

Mempel, Thorsten R.; Krappmann, Daniel

CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

IMMUNITY

IF26.3

2022-01-01

OAAI

Ozga, Aleksandra J.; Chow, Melvyn T.; Lopes, Mateus E.; Servis, Rachel L.; Di Pilato, Mauro; Dehio, Philippe; Lian, Jeffrey; Mempel, Thorsten R.; Luster, Andrew D.

Reprogramming regulatory T cells (Treg) using a MALT1 inhibitor for cancer therapy

MOLECULAR CANCER THERAPEUTICS

IF5.5

2021-12-01

PREAI

Keller, Peter; Mazo, Irina; Gao, Yun; Reddy, Vijayapal; Caballero, Francisco; Kazer, Sam; Miller, Dannah; Gianani, Roberto; Marvin, James E.; Stephens, Bret; Beatty, Gregory L.; Von Andrian, Ulrich H.; Mempel, Thorsten R.

MPT-0118 a clinical drug candidate to assess Treg reprogramming via MALT1 blockade

ANNALS OF ONCOLOGY

IF65.4

2021-09-01

OAAI

Keller, P.; Mazo, I.; Gao, Y.; Reddy, V.; Caballero, F.; Stephens, B.; Marvin, J. E.; Fu, A.; Sun, Y.; Jenkins, R. W.; von Andrian, U. H.; Mempel, T. R.

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

SCIENCE ADVANCES

IF12.5

2021-06-11

OAAI

Cadilha, Bruno L.; Benmebarek, Mohamed-Reda; Dorman, Klara; Oner, Arman; Lorenzini, Theo; Obeck, Hannah; Vaenttinen, Mira; Di Pilato, Mauro; Pruessmann, Jasper N.; Stoiber, Stefan; Duc Huynh; Maerkl, Florian; Seifert, Matthias; Manske, Katrin; Suarez-Gosalvez, Javier; Zeng, Yi; Lesch, Stefanie; Karches, Clara H.; Heise, Constanze; Gottschlich, Adrian; Thomas, Moritz; Marr, Carsten; Zhang, Jin; Pandey, Dharmendra; Feuchtinger, Tobias; Subklewe, Marion; Mempel, Thorsten R.; Endres, Stefan; Kobold, Sebastian

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours 带有c-x-c趋化因子受体6型的T细胞可增强胰腺肿瘤的过继细胞疗法

NATURE BIOMEDICAL ENGINEERING

IF26.6

2021-06-03

107

OAAI

Lesch, Stefanie; Blumenberg, Viktoria; Stoiber, Stefan; Gottschlich, Adrian; Ogonek, Justyna; Cadilha, Bruno L.; Dantes, Zahra; Rataj, Felicitas; Dorman, Klara; Lutz, Johannes; Karches, Clara H.; Heise, Constanze; Kurzay, Mathias; Larimer, Benjamin M.; Grassmann, Simon; Rapp, Moritz; Nottebrock, Alessia; Kruger, Stephan; Tokarew, Nicholas; Metzger, Philipp; Hoerth, Christine; Benmebarek, Mohamed-Reda; Dhoqina, Dario; Grunmeier, Ruth; Seifert, Matthias; Oener, Arman; Umut, Oyku; Joaquina, Sandy; Vimeux, Lene; Tran, Thi; Hank, Thomas; Baba, Taisuke; Huynh, Duc; Megens, Remco T. A.; Janssen, Klaus-Peter; Jastroch, Martin; Lamp, Daniel; Ruehland, Svenja; Di Pilato, Mauro; Pruessmann, Jasper N.; Thomas, Moritz; Marr, Carsten; Ormanns, Steffen; Reischer, Anna; Hristov, Michael; Tartour, Eric; Donnadieu, Emmanuel; Rothenfusser, Simon; Duewell, Peter; Konig, Lars M.; Schnurr, Max; Subklewe, Marion; Liss, Andrew S.; Halama, Niels; Reichert, Maximilian; Mempel, Thorsten R.; Endres, Stefan; Kobold, Sebastian

Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation

CANCER DISCOVERY

IF33.3

2021-05-03

OAAI

Heckler, Max; Ali, Lestat R.; Clancy-Thompson, Eleanor; Qiang, Li; Ventre, Katherine S.; Lenehan, Patrick; Roehle, Kevin; Luoma, Adrienne; Boelaars, Kelly; Peters, Vera; McCreary, Julia; Boschert, Tamara; Wang, Eric S.; Suo, Shengbao; Marangoni, Francesco; Mempel, Thorsten R.; Long, Henry W.; Wucherpfennig, Kai W.; Dougan, Michael; Gray, Nathanael S.; Yuan, Guo-Cheng; Goel, Shom; Tolaney, Sara M.; Dougan, Stephanie K.

Cancer cells relax and resist cytotoxic attack

IMMUNITY

IF26.3

2021-05-01

OAAI

Usmani, Shariq M.; Mempel, Thorsten R.

Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation

SCIENCE IMMUNOLOGY

IF16.3

2019-05-24

OAAI

Miyabe, Yoshishige; Miyabe, Chie; Mani, Vinidhra; Mempel, Thorsten R.; Luster, Andrew D.

Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response

IMMUNOLOGICAL REVIEWS

IF8.3

2019-04-11

OAAI

Mempel, Thorsten R.; Marangoni, Francesco

Multidimensional communication in the microenvirons of glioblastoma

NATURE REVIEWS NEUROLOGY

IF33.1

2018-07-09

406

OAAI

Broekman, Marike L.; Maas, Sybren L. N.; Abels, Erik R.; Mempel, Thorsten R.; Krichevsky, Anna M.; Breakefield, Xandra O.

Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin 调节性T细胞的肿瘤耐受促进功能由CD28优化，但严格依赖于钙调神经磷酸酶

JOURNAL OF IMMUNOLOGY

IF3.4

2018-05-15

OAAI

Marangoni, Francesco; Zhang, Ruan; Mani, Vinidhra; Thelen, Martin; Akbar, Noor J. Ali; Warner, Ross D.; Aijo, Tarmo; Zappulli, Valentina; Martinez, Gustavo J.; Turka, Laurence A.; Mempel, Thorsten R.

研究方向