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K

Kevin R. MacKenzie

baylor college of medicine

26H指数
90论文数
4.2K被引数
收录论文 43
发表时间
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Characterizing the Reactive Metabolites of Colony-Stimulating Factor 1 Receptor Inhibitor PLX5622 in Liver Microsomes and Mice表征集落刺激因子1受体抑制剂PLX5622在肝微粒体和小鼠中的活性代谢物
errChemical Research in Toxicology
IF3.8
err2026-06-27
err0
PREAI
errShenzhi Zhou; Thomas Lee; Xingyu Ji; Kevin R. Mackenzie; Feng Li
err分享
err收藏
Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded libraries利用DNA编码化合物库发现一种新型小分子降解剂，可靶向野生型和突变型雌激素受体
errnpj Breast Cancer
IF7.6
err2025-11-12
err0
errOAAI
errAnil Kumar Devakrishnan; Chandrashekhar Madasu; Yong Wang; Ramkumar Modukuri; Kurt M. Bohren; Kevin R. MacKenzie; Damian W. Young; Suzanne A. W. Fuqua; Martin M. Matzuk; Murugesan Palaniappan
err分享
err收藏
Phytoconstituents as therapeutic agents in combating methotrexate-induced hepatotoxicity and nephrotoxicity植物成分作为治疗剂在对抗甲氨蝶呤诱导的肝毒性和肾毒性中的作用
errExpert Opinion on Drug Metabolism & Toxicology
IF3.4
err2025-11-06
err0
PREAI
errAshish Dogra; Mary Paine; Kevin R. Mackenzie; Feng Li
err分享
err收藏
Metabolism, Pharmacokinetics, and Tissue Distribution of a Selective FK506-Binding Protein 12 F36V Mutant Degrader in Mice代谢、药代动力学及组织分布：一种选择性FK506结合蛋白12 F36V突变体降解剂在小鼠中的研究
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-11-01
err0
PREAI
errZhou, Shenzhi; Qin, Xuan; Tran, Kevin; Wang, Jian; Ji, Xingyu; Mackenzie, Kevin R.; Chamakuri, Srinivas; Wang, Jin; Li, Feng
err分享
err收藏
Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver表征酪氨酸激酶抑制剂pexidartinib在小鼠粪便、尿液、血浆和肝脏中的代谢物
errJournal of Pharmaceutical and Biomedical Analysis
IF3.1
err2025-06-16
err0
PREAI
errXuan Qin; Si Chen; John M. Hakenjos; Jian Wang; Lei Guo; Ashish Dogra; Zhaoyong Hu; Kevin R. MacKenzie; Feng Li
err分享
err收藏
CSF1R Kinase Inhibitor Pexidartinib Disrupts Bile Acid Homeostasis in MiceCSF1R激酶抑制剂培希坦尼在 mice 中破坏胆汁酸稳态
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errLi, Feng; Qin, Xuan; Chen, Si; Zhou, Shenzhi; Hakenjos, John M.; Guo, Lei; Mackenzie, Kevin R.
err分享
err收藏
Discovery of highly potent and ALK2/ALK 1 selective kinase inhibitors using DNA- encoded chemistry technology
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-11-14
err0
errOAAI
errJimmidi, Ravikumar; Monsivais, Diana; Ta, Hai Minh; Sharma, Kiran L.; Bohren, Kurt M.; Chamakuri, Srinivas; Liao, Zian; Li, Feng; Hakenjos, John M.; Li, Jian - Yuan; Mishina, Yuji; Pan, Haichun; Qin, Xuan; Robers, Matthew B.; Sankaran, Banumathi; Tan, Zhi; Tang, Suni; Vasquez, Yasmin M.; Wilkinson, Jennifer; Young, Damian W.; Palmer, Stephen S.; Mackenzie, Kevin R.; Kim, Choel; Matzuk, Martin M.
err分享
err收藏
On-demand modular assembly for expedited PROTAC development用于加速PROTAC开发的按需模块化组装
errEXPERT OPINION ON DRUG DISCOVERY
IF4.9
err2024-06-06
err0
errOAAI
errMukherjee, Ayan; Kadam, Vilas D.; Miao, Qi; Zhang, Wanheng; MacKenzie, Kevin R.; Tan, Zhi; Teng, Mingxing
err分享
err收藏
CYP3A Mediates an Unusual C(sp2)-C(sp3) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-04-29
err0
errOAAI
errQin, Xuan; Wang, Yong; Ye, Qiuji; Hakenjos, John M.; Wang, Jin; Teng, Mingxing; Guo, Lei; Tan, Zhi; Young, Damian W.; Mackenzie, Kevin R.; Li, Feng
err分享
err收藏
Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-03-29
err1
errOAAI
errLu, Dong; Chen, Jianwei; Qin, Li; Bijou, Imani; Yi, Ping; Li, Feng; Song, Xianzhou; Mackenzie, Kevin R.; Yu, Xin; Yang, Bin; Roy Chowdhury, Sandipan; Korp, James D.; O'Malley, Bert W.; Lonard, David M.; Wang, Jin
err分享
err收藏
Expanding Complex Morpholines Using Systematic Chemical Diversity
errORGANIC LETTERS
IF5
err2024-03-20
err1
PREAI
errTang, Sunny Ann; Fults, Afton; Boyd, Shelton R.; Gattu, Nikhil; Tran, Kevin A.; Fan, Jiayi; Mackenzie, Kevin R.; Palzkill, Timothy; Young, Damian W.; Chamakuri, Srinivas
err分享
err收藏
Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity
errDRUG METABOLISM REVIEWS
IF3.8
err2024-02-20
err2
PREAI
errKhalil, Saleh M.; Mackenzie, Kevin R.; Maletic-Savatic, Mirjana; Li, Feng
err分享
err收藏
Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2024-01-02
err3
errOAAI
errHolmes, Secondra; Jain, Prashi; Rodriguez, Kenneth Guzman; Williams, Jade; Yu, Zhifeng; Cerda-Smith, Christian; Samuel, Errol L. G.; Campbell, James; Hakenjos, John Michael; Monsivais, Diana; Li, Feng; Chamakuri, Srinivas; Matzuk, Martin M.; Santini, Conrad; Mackenzie, Kevin R.; Young, Damian W.
err分享
err收藏
Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2023-08-29
err2
errOAAI
errViveki, Amol B.; Mansfield, Timothy M.; Tran, Kevin A.; Lenkeit, Evan; Mackenzie, Kevin R.; Young, Damian W.; Chamakuri, Srinivas
err分享
err收藏
Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC-MS-Based Metabolomic Approaches使用基于lc-ms的代谢组学方法体外鉴定酪氨酸激酶抑制剂Pexidartinib的反应性代谢物
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2023-08-02
err4
errOAAI
errQin, Xuan; Wang, Yong; MacKenzie, Kevin R.; Hakenjos, John M.; Chen, Si; Khalil, Saleh M.; Jung, Sung Yun; Young, Damian W.; Guo, Lei; Li, Feng
err分享
err收藏
Impairing Cytochrome P450-mediated metabolism aggravates the hepatoxicity of serotonin and norepinephrine reuptake inhibitor duloxetine
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errLi, Feng; Qin, Xuan; Hakenjos, John M.; Mackenzie, Kevin; Guo, Lei
err分享
err收藏
The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice
errEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
IF4.7
err2023-02-01
err4
errOAAI
errQin, Xuan; Xie, Cen; Hakenjos, John M.; MacKenzie, Kevin R.; Boyd, Shelton R.; Barzi, Mercedes; Bissig, Karl-Dimiter; Young, Damian W.; Li, Feng
err分享
err收藏
Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections
errANDROLOGY
IF3.4
err2022-11-02
err3
errOAAI
errYe, Qiuji; Belabed, Hassane; Wang, Yong; Yu, Zhifeng; Palaniappan, Murugesan; Li, Jian-Yuan; Kalovidouris, Stacey A.; MacKenzie, Kevin R.; Teng, Mingxing; Young, Damian W.; Fujihara, Yoshitaka; Matzuk, Martin M.
err分享
err收藏
An auto-inhibited state of protein kinase G and implications for selective activation蛋白激酶G的自动抑制状态及其对选择性激活的影响
errELIFE
IF0
err2022-08-05
err3
errOAAI
errSharma, Rajesh; Kim, Jeong Joo; Qin, Liying; Henning, Philipp; Akimoto, Madoka; VanSchouwen, Bryan; Kaur, Gundeep; Sankaran, Banumathi; MacKenzie, Kevin R.; Melacini, Giuseppe; Casteel, Darren E.; Herberg, Friedrich W.; Kim, Choel
err分享
err收藏
A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines
errMOLECULES
IF4.6
err2022-05-25
err5
errOAAI
errChamakuri, Srinivas; Tang, Sunny Ann; Tran, Kevin A.; Guduru, Shiva Krishna Reddy; Bolin, Peter K.; MacKenzie, Kevin R.; Young, Damian W.
err分享
err收藏

研究方向

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合作学者
合作期刊
B
Bert W. O’Malley
H 指数: 160 · 论文数: 1.4K
J
Johannes Lehmann
H 指数: 122 · 论文数: 1.2K
M
Martin M. Matzuk
H 指数: 118 · 论文数: 571
H
Hugo J. Bellen
H 指数: 117 · 论文数: 611
A
Axel T. Brünger
H 指数: 115 · 论文数: 533
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