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PNPLA3-I148M genetic variant rewires lipid metabolism to drive programmed cell death in human hepatocytes PNPLA3-I148M基因变异重编程脂质代谢，驱动人肝细胞程序性死亡。 Florentino, Rodrigo M.; Animasahun, Olamide; Haep, Nils; Nenwani, Minal; Omoloja, Kehinde; Altay, Leyla Nurcihan; Achreja, Abhinav; Morita, Kazutoyo; Motomura, Takashi; Diaz-Aragon, Ricardo; Faccioli, Lanuza A. P.; Sun, Yiyue; Liu, Zhenghao; Hu, Zhiping; Yang, Bo; Wuchu, Fulei; Shankaran, Ajay; Paserba, Miya; Baratta, Annalisa M.; Arazov, Shohrat; Kocas-Kilicarslan, Zehra N.; Meurs, Noah; Behari, Jaideep; Tafaleng, Edgar N.; Franks, Jonathan; Ostrowska, Alina; Tomiyama, Takahiro; Yugawa, Kyohei; Morinaga, Akinari; Wang, Zi; Takeishi, Kazuki; Gavlock, Dillon C.; Miedel, Mark; Taylor, D. Lansing; Fox, Ira J.; Yoshizumi, Tomoharu; Nagrath, Deepak; Soto-Gutierrez, Alejandro 分享 收藏
Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice Chowdhury, Olivia; Bammidi, Sridhar; Gautam, Pooja; Babu, Vishnu Suresh; Liu, Haitao; Shang, Peng; Xin, Ying; Mahally, Emma; Nemani, Mihir; Koontz, Victoria; Lathrop, Kira; Kedziora, Katarzyna M.; Franks, Jonathan; Sun, Ming; Smith, Joshua W.; Devine, Lauren R.; Cole, Robert N.; Stepicheva, Nadezda; Strizhakova, Anastasia; Chattopadhyay, Sreya; Hose, Stacey; Zigler, Jacob Samuel; Sahel, Jose-Alain; Qian, Jiang; Guha, Prasun; Handa, James T.; Ghosh, Sayan; Sinha, Debasish 分享 收藏
A genetically inducible endothelial niche enables vascularization of human kidney organoids see commentary with multilineage maturation and emergence of renin expressing cells 遗传诱导的内皮生态位使人类肾脏类器官的血管化参见多谱系成熟和肾素表达细胞出现的评论 Maggiore, Joseph C.; Legraw, Ryan; Przepiorski, Aneta; Velazquez, Jeremy; Chaney, Christopher; Vanichapol, Thitinee; Streeter, Evan; Almuallim, Zainab; Oda, Akira; Chiba, Takuto; Silva-Barbosa, Anne; Franks, Jonathan; Hislop, Joshua; Hill, Alex; Wu, Haojia; Pfister, Katherine; Howden, Sara E.; Watkins, Simon C.; Little, Melissa H.; Humphreys, Benjamin D.; Kiani, Samira; Watson, Alan; Stolz, Donna B.; Davidson, Alan J.; Carroll, Tom; Cleaver, Ondine; Sims-Lucas, Sunder; Ebrahimkhani, Mo R.; Hukriede, Neil A. 分享 收藏
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Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant 基于人类诱导多能干细胞的脂质代谢相关TM6SF2-E167K变体的肝脏建模 Faccioli, Lanuza A. P.; Sun, Yiyue; Animasahun, Olamide; Motomura, Takashi; Liu, Zhenghao; Kurihara, Takeshi; Hu, Zhiping; Yang, Bo; Cetin, Zeliha; Baratta, Annalisa M.; Shankaran, Ajay; Nenwani, Minal; Altay, Leyla Nurcihan; Huang, Linqi; Meurs, Noah; Franks, Jonathan; Stolz, Donna; Gavlock, Dillon C.; Miedel, Mark T.; Ostrowska, Alina; Florentino, Rodrigo M.; Fox, Ira J.; Nagrath, Deepak; Soto-Gutierrez, Alejandro 分享 收藏
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD Ghosh, Sayan; Sharma, Ruchi; Bammidi, Sridhar; Koontz, Victoria; Nemani, Mihir; Yazdankhah, Meysam; Kedziora, Katarzyna M.; Stolz, Donna Beer; Wallace, Callen T.; Cheng, Yu-Wei; Franks, Jonathan; Bose, Devika; Shang, Peng; Ambrosino, Helena M.; Dutton, James R.; Geng, Zhaohui; Montford, Jair; Ryu, Jiwon; Rajasundaram, Dhivyaa; Hose, Stacey; Sahel, Jose-Alain; Puertollano, Rosa; Finkel, Toren; Zigler, J. Samuel; Sergeev, Yuri; Watkins, Simon C.; Goetzman, Eric S.; Ferrington, Deborah A.; Flores-Bellver, Miguel; Kaarniranta, Kai; Sodhi, Akrit; Bharti, Kapil; Handa, James T.; Sinha, Debasish 分享 收藏
Phenotypic and transcriptional characterization of F. tularensis LVS during transition into a viable but non-culturable state (vol 15, 1347488, 2024) Cantlay, Stuart; Garrison, Nicole L.; Patterson, Rachelle; Wagner, Kassey; Kirk, Zoei; Fan, Jun; Primerano, Donald A.; Sullivan, Mara L. G.; Franks, Jonathan M.; Stolz, Donna B.; Horzempa, Joseph 分享 收藏
Phenotypic and transcriptional characterization of F. tularensis LVS during transition into a viable but non-culturable state Cantlay, Stuart; Garrison, Nicole L.; Patterson, Rachelle; Wagner, Kassey; Kirk, Zoei; Fan, Jun; Primerano, Donald A.; Sullivan, Mara L. G.; Franks, Jonathan M.; Stolz, Donna B.; Horzempa, Joseph 分享 收藏
In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection 具有wcaJ突变的肺炎克雷伯菌荚膜缺陷的体内进化促进了反复感染期间补体介导的调理吞噬作用 Bain, William; Ahn, Brian; Penaloza, Hernan F.; McElheny, Christi L.; Tolman, Nathanial; van der Geest, Rick; Gonzalez-Ferrer, Shekina; Chen, Nathalie; An, Xiaojing; Hosuru, Ria; Tabary, Mohammadreza; Papke, Erin; Kohli, Naina; Farooq, Nauman; Bachman, William; Olonisakin, Tolani F.; Xiong, Zeyu; Griffith, Marissa P.; Sullivan, Mara; Franks, Jonathan; Mustapha, Mustapha M.; Iovleva, Alina; Suber, Tomeka; Shanks, Robert Q.; Ferreira, Viviana P.; Stolz, Donna B.; Van Tyne, Daria; Doi, Yohei; Lee, Janet S. 分享 收藏
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model Romanowski, Eric G.; Stella, Nicholas A.; Brazile, Bryn L.; Lathrop, Kira L.; Franks, Jonathan M.; Sigal, Ian A.; Kim, Tami; Elsayed, Mennat; Kadouri, Daniel E.; Shanks, Robert M. Q. 分享 收藏
Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts Han, Lu; Mich-Basso, Jocelyn D.; Li, Yao; Ammanamanchi, Niyatie; Xu, Jianquan; Bargaje, Anita P.; Liu, Honghai; Wu, Liwen; Jeong, Jong-Hyeon; Franks, Jonathan; Stolz, Donna B.; Wu, Yijen L.; Rajasundaram, Dhivyaa; Liu, Yang; Kuhn, Bernhard 分享 收藏
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction (vol 123, pg 5212, 2013) Lam, Hilaire C.; Cloonan, Suzanne M.; Bhashyam, Abhiram R.; Haspel, Jeffery A.; Singh, Anju; Sathirapongsasuti, J. Fah; Cervo, Morgan; Yao, Hongwei; Chung, Anna L.; Mizumura, Kenji; An, Chang Hyeok; Shan, Bin; Franks, Jonathan M.; Haley, Kathleen J.; Owen, Caroline A.; Tesfaigzi, Yohannes; Washko, George R.; Quackenbush, John; Silverman, Edwin K.; Rahman, Irfan; Kim, Hong Pyo; Mahmood, Ashfaq; Biswal, Shyam S.; Ryter, Stefan W.; Choi, Augustine M. K. 分享 收藏
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells Takeishi, Kazuki; de l'Hortet, Alexandra Collin; Wang, Yang; Handa, Kan; Guzman-Lepe, Jorge; Matsubara, Kentaro; Morita, Kazutoyo; Jang, Sae; Haep, Nils; Florentino, Rodrigo M.; Yuan, Fangchao; Fukumitsu, Ken; Tobita, Kimimasa; Sun, Wendell; Franks, Jonathan; Delgado, Evan R.; Shapiro, Erik M.; Fraunhoffer, Nicolas A.; Duncan, Andrew W.; Yagi, Hiroshi; Mashimo, Tomoji; Fox, Ira J.; Soto-Gutierrez, Alejandro 分享 收藏
Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition 通过T抗原抑制将Sox2-dependent默克尔细胞癌转化为分化的神经元样表型 Harold, Alexis; Amako, Yutaka; Hachisuka, Junichi; Bai, Yulong; Li, Meng Yen; Kubat, Linda; Gravemeyer, Jan; Franks, Jonathan; Gibbs, Julia R.; Park, Hyun Jung; Ezhkova, Elena; Becker, Juergen C.; Shuda, Masahiro 分享 收藏
Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells Brothers, Kimberly M.; Callaghan, Jake D.; Stella, Nicholas A.; Bachinsky, Julianna M.; AlHigaylan, Mohammed; Lehner, Kara L.; Franks, Jonathan M.; Lathrop, Kira L.; Collins, Elliot; Schmitt, Deanna M.; Horzempa, Joseph; Shanks, Robert M. Q. 分享 收藏
Serralysin family metalloproteases protects Serratia marcescens from predation by the predatory bacteria Micavibrio aeruginosavorus Garcia, Carlos J.; Pericleous, Androulla; Elsayed, Mennat; Tran, Michael; Gupta, Shilpi; Callaghan, Jake D.; Stella, Nicholas A.; Franks, Jonathan M.; Thibodeau, Patrick H.; Shanks, Robert M. Q.; Kadouri, Daniel E. 分享 收藏
Murine models of Pneumocystis infection recapitulate human primary immune disorders Elsegeiny, Waleed; Zheng, Mingquan; Eddens, Taylor; Gallo, Richard L.; Dai, Guixiang; Trevejo-Nunez, Giraldina; Castillo, Patricia; Kracinovsky, Kara; Cleveland, Hillary; Horne, William; Franks, Jonathan; Pociask, Derek; Pilarski, Mark; Alcorn, John F.; Chen, Kong; Kolls, Jay K. 分享 收藏
Ultrastructure of Diaschisis Lesions after Traumatic Brain Injury Wiley, Clayton A.; Bissel, Stephanie J.; Lesniak, Andrew; Dixon, C. Edward; Franks, Jonathan; Stolz, Donna Beer; Sun, Ming; Wang, Guoji; Switzer, Robert; Kochanek, Patrick M.; Murdoch, Geoffrey 分享 收藏
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