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Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase Palmer, Nick; Agnew, Christopher; Benn, Caroline; Buffham, William J.; Castro, Joan N.; Chessari, Gianni; Clark, Mellissa; Cons, Benjamin D.; Coyle, Joseph E.; Dawson, Lee A.; Hamlett, Christopher C. F.; Hodson, Charlotte; Holding, Finn; Johnson, Christopher N.; Liebeschuetz, John W.; Mahajan, Pravin; McCarthy, James M.; Murray, Christopher W.; O'Reilly, Marc; Peakman, Torren; Price, Amanda; Rapti, Magdalini; Reeks, Judith; Schopf, Patrick; St-Denis, Jeffrey D.; Valenzano, Chiara; Wallis, Nicola G.; Walser, Reto; Weir, Heather; Wilsher, Nicola E.; Woodhead, Andrew; Bento, Carla F.; Tisi, Dominic 分享 收藏
X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor St Denis, Jeffrey D.; Chessari, Gianni; Cleasby, Anne; Cons, Benjamin D.; Cowan, Suzanna; Dalton, Samuel E.; East, Charlotte; Murray, Christopher W.; O'Reilly, Marc; Peakman, Torren; Rapti, Magdalini; Stow, Jessie L. 分享 收藏
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2 Heightman, Tom D.; Berdini, Valerio; Bevan, Luke; Buck, Ildiko M.; Carr, Maria G.; Courtin, Aurelie; Coyle, Joseph E.; Day, James E. H.; East, Charlotte; Fazal, Lynsey; Griffiths-Jones, Charlotte M.; Howard, Steven; Kucia-Tran, Justyna; Martins, Vanessa; Muench, Sandra; Munck, Joanne M.; Norton, David; O'Reilly, Marc; Palmer, Nicholas; Pathuri, Puja; Peakman, Torren M.; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Wallis, Nicola G.; Walton, Hugh; Wilsher, Nicola E.; Woolford, Alison J-A; Cooke, Michael; Cousin, David; Onions, Stuart; Shannon, Jonathan; Watts, John; Murray, Christopher W. 分享 收藏
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK Munck, Joanne M.; Berdini, Valerio; Bevan, Luke; Brothwood, Jessica L.; Castro, Juan; Courtin, Aurelie; East, Charlotte; Ferraldeschi, Roberta; Heightman, Tom D.; Hindley, Christopher J.; Kucia-Tran, Justyna; Lyons, John F.; Martins, Vanessa; Muench, Sandra; Murray, Christopher W.; Norton, David; O'Reilly, Marc; Reader, Michael; Rees, David C.; Rich, Sharna J.; Richardson, Caroline J.; Shah, Alpesh D.; Stanczuk, Lukas; Thompson, Neil T.; Wilsher, Nicola E.; Woolford, Alison J-A; Wallis, Nicola G. 分享 收藏
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Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2 Heightman, Tom D.; Berdini, Valerio; Braithwaite, Hannah; Buck, Ildiko M.; Cassidy, Megan; Castro, Juan; Courtin, Aurelie; Day, James E. H.; East, Charlotte; Fazal, Lynsey; Graham, Brent; Griffiths-Jones, Charlotte M.; Lyons, John F.; Martins, Vanessa; Muench, Sandra; Munck, Joanne M.; Norton, David; O'Reilly, Marc; Palmer, Nick; Pathuri, Puja; Reader, Michael; Rees, David C.; Rich, Sharna J.; Richardson, Caroline; Saini, Harpreet; Thompson, Neil T.; Wallis, Nicola G.; Walton, Hugh; Wilsher, Nicola E.; Woolford, Alison J. -A.; Cooke, Michael; Cousin, David; Onions, Stuart; Shannon, Jonathan; Watts, John; Murray, Christopher W. 分享 收藏
Characterization of a novel ERK1/2 inhibitor, which modulates the phosphorylation and catalytic activity of ERK1/2 Munck, Joanne M.; Berdini, Valerio; Bevan, Luke D.; Braithwaite, Hannah; Buck, Ildiko M.; Cassidy, Megan; Castro, Juan; Courtin, Aurelie; Day, James E.; East, Charlotte; Fazal, Lynsey; Graham, Brent; Griffiths-Jones, Charlotte M.; Heightman, Tom D.; Hindley, Chris J.; Kidane, Birikiti; Kucia-Tran, Justyna; Lyons, John F.; Martins, Vanessa; Muench, Sandra; Murray, Chris W.; Norton, David; O'Reilly, Marc; Palmer, Nick; Pathuri, Puja; Reader, Mike; Rees, David C.; Rich, Sharna J.; Richardson, Caroline J.; Saini, Harpreet K.; Shah, Alpesh; Stanczuk, Lukas; Thompson, Neil T.; Walton, Hugh; Wilsher, Nicola E.; Woolford, Alison J.; Wallis, Nicola G. 分享 收藏
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Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor Perera, Timothy P. S.; Jovcheva, Eleonora; Mevellec, Laurence; Vialard, Jorge; De lange, Desiree; Verhulst, Tinne; Paulussen, Caroline; Van De Ven, Kelly; King, Peter; Freyne, Eddy; Rees, David C.; Squires, Matthew; Saxty, Gordon; Page, Martin; Murray, Christopher W.; Gilissen, Ron; Ward, George; Thompson, Neil T.; Newell, David R.; Cheng, Na; Xie, Liang; Yang, Jennifer; Platero, Suso J.; Karkera, Jayaprakash D.; Moy, Christopher; Angibaud, Patrick; Laquerre, Sylvie; Lorenzi, Matthew V. 分享 收藏
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Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Woolford, Alison J. -A.; Day, Philip J.; Beneton, Veronique; Berdini, Valerio; Coyle, Joseph E.; Dudit, Yann; Grondin, Pascal; Huet, Pascal; Lee, Lydia Y. W.; Manas, Eric S.; McMenamin, Rachel L.; Murray, Christopher W.; Page, Lee W.; Patel, Vipulkumar K.; Potvain, Florent; Rich, Sharna J.; Sang, Yingxia; Somers, Don O.; Trottet, Lionel; Wan, Zehong; Zhang, Xiaomin 分享 收藏
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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening Woolford, Alison J. -A.; Pero, Joseph E.; Aravapalli, Sridhar; Berdini, Valerio; Coyle, Joseph E.; Day, Philip J.; Dodson, Andrew M.; Grondin, Pascal; Holding, Finn P.; Lee, Lydia Y. W.; Li, Peng; Manas, Eric S.; Marino, Joseph, Jr.; Martin, Agnes C. L.; McCleland, Brent W.; McMenamin, Rachel L.; Murray, Christopher W.; Neipp, Christopher E.; Page, Lee W.; Patel, Vipulkumar K.; Potvain, Florent; Rich, Sharna; Rivero, Ralph A.; Smith, Kirsten; Somers, Donald O.; Trottet, Lionel; Velagaleti, Ranganadh; Williams, Glyn; Xie, Ren 分享 收藏
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Discovery of quinazolinones as fibroblast growth factor receptor (FGFR1-4) kinase inhibitors Querolle, Olivier; Angibaud, Patrick; Colombel, Helene; Caron, Virginie; Pilatte, Isabelle; Poncelet, Virginie; Esser, Norbert; Gilissen, Ron; King, Peter; Meerpoel, Lieven; Verhulst, Tinne; Wroblowski, Berthold; Vialard, Jorge; Murray, Chris W.; Rees, David C.; Reningovolo, Anita; Saxty, Gordon 分享 收藏
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors Murray, Christopher W.; Berdini, Valerio; Buck, Ildiko M.; Carr, Maria E.; Cleasby, Anne; Coyle, Joseph E.; Curry, Jayne E.; Day, James E. H.; Day, Phillip J.; Hearn, Keisha; Iqbal, Aman; Lee, Lydia Y. W.; Martins, Vanessa; Mortenson, Paul N.; Munck, Joanne M.; Page, Lee W.; Patel, Sahil; Roomans, Susan; Smith, Kirsten; Tamanini, Emiliano; Saxty, Gordon 分享 收藏
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