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Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer 髓系靶向抗体PY159和PY314用于铂耐药性卵巢癌 Yeku, Oladapo O.; Barve, Minal; Tan, Winston W.; Wang, Judy; Patnaik, Amita; Lorusso, Patricia; Richardson, Debra L.; Naqash, Abdul Rafeh; Lynam, Sarah K.; Fu, Siqing; Gordon, Michael; Hubbard, Joleen; Kummar, Shivaani; Kyriakopoulos, Christos; Dowlati, Afshin; Chamberlain, Marc; Winer, Ira 分享 收藏
Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial 奥拉帕尼治疗难治性异柠檬酸脱氢酶1 (IDH1) 和IDH2-mutant胆管癌: 来自美国国家癌症研究所10129期2试验的安全性和抗肿瘤活性 Cecchini, Michael; Pilat, Mary Jo; Uboha, Nataliya; Azad, Nilofer S.; Cho, May; Davis, Elizabeth J.; Ahnert, Jordi Rodon; Tinoco, Gabriel; Shapiro, Geoffrey I.; Khagi, Simon; Powers, Benjamin; Spencer, Kristen; Groisberg, Roman; Drappatz, Jan; Chen, Li; Das, Biswajit; Bao, Xun; Li, Jing; Narayan, Azeet; Vu, Dennis; Patel, Abhijit; Niger, Monica; Doroshow, Deborah; Durecki, Diane; Boerner, Scott A.; Bindra, Ranjit; Ivy, Percy; Shyr, Derek; Shyr, Yu; Lorusso, Patricia M. 分享 收藏
First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP: TGF-ß1 complex, as monotherapy and in combination with the anti-PD-1 antibody budigalimab in patients with advanced solid tumors (vol 14, 1376551, 2024) Shimizu, Toshio; Powderly, John; Abdul Razak, Albiruni; Lorusso, Patricia; Miller, Kathy D.; Kao, Steven; Kongpachith, Sarah; Tribouley, Catherine; Graham, Michelle; Stoll, Brian; Patel, Maulik; Sahtout, Mohammad; Blaney, Martha; Leibman, Rachel; Golan, Talia; Tolcher, Anthony 分享 收藏
Open-label, phase Ia study of STING agonist BI 1703880 plus ezabenlimab for patients with advanced solid tumors STING激动剂BI 1703880加ezabenlimab用于晚期实体瘤患者的开放标签Ia期研究 Harrington, Kevin; Kitano, Shigehisa; Gambardella, Valentina; Parkes, Eileen E.; Moreno, Irene; Alonso, Guzman; Doi, Toshihiko; Berz, David; Gutierrez, Martin E.; Fernandez, Natalia; Schmohl, Michael; Barrueco, Jose; LoRusso, Patricia 分享 收藏
First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti-PD-1 antibody budigalimab in patients with advanced solid tumors Shimizu, Toshio; Powderly, John; Abdul Razak, Albiruni; Lorusso, Patricia; Miller, Kathy D.; Kao, Steven; Kongpachith, Sarah; Tribouley, Catherine; Graham, Michelle; Stoll, Brian; Patel, Maulik; Sahtout, Mohammad; Blaney, Martha; Leibman, Rachel; Golan, Talia; Tolcher, Anthony 分享 收藏
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First Clinical Results from A Phase 1 Trial of PRT3789, a First-in-Class Intravenous SMARCA2 Degrader, in Patients with Advanced Solid Tumors with a SMARCA4 Mutation Yap, T. A.; Dowlati, A.; Dagogo-Jack, I.; Vibert, J.; Spira, A. I.; Garcia, V. Moreno; Punekar, S. R.; Calvo, E.; Sonpavde, G. P.; Awad, M.; Riess, J. W.; Hernandez-Guerrero, T.; Herzberg, B.; Italiano, A.; Swalduz, A.; LoRusso, P.; Smit, E. F.; Garon, E. B.; Novotny, W.; Guo, R. 分享 收藏
ATRN-119, a Novel Macrocyclic ATR Inhibitor, in Patients with Advanced Solid Malignancies: A Phase 1/2a Trial (ABOYA-119) Mahipal, A.; LoRusso, P.; Schneider, R.; Miller, C.; Stenehjem, D.; Gullbo, J.; Brown, E.; Carleton, M.; Mirza, N.; Simpkins, F. 分享 收藏
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CBX-12-101: Final results of a phase I study of CBX-12, a peptide drug conjugate (PDC) in patients (pts) with metastatic solid tumors CBX-12-101：CBX-12（一种肽偶联药物，PDC）在转移性实体瘤患者(pts)中进行的I期研究的最终结果 Lorusso, P.; Meric-Bernstam, F.; Hafez, N.; Rivera, I. I. Rodriguez; Tripathy, D.; Wilks, S.; Pearson, P.; Needle, M. N.; Tolcher, A. W. 分享 收藏
Long-term follow-up of single-agent divarasib in patients with KRAS G12C-positive solid tumors 单药divarasib在KRAS G12C阳性实体瘤患者中的长期随访研究 Garralda, E.; Patel, M. R.; Kim, T. W.; Sacher, A. G.; Forster, M. D.; Santoro, A.; Desai, J.; Paz-Ares, L. G.; Falcon Gonzalez, A.; De Miguel, M.; Bowyer, S. E.; Dziadziuszko, R.; Kim, S. H.; Han, S-W.; Krebs, M. G.; Lorusso, P.; Cosman, R.; Chang, J.; Jun, T.; Miller, W. H. 分享 收藏
PYNNACLE phase II trial of rezatapopt (PC14586) in solid tumors with a TP53 Y220C mutation PYNNACLE II期临床试验：评估rezatapopt（PC14586）在携带TP53 Y220C突变的实体瘤中的疗效 Schram, A. M.; Lopes, G.; El-Khoueiry, A. B.; Fontana, E.; Karasic, T. B.; Kummar, S.; Lorusso, P.; Gregorc, V.; Millward, M.; Aix, S. Ponce; Richardson, D. L.; Perez, D. Roda; Spira, A. I.; Tan, D. S.; Thompson, J. A.; Uprety, D.; Fellous, M.; Qin, Y. G.; Dumbrava, E. E. 分享 收藏
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Inhibition of lysine acetyltransferase KAT6 in ER+HER2- metastatic breast cancer: a phase 1 trial (jun, 10.1038/s41591-024-03060-0, 2024) Mukohara, Toru; Park, Yeon Hee; Sommerhalder, David; Yonemori, Kan; Hamilton, Erika; Kim, Sung-Bae; Kim, Jee Hyun; Iwata, Hiroji; Yamashita, Toshinari; Layman, Rachel M.; Mita, Monica; Clay, Timothy; Chae, Yee Soo; Oakman, Catherine; Yan, Fengting; Kim, Gun Min; Im, Seock-Ah; Lindeman, Geoffrey J.; Rugo, Hope S.; Liyanage, Marlon; Saul, Michelle; Le Corre, Christophe; Skoura, Athanasia; Liu, Li; Li, Meng; LoRusso, Patricia M. 分享 收藏
Inhibition of lysine acetyltransferase KAT6 in ER+HER2- metastatic breast cancer: a phase 1 trial Mukohara, Toru; Park, Yeon Hee; Sommerhalder, David; Yonemori, Kan; Hamilton, Erika; Kim, Sung-Bae; Kim, Jee Hyun; Iwata, Hiroji; Yamashita, Toshinari; Layman, Rachel M.; Mita, Monica; Clay, Timothy; Chae, Yee Soo; Oakman, Catherine; Yan, Fengting; Kim, Gun Min; Im, Seock-Ah; Lindeman, Geoffrey J.; Rugo, Hope S.; Liyanage, Marlon; Saul, Michelle; Le Corre, Christophe; Skoura, Athanasia; Liu, Li; Li, Meng; LoRusso, Patricia M. 分享 收藏
A phase 1/2, first-in-human study of STX-478 monotherapy or in combination with fulvestrant in patients with breast cancer or other advanced solid tumors (trial in progress) Montero, Alberto; Orr, Douglas; Munster, Pamela; LoRusso, Patricia; Jhaveri, Komal; Pluard, Timothy; Winer, Ira; Streit, Michael; Patterson, Monica; Roberts, Simon; Corsi-Travali, Stefani; Ewert, Courtney; Juric, Dejan 分享 收藏
Phase 2 study of oral CCR4 antagonist FLX475 (tivumecirnon) plus pembrolizumab in subjects with head and neck squamous cell carcinoma (HNSCC) previously treated with checkpoint inhibitor Muzaffar, Jameel; Kirtane, Kedar; Redman, Rebecca; Yang, Muh-Hwa; Kim, Tae Min; Liu, Stephen; Lynch, Ryan; Brahmer, Julie; LoRusso, Patricia; Henick, Brian; Kim, Sung-Bae; Feng, Yin-Hsun; Chisamore, Michael; Kassner, Paul; Brockstedt, Dirk; Nasrah, Nicole; Goyal, Rakesh; Ho, William Y.; Villaflor, Victoria 分享 收藏
First-in-human phase 1/2a trial of a macrocyclic ATR inhibitor (ATRN-119) in patients with advanced solid tumors Simpkins, Fiona; Mahipal, Amit; LoRusso, Patricia; Schneider, Reva; Miller, Crystal; Stenehjem, David; Brown, Eric J.; Carleton, Mike; Gullbo, Joachim; Mirza, Nadeem Q. 分享 收藏
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