未登录 Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells Singha, Prosanta K.; Maklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio J.; Patil, Mahadeo R.; Tonduru, Arun K.; Poso, Antti; Laitinen, Jarmo T.; Savinainen, Juha R. 分享 收藏
High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Aaltonen, Niina; Singha, Prosanta K.; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppanen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura E.; Kasperkiewicz, Paulina; Drag, Marcin; Kalvala, Sara; Moisio, Eemeli; Savinainen, Juha R.; Laitinen, Jarmo T. 分享 收藏
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Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors 自分泌运动因子抑制剂2，4-二氢吡喃并 [2，3-c] 吡唑衍生物的设计、合成及生物学评价 Pantsar, Tatu; Singha, Prosanta; Nevalainen, Tapio J.; Koshevoy, Igor; Leppanen, Jukka; Poso, Antti; Niskanen, Juha M. A.; Pasonen-Seppanen, Sanna; Savinainen, Juha R.; Laitinen, Tuomo; Laitinen, Jarmo T. 分享 收藏
Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL) Ahamed, Muneer; Attili, Bala; van Veghel, Daisy; Ooms, Maarten; Berben, Philippe; Celen, Sofie; Koole, Michel; Declercq, Lieven; Savinainen, Juha R.; Laitinen, Jarmo T.; Verbruggen, Alfons; Bormans, Guy 分享 收藏
In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048) Aaltonen, Niina; Kedzierska, Ewa; Orzelska-Gorka, Jolanta; Lehtonen, Marko; Navia-Paldanius, Dina; Jakupovic, Hermina; Savinainen, Juha R.; Nevalainen, Tapio; Laitinen, Jarmo T.; Parkkari, Teija; Gynther, Mikko 分享 收藏
Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α/β-hydrolase domain containing 11 (ABHD11) Navia-Paldanius, Dina; Patel, Jayendra Z.; Navarro, Miriam Lopez; Jakupovic, Hermina; Goffart, Steffi; Pasonen-Seppanen, Sanna; Nevalainen, Tapio J.; Jaaskelainen, Tiina; Laitinen, Tuomo; Laitinen, Jarmo T.; Savinainen, Juha R. 分享 收藏
Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists Yrjola, Sari; Parkkari, Teija; Navia-Paldanius, Dina; Laitinen, Tuomo; Kaczor, Agnieszka A.; Kokkola, Tarja; Adusei-Mensah, Frank; Savinainen, Juha R.; Laitinen, Jarmo T.; Poso, Antti; Alexander, Amy; Penman, June; Stott, Lisa; Anskat, Marie; Irving, Andrew J.; Nevalainen, Tapio J. 分享 收藏
Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors Patel, Jayendra Z.; van Bruchem, John; Laitinen, Tuomo; Kaczor, Agnieszka A.; Navia-Paldanius, Dina; Parkkari, Teija; Savinainen, Juha R.; Laitinen, Jarmo T.; Nevalainen, Tapio J. 分享 收藏
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Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors 1,2，5-噻二唑氨基甲酸酯作为有效和选择性ABHD6抑制剂的优化 Patel, Jayendra Z.; Nevalainen, Tapio J.; Savinainen, Juha R.; Adams, Yahaya; Laitinen, Tuomo; Runyon, Robert S.; Vaara, Miia; Ahenkorah, Stephen; Kaczor, Agnieszka A.; Navia-Paldanius, Dina; Gynther, Mikko; Aaltonen, Niina; Joharapurkar, Amit A.; Jain, Mukul R.; Haka, Abigail S.; Maxfield, Frederick R.; Laitinen, Jarmo T.; Parkkari, Teija 分享 收藏
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) Korhonen, Jani; Kuusisto, Anne; van Bruchem, John; Patel, Jayendra Z.; Laitinen, Tuomo; Navia-Paldanius, Dina; Laitinen, Jarmo T.; Savinainen, Juha R.; Parkkari, Teija; Nevalainen, Tapio J. 分享 收藏
Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) 人单酰基甘油脂肪酶 (MAGL) 对前列腺素甘油酯的强力水解 Savinainen, Juha R.; Kansanen, Emilia; Pantsar, Tatu; Navia-Paldanius, Dina; Parkkari, Teija; Lehtonen, Marko; Laitinen, Tuomo; Nevalainen, Tapio; Poso, Antti; Levonen, Anna-Liisa; Laitinen, Jarmo T. 分享 收藏
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Mutation of Cys242 of Human Monoacylglycerol Lipase Disrupts Balanced Hydrolysis of 1-and 2-Monoacylglycerols and Selectively Impairs Inhibitor Potency 人类单酰基甘油脂肪酶Cys242的突变破坏了1-和2-单酰基甘油的平衡水解，并选择性地损害了抑制剂的效力 Laitinen, Tuomo; Navia-Paldanius, Dina; Rytilahti, Roosa; Marjamaa, Joona J. T.; Karizkova, Julie; Parkkari, Teija; Pantsar, Tatu; Poso, Antti; Laitinen, Jarmo T.; Savinainen, Juha R. 分享 收藏
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Chiral 1,3,4-Oxadiazol-2-ones as Highly Selective FAAH Inhibitors Patel, Jayendra Z.; Parkkari, Teija; Laitinen, Tuomo; Kaczor, Agnieszka A.; Saario, Susanna M.; Savinainen, Juha R.; Navia-Padanius, Dina; Cipriano, Mariateresa; Leppanen, Jukka; Koshevoy, Igor O.; Poso, Antti; Fowler, Christopher J.; Laitinen, Jarmo T.; Nevalainen, Tapio 分享 收藏
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