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Reversible Chemical Modification of Antibody Effector Function Mitigates Unwanted Systemic Immune Activation Moquist, Philip N.; Zhang, Xinqun; Leiske, Chris I.; Eng-Duncan, Nicole M. -L.; Zeng, Weiping; Bindman, Noah A.; Wo, Serena W.; Wong, Abbie; Henderson, Clark M.; Crowder, Karalyne; Lyon, Robert; Doronina, Svetlana O.; Senter, Peter D.; Neff-LaFord, Haley D.; Sussman, Django; Gardai, Shyra J.; Levengood, Matthew R. 分享 收藏
Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure Pottenger, Ayumi E.; Roy, Debashish; Srinivasan, Selvi; Chavas, Thomas E. J.; Vlaskin, Vladmir; Ho, Duy-Khiet; Livingston, Vincent C.; Maktabi, Mahdi; Lin, Hsiuling; Zhang, Jing; Pybus, Brandon; Kudyba, Karl; Roth, Alison; Senter, Peter; Tyson, George; Huber, Hans E.; Wesche, David; Rochford, Rosemary; Burke, Paul A.; Stayton, Patrick S. 分享 收藏
Development of a topoisomerase 1 inhibitor platform technology for efficacious and well tolerated ADCs Lyski, Ryan; Bou, Lauren; Sigurjonsson, Johann; Meyer, David; Neace, Calvin; Ortiz, David; Snead, Katie; Smith, Kaleb; Jin, Steven; Stevens, Nicole; Cochran, Julia; Alizadeh, Kaveh; Yeddula, Narayana; McKinney, Erica; Peterson, Adam; Dotloe, Lindsay; Simmons, Jessica; Carosino, Christopher; Emmerton, Kim; Everds, Nancy; Jeffrey, Scott; Senter, Peter 分享 收藏
Novel auristatins with improved tolerability and unique bystander activity profile Moquist, Philip N.; Eng-Duncan, Nicole M.; Bovee, Tim; Snead, Katie; Wright, Jenn; Smith, Kaleb; Blevins, Teri; Blackburn, Brittney; Ulrich, Michelle; Magunda, Forgivemore; Simmons, Jessica; Senter, Peter D.; Doronina, Svetlana O. 分享 收藏
Discovery of a novel auristatin antibody drug conjugate drug linker with equal efficacy and reduced bone marrow toxicity compared to vedotin Bindman, Noah A.; Yumul, Roma; McKinney, Erica E.; Blackburn, Scott; Blesie, Nicole; Zhang, Xinqun; Drouhard, Brendan; Anderson, Sarah; Neace, Calvin; Ortiz, David; Crowder, K. C.; Everds, Nancy; Carosino, Chris; Magunda, Forgivemore; Sussman, Django; Trueblood, Esther; Okeley, Nicole M.; Senter, Peter 分享 收藏
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Improving Antibody-Tubulysin Conjugates through Linker Chemistry and Site-Specific Conjugation Hamilton, Joseph Z.; Pires, Thomas A.; Mitchell, Jamie A.; Cochran, Julia H.; Emmerton, Kim K.; Zaval, Margo; Stone, Ivan J.; Anderson, Martha E.; Jin, Steven; Waight, Andrew B.; Lyon, Robert P.; Senter, Peter D.; Jeffrey, Scott C.; Burke, Patrick J. 分享 收藏
Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models Moquist, Philip N.; Bovee, Tim D.; Waight, Andrew B.; Mitchell, Jamie A.; Miyamoto, Jamie B.; Mason, Marsha L.; Emmerton, Kim K.; Stevens, Nicole; Balasubramanian, Cindy; Simmons, Jessica K.; Lyon, Robert P.; Senter, Peter D.; Doronina, Svetlana O. 分享 收藏
Discovery of a tripeptide-based camptothecin drug-linker for antibody-drug conjugates with potent antitumor activity and a broad therapeutic window Lyski, Ryan; Bou, Lauren; Zaval, Margo; Emmerton, Kim; Okeley, Nicole; Simmons, Jessica; Zapata, Francisco; Ortiz, David; McKinney, Erica; Meyer, David; Ryan, Maureen; Senter, Peter; Jeffrey, Scott 分享 收藏
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SGN-CD30C, a new CD30-directed camptothecin antibody-drug conjugate (ADC), shows strong anti-tumor activity and superior tolerability in preclinical studies Ryan, Maureen; Lyski, Ryan; Bou, Lauren; Meyer, David; Jin, Steven; Simmons, Jessica; Benjamin, Dennis; Senter, Peter; Jeffrey, Scott 分享 收藏
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Antibody-drug conjugates of NAMPT inhibitors: Discovery, optimization, and preclinical characterization Neumann, Chris; Olivas, Kathleen C.; Wang, Kung Pern; Waight, Andrew B.; Meyer, David W.; Loftus, Luke V.; Zaval, Margo C.; Anderson, Martha E.; Jin, Steven; Cochran, Julia H.; Simmons, Jessica K.; Pittman, Paul G.; Li, Fu; Ulrich, Michelle L.; Wong, Abbie; Zeng, Weiping; Lyon, Robert P.; Senter, Peter D. 分享 收藏
A coiled-coil masking domain for selective activation of therapeutic antibodies Trang, Vivian H.; Zhang, Xinqun; Yumul, Roma C.; Zeng, Weiping; Stone, Ivan J.; Wo, Serena W.; Dominguez, Melissa M.; Cochran, Julia H.; Simmons, Jessica K.; Ryan, Maureen C.; Lyon, Robert P.; Senter, Peter D.; Levengood, Matthew R. 分享 收藏
Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates Neumann, Christopher S.; Olivas, Kathleen C.; Anderson, Martha E.; Cochran, Julia H.; Jin, Steven; Li, Fu; Loftus, Luke, V; Meyer, David W.; Neale, Jason; Nix, Jay C.; Pittman, Paul G.; Simmons, Jessica K.; Ulrich, Michelle L.; Waight, Andrew B.; Wong, Abbie; Zaval, Margo C.; Zeng, Weiping; Lyon, Robert P.; Senter, Peter D. 分享 收藏
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