未登录 Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool Blackwell, J. Henry; Lucas, Simon C. C.; Battocchio, Giovanni; Borjesson, Ulf; Bostock, Mark J.; Braybrooke, Erin L.; Cheung, Tony; Cottee, Matthew A.; Beaumont, Kevin C.; Gohlke, Andrea; Hargreaves, David; Van Hoek- Emmelot, Maaike; Van Hoeven, Vera; Jansen, Chimed; Kawatkar, Aarti; Kinzel, Olaf; Kumar, Praveen; Kupcova, Lea; Lainchbury, Michael D.; Leon, Leonardo; Milbradt, Alexander G.; Palisse, Adeline; Schade, Markus; Van Rijbroek, Kim; Sacchetto, Claudia; Schellekens, Rick; Su, Nancy; Xu, Hua; Zhao, Heng; Chen, Yunhua; Huang, Shen 分享 收藏
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Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors Palisse, Adeline; Cheung, Tony; Blokhuis, Aileen; Cogswell, Thomas; Martins, Bruna S.; Riemens, Rick; Schellekens, Rick; Battocchio, Giovanni; Jansen, Chimed; Cottee, Matthew A.; Ornell, Kimberly; Sacchetto, Claudia; Leon, Leonardo; van Hoek- Emmelot, Maaike; Bostock, Mark; Brauer, Brooke Leann; Beaumont, Kevin; Lucas, Simon C. C.; Ahmed, Samiyah; Blackwell, J. Henry; Boerjesson, Ulf; Gohlke, Andrea; Gramatikov, Iva Monique T.; Hargreaves, David; van Hoeven, Vera; Kantae, Vasudev; Kupcova, Lea; Milbradt, Alexander G.; Seneviratne, Uthpala; Su, Nancy; Vales, John; Wang, Haiyun; White, Michael J.; Kinzel, Olaf 分享 收藏
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors Lucas, Simon C. C.; Blackwell, J. Henry; Borjesson, Ulf; Hargreaves, David; Milbradt, Alexander G.; Bostock, Mark J.; Ahmed, Samiyah; Beaumont, Kevin; Cheung, Tony; Demanze, Sylvain; Gohlke, Andrea; Guerot, Carine; Haider, Afreen; Kantae, Vasudev; Kauffman, Gregory W.; Kinzel, Olaf; Kupcova, Lea; Lainchbury, Michael D.; Lamb, Michelle L.; Leon, Leonardo; Palisse, Adeline; Sacchetto, Claudia; Storer, R. Ian; Su, Nancy; Thomson, Clare; Vales, John; Chen, Yunhua; Hu, Xiaolong 分享 收藏
First disclosure of AZD8421, a highly selective CDK2 inhibitor to address resistance to CDK4/6 inhibitors in breast and CCNE1-high cancers Denz, Christopher R.; Grondine, Michael; Fan, Jun; Hsu, Jessie Hao-Ru; Jackson, Anne; Robinson, James; Guo, Grace; Li, Wen; Wang, Yanjun; Martin, Maryann San; Prickett, Laura; Johannes, Jeffrey; Ghosh, Avipsa; Song, Kun; Sudhan, Dhivya; Vasalou, Christina; Richards, Ryan; Beaumont, Kevin; Peters, Matthew; Drew, Lisa; Fawell, Stephen; Goldberg, Frederick W. 分享 收藏
Targeting the cell cycle with AZD8421, a potent and highly selective CDK2 inhibitor Denz, Christopher R.; Grondine, Michael; Fan, Jun; Hsu, Jessie Hao-Ru; Jackson, Anne; Robinson, James; Guo, Grace; Li, Wen; Wang, Yanjun; Martin, Maryann San; Prickett, Laura; Johannes, Jeffrey; Ghosh, Avipsa; Sudhan, Dhivya; Vasalou, Christina; Richards, Ryan; Beaumont, Kevin; Peters, Matt; Drew, Lisa; Fawell, Stephen; Goldberg, Frederick W. 分享 收藏
Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model (vol 41, pg 223, 2024) Bodenlenz, Manfred; Yeoh, Thean; Berstein, Gabriel; Mathew, Shibin; Shah, Jaymin; Banfield, Christopher; Hollingshead, Brett; Steyn, Stefanus J.; Osgood, Sarah M.; Beaumont, Kevin; Kainz, Sonja; Holecek, Christian; Trausinger, Gert; Raml, Reingard; Birngruber, Thomas 分享 收藏
AZD9592: An EGFR-cMET bispecific antibody-drug conjugate (ADC) targeting key oncogenic drivers in non-small-cell lung cancer (NSCLC) and beyond Comer, Frank; Mazor, Yariv; Hurt, Elaine; Yang, Chunning; Fleming, Ryan; Shandilya, Harini; Vijayakrishnan, Balakumar; Sterba, Meghan; Chen, Ruoyan; Rosfjord, Edward; Floch, Nicolas; Rosenbaum, Anton I.; Huang, Yue; Yuan, Jiaqi; Beaumont, Kevin; Godfrey, Lisa; McGrath, Lara; Arnaldez, Fernanda; Sapra, Puja 分享 收藏
Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors Rosin, Diane L.; Hall, J. Perry; Zheng, Shuqiu; Huang, Liping; Campos-Bilderback, Silvia; Sandoval, Ruben; Bree, Andrea; Beaumont, Kevin; Miller, Emily; Larsen, Jennifer; Hariri, Ghazal; Kaila, Neelu; Encarnacion, Iain M.; Gale, Jeremy D.; van Elsas, Andrea; Molitoris, Bruce A.; Okusa, Mark D. 分享 收藏
An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis Hollingshead, Brett D.; Tomlinson, Lindsay; Finley, Jim; Doshna, Colleen; Ritenour, Casey; Barricklow, Jason; Oppenheimer, Stacey R.; O'Neil, Shawn P.; Moore, Jessica L.; Patterson, Nathan Heath; Nicholson, Sarah P.; Norris, Jeremy L.; Caprioli, Richard M.; Beaumont, Kevin; King-Ahmad, Amanda J.; Vispute, Saurabh; Cook, Jon C.; Radi, Zaher; Schuler, Maik 分享 收藏
PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease Knee, Kelly M.; Jasuja, Reema; Barakat, Amey; Rao, Dharani; Wenzel, Zane; Jasti, Jayasankar; Novak, Jonathan; Beaumont, Kevin; Piotrowski, David W.; Jeffrey, Phil; Bulawa, Christine; Murphy, John E.; Janz, Jay M. 分享 收藏
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease Gopalsamy, Ariamala; Aulabaugh, Ann E.; Barakat, Amey; Beaumont, Kevin C.; Cabral, Shawn; Canterbury, Daniel P.; Casimiro-Garcia, Agustin; Chang, Jeanne S.; Chen, Ming Z.; Choi, Chulho; Dow, Robert L.; Fadeyi, Olugbeminiyi O.; Feng, Xidong; France, Scott P.; Howard, Roger M.; Janz, Jay M.; Jasti, Jayasankar; Jasuja, Reema; Jones, Lyn H.; King-Ahmad, Amanda; Knee, Kelly M.; Kohrt, Jeffrey T.; Limberakis, Chris; Liras, Spiros; Martinez, Carlos A.; McClure, Kim F.; Narayanan, Arjun; Narula, Jatin; Novak, Jonathan J.; O'Connell, Thomas N.; Parikh, Mihir D.; Piotrowski, David W.; Plotnikova, Olga; Robinson, Ralph P.; Sahasrabudhe, Parag, V; Sharma, Raman; Thuma, Benjamin A.; Vasa, Dipy; Wei, Liuqing; Wenzel, A. Zane; Withka, Jane M.; Xiao, Jun; Yayla, Hatice G. 分享 收藏
A phase I, randomized, double-blind study to assess the safety, tolerability and efficacy of the topical RORC2 inverse agonist PF-06763809 in participants with mild-to-moderate plaque psoriasis Berstein, G.; Zhang, Y.; Berger, Z.; Kieras, E.; Li, G.; Samuel, A.; Yeoh, T.; Dowty, H.; Beaumont, K.; Wigger-Alberti, W.; von Mackensen, Y.; Kroencke, U.; Hamscho, R.; Garcet, S.; Krueger, J. G.; Banfield, C.; Oemar, B. 分享 收藏
Growth differentiation factor 15 (GDF-15) inhibition attenuates platinum-based chemotherapy-induced emesis, anorexia and weight loss and increases survival Breen, Danna M.; Beaumont, Kevin; Bennett, Donald; Brosnan, Julia; Calle, Roberto; Chabot, Jeffrey R.; Collins, Susie; Cunio, Teresa; Esquejo, Ryan M.; Joaquim, Stephanie; Joyce, Alison; Kim, Hanna; Lin, Laura; Pettersen, Betty; Qiao, Shuxi; Rossulek, Michelle; Tierney, Brendan; Walters, Karen M.; Weber, Gregory; Wu, Zhidan; Zhang, Bei B.; Birnbaum, Morris J. 分享 收藏
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Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis Menhaji-Klotz, Elnaz; Hesp, Kevin D.; Londregan, Allyn T.; Kalgutkar, Amit S.; Piotrowski, David W.; Boehm, Markus; Song, Kun; Ryder, Tim; Beaumont, Kevin; Jones, Rhys M.; Atkinson, Karen; Brown, Janice A.; Litchfield, John; Xiao, Jun; Canterbury, Daniel P.; Burford, Kristen; Thuma, Benjamin A.; Limberakis, Chris; Jiao, Wenhua; Bagley, Scott W.; Agarwal, Saket; Crowell, Danielle; Pazdziorko, Stephen; Ward, Jessica; Price, David A.; Clerint, Valerie 分享 收藏
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis McClure, Kim F.; Piotrowski, David W.; Petersen, Donna; Wei, Liuqing; Xiao, Jun; Londregan, Allyn T.; Kamlet, Adam S.; Dechert-Schmitt, Anne-Marie; Raymer, Brian; Ruggeri, Roger B.; Canterbury, Daniel; Limberakis, Chris; Liras, Spiros; DaSilva-Jardine, Paul; Dullea, Robert G.; Loria, Paula M.; Reidich, Benjamin; Salatto, Christopher T.; Eng, Heather; Kimoto, Emi; Atkinson, Karen; King-Ahmad, Amanda; Scott, Dennis; Beaumont, Kevin; Chabot, Jeffrey R.; Bolt, Michael W.; Maresca, Kevin; Dahl, Kenneth; Arakawa, Ryosuke; Takano, Akihiro; Halldin, Christer 分享 收藏
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