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Remdesivir is active in vitro against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase Nystrom, Kristina; Trybala, Edward; Said, Joanna; Roth, Anette; Patzi Churqui, Marianela; Karmander, Ambjorn; Cihlar, Tomas; Bilello, John P.; Bergstrom, Tomas; Lagging, Martin 分享 收藏
Activating PKC-ε induces HIV expression with improved tolerability Irrinki, Alivelu M.; Kaur, Jasmine; Randhawa, Bally; Mcfadden, Ryan; Snyder, Chelsea; Truong, Hoa; Soohoo, Daniel; Hu, Eric; Yu, Helen; Murray, Bernard P.; Lu, Bing; Kornyeyev, Dmytro; Irwan, Ishak Darryl; Nguyen, Lan; Yang, Yu-San; Belzile, Jean-Philippe; Schmitz, Uli; Appleby, Todd C.; Schultz, Brian; Lalezari, Jay; Deeks, Steven; Cihlar, Tomas; Murry, Jeffrey P. 分享 收藏
A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques Zumbrun, Elizabeth E.; Garvey, Carly B.; Wells, Jay B.; Lynn, Ginger C.; Van Tongeren, Sean A.; Steffens, Jesse T.; Wetzel, Kelly S.; Wetzel, Darrell L.; Esham, Heather L.; Garza, Nicole L.; Lee, Eric D.; Scruggs, Jennifer L.; Rossi, Franco D.; Brown, Elizabeth S.; Weidner, Jessica M.; Gomba, Laura M.; O'Brien, Kristan A.; Jay, Alexandra N.; Zeng, Xiankun; Akers, Kristen S.; Kallgren, Paul A.; Englund, Ethan; Meinig, J. Matthew; Kugelman, Jeffrey R.; Moore, Joshua L.; Bloomfield, Holly A.; Norris, Sarah L.; Bryan, Tameka; Scheuerell, Christie H.; Walters, Jesse; Mollova, Nevena; Blair, Christiana; Babusis, Darius; Cihlar, Tomas; Porter, Danielle P.; Singh, Bali; Hedskog, Charlotte; Bavari, Sina; Warren, Travis K.; Bannister, Roy 分享 收藏
Antiviral target compound profile for pandemic preparedness Demarest, James F.; Draghia-Akli, Ruxandra; Cihlar, Tomas; Bradley, Kenneth; Young, John A. T.; Chandra, Richa; Vaidyanathan, Sujata; Chu-Moyer, Margaret; Lynch, Christopher L.; Campbell, Andrew; Saikatendu, Kumar Singh; Bilello, John P.; Murata, Yoshihiko; van Loock, Marnix; Hurt, Aeron C.; Tellinghuisen, Timothy; Ruggiero, Lee; Mackman, Richard; Hill, Nina M.; Pottage, John C.; van Loock, Marnix 分享 收藏
Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys Siegel, Dustin S.; Hui, Hon C.; Pitts, Jared; Vermillion, Meghan S.; Ishida, Kazuya; Rautiola, Davin; Keeney, Michael; Irshad, Hammad; Zhang, Lijun; Chun, Kwon; Chin, Gregory; Goyal, Bindu; Doerffler, Edward; Yang, Hai; Clarke, Michael O.; Palmiotti, Chris; Vijjapurapu, Arya; Riola, Nicholas C.; Stray, Kirsten; Murakami, Eisuke; Ma, Bin; Wang, Ting; Zhao, Xiaofeng; Xu, Yili; Lee, Gary; Marchand, Bruno; Seung, Minji; Nayak, Arabinda; Tomkinson, Adrian; Kadrichu, Nani; Ellis, Scott; Barauskas, Ona; Feng, Joy Y.; Perry, Jason K.; Perron, Michel; Bilello, John P.; Kuehl, Philip J.; Subramanian, Raju; Cihlar, Tomas; Mackman, Richard L. 分享 收藏
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses Martinez, David R.; Moreira, Fernando R.; Catanzaro, Nicholas J.; Diefenbacher, Meghan V.; Zweigart, Mark R.; Gully, Kendra L.; De la Cruz, Gabriela; Brown, Ariane J.; Adams, Lily E.; Yount, Boyd; Baric, Thomas J.; Mallory, Michael L.; Conrad, Helen; May, Samantha R.; Dong, Stephanie; Scobey, D. Trevor; Nguyen, Cameron; Montgomery, Stephanie A.; Perry, Jason K.; Babusis, Darius; Barrett, Kimberly T.; Nguyen, Anh-Hoa; Nguyen, Anh-Quan; Kalla, Rao; Bannister, Roy; Feng, Joy Y.; Cihlar, Tomas; Baric, Ralph S.; Mackman, Richard L.; Bilello, John P.; Schaefer, Alexandra; Sheahan, Timothy P. 分享 收藏
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability 具有改善的代谢稳定性的非肽模拟HIV蛋白酶抑制剂的临床前表征 Mulato, Andrew; Lansdon, Eric; Aoyama, Ron; Voigt, Johannes; Lee, Michael; Liclican, Albert; Lee, Gary; Singer, Eric; Stafford, Brian; Gong, Ruoyu; Murray, Bernard; Chan, Julie; Lee, Johnny; Xu, Yili; Ahmadyar, Shekeba; Gonzalez, Ana; Cho, Aesop; Stepan, George J.; Schmitz, Uli; Schultz, Brian; Marchand, Bruno; Brumshtein, Boris; Wang, Ruth; Yu, Helen; Cihlar, Tomas; Xu, Lianhong; Yant, Stephen R. 分享 收藏
Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing Zumbrun, Elizabeth E.; Garvey, Carly B.; Wells, Jay B.; Lynn, Ginger C.; Van Tongeren, Sean; Steffens, Jesse T.; Wetzel, Kelly S.; Gomba, Laura M.; O'Brien, Kristan A.; Rossi, Franco D.; Zeng, Xiankun; Lee, Eric D.; Raymond, Jo Lynne W.; Hoffman, Diana A.; Jay, Alexandra N.; Brown, Elizabeth S.; Kallgren, Paul A.; Norris, Sarah L.; Cantey-Kiser, Jean; Kudiya, Humza; Arthur, Chris; Blair, Christiana; Babusis, Darius; Chu, Victor C.; Singh, Bali; Bannister, Roy; Porter, Danielle P.; Cihlar, Tomas; Dye, John M. 分享 收藏
No virologic resistance to bulevirtide monotherapy detected in patients through 24 weeks treatment in phase II and III clinical trials for chronic hepatitis delta Hollnberger, Julius; Liu, Yang; Xu, Simin; Chang, Silvia; Martin, Ross; Manhas, Savrina; Aeschbacher, Thomas; Han, Bin; Yazdi, Tahmineh; May, Lindsey; Han, Dong; Shornikov, Alex; Flaherty, John; Manuilov, Dmitry; Suri, Vithika; Asselah, Tarik; Lampertico, Pietro; Wedemeyer, Heiner; Aleman, Soo; Richards, Christopher; Mateo, Roberto; Maiorova, Evguenia; Cihlar, Tomas; Mo, Hongmei; Urban, Stephan 分享 收藏
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys Mackman, Richard L.; Kalla, Rao V.; Babusis, Darius; Pitts, Jared; Barrett, Kimberly T.; Chun, Kwon; Du Pont, Venice; Rodriguez, Lauren; Moshiri, Jasmine; Xu, Yili; Lee, Michael; Lee, Gary; Bleier, Blake; Nguyen, Anh-Quan; O'Keefe, B. Michael; Ambrosi, Andrea; Cook, Meredith; Yu, Joy; Dempah, Kassibla Elodie; Bunyan, Elaine; Riola, Nicholas C.; Lu, Xianghan; Liu, Renmeng; Davie, Ashley; Hsiang, Tien-Ying; Dearing, Justin; Vermillion, Meghan; Gale Jr, Michael; Niedziela-Majka, Anita; Feng, Joy Y.; Hedskog, Charlotte; Bilello, John P.; Subramanian, Raju; Cihlar, Tomas 分享 收藏
Perspectives on Advancing Countermeasures for Filovirus Disease: Report From a Multisector Meeting Sprecher, Armand; Cross, Robert; Marzi, Andrea; Martins, Karen A.; Wolfe, Daniel; Montgomery, Joel M.; Spiropoulou, Christina F.; Cihlar, Tomas; Ahuka-Mundeke, Steve; Nyhuis, Tara; Teicher, Carrie; Crozier, Ian; Strong, Jim; Kobinger, Gary; Woolsey, Courtney; Geisbert, Thomas W.; Feldmann, Heinz; Muyembe, Jean-Jacques 分享 收藏
Effect of remdesivir post-exposure prophylaxis and treatment on pathogenesis of measles in rhesus macaques Akindele, Nadine A. Peart A.; Katamoni, Laharika Dasharath; Brockhurst, Jacqueline; Ghimire, Shristi; Suwanmanee, San; Pieterse, Lisa; Metcalf Pate, Kelly A. A.; Bunyan, Elaine; Bannister, Roy; Cihlar, Tomas; Porter, Danielle P. P.; Griffin, Diane E. E. 分享 收藏
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro Radoshitzky, Sheli R.; Iversen, Patrick; Lu, Xianghan; Zou, Jing; Kaptein, Suzanne J. F.; Stuthman, Kelly S.; Van Tongeren, Sean A.; Steffens, Jesse; Gong, Ruoyu; Truong, Hoa; Sapre, Annapurna A.; Yang, Huiling; Xie, Xiaodong; Chia, Jia Jun; Song, Zhijuan J.; Leventhal, Stacey M.; Chan, Josolyn; Shornikov, Alex; Zhang, Xin; Cowfer, David; Yu, Helen; Warren, Travis; Cihlar, Tomas; Porter, Danielle P.; Neyts, Johan; Shi, Pei-Yong; Wells, Jay; Bilello, John P.; Feng, Joy Y. 分享 收藏
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms Stevens, Laura J.; Pruijssers, Andrea J.; Lee, Hery W.; Gordon, Calvin J.; Tchesnokov, Egor P.; Gribble, Jennifer; George, Amelia S.; Hughes, Tia M.; Lu, Xiaotao; Li, Jiani; Perry, Jason K.; Porter, Danielle P.; Cihlar, Tomas; Sheahan, Timothy P.; Baric, Ralph S.; Gotte, Matthias; Denison, Mark R. 分享 收藏
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2 Feng, Joy Y.; Du Pont, Venice; Babusis, Darius; Gordon, Calvin J.; Tchesnokov, Egor P.; Perry, Jason K.; Duong, Vincent; Vijjapurapu, Arya; Zhao, Xiaofeng; Chan, Julie; Cohen, Cal; Juneja, Kavita; Cihlar, Tomas; Gotte, Matthias; Bilello, John P. 分享 收藏
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants Remdesivir和GS-441524保留对Delta，Omicron和其他紧急SARS-CoV-2变体的抗病毒活性 Pitts, Jared; Li, Jiani; Perry, Jason K.; Du Pont, Venice; Riola, Nicholas; Rodriguez, Lauren; Lu, Xianghan; Kurhade, Chaitanya; Xie, Xuping; Camus, Gregory; Manhas, Savrina; Martin, Ross; Shi, Pei-Yong; Cihlar, Tomas; Porter, Danielle P.; Mo, Hongmei; Maiorova, Evguenia; Bilello, John P. 分享 收藏
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