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Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage HIV-1顶端定向PGT145-PGDM1400抗体谱系的构象发育 Mason, Rosemarie D.; Zhang, Baoshan; Morano, Nicholas C.; Shen, Chen-Hsiang; Mckee, Krisha; Heimann, Ashley; Du, Renguang; Nazzari, Alexandra F.; Hodges, Shelby; Kanai, Tapan; Lin, Bob C.; Louder, Mark K.; Doria-Rose, Nicole A.; Zhou, Tongqing; Shapiro, Lawrence; Roederer, Mario; Kwong, Peter D.; Gorman, Jason 分享 收藏
Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains Wang, Shixia; Chan, Kun-Wei; Wei, Danlan; Ma, Xiuwen; Liu, Shuying; Hu, Guangnan; Park, Saeyoung; Pan, Ruimin; Gu, Ying; Nazzari, Alexandra F.; Olia, Adam S.; Xu, Kai; Lin, Bob C.; Louder, Mark K.; Mckee, Krisha; Doria-Rose, Nicole A.; Montefiori, David; Seaman, Michael S.; Zhou, Tongqing; Kwong, Peter D.; Arthos, James; Kong, Xiang-Peng; Lu, Shan 分享 收藏
Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1 超广谱广谱中和人-美洲驼双特异性HIV-1抗体 Xu, Jianliang; Zhou, Tongqing; McKee, Krisha; Zhang, Baoshan; Liu, Cuiping; Nazzari, Alexandra F.; Pegu, Amarendra; Shen, Chen-Hsiang; Becker, Jordan E.; Bender, Michael F.; Chan, Payton; Changela, Anita; Chaudhary, Ridhi; Chen, Xuejun; Einav, Tal; Kwon, Young Do; Lin, Bob C.; Louder, Mark K.; Merriam, Jonah S.; Morano, Nicholas C.; O'Dell, Sijy; Olia, Adam S.; Rawi, Reda; Roark, Ryan S.; Stephens, Tyler; Teng, I-Ting; Tourtellott-Fogt, Emily; Wang, Shuishu; Yang, Eun Sung; Shapiro, Lawrence; Tsybovsky, Yaroslav; Doria-Rose, Nicole A.; Casellas, Rafael; Kwong, Peter D. 分享 收藏
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site Banach, Bailey B.; Pletnev, Sergei; Olia, Adam S.; Xu, Kai; Zhang, Baoshan; Rawi, Reda; Bylund, Tatsiana; Doria-Rose, Nicole A.; Nguyen, Thuy Duong; Fahad, Ahmed S.; Lee, Myungjin; Lin, Bob C.; Liu, Tracy; Louder, Mark K.; Madan, Bharat; Mckee, Krisha; O'Dell, Sijy; Sastry, Mallika; Schoen, Arne; Bui, Natalie; Shen, Chen-Hsiang; Wolfe, Jacy R.; Chuang, Gwo-Yu; Mascola, John R.; Kwong, Peter D.; Dekosky, Brandon J. 分享 收藏
Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design Holt, Graham T.; Gorman, Jason; Wang, Siyu; Lowegard, Anna U.; Zhang, Baoshan; Liu, Tracy; Lin, Bob C.; Louder, Mark K.; Frenkel, Marcel S.; McKee, Krisha; O'Dell, Sijy; Rawi, Reda; Shen, Chen-Hsiang; Doria-Rose, Nicole A.; Kwong, Peter D.; Donald, Bruce R. 分享 收藏
Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain Kwon, Young D.; Pegu, Amarendra; Yang, Eun Sung; Zhang, Baoshan; Bender, Michael F.; Asokan, Mangaiarkarasi; Liu, Qingbo; McKee, Krisha; Lin, Bob C.; Liu, Tracy; Louder, Mark K.; Rawi, Reda; Reveiz, Mateo; Schaub, Andrew J.; Shen, Chen-Hsiang; Doria-Rose, Nicole A.; Lusso, Paolo; Mascola, John R.; Kwong, Peter D. 分享 收藏
Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization Sastry, Mallika; Changela, Anita; Gorman, Jason; Xu, Kai; Chuang, Gwo-Yu; Shen, Chen-Hsiang; Cheng, Cheng; Geng, Hui; O'Dell, Sijy; Ou, Li; Rawi, Reda; Reveiz, Mateo; Stewart-Jones, Guillaume B. E.; Wang, Shuishu; Zhang, Baoshan; Zhou, Tongqing; Biju, Andrea; Chambers, Michael; Chen, Xuejun; Corrigan, Angela R.; Lin, Bob C.; Louder, Mark K.; McKee, Krisha; Nazzari, Alexandra F.; Olia, Adam S.; Parchment, Danealle K.; Sarfo, Edward K.; Stephens, Tyler; Stuckey, Jonathan; Tsybovsky, Yaroslav; Verardi, Raffaello; Wang, Yiran; Zheng, Cheng-Yan; Chen, Yuling; Doria-Rose, Nicole A.; McDermott, Adrian B.; Mascola, John R.; Kwong, Peter D. 分享 收藏
Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency Zhang, Baoshan; Gorman, Jason; Kwon, Young D.; Pegu, Amarendra; Chao, Cara W.; Liu, Tracy; Asokan, Mangaiarkarasi; Bender, Michael F.; Bylund, Tatsiana; Damron, Leland; Gollapudi, Deepika; Lei, Paula; Li, Yile; Liu, Cuiping; Louder, Mark K.; McKee, Krisha; Olia, Adam S.; Rawi, Reda; Schon, Arne; Wang, Shuishu; Yang, Eun Sung; Yang, Yongping; Carlton, Kevin; Doria-Rose, Nicole A.; Shapiro, Lawrence; Seaman, Michael S.; Mascola, John R.; Kwong, Peter D. 分享 收藏
Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life Zhang, Baoshan; Gollapudi, Deepika; Gorman, Jason; O'Dell, Sijy; Damron, Leland F.; McKee, Krisha; Asokan, Mangaiarkarasi; Yang, Eun Sung; Pegu, Amarendra; Lin, Bob C.; Chao, Cara W.; Chen, Xuejun; Gama, Lucio; Ivleva, Vera B.; Law, William H.; Liu, Cuiping; Louder, Mark K.; Schmidt, Stephen D.; Shen, Chen-Hsiang; Shi, Wei; Stein, Judith A.; Seaman, Michael S.; McDermott, Adrian B.; Carlton, Kevin; Mascola, John R.; Kwong, Peter D.; Lei, Q. Paula; Doria-Rose, Nicole A. 分享 收藏
Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2 Gao, Nan; Gai, Yanxin; Meng, Lina; Wang, Chu; Wang, Wei; Li, Xiaojun; Gu, Tiejun; Louder, Mark K.; Doria-Rose, Nicole A.; Wiehe, Kevin; Nazzari, Alexandra F.; Olia, Adam S.; Gorman, Jason; Rawi, Reda; Wu, Wenmin; Smith, Clayton; Khant, Htet; de Val, Natalia; Yu, Bin; Luo, Junhong; Niu, Haitao; Tsybovsky, Yaroslav; Liao, Huaxin; Kepler, Thomas B.; Kwong, Peter D.; Mascola, John R.; Qin, Chuan; Zhou, Tongqing; Yu, Xianghui; Gao, Feng 分享 收藏
Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces Lee, Myungjin; Changela, Anita; Gorman, Jason; Rawi, Reda; Bylund, Tatsiana; Chao, Cara W.; Lin, Bob C.; Louder, Mark K.; Olia, Adam S.; Zhang, Baoshan; Doria-Rose, Nicole A.; Zolla-Pazner, Susan; Shapiro, Lawrence; Chuang, Gwo-Yu; Kwong, Peter D. 分享 收藏
Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies Cottrell, Christopher A.; Manne, Kartik; Kong, Rui; Wang, Shuishu; Zhou, Tongqing; Chuang, Gwo-Yu; Edwards, Robert J.; Henderson, Rory; Janowska, Katarzyna; Kopp, Megan; Lin, Bob C.; Louder, Mark K.; Olia, Adam S.; Rawi, Reda; Shen, Chen-Hsiang; Taft, Justin D.; Torres, Jonathan L.; Wu, Nelson R.; Zhang, Baoshan; Doria-Rose, Nicole A.; Cohen, Myron S.; Haynes, Barton F.; Shapiro, Lawrence; Ward, Andrew B.; Acharya, Priyamvada; Mascola, John R.; Kwong, Peter D. 分享 收藏
Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations Swanson, Olivia; Rhodes, Brianna; Wang, Avivah; Xia, Shi-Mao; Parks, Robert; Chen, Haiyan; Sanzone, Aja; Cooper, Melissa; Louder, Mark K.; Lin, Bob C.; Doria-Rose, Nicole A.; Bonsignori, Mattia; Saunders, Kevin O.; Wiehe, Kevin; Haynes, Barton F.; Azoitei, Mihai L. 分享 收藏
A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention Kwon, Young D.; Asokan, Mangaiarkarasi; Gorman, Jason; Zhang, Baoshan; Liu, Qingbo; Louder, Mark K.; Lin, Bob C.; McKee, Krisha; Pegu, Amarendra; Verardi, Raffaello; Yang, Eun Sung; Carlton, Kevin; Doria-Rose, Nicole A.; Lusso, Paolo; Mascola, John R.; Kwong, Peter D. 分享 收藏
Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody 突变适应性景观揭示了疫苗引发的HIV-1广泛中和抗体的遗传和结构改善途径 Madan, Bharat; Zhang, Baoshan; Xu, Kai; Chao, Cara W.; O'Dell, Sijy; Wolfe, Jacy R.; Chuang, Gwo-Yu; Fahad, Ahmed S.; Geng, Hui; Kong, Rui; Louder, Mark K.; Thuy Duong Nguyen; Rawi, Reda; Schon, Arne; Sheng, Zizhang; Nimrania, Rajani; Wang, Yiran; Zhou, Tongqing; Lin, Bob C.; Doria-Rose, Nicole A.; Shapiro, Lawrence; Kwong, Peter D.; DeKosky, Brandon J. 分享 收藏
Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth Chen, Xuejun; Zhou, Tongqing; Schmidt, Stephen D.; Duan, Hongying; Cheng, Cheng; Chuang, Gwo-Yu; Gu, Ying; Louder, Mark K.; Lin, Bob C.; Shen, Chen-Hsiang; Sheng, Zizhang; Zheng, Michelle X.; Doria-Rose, Nicole A.; Joyce, M. Gordon; Shapiro, Lawrence; Tian, Ming; Alt, Frederick W.; Kwong, Peter D.; Mascola, John R. 分享 收藏
Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies 去除可变结构域N-连接糖基化以提高HIV-1广泛中和抗体的同质性 Chuang, Gwo-Yu; Asokan, Mangaiarkarasi; Ivleva, Vera B.; Pegu, Amarendra; Yang, Eun Sung; Zhang, Baoshan; Chaudhuri, Rajoshi; Geng, Hui; Lin, Bob C.; Louder, Mark K.; McKee, Krisha; O'Dell, Sijy; Wang, Hairong; Zhou, Tongqing; Doria-Rose, Nicole A.; Kueltzo, Lisa A.; Lei, Q. Paula; Mascola, John R.; Kwong, Peter D. 分享 收藏
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates Corbett, Kizzmekia S.; Flynn, Barbara; Foulds, Kathryn E.; Francica, Joseph R.; Boyoglu-Barnum, Seyhan; Werner, Anne P.; Flach, Britta; O'Connell, Sarah; Bock, Kevin W.; Minai, Mahnaz; Nagata, Bianca M.; Andersen, Hanne; Martinez, David R.; Noe, Amy T.; Douek, Naomi; Donaldson, Mitzi M.; Nji, Nadesh N.; Alvarado, Gabriela S.; Edwards, Darin K.; Flebbe, Dillon R.; Lamb, Evan; Doria-Rose, Nicole A.; Lin, Bob C.; Louder, Mark K.; O'Dell, Sijy; Schmidt, Stephen D.; Phung, Emily; Chang, Lauren A.; Yap, Christina; Todd, John-Paul M.; Pessaint, Laurent; Van Ry, Alex; Browne, Shanai; Greenhouse, Jack; Putman-Taylor, Tammy; Strasbaugh, Amanda; Campbell, Tracey-Ann; Cook, Anthony; Dodson, Alan; Steingrebe, Katelyn; Shi, Wei; Zhang, Yi; Abiona, Olubukola M.; Wang, Lingshu; Pegu, Amarendra; Yang, Eun Sung; Leung, Kwanyee; Zhou, Tongqing; Teng, I-Ting; Widge, Alicia; Gordon, Ingelise; Novik, Laura; Gillespie, Rebecca A.; Loomis, Rebecca J.; Moliva, Juan I.; Stewart-Jones, Guillaume; Himansu, Sunny; Kong, Wing-Pui; Nason, Martha C.; Morabito, Kaitlyn M.; Ruckwardt, Tracy J.; Ledgerwood, Julie E.; Gaudinski, Martin R.; Kwong, Peter D.; Mascola, John R.; Carfi, Andrea; Lewis, Mark G.; Baric, Ralph S.; McDermott, Adrian; Moore, Ian N.; Sullivan, Nancy J.; Roederer, Mario; Seder, Robert A.; Graham, Barney S. 分享 收藏
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