Thomas G. Davies - Publications, H-index & Citations

Thomas G. Davies

university of london

31H指数

80论文数

3.2K被引数

收录论文 18

发表时间

Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2) (vol 67, pg 4655, 2024)基于片段的SH2结构域蛋白酪氨酸磷酸酶-2（SHP2）别构抑制剂的发现（vol 67, pg 4655, 2024）

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-05-08

PREAI

Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; Denis, Jeffrey D. St; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N.

Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-03-11

PREAI

Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; St. Denis, Jeffrey D.; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N.

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-10-27

PREAI

Norton, David; Bonnette, William G.; Callahan, James F.; Carr, Maria G.; Griffiths-Jones, Charlotte M.; Heightman, Tom D.; Kerns, Jeffrey K.; Nie, Hong; Rich, Sharna J.; Richardson, Caroline; Rumsey, William; Sanchez, Yolanda; Verdonk, Marcel L.; Willems, Henriette M. G.; Wixted, William E.; Wolfe, Lawrence, III; Woolford, Alison J-A; Wu, Zining; Davies, Thomas G.

Fragment-based drug discovery to identify small molecule allosteric inhibitors of SHP2

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Day, Philip J.; Berdini, Valerio; Castro, Juan; Chessari, Gianni; Davies, Thomas G.; Day, James E.; Fukaya, Satoshi; Hamlett, Chris; Hearn, Keisha; Hiscock, Steve; Holvey, Rhian; Ito, Satoru; Kodama, Yasuo; Matsuo, Kenichi; Nakatsuru, Yoko; Palmer, Nick; Price, Amanda; Shimamura, Tadashi; St Denis, Jeffrey D.; Wallis, Nicola G.; Williams, Glyn; Johnson, Christopher N.

Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design

DRUG DISCOVERY TODAY

IF7.5

2019-05-01

OAAI

O'Reilly, Marc; Cleasby, Anne; Davies, Thomas G.; Hall, Richard J.; Ludlow, R. Frederick; Murray, Christopher W.; Tisi, Dominic; Jhoti, Harren

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-04-11

OAAI

Heightman, Tom D.; Callahan, James F.; Chiarparin, Elisabetta; Coyle, Joseph E.; Griffiths-Jones, Charlotte; Lakdawala, Ami S.; McMenamin, Rachel; Mortenson, Paul N.; Norton, David; Peakman, Torren M.; Rich, Sharna J.; Richardson, Caroline; Rumsey, William L.; Sanchez, Yolanda; Saxty, Gordon; Willems, Henriette M. G.; Wolfe, Lawrence, III; Woolford, Alison J. -A.; Wu, Zining; Yan, Hongxing; Kerns, Jeffrey K.; Davis, Thomas G.

Open data and digital morphology

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

IF3.5

2017-04-12

124

OAAI

Davies, Thomas G.; Rahman, Imran A.; Lautenschlager, Stephan; Cunningham, John A.; Asher, Robert J.; Barrett, Paul M.; Bates, Karl T.; Bengtson, Stefan; Benson, Roger B. J.; Boyer, Doug M.; Braga, Jose; Bright, Jen A.; Claessens, Leon P. A. M.; Cox, Philip G.; Dong, Xi-Ping; Evans, Alistair R.; Falkingham, Peter L.; Friedman, Matt; Garwood, Russell J.; Goswami, Anjali; Hutchinson, John R.; Jeffery, Nathan S.; Johanson, Zerina; Lebrun, Renaud; Martinez-Perez, Carlos; Marugan-Lobon, Jesus; O'Higgins, Paul M.; Metscher, Brian; Orliac, Maeva; Rowe, Timothy B.; Rucklin, Martin; Sanchez-Villagra, Marcelo R.; Shubin, Neil H.; Smith, Selena Y.; Starck, J. Matthias; Stringer, Chris; Summers, Adam P.; Sutton, Mark D.; Walsh, Stig A.; Weisbecker, Vera; Witmer, Lawrence M.; Wroe, Stephen; Yin, Zongjun; Rayfield, Emily J.; Donoghue, Philip C. J.

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-04-12

256

PREAI

Davies, Thomas G.; Wixted, William E.; Coyle, Joseph E.; Griffiths-Jones, Charlotte; Hearn, Keisha; McMenamin, Rachel; Norton, David; Rich, Sharna J.; Richardson, Caroline; Saxty, Gordon; Willems, Henriette M. G.; Woolford, Alison J. -A.; Cottom, Joshua E.; Kou, Jen-Pyng; Yonchuk, John G.; Feldser, Heidi G.; Sanchez, Yolanda; Foley, Joseph P.; Bolognese, Brian J.; Logan, Gregory; Podolin, Patricia L.; Yan, Hongxing; Callahan, James F.; Heightman, Tom D.; Kerns, Jeffrey K.

Evolutionary Trade-Off between Vocal Tract and Testes Dimensions in Howler Monkeys

CURRENT BIOLOGY

IF7.5

2015-11-01

OAAI

Dunn, Jacob C.; Halenar, Lauren B.; Davies, Thomas G.; Cristobal-Azkarate, Jurgi; Reby, David; Sykes, Dan; Dengg, Sabine; Fitch, W. Tecumseh; Knapp, Leslie A.

The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and demonstrates a mechanism of action distinct from AKT inhibitors

CANCER RESEARCH

IF16.6

2012-04-01

PREAI

Yap, Timothy A.; Walton, Michael I.; Grimshaw, Kyla M.; to Poele, Robert H.; Eve, Paul D.; Valenti, Melanie R.; Brandon, Alexis K. de Haven; Martins, Vanessa; Zetterlund, Anna; Heaton, Simon P.; Heinzmann, Kathrin; Jones, Paul S.; Feltel, Ruth E.; Reule, Matthias; Woodhead, Steven J.; Davies, Thomas G.; Lyons, John F.; Raynaud, Florence I.; Eccles, Suzanne A.; Workman, Paul; Thompson, Neil T.; Garrett, Michelle D.

AT7867 Is a Potent and Oral Inhibitor of AKT and p70 S6 Kinase That Induces Pharmacodynamic Changes and Inhibits Human Tumor Xenograft Growth

MOLECULAR CANCER THERAPEUTICS

IF5.5

2010-05-09

OAAI

Grimshaw, Kyla M.; Hunter, Lisa-Jane K.; Yap, Timothy A.; Heaton, Simon P.; Walton, Mike I.; Woodhead, Steven J.; Fazal, Lynsey; Reule, Matthias; Davies, Thomas G.; Seavers, Lisa C.; Lock, Victoria; Lyons, John F.; Thompson, Neil T.; Workman, Paul; Garrett, Michelle D.

Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-02-12

OAAI

McHardy, Tatiana; Caldwell, John J.; Cheung, Kwai-Ming; Hunter, Lisa J.; Taylor, Kevin; Rowlands, Martin; Ruddle, Ruth; Henley, Alan; Brandon, Alexis de Haven; Valenti, Melanie; Davies, Thomas G.; Fazal, Lynsey; Seavers, Lisa; Raynaud, Florence I.; Eccles, Suzanne A.; Aherne, G. Wynne; Garrett, Michelle D.; Collins, Ian

Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-03-18

PREAI

Caldwell, John J.; Davies, Thomas G.; Doiiald, Alastai R. R.; McHardy, Tatiana; Rowlands, Martin G.; Aherne, G. Wynne; HLinter, Lisa K.; Taylor, Kevin; Ruddle, Ruth; Raynaud, Florence I.; Verdonk, Marcel; Workman, Paul; Garrett, Michelle D.; Collins, Ian

Identification of inhibitors of protein kinase B using fragment-based lead discovery

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2007-04-24

135

PREAI

Saxty, Gordon; Woodhead, Steven J.; Berdini, Valerio; Davies, Thomas G.; Verdonk, Marcel L.; Wyatt, Paul G.; Boyle, Robert G.; Barford, David; Downham, Robert; Garrett, Michelle D.; Carr, Robin A.

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2007-04-24

PREAI

Donald, Alastair; McHardy, Tatiana; Rowlands, Martin G.; Hunter, Lisa-Jane K.; Davies, Thomas G.; Berdini, Valerio; Boyle, Robert G.; Aherne, G. Wynne; Garrett, Michelle D.; Collins, Ian

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B 基于结构的isoquinoline-5-sulfonamide蛋白激酶B抑制剂的设计

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2006-02-01

PREAI

Collins, I; Caldwell, J; Fonseca, T; Donald, A; Bavetsias, V; Hunter, LJK; Garrett, MD; Rowlands, MG; Aherne, GW; Davies, TG; Berdini, V; Woodhead, SJ; Davis, D; Seavers, LCA; Wyatt, PG; Workman, P; McDonald, E

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O6_substituted guanine derivatives

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2002-07-04

103

PREAI

Gibson, AE; Arris, CE; Bentley, J; Boyle, FT; Curtin, NJ; Davies, TG; Endicott, JA; Golding, BT; Grant, S; Griffin, RJ; Jewsbury, P; Johnson, LN; Mesguiche, V; Newell, DR; Noble, MEM; Tucker, JA; Whitfield, HJ

Structure-based design of cyclin-dependent kinase inhibitors 基于结构的细胞周期蛋白依赖性激酶抑制剂的设计

PHARMACOLOGY & THERAPEUTICS

IF12.5

2002-02-01

PREAI

Davies, TG; Pratt, DJ; Endicott, JA; Johnson, LN; Noble, MEM

研究方向