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T

Timothy A. Yap

University of Texas MD Anderson Cancer Center
H指数:77
被引数:2.6万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial

Werner解旋酶抑制剂用于高级别微卫星不稳定性实体瘤：一项1期临床试验

Nature Medicine
IF50
2026-09-290
OA
Timothy A. Yap; Elisa Fontana; Natalie Cook; Marwan Fakih; Oliver Bechter; Erica S. Tsang; Emiliano Calvo; Kristoffer S. Rohrberg; Javier Ros; Ignacio Matos; John H. Strickler; Malaka Ameratunga; Meredith Pelster; Adam Sharp; Jaspreet Grewal; Susanna Ulahannan; Rajesh Belani; Matthew P. Patricelli; Sophia M. Blake; David Dejardin; Stephen Fowler; Christina Godfried Sie; Astrid Heller; Nina Henkel; Michael Hettich; Angelika Lahr; David Lamparter; Charlotte Lane; Ting Liu; Hélène Meistermann; Christophe Meille; Neil Parrott; Sotirios K. Sotiriou; Denise Reeves; Barbara Romagnoli; Piergiorgio Pettazzoni; Daniel Waterkamp; Matthias Wittwer; Yali Fu; Sophie Postel-Vinay
Linavonkibart and pembrolizumab in immune checkpoint blockade-resistant advanced solid tumors: a phase 1 trial

Linavonkibart和pembrolizumab在免疫检查点阻断耐药的晚期实体瘤中的应用: 1期试验

Nature Medicine
IF50
2026-01-130
OAAI
Timothy A. Yap; Randy F. Sweis; Ulka Vaishampayan; Deepak Kilari; Justin F. Gainor; Meredith McKean; Minal Barve; Ahmad A. Tarhini; Bruno Bockorny; Guru Sonpavde; David Park; Sunil Babu; Yawen Ju; Lan Liu; Susan Henry; Giridhar S. Tirucherai; Stephen DeWall; Mohammed Qatanani; Jing L. Marantz; Lu Gan
The actionable transcriptome: a framework for incorporating RNA sequencing into precision oncology

可操作的转录组: 将RNA测序纳入精确肿瘤学的框架

Nature Reviews Clinical Oncology
IF82.2
2026-01-050
PRE
Amber Johnson; Yifei Shen; Xiaofeng Zheng; Fei Su; Jia Zeng; Burak Uzunparmak; Eun-Kyoung Breuer; Vijaykumar Holla; Michael Kahle; Sun-Hee Kim; Thuy Vu; Kenna R. Mills Shaw; Ecaterina Ileana Dumbrava; Timothy A. Yap; Jordi Rodon; Mark Routbort; Keyur Patel; Shashikant Kulkarni; Donna Hansel; Julian Bryan; Anil Korkut; Ken Chen; Funda Meric-Bernstam
CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

CDK2抑制增强了CDK4/6抑制剂在综合乳腺癌PDX模型筛选中的抗肿瘤活性

npj Breast Cancer
IF7.6
2025-12-030
OAAI
Nealia C. House; Maxine M. Chen; Sima Khazaei; Victoria Brown; Philip Ramsden; David H. Peng; Sydney Moore; Liang Yuan; Rentian Wu; Fangyang Wang; Linjie Luo; Ningping Feng; Christopher A. Bristow; Timothy A. Yap; Khandan Keyomarsi; Joseph R. Marszalek; Scott Ribich; Mikael L. Rinne; Lakshmi B. Muthuswamy; Kerrie L. Faia
YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial

YAP/TEAD抑制剂VT3989在实体瘤中的研究：一项1/2期临床试验

Nature Medicine
IF50
2025-10-190
PRE
Timothy A. Yap; David J. Kwiatkowski; Ibiayi Dagogo-Jack; Michael Offin; Marjorie G. Zauderer; Robert Kratzke; Jayesh Desai; Amy Body; Michael Millward; Anthony W. Tolcher; Kanwal P. S. Raghav; Archie Thurston; Len Post; F. Andrew Dorr; Tracy T. Tang; Yufeng Li; Neelesh Sharma; Hedy L. Kindler
Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

整合群体药代动力学、药效动力学和安全性的综合分析，以指导ATR抑制剂Tuvusertib在临床开发中的剂量选择

Clinical Pharmacology & Therapeutics
IF5.5
2025-08-210
OAAI
Jatinder Kaur Mukker; Paul Matthias Diderichsen; Farina Hellmann; Timothy A. Yap; Ruth Plummer; Anthony W. Tolcher; Johann S. de Bono; Ioannis Gounaris; Zoltan Szucs; Astrid Zimmermann; Irina Kareva; Jayaprakasam Bolleddula; Annick Seithel-Keuth; Giuseppe Locatelli; Marta Enderlin; Christine Hicking; Anup Zutshi; Wei Gao; Rainer Strotmann; Lisa Benincosa; Karthik Venkatakrishnan
Overcoming Resistance to CDK4/6 inhibitors in Hormone Receptor positive, HER2 negative breast cancer: Innovative Combinations and Emerging Strategies

克服激素受体阳性、HER2阴性乳腺癌对CDK4/6抑制剂的耐药性：创新联合疗法与新兴策略

Cancer Treatment Reviews
IF10.5
2025-06-140
OAAI
Federica Giugliano; Carmine De Angelis; Barbara Pistilli; Giulia Viale; Giampaolo Bianchini; Mario Giuliano; Luca Malorni; Beatrice Taurelli Salimbeni; Angela Esposito; Antonio Giordano; Timothy A. Yap; Giuseppe Curigliano; Carmen Criscitiello
The DNA-PK inhibitor AZD7648 alone or combined with pegylated liposomal doxorubicin in patients with advanced cancer: results of a first-in-human Phase I/IIa study

DNA-PK抑制剂AZD7648单药或联合聚乙二醇化脂质体多柔比星用于晚期癌症患者：一项首次人体I/IIa期研究的结果

BRITISH JOURNAL OF CANCER
IF6.8
2025-05-170
OA
Yap, Timothy A.; LoRusso, Patricia; Miller, Rowan E.; Kristeleit, Rebecca; Paulovich, Amanda G.; McMorn, Stephen; O'Connor, Lenka Oplustil; Lombardi, Benedetta; Marco-Casanova, Paola; Gangl, Eric T.; Patel, Bharat; O'Connor, Mark J.; Dean, Emma; Zviezdin, Roman; Plummer, Ruth
Selinexor in combination with carboplatin and paclitaxel in patients with advanced solid tumors: results of a single-center, multi-arm phase Ib study (vol 40, pg 290, 2022)
INVESTIGATIONAL NEW DRUGS
IF2.7
2025-02-200
OAAI
Thein, Kyaw Z.; Karp, Daniel D.; Tsimberidou, Apostolia; Gong, Jing; Sulovic, Selma; Shah, Jatin; Milton, Denai R.; Hong, David S.; Janku, Filip; Mcquinn, Lacey; Stephen, Bettzy A.; Colen, Rivka; Carter, Brett W.; Yap, Timothy A.; Piha-Paul, Sarina A.; Fu, Siqing; Meric-Bernstam, Funda; Naing, Aung
Early tolerance and late persistence as alternative drug responses in cancer

早期耐受和晚期持续作为癌症中替代的药物反应

NATURE COMMUNICATIONS
IF15.7
2025-02-030
OA
Punzi, Simona; Cittaro, Davide; Gatti, Guido; Crupi, Gemma; Botrugno, Oronza A.; Cartalemi, Antonino Alex; Gutfreund, Alon; Oneto, Caterina; Giansanti, Valentina; Battistini, Chiara; Santacatterina, Giovanni; Patruno, Lucrezia; Villanti, Ilaria; Palumbo, Martina; Laverty, Daniel J.; Giannese, Francesca; Graudenzi, Alex; Caravagna, Giulio; Antoniotti, Marco; Nagel, Zachary; Cavallaro, Ugo; Lanfrancone, Luisa; Yap, Timothy A.; Draetta, Giulio; Balaban, Nathalie; Tonon, Giovanni

研究方向

暂未获取到该数据
F
Funda Meric‐Bernstam
H 指数:146论文数:2,622被引数:10.6万
J
Johann S. de Bono
H 指数:160论文数:2,491被引数:13.5万
S
Sarina A. Piha‐Paul
H 指数:72论文数:1,085被引数:3.1万
D
David S. Hong
H 指数:104论文数:1,964被引数:4.6万
J
Jordi Rodón
H 指数:70论文数:1,120被引数:2.2万
A
Aung Naing
H 指数:74论文数:1,070被引数:2.3万
A
Apostolia M. Tsimberidou
H 指数:75论文数:1,002被引数:2.3万
Siqing Fu 封面图
Siqing Fu
H 指数:64论文数:924被引数:1.5万
D
Daniel D. Karp
H 指数:55论文数:521被引数:1.8万
U
Udai Banerji
H 指数:52论文数:647被引数:1.2万