Lawrence A. Loeb - Publications, H-index & Citations

Lawrence A. Loeb

University of Washington

96H指数

480论文数

3.7W被引数

收录论文 131

发表时间

Mutation at the polymerase active site of mouse DNA polymerase δ increases genomic instability and accelerates tumorigenesis

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

112

OAAI

Venkatesan, Ranga N.; Treuting, Piper M.; Fuller, Evan D.; Goldsby, Robert E.; Norwood, Thomas H.; Gooley, Ted A.; Ladiges, Warren C.; Preston, Bradley D.; Loeb, Lawrence A.

PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-07-30

OAAI

Zhang, Yuezheng; Kohrn, Brendan F.; Yang, Ming; Nachmanson, Daniela; Soong, T. Rinda; Lee, I-Hsiu; Tao, Yong; Clevers, Hans; Swisher, Elizabeth M.; Brentnall, Teresa A.; Loeb, Lawrence A.; Kennedy, Scott R.; Salk, Jesse J.; Naxerova, Kamila; Risques, Rosa Ana

Rare Mutations in Cancer Drug Resistance and Implications for Therapy 癌症耐药性的罕见突变及其对治疗的影响

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2020-07-10

OAAI

Beckman, Robert A.; Loeb, Lawrence A.

Extensive subclonal mutational diversity in human colorectal cancer and its significance 人类结直肠癌广泛亚克隆突变多样性及其意义

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-12-05

OAAI

Loeb, Lawrence A.; Kohrn, Brendan F.; Loubet-Senear, Kaitlyn J.; Dunn, Yasmin J.; Ahn, Eun Hyun; O'Sullivan, Jacintha N.; Salk, Jesse J.; Bronner, Mary P.; Beckman, Robert A.

A high-resolution landscape of mutations in the BCL6 super-enhancer in normal human B cells 正常人b细胞中BCL6超级增强子突变的高分辨率景观

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-11-20

OAAI

Shen, Jiang-Cheng; Kamath-Loeb, Ashwini S.; Kohrn, Brendan F.; Loeb, Keith R.; Preston, Bradley D.; Loeb, Lawrence A.

Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan 用于癌症检测的超灵敏TP53测序揭示了人类寿命一个世纪以来正常组织中的渐进克隆选择

CELL REPORTS

IF6.9

2019-07-01

OAAI

Salk, Jesse J.; Loubet-Senear, Kaitlyn; Maritschnegg, Elisabeth; Valentine, Charles C.; Williams, Lindsey N.; Higgins, Jacob E.; Horvat, Reinhard; Vanderstichele, Adriaan; Nachmanson, Daniela; Baker, Kathryn T.; Emond, Mary J.; Loter, Emily; Tretiakova, Maria; Soussi, Thierry; Loeb, Lawrence A.; Zeillinger, Robert; Speiser, Paul; Risques, Rosa Ana

Unexpectedly high subclonal mutational diversity in human colorectal cancer and its significance

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Beckman, Robert A.; Kohrn, Brendan; Loubet-Senear, Kaitlyn; Dunn, Jasmin; OSullivan, Jacintha; Bronner, Mary; Loeb, Lawrence A.

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

NATURE REVIEWS GENETICS

IF52

2018-03-26

386

OAAI

Salk, Jesse J.; Schmitt, Michael W.; Loeb, Lawrence A.

Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-08-10

OAAI

Reid-Bayliss, Kate S.; Loeb, Lawrence A.

Evolutionary dynamics and significance of multiple subclonal mutations in cancer 癌症多个亚克隆突变的进化动力学及意义

DNA REPAIR

IF2.7

2017-08-01

OAAI

Beckman, Robert A.; Loeb, Lawrence A.

Sub-clonal heterogeneity and risk of treatment failure in Philadelphia-positive leukemias

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Schmitt, Michael W.; Pritchard, Justin R.; Beppu, Lan; Hodgson, J. Graeme; Rivera, Victor M.; Loeb, Lawrence A.; Radich, Jerald P.

Duplex Sequencing detects cancer-associated mutations arising during normal aging: Clonal evolution over a century of human lifetime

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Salk, Jesse J.; Maritschnegg, Elisabeth; Speiser, Paul; Zeillinger, Robert; Risques, Rosana; Loeb, Lawrence A.

Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma 黄曲霉毒素B1在体内的突变光谱建立人类肝细胞癌暴露的生物标志物

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-03-28

103

OAAI

Chawanthayatham, Supawadee; Valentine, Charles C.; Fedeles, Bogdan I.; Fox, Edward J.; Loeb, Lawrence A.; Levine, Stuart S.; Slocum, Stephen L.; Wogan, Gerald N.; Croy, Robert G.; Essigmann, John M.

Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype

SCIENTIFIC REPORTS

IF3.9

2017-03-09

OAAI

Kamath-Loeb, Ashwini S.; Zavala-van Rankin, Diego G.; Flores-Morales, Jeny; Emond, Mary J.; Sidorova, Julia M.; Carnevale, Alessandra; del Carmen Cardenas-Cortes, Maria; Norwood, Thomas H.; Monnat, Raymond J.; Loeb, Lawrence A.; Mercado-Celis, Gabriela E.

Extensive subclonal mutations in human colorectal cancers detected by Duplex Sequencing

CANCER RESEARCH

IF16.6

2017-01-31

PREAI

Fox, Edward John Paul; Schmitt, Michael W.; Reid-Bayliss, Kate S.; Beckman, Robert A.; Loeb, Lawrence A.

Richmond T. Prehn: In Memoriam (1922-2016) Obituary

CANCER RESEARCH

IF16.6

2017-01-31

PREAI

Loeb, Lawrence A.

Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-08-19

OAAI

Reid-Bayliss, Kate S.; Arron, Sarah T.; Loeb, Lawrence A.; Bezrookove, Vladimir; Cleaver, James E.

Decreased Mitochondrial Mutagenesis during Transformation of Human Breast Stem Cells into Tumorigenic Cells

CANCER RESEARCH

IF16.6

2016-07-31

OAAI

Ahn, Eun Hyun; Lee, Seung Hyuk; Kim, Joon Yup; Chang, Chia-Cheng; Loeb, Lawrence A.

Extensive subclonal mutations in human colorectal cancers detected by duplex sequencing

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Fox, Edward J. P.; Schmitt, Michael W.; Reid-Bayliss, Kate S.; Beckman, Robert A.; Loeb, Lawrence A.

Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Schmitt, Michael W.; Salk, Jesse J.; Fox, Edward J.; Pritchard, Justin R.; Hodgson, J. Graeme; Rivera, Victor M.; Becker, Pamela S.; Radich, Jerald P.; Loeb, Lawrence A.

研究方向