未登录Rhodium-catalyzed enantioselective intermolecular C-H silylation of simple arenes: synergistic substituent effects overcome silane redistribution to enable synthesis of Si-stereogenic arylsilanes钯催化简单芳烃的不对称分子间C-H键硅化:协同取代基效应克服硅烷重分布以实现Si立体中心的芳基硅烷合成
Liu, Lichuan; Chen, Xingliang; Guan, Guiyu; Su, Xinyue; Liu, Mengqing; Hu, Yuefei; He, Wei; Zhang, Linxing; Ma, Wenpeng; An, Kun
分享
收藏
分享
收藏
分享
收藏
分享
收藏
分享
收藏Evaluation of omadacycline dosing regimens in Chinese using population pharmacokinetic-pharmacodynamic analysis
Wang, Kun; Zhu, Yusong; Xu, Fengyan; Liu, Lucy; Liu, Lichuan; Shi, Mengling; Nie, Jing; Reinhart, Harald; Liu, Jing; Gao, Yuying; Pu, Xia
分享
收藏
分享
收藏
分享
收藏
分享
收藏Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity
Crawford, James J.; Lee, Wendy; Johnson, Adam R.; Delatorre, Kelly J.; Chen, Jacob; Eigenbrot, Charles; Heidmann, Julia; Kakiuchi-Kiyota, Satoko; Katewa, Arna; Kiefer, James R.; Liu, Lichuan; Lubach, Joseph W.; Misner, Dinah; Purkey, Hans; Reif, Karin; Vogt, Jennifer; Wong, Harvey; Yu, Christine; Young, Wendy B.
分享
收藏A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-9545, in postmenopausal women with estrogen receptor-positive (ER+) HER2-negative (HER2-) metastatic breast cancer
Jhaveri, Komal; Winer, Eric Paul; Lim, Elgene; Fidalgo, Jose AlejandroPerez; Bellet, Meritxell; Mayer, Ingrid Alina; Boni, Valentina; Patel, Jaymin M.; Bardia, Aditya; Garcia, Jose Manuel; Kabos, Peter; Gates, Mary; Chen, Ya-Chi; Fredrickson, Jill; Wang, Xiaojing; Friedman, Lori Sickels; Spoerke, Jill; Gendreau, Steven; Metcalfe, Ciara; Liu, Lichuan; Chang, Ching-Wei; Monemi, Sharareh; Gonzalez, Monica; McCurry, Ursula; Milan, Sandra; Humke, Eric William; Loi, Sherene
分享
收藏Recommendations for the Design of Clinical Drug-Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically-Based Pharmacokinetic Model
Chen, Yuan; Cabalu, Tamara D.; Callegari, Ernesto; Einolf, Heidi; Liu, Lichuan; Parrott, Neil; Peters, Sheila Annie; Schuck, Edgar; Sharma, Pradeep; Tracey, Helen; Upreti, Vijay V.; Zheng, Ming; Zhu, Andy Z. X.; Hall, Stephen D.
分享
收藏
分享
收藏
分享
收藏
分享
收藏
分享
收藏Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects (vol 35, 233, 2018)
Cheeti, Sravanthi; Hou, Hao Helen; Nelson, Eric; Walker, Helen; Chen, Buyun; Morley, Roland; Gates, Mary; Musib, Luna; Girish, Sandhya; Sahasranaman, Srikumar; Liu, Lichuan
分享
收藏Application of a Novel Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects
Cheeti, Sravanthi; Hou, Hao Helen; Nelson, Eric; Walker, Helen; Chen, Buyun; Morley, Roland; Gates, Mary; Musib, Luna; Girish, Sandhya; Sahasranaman, Srikumar; Liu, Lichuan
分享
收藏
分享
收藏Practical strategies when using a stable isotope labeled microtracer for absolute bioavailability assessment: A case study of a high oral dose clinical candidate GDC-0810
Chen, Buyun; Lu, Pingping; Freeman, Dugan; Gao, Yang; Choo, Edna; DeMent, Kevin; Savage, Scott; Zhang, Kelly; Milanwoski, Dennis; Liu, Lichuan; Dean, Brian; Deng, Yuzhong
分享
收藏