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P. Jeffrey Conn

vanderbilt university

97H指数
684论文数
3.8W被引数
收录论文 251
发表时间
Discovery of VU6052254: A Novel; Potent M1 Positive Allosteric ModulatorVU6052254的发现:一种新型的强效M1正向别构调节剂
err2025-11-26
err0
errOAAI
errJulie L. Engers; Joseph D. Bungard; Christopher C. Presley; Irene Zagol-Ikapitte; Katherine J. Watson; Sichen Chang; Colin O’Carroll; P. Markus Dey; Ethan S. Burstein; Jonathan W. Dickerson; Analisa Thompson Gray; Michael Bubser; Jerri M. Rook; Hyekyung P. Cho; Valerie M. Kramlinger; Olivier Boutaud; Carrie K. Jones; P. Jeffrey Conn; Darren W. Engers; Craig W. Lindsley
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Investigating the role of rostral pedunculopontine nucleus M4 receptors in motor deficits and dyskinesia in hemiparkinsonian rats研究延脑被盖网状核M4受体在偏侧帕金森病大鼠运动障碍和运动过多中的作用
err2025-09-24
err0
PREAI
errNicole E. Chambers; Annique McLune; Michael Coyle; Ashley Centner; Jordan Sergio; Isabella Del Priore; Kathryn Lanza; Craig W. Lindsley; P. Jeffrey Conn; Christopher Bishop
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Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
err2025-04-01
err0
errOAAI
errCrocker, Katherine E.; Henderson, Scott H.; Capstick, Rory A.; Whomble, David L.; Bender, Aaron M.; Felts, Andrew S.; Han, Changho; Engers, Julie L.; Billard, Natasha B.; Maurer, Mallory A.; Cho, Hyekyung P.; Rodriguez, Alice L.; Niswender, Colleen M.; O'Neill, Jordan; Watson, Katherine J.; Chang, Sichen; Blobaum, Anna L.; Boutaud, Olivier; Peng, Weimin; Rook, Jerri M.; Conn, P. Jeffrey; Lindsley, Craig W.; Temple, Kayla J.
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Application of Deuterium in an M1 Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422氘在M1阳性别构调节剂备用项目中的应用:VU6045422的发现
err2025-03-25
err0
errOAAI
errEngers, JL; Li, JM; Han, CH; Long, MF; Gregro, AR; Presley, CC; Dickerson, JW; Peng, WM; Cho, HP; Rodriguez, AL; Xiang, ZX; Boutaud, O; O'Carroll, C; Dey, PM; Burstein, ES; Niswender, CM; Rook, JM; Conn, PJ; Engers, DW; Lindsley, CW
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Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndromeShank3通过mGlu5调节Rpl3的表达和蛋白质合成:对Phelan McDermid综合征的启示
err2025-03-15
err0
errOAAI
errGiona, Federica; Beretta, Stefania; Zippo, Antonio; Stefanoni, Alessia; Tomasoni, Zaira; Vicidomini, Cinzia; Ponzoni, Luisa; Sala, Mariaelvina; Jones, Carrie K.; Conn, P. Jeffrey; Boeckers, Tobias M.; Sala, Carlo; Verpelli, Chiara
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Further Optimization of the mGlu1 PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685
err2025-02-05
err0
errOAAI
errReed, Carson W.; Kalbfleisch, Jacob F.; Turkett, Jeremy A.; Trombley, Trevor A.; Spearing, Paul K.; Haymer, Daniel H.; Quitalig, Marc; Dickerson, Jonathan W.; Foster, Daniel J.; Blobaum, Annie L.; Boutaud, Olivier; Cho, Hyekyung P.; Niswender, Colleen M.; Rook, Jerri M.; Priepke, Henning; Sommer, Heiko; Scheuerer, Stefan; Ursu, Daniel; Conn, P. Jeffrey; Melancon, Bruce J.; Lindsley, Craig W.
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Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical Trials
err2024-12-11
err0
errOAAI
errPoslunsey, Michael S.; Wood, Michael R.; Han, Changho; Stauffer, Shaun R.; Panarese, Joseph D.; Melancon, Bruce J.; Engers, Julie L.; Dickerson, Jonathan W.; Peng, Weimin; Noetzel, Meredith J.; Cho, Hyekyung P.; Rodriguez, Alice L.; Hopkins, Corey R.; Morrison, Ryan; Crouch, Rachel D.; Bridges, Thomas M.; Blobaum, Anna L.; Boutaud, Olivier; Daniels, J. Scott; Kates, Michael J.; Castelhano, Arlindo; Rook, Jerri M.; Niswender, Colleen M.; Jones, Carrie K.; Conn, P. Jeffrey; Lindsley, Craig W.
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Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
err2024-11-18
err0
errOAAI
errChildress, Elizabeth S.; Capstick, Rory A.; Crocker, Katherine E.; Ledyard, Miranda L.; Bender, Aaron M.; Maurer, Mallory A.; Billard, Natasha B.; Cho, Hyekyung P.; Rodriguez, Alice L.; Niswender, Colleen M.; Peng, Weimin; Rook, Jerri M.; Chang, Sichen; Blobaum, Anna L.; Boutaud, Olivier; Thompson Gray, Analisa; Jones, Carrie K.; Conn, P. Jeffrey; Felts, Andrew S.; Lindsley, Craig W.; Temple, Kayla J.
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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)
err2024-09-24
err0
errOAAI
errEngers, Julie L.; Baker, Logan A.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Cho, Hyekyung P.; Bubser, Michael; Gray, Analisa Thompson; Jones, Carrie K.; Peng, Weimin; Rook, Jerri M.; Bridges, Thomas M.; Boutaud, Olivier; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.; Temple, Kayla J.
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Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate
err2024-08-28
err2
errOAAI
errEngers, Julie L.; Bollinger, Katrina A.; Capstick, Rory A.; Long, Madeline F.; Bender, Aaron M.; Dickerson, Jonathan W.; Peng, Weimin; Presley, Christopher C.; Cho, Hyekyung P.; Rodriguez, Alice L.; Niswender, Colleen M.; Moran, Sean P.; Xiang, Zixiu; Blobaum, Anna L.; Boutaud, Olivier; Rook, Jerri M.; Engers, Darren W.; Conn, P. Jeffrey; Lindsley, Craig W.
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Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor
err2024-08-06
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errOAAI
errLi, Jinming; Orsi, Douglas L.; Engers, Julie L.; Long, Madeline F.; Capstick, Rory A.; Maurer, Mallory A.; Presley, Christopher C.; Vinson, Paige N.; Rodriguez, Alice L.; Han, Allie; Cho, Hyekyung P.; Chang, Sichen; Jackson, Megan; Bubser, Michael; Blobaum, Anna L.; Boutaud, Olivier; Nader, Michael A.; Niswender, Colleen M.; Conn, P. Jeffrey; Jones, Carrie K.; Lindsley, Craig W.; Han, Changho
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Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral De fi cits
err2024-08-01
err0
PREAI
errDogra, Shalini; Aguayo, Caleb; Xiang, Zixiu; Putnam, Jason; Smith, Joshua; Johnston, Curran; Foster, Daniel J.; Lindsley, Craig W.; Niswender, Colleen M.; Conn, P. Jeffrey
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Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile
err2024-07-03
err2
errOAAI
errCapstick, Rory A.; Bollinger, Sean R.; Engers, Julie L.; Long, Madeline F.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Boutaud, Olivier; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.; Temple, Kayla J.
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D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning
errNEURON
IF15
err2024-03-01
err8
PREAI
errZachry, Jennifer E.; Kutlu, Munir Gunes; Yoon, Hye Jean; Leonard, Michael Z.; Chevee, Maxime; Patel, Dev D.; Gaidici, Anthony; Kondev, Veronika; Thibeault, Kimberly C.; Bethi, Rishik; Tat, Jennifer; Melugin, Patrick R.; Isiktas, Atagun U.; Joffe, Max E.; Cai, Denise J.; Conn, P. Jeffrey; Grueter, Brad A.; Calipari, Erin S.
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