未登录
分享
收藏
分享
收藏
分享
收藏
分享
收藏
分享
收藏The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma
Le Moigne, Ronan; Aftab, Blake T.; Djakovic, Stevan; Dhimolea, Eugen; Valle, Eduardo; Murnane, Megan; King, Emily M.; Soriano, Ferdie; Menon, Mary-Kamala; Wu, Zhi Yong; Wong, Stephen T.; Lee, Grace J.; Yao, Bing; Wiita, Arun P.; Lam, Christine; Rice, Julie; Wang, Jinhai; Chesi, Marta; Bergsagel, P. Leif; Kraus, Marianne; Driessen, Christoph; Von Soly, Szerenke Kiss; Yakes, F. Michael; DavidWustrow; Shawver, Laura; Zhou, Han-Jie; Martin, Thomas G., III; Wolf, Jeffrey L.; Mitsiades, Constantine S.; Anderson, Daniel J.; Rolfe, Mark
分享
收藏
分享
收藏
分享
收藏
分享
收藏Utilization of K48 poly-ubiquitin modulation as a biomarker of target engagement for a protein homeostasis inhibitor in the clinic: Preclinical validation with CB-5083 a first-in-class inhibitor of the AAA ATPase p97
Menon, Mary-Kamala; Soriano, Ferdie; Wong, Steve; Valle, Eduardo; Djakovic, Stevan; Kumar, Brajesh; Yao, Bing; Madriaga, Antonett; Wu, Tony; Rice, Julie; Wang, Jinhai; Cesano, Alessandra; Shawver, Laura; Zhou, Han-Jie; Wustrow, David; Anderson, Daniel; Rolfe, Mark; Le Moigne, Ronan
分享
收藏Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)
Zhou, Han-Jie; Wang, Jinhai; Yao, Bing; Wong, Steve; Djakovic, Stevan; Kumar, Brajesh; Rice, Julie; Valle, Eduardo; Soriano, Ferdie; Menon, Mary-Kamala; Madriaga, Antonett; von Soly, Szerenke Kiss; Kumar, Abhinav; Parlati, Francesco; Yakes, F. Michael; Shawver, Laura; Le Moigne, Ronan; Anderson, Daniel J.; Rolfe, Mark; Wustrow, David
分享
收藏Inhibition of the AAA-ATPase p97 with the first in class inhibitor CB-5083 as a novel approach to treat cancer
Anderson, Daniel J.; Le Moigne, Ronan; Djakovic, Stevan; Kumar, Brajesh; Rice, Julie; Wong, Steve; Wang, Jinhai; Yao, Bing; Valle, Eduardo; Menon, M. K.; von Soly, Szerenke Kiss; Madriaga, Antonett; Soriano, Ferdie; Longhi, Mike; Cesano, Alessandra; Zhou, Han-Jie; Wustrow, David; Rolfe, Mark
分享
收藏CB-5083 is a novel first in class p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models
Moigne, Ronan L.; Wong, Steve; Soriano, Ferdie; Valle, Eduardo; Anderson, Daniel J.; Djakovic, Stevan; Menon, Mary-Kamala; Yao, Bing; Rice, Julie; Wang, Jinhai; Von Soly, Szerenke Kiss; Kumar, Brajesh; Chesi, Marta; Bergsagel, P. Leif; Zhou, Han-Jie; Wustrow, David; Rolfe, Mark; Yakes, F. Michael
分享
收藏
分享
收藏
分享
收藏
分享
收藏