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Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia 病理学上的α-突触核蛋白失调调节表观转录组写入器METTL3,从而驱动小胶质细胞中的神经炎症。 Miller, Cameron; Ealy, Alyssa; Gregory, Amanda; Janarthanam, Chelva; Albers, William; Richardson, Gabriel; Jin, Huajun; Zenitsky, Gary; Anantharam, Vellareddy; Kanthasamy, Arthi; Kanthasamy, Anumantha G. 分享 收藏
Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases 线粒体应激通过蛋白水解激活PKCδ和Lamin B1磷酸化来解聚神经元细胞中的核结构:对年龄相关神经退行性疾病发病机制的启示 Charli, Adhithiya; Chang, Yuan-Teng; Luo, Jie; Palanisamy, Bharathi; Malovic, Emir; Riaz, Zainab; Miller, Cameron; Samidurai, Manikandan; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi 分享 收藏
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Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson's disease Ay, Muhammet; Charli, Adhithiya; Langley, Monica; Jang, Ahyoung; Padhi, Piyush; Jin, Huajun; Anantharam, Vellareddy; Kalyanaraman, Balaraman; Kanthasamy, Arthi; Kanthasamy, Anumantha G. 分享 收藏
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Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Parkinson's disease pathogenesis Palanisamy, Bharathi N.; Sarkar, Souvarish; Malovic, Emir; Samidurai, Manikandan; Charli, Adhithiya; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Kanthasamy, Anumantha G. 分享 收藏
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Emerging Microbiome Genetic Engineering Technology for Stable Levodopa Delivery in Parkinson's Disease Padhi, Piyush; Abdalla, Ahmed; Backes, Nicholas; Wurtz, Joseph; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Phillips, Gregory; Kanthasamy, Anumantha 分享 收藏
Mitochondrial dysfunction-induced H3K27 hyperacetylation perturbs enhancers in Parkinson's disease 帕金森氏病中线粒体功能障碍诱导的H3K27高乙酰化干扰增强剂 Huang, Minhong; Lou, Dan; Charli, Adhithiya; Kong, Dehui; Jin, Huajun; Zenitsky, Gary; Anantharam, Vellareddy; Kanthasamy, Arthi; Wang, Zhibin; Kanthasamy, Anumantha G. 分享 收藏
Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study Ghaisas, Shivani; Harichandra, Dilshan S.; Palaniswamy, Bharathi; Proctor, Alexandra; Jin, Huajun; Dutta, Somak; Sarkar, Souvarish; Langley, Monica; Zenitsky, Gary; Anantharam, Vellareddy; Kanthasamy, Arthi; Phillips, Gregory J.; Kanthasamy, Anumantha 分享 收藏
PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway Samidurai, Manikandan; Palanisamy, Bharathi N.; Bargues-Carot, Alejandra; Hepker, Monica; Kondru, Naveen; Manne, Sireesha; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Anumantha G.; Kanthasamy, Arthi 分享 收藏
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Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson's Disease Samidurai, Manikandan; Tarale, Prashant; Janarthanam, Chelva; Estrada, Crystal Gomez; Gordon, Richard; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Anumantha G.; Kanthasamy, Arthi 分享 收藏
Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research Saminathan, Hariharan; Charli, Adhithiya; Luo, Jie; Panicker, Nikhil; Gordon, Richard; Hostetter, Jesse M.; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Anumantha G.; Kanthasamy, Arthi 分享 收藏