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ABBV-400, a c-Met proteinetargeting antibody-drug conjugate (ADC), in patients (pts) with advanced gastric/gastroesophageal junction adenocarcinoma (GEA): Results from a phase I study ABBV-400，一种靶向c-Met蛋白的抗体偶联药物（ADC），用于晚期胃/胃食管结合部腺癌（GEA）患者（pts）的I期研究结果 Strickler, J. H.; Raimbourg, J.; Ghiringhelli, F.; Cohen, J. E.; Kitagawa, C.; Sharma, M. R.; Lee, K. H.; De Miguel, M.; Hunter, Z. N.; Burns, M.; Li, R. R.; Rudraganguly, N.; de Almeida, C. Biesdorf; Freise, K. J.; Blaney, M. E.; Morrison-Thiele, G.; Aristide, M. R. Neagu; Kuboki, Y. 分享 收藏
Phase 1/2 Dose Expansion Study Evaluating First-In-Class eIF4A Inhibitor Zotatifin in Patients with ER plus Metastatic Breast Cancer Rosen, Ezra Y.; Sharma, Manish; Berz, David; Caswell-Jin, Jennifer; Fulgar, Georgina; Densel, Mark; Chiang, Gary; Sperry, Samuel; Warner, Douglas; Meric-Bernstam, Funda 分享 收藏
Activity of alpelisib in a panel of breast XPDX models harboring hotspot and uncommon PIK3CA mutations Castaneda, Mercedes; Simonson, Alyssa; Flores, Johnnie; DeBoer, Maci; Lund, Jim; Rouzbahan, Tahmi; Papadopoulos, Kyriakos P.; Lang, Amy; Rodriguez, Gladys; Elmi, Maryam; Rosenthal, Arthur; Rasco, Drew; Moreno, Victor; Patnaik, Amita; Hernandez, Tatiana; Calvo, Emiliano; Smith, Lon; Sharma, Manish; Beeram, Muralidhar; Wick, Michael 分享 收藏
A phase 1 trial of the MEK inhibitor selumetinib in combination with pembrolizumab for advanced or metastatic solid tumors MEK抑制剂selumetinib联合pembrolizumab治疗晚期或转移性实体瘤的1期试验 Chenard-Poirier, Maxime; Hansen, Aaron R.; Gutierrez, Martin E.; Rasco, Drew; Xing, Yan; Chen, Lin-Chi; Zhou, Heng; Webber, Andrea L.; Freshwater, Tomoko; Sharma, Manish R. 分享 收藏
A Relative Bioavailability, Bioequivalence, and Food Effect Study of Niraparib Tablets in Patients with Advanced Solid Tumors 尼拉帕尼片在晚期实体瘤患者中的相对生物利用度，生物等效性和食物效应研究 Falchook, Gerald; Patnaik, Amita; Richardson, Debra L.; Harvey, R. Donald; Sharma, Manish R.; Hafez, Navid; Hamilton, Erika; Piha-Paul, Sarina A.; Barve, Minal; Wise-Draper, Trisha; Patel, Manish R.; Dowlati, Afshin; Pascuzzo, Joseph; Tang, Shou-Ching; Faltermeier, Christina; Malinowska, Izabela A.; Shtessel, Luda; Striha, Alina; Potocka, Elizabeth 分享 收藏
Phase 1 study of ABBV-400, a novel anti-Met antibody drug conjugate, in advanced solid tumors Shimizu, Toshio; Powderly, John; Sharma, Manish R.; Guan, Xiaowen; Vasilopoulos, Athanasios; Li, Martha; Li, Rui; Cunningham, Alexis; Reilly, Regina; Morrison-Thiele, Gladys; Freise, Kevin; Aristide, Martha Neagu; Camidge, D. Ross 分享 收藏
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Recommended phase II dose (RP2D) selection and pharmacodynamic (PD) data of the first-in-human immune-stimulating antibody conjugate (ISAC) BDC-1001 in patients (pts) with advanced HER2-expressing solid tumors Li, B. T.; Lee, K-W.; Pegram, M.; Sharma, M. R.; Lee, J.; Spira, A. I.; Kang, Y-K.; Moore, K. N.; Rasco, D.; Hanna, G. J.; Weinberg, B. A.; Yu, T.; Alonso, M.; Ptacek, J.; Yin, M.; Tapia, C.; Xu, L.; Perez, E. A.; Dumbrava, E. E. 分享 收藏
Phase I study of ABBV-706, an anti-SEZ6 antibody-drug conjugate, alone or in combination in adults with advanced solid tumors Chandana, S.; Garmezy, B.; Dowlati, A.; Sharma, M. R.; Henner, W.; Robinson, R.; Hingorani, P.; Jeng, E.; Papadopoulos, K. P. 分享 收藏
Phase 1/1b study evaluating KIN-3248, a next-generation, irreversible pan-FGFR inhibitor (FGFRi), in patients (pts) with advanced cholangiocarcinoma (CCA) and other solid tumors harboring FGFR2 and/or FGFR3 gene alterations Harding, J.; Perez, C.; Kato, S.; Sharma, M.; Garmezy, B.; Quah, C.; Tam, B.; Severson, P. 分享 收藏
GLIMMER-01: initial results from a phase 1 dose escalation trial of a first-in-class bi-sialidase (E-602) in solid tumors Luke, Jason J.; Johnson, Melissa; Tolcher, Anthony; Chen, Christopher T.; Dai, Tong; Curti, Brendan D.; El-Khoueiry, Anthony; Sznol, Mario; Henick, Brian S.; Horak, Christine; Jayaraman, Pushpa; Cole, Christopher B.; Wilson, Dawn; Cao, Lizhi; Peng, Li; Feltquate, David; Lathers, Deanne; Sharma, Manish R. 分享 收藏
Establishment and characterization of a panel of breast XPDX models representing innate or acquired resistance to trastuzumab deruxtecan (T-DXd) DeBoer, Maci; Paez, Albert; Flores, Johnnie; Baeza, Robyn; Simonson, Alyssa; Lund, Jim; Papadopoulos, Kyriakos; Gribbin, Thomas; Lang, Amy; Rodriguez, Gladys; Mozas, Lorena; Gonzalez, Lorena; Sharma, Manish; Calvo, Emiliano; Hernandez, Tatiana; Wick, Michael J. 分享 收藏
Correlation of Trop2 expression with in vivo sensitivity to sacituzumab govitecan in a panel of breast XPDX models Simonson, Alyssa; Flores, Johnnie; Anderson, Ebony; Moreno, Crystal; Plasko, George; Papadopoulos, Kyriakos P.; Patnaik, Amita; Rasco, Drew; Rodriguez, Gladys; Lang, Amy; Beeram, Muralidhar; Rodriguez, Luis; Drengler, Ronald; Abbate, Steven; Salih, Hanni; Smith, Lon; Elmi, Maryam; DeBerry, Brittany; Rosenthal, Arthur; Hernandez, Tatiana; Lakhani, Nehal; Sharma, Manish; Wick, Michael 分享 收藏
Phase 1 Randomized Trial of Stereotactic Body Radiation Therapy Followed by Nivolumab plus Ipilimumab or Nivolumab Alone in Advanced/Unresectable Hepatocellular Carcinoma 晚期/不可切除肝细胞癌立体定向放射治疗后Nivolumab加Ipilimumab或单独Nivolumab的1期随机试验 Juloori, Aditya; Katipally, Rohan R.; Lemons, Jeffrey M.; Singh, Anurag K.; Iyer, Renuka; Robbins, Jared R.; George, Ben; Hall, William A.; Pitroda, Sean P.; Arif, Fauzia; Fung, John; Pillai, Anjana; Liao, Chih-Yi; Sharma, Manish; Liauw, Stanley L. 分享 收藏
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Tolerability and preliminary clinical activity of SY-5609, a highly potent and selective oral CDK7 inhibitor, in patients with advanced solid tumors Sharma, M.; Bashir, B.; Hamilton, E.; Juric, D.; Papadopoulos, K.; Richardson, D.; Shapiro, G.; Hodgson, G.; Ke, N.; D'Ippolito, A.; Henry, S.; Zhu, L.; Rosario, M.; Jolin, H.; Roth, D.; Klimek, V.; Madigan, C.; Kelly, M. 分享 收藏
Phase 1/2 study of a novel HER2 targeting TLR7/8 immune-stimulating antibody conjugate (ISAC), BDC-1001, alone and in combination with pembrolizumab (pembro) in patients (pts) with HER2-expressing advanced solid tumors. Sharma, Manish R.; Carvajal, Richard D.; Catenacci, Daniel; Emens, Leisha A.; Hanna, Glenn J.; Juric, Dejan; Kang, Yoon-Koo; Lee, Jeeyun; Lee, Keun-Wook; Li, Bob T.; Moore, Kathleen; Pegram, Mark D.; Pohlmann, Paula R.; Rasco, Drew; Spira, Alexander; Heeke, Arielle L.; Wang, Ding; Garbo, Lawrence; Manda, Sudhir; Sachdev, Jasgit; Ackerman, Shelley E.; LeBlanc, Heidi; Dornan, David; Kowanetz, Marcin; Alonso, Michael N.; Husain, Amreen; Perez, Edith A.; Dumbrava, Ecaterina Ileana 分享 收藏
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