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收藏分享 收藏 Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade纤连蛋白抗体-药物偶联物的抗外域B剪接变体与检查点阻断相结合可消除肿瘤，并提高疗效
Hooper, Andrea T.; Marquette, Kimberly; Chang, Chao -Pei Betty; Golas, Jonathon; Jain, Sadhana; Lam, My-Hanh; Guffroy, Magali; Leal, Mauricio; Falahatpisheh, Hadi; Mathur, Divya; Chen, Ting; Kelleher, Kerry; Khandke, Kiran; Muszynska, Elwira; Loganzo, Frank; Rosfjord, Edward; Lucas, Judy; Kan, Zhengyan; Subramanyam, Chakrapani; O'Donnell, Christopher; Neri, Dario; Gerber, Hans-Peter; May, Chad; Sapra, Puja 分享 收藏 分享 收藏 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cellsGeles, Kenneth G.; Gao, Yijie; Giannakou, Andreas; Sridharan, Latha; Yamin, Ting-Ting; Zhang, Jing; Karim, Riyez; Bard, Joel; Piche-Nicholas, Nicole; Charati, Manoj; Maderna, Andreas; Lucas, Judy; Golas, Jonathon; Guffroy, Magali; Pirie-Shepherd, Steven; Roy, Marc; Qian, Jessie; Franks, Tania; Zhong, Wenyan; O'Donnell, Christopher J.; Tchistiakova, Lioudmila; Gerber, Hans-Peter; Sapra, Puja 分享 收藏 PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung CancersGraziani, Edmund, I; Sung, Matthew; Ma, Dangshe; Narayanan, Bitha; Marquette, Kimberly; Puthenveetil, Sujiet; Tumey, L. Nathan; Bikker, Jack; Casavant, Jeffrey; Bennett, Eric M.; Charati, Manoj B.; Golas, Jonathon; Hosselet, Christine; Rohde, Cynthia M.; Hu, George; Guffroy, Magali; Falahatpisheh, Hadi; Finkelstein, Martin; Clark, Tracey; Barletta, Frank; Tchistiakova, Lioudmila; Lucas, Judy; Rosfjord, Edward; Loganzo, Frank; O'Donnell, Christopher J.; Gerber, Hans-Peter; Sapra, Puja 分享 收藏 分享 收藏 分享 收藏 NG-HER2 ADC (PF-06804103) is superior to trastuzumab emtansine in a mouse 'avatar' head-to-head clinical trialSung, Matthew S.; Hopf, Christine; Upeslacis, Erik; Golas, Jonathon; Kaplan, Mark; Khandke, Kiran; Charati, Manoj; Kotch, Frank; Loganzo, Frank; Geles, Ken; Lucas, Judy; Gerber, Hans-Peter; Sapra, Puja; Rosfjord, Edward 分享 收藏 Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)小窝介导的内吞作用是对曲妥珠单抗Emtansine (T-DM1) 耐药的新机制Sung, Matthew; Tan, Xingzhi; Lu, Bingwen; Golas, Jonathan; Hosselet, Christine; Wang, Fang; Tylaska, Laurie; King, Lindsay; Zhou, Dahui; Dushin, Russell; Myers, Jeremy S.; Rosfjord, Edward; Lucas, Judy; Gerber, Hans-Peter; Loganzo, Frank 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Creating a superior, site-specific anti-HER2 antibody-drug conjugate (NG-HER2 ADC) for treatment of solid tumorsMa, Dangshe; Narayanan, Bitha; Marquette, Kim; Graziani, Edmund; Loganzo, Frank; Charati, Manoj; Prashad, Nadira; Tumey, Nathan; Golas, Jon; Hosselet, Christine; Hu, George; Barletta, Frank; Betts, Alison; Lucas, Judy; O'Donnell, Chris; Tchistiakova, Lioudmila; Gerber, Hans-Peter; Sapra, Puja 分享 收藏 Caveolae-mediated endocytosis as a novel mechanism of resistance to T-DM1 ADCSung, Matthew S.; Tan, Xingzhi; Hosselet, Christine; Cinque, Michael; Upeslacis, Erik; Goias, Jonathon; Wang, Fang; Lu, Bingwen; Tylaska, Laurie; King, Lindsay; Myers, Jeremy; Rosfjord, Edward; Lucas, Judy; Gerber, Hans-Peter; Loganzo, Frank 分享 收藏 Liver microvascular injury and thrombocytopenia of antibody-calicheamicin conjugates: mechanism and monitoringGuffroy, Magali; Falahatpisheh, Hadi; Biddle, Kathleen; Kreeger, John; Obert, Leslie; Walters, Karen; Goldstein, Richard; Boucher, Germaine; Coskran, Timothy; Reagan, William; Sullivan, Danielle; Sokolowski, Sharon; Giovanelli, Richard; Gerber, Hans-Peter; Finkelstein, Martin; Khan, Nasir 分享 收藏 分享 收藏 分享 收藏 Patient derived xenograft (PDX) models: improving predictability of experimental cancer therapiesRosfjord, Edward; Han, Xin; Leahy, Danielle; Upeslacis, Erik; Lucas, Justin; Golas, Jonathon; Hooper, Andrea; Immermann, Fred; Lu, Bingwen; Myers, Jeremy; Kan, Zhengyan; Hardwick, James; Powell, Eric; Sapra, Puja; Rejto, Paul; Gerber, Hans-Peter; Lucas, Judy 分享 收藏 Therapeutic targeting the NOTCH3 receptor with antibody drug conjugatesGeles, Kenneth G.; Gao, Yijie; Sridharan, Latha; Giannakou, Andreas; Yamin, Ting-Ting; GoIas, Jonathan; Lucas, Judy; Charati, Manoj; Li, Xiantang; Guffroy, Magali; Nichols, Tim; Wang, Kai; Follettie, Max; Maderna, Andreas; Tchistiakova, Lioudmila; Gerber, Hans-Peter; Sapra, Puja 分享 收藏 
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