未登录 Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis 设计和机制分析：一种强效的双价转甲状腺素蛋白淀粉样纤维形成抑制剂 Mangione, P. Patrizia; Verona, Guglielmo; Cantarutti, Cristina; Nocerino, Paola; Mimmi, Maria Chiara; Swain, Christopher J.; Canetti, Diana; Giorgetti, Sofia; Uings, Iain; Gillmore, Julian D.; Taylor, Graham W.; Pepys, Mark B.; Bellotti, Vittorio; Corazza, Alessandra 分享 收藏
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis Slamova, Ivana; Adib, Rozita; Ellmerich, Stephan; Golos, Michal R.; Gilbertson, Janet A.; Botcher, Nicola; Canetti, Diana; Taylor, Graham W.; Rendell, Nigel; Tennent, Glenys A.; Verona, Guglielmo; Porcari, Riccardo; Mangione, P. Patrizia; Gillmore, Julian D.; Pepys, Mark B.; Bellotti, Vittorio; Hawkins, Philip N.; Al-Shawi, Raya; Simons, J. Paul 分享 收藏
Dementia in the older population is associated with neocortex content of serum amyloid P component Ellmerich, Stephan; Taylor, Graham W.; Richardson, Connor D.; Minett, Thais; Schmidt, Amand Floriaan; Brayne, Carol; Matthews, Fiona E.; Ince, Paul G.; Wharton, Stephen B.; Pepys, Mark B. 分享 收藏
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Comparative study of the stabilities of syntheticin vitroand naturalex vivotransthyretin amyloid fibrils Raimondi, Sara; Mangione, P. Patrizia; Verona, Guglielmo; Canetti, Diana; Nocerino, Paola; Marchese, Loredana; Piccarducci, Rebecca; Mondani, Valentina; Faravelli, Giulia; Taylor, Graham W.; Gillmore, Julian D.; Corazza, Alessandra; Pepys, Mark B.; Giorgetti, Sofia; Bellotti, Vittorio 分享 收藏
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short-and Long-Distance Conformational Changes Corazza, Alessandra; Verona, Guglielmo; Waudby, Christopher A.; Mangione, Patrizia; Bingham, Ryan; Uings, Iain; Canetti, Diana; Nocerino, Paola; Taylor, Graham W.; Pepys, Mark B.; Christodoulou, John; Bellotti, Vittorio 分享 收藏
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Plasminogen activation triggers transthyretin amyloidogenesis in vitro Mangione, P. Patrizia; Verona, Guglielmo; Corazza, Alessandra; Marcoux, Julien; Canetti, Diana; Giorgetti, Sofia; Raimondi, Sara; Stoppini, Monica; Esposito, Marilena; Relini, Annalisa; Canale, Claudio; Valli, Maurizia; Marchese, Loredana; Faravelli, Giulia; Obici, Laura; Hawkins, Philip N.; Taylor, Graham W.; Gillmore, Julian D.; Pepys, Mark B.; Bellotti, Vittorio 分享 收藏
Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis Richards, Duncan B.; Cookson, Louise M.; Barton, Sharon V.; Liefaard, Lia; Lane, Thirusha; Hutt, David F.; Ritter, James M.; Fontana, Marianna; Moon, James C.; Gillmore, Julian D.; Wechalekar, Ashutosh; Hawkins, Philip N.; Pepys, Mark B. 分享 收藏
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel Verona, Guglielmo; Mangione, P. Patrizia; Raimondi, Sara; Giorgetti, Sofia; Faravelli, Giulia; Porcari, Riccardo; Corazza, Alessandra; Gillmore, Julian D.; Hawkins, Philip N.; Pepys, Mark B.; Taylor, Graham W.; Bellotti, Vittorio 分享 收藏
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Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component Richards, Duncan B.; Cookson, Louise M.; Berges, Alienor C.; Barton, Sharon V.; Lane, Thirusha; Ritter, James M.; Fontana, Marianna; Moon, James C.; Pinzani, Massimo; Gillmore, Julian D.; Hawkins, Philip N.; Pepys, Mark B. 分享 收藏
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis Marcoux, Julien; Mangione, P. Patrizia; Porcari, Riccardo; Degiacomi, Matteo T.; Verona, Guglielmo; Taylor, Graham W.; Giorgetti, Sofia; Raimondi, Sara; Sanglier-Cianferani, Sarah; Benesch, Justin L. P.; Cecconi, Ciro; Naqvi, Mohsin M.; Gillmore, Julian D.; Hawkins, Philip N.; Stoppini, Monica; Robinson, Carol V.; Pepys, Mark B.; Bellotti, Vittorio 分享 收藏
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Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis Mangione, P. Patrizia; Porcari, Riccardo; Gillmore, Julian D.; Pucci, Piero; Monti, Maria; Porcari, Mattia; Giorgetti, Sofia; Marchese, Loredana; Raimondi, Sara; Serpelle, Louise C.; Chen, Wenjie; Relini, Annalisa; Marcoux, Julien; Clatworthy, Innes R.; Taylor, Graham W.; Tennent, Glenys A.; Robinson, Carol V.; Hawkins, Philip N.; Stoppini, Monica; Wood, Stephen P.; Pepys, Mark B.; Bellotti, Vittorio 分享 收藏
Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN Mangione, P. Patrizia; Esposito, Gennaro; Relini, Annalisa; Raimondi, Sara; Porcari, Riccardo; Giorgetti, Sofia; Corazza, Alessandra; Fogolari, Federico; Penco, Amanda; Goto, Yuji; Lee, Young-Ho; Yagi, Hisashi; Cecconi, Ciro; Naqvi, Mohsin M.; Gillmore, Julian D.; Hawkins, Philip N.; Chiti, Fabrizio; Rolandi, Ranieri; Taylor, Graham W.; Pepys, Mark B.; Stoppini, Monica; Bellotti, Vittorio 分享 收藏
Pathogenetic mechanisms of amyloid A amyloidosis Simons, J. Paul; Al-Shawi, Raya; Ellmerich, Stephan; Speck, Ivana; Aslam, Samrina; Hutchinson, Winston L.; Mangione, Palma P.; Disterer, Petra; Gilbertson, Janet A.; Hunt, Toby; Millar, David J.; Minogue, Shane; Bodin, Karl; Pepys, Mark B.; Hawkins, Philip N. 分享 收藏
Monitoring systemic amyloidosis using MRI measurements of the extracellular volume fraction Campbell-Washburn, Adrienne E.; Price, Anthony N.; Ellmerich, Stephan; Simons, J. Paul; Al-Shawi, Raya; Kalber, Tammy L.; Ghatrora, Rupinder; Hawkins, Philip N.; Moon, James C.; Ordidge, Roger J.; Pepys, Mark B.; Lythgoe, Mark F. 分享 收藏
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