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BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding Maciag, Anna E.; Stice, James; Wang, Bin; Sharma, Alok; Chan, Albert; Lin, Ken; Singh, Devansh; Dyba, Marcin; Yang, Yue; Setoodeh, Saman; Smith, Brian P.; Rabara, Dana; Zhang, Zuhui; Larsen, Erik K.; Esposito, Dom; Denson, John Paul; Ranieri, Michela; Meynardie, Mary; Mehdizadeh, Sadaf; Alexander, Patrick; Blanco, Maria Abreu; Turner, David; Xu, Rui; Lightstone, Felice C.; Wong, Kwok Kin; Simanshu, Dhirendra; Wang, Keshi; Stephen, Andrew G.; Sinkevicius, Kerstin; Nissley, Dwight V.; Wallace, Eli; McCormick, Frank; Beltran, Pedro J. 分享 收藏
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome Bonsor, Daniel A.; Alexander, Patrick; Snead, Kelly; Hartig, Nicole; Drew, Matthew; Messing, Simon; Finci, Lorenzo, I; Nissley, Dwight, V; McCormick, Frank; Esposito, Dominic; Rodriguez-Viciana, Pablo; Stephen, Andrew G.; Simanshu, Dhirendra K. 分享 收藏
Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum Senadeera, Sarath P. D.; Wang, Dongdong; Kim, Chang-Kwon; Smith, Emily A.; Durrant, David E.; Alexander, Patrick A.; Wendt, Karen L.; Stephen, Andrew G.; Morrison, Deborah K.; Cichewicz, Robert H.; Henrich, Curtis J.; Beutler, John A. 分享 收藏
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Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane Van, Que N.; Lopez, Cesar A.; Tonelli, Marco; Taylor, Troy; Niu, Ben; Stanley, Christopher B.; Bhowmik, Debsindhu; Tran, Timothy H.; Frank, Peter H.; Messing, Simon; Alexander, Patrick; Scott, Daniel; Ye, Xiaoying; Drew, Matt; Chertov, Oleg; Losche, Mathias; Ramanathan, Arvind; Gross, Michael L.; Hengartner, Nicolas W.; Westler, William M.; Markley, John L.; Simanshu, Dhirendra K.; Nissley, Dwight, V; Gillette, William K.; Esposito, Dominic; McCormick, Frank; Gnanakaran, S.; Heinrich, Frank; Stephen, Andrew G. 分享 收藏
The small molecule BI-2852 induces a nonfunctional dimer of KRAS Tran, Timothy H.; Alexander, Patrick; Dharmaiah, Srisathiyanarayanan; Agamasu, Constance; Nissley, Dwight V.; McCormick, Frank; Esposito, Dominic; Simanshu, Dhirendra K.; Stephen, Andrew G.; Balius, Trent E. 分享 收藏
Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder Donohue, Elizabeth; Khorsand, Sina; Mercado, Gabriel; Varney, Kristen M.; Wilder, Paul T.; Yu, Wenbo; MacKerell, Alexander D., Jr.; Alexander, Patrick; Van, Que N.; Moree, Ben; Stephen, Andrew G.; Weber, David J.; Salafsky, Joshua; McCormick, Frank 分享 收藏
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation Dharmaiah, Srisathiyanarayanan; Tran, Timothy H.; Messing, Simon; Agamasu, Constance; Gillette, William K.; Yan, Wupeng; Waybright, Timothy; Alexander, Patrick; Esposito, Dominic; Nissley, Dwight V.; McCormick, Frank; Stephen, Andrew G.; Simanshu, Dhirendra K. 分享 收藏
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Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions Gillette, William K.; Esposito, Dominic; Blanco, Maria Abreu; Alexander, Patrick; Bindu, Lakshman; Bittner, Cammi; Chertov, Oleg; Frank, Peter H.; Grose, Carissa; Jones, Jane E.; Meng, Zhaojing; Perkins, Shelley; Van, Que; Ghirlando, Rodolfo; Fivash, Matthew; Nissley, Dwight V.; McCormick, Frank; Holderfield, Matthew; Stephen, Andrew G. 分享 收藏
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