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Frank McCormick

national institutes of health (nih) - usa

130H指数
787论文数
8.1W被引数
收录论文 216
发表时间
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Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass重新审视RAS家族GTP酶信号传导：效应器选择性和致癌性绕过
errBiochemical Journal
IF4.3
err2026-05-01
err1
PREAI
errSimanshu, Dhirendra K.; McCormick, Frank
err分享
err收藏
Disulfide tethering reveals cryptic pockets in oncogenic KRAS二硫键连接技术揭示了致癌性KRAS中的隐匿口袋
errCommunications Chemistry
IF6.2
err2026-03-30
err0
errOAAI
errTrent E. Balius; Marcin Dyba; Vandana Kumari; John-Paul Denson; Ming Yi; Alok K. Sharma; Priyanka Prakash; Emily Alberico; Simon Messing; Vanessa Wall; Albert H. Chan; Dhirendra K. Simanshu; Dwight V. Nissley; Frank McCormick; Dominic Esposito; Anna E. Maciag; David M. Turner
err分享
err收藏
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitorsSHOC2-KRAS-PP1C复合物的结构揭示了RAS亚型特异性的决定因素以及RAS抑制剂靶向复合物组装的见解
errNature Communications
IF15.7
err2026-01-10
err0
errOAAI
errDaniel A. Bonsor; Lorenzo I. Finci; Jacob R. Potter; Lucy C. Young; Vanessa E. Wall; Ruby Goldstein de Salazar; Katie R. Geis; Tyler Stephens; Joseph Finney; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu
err分享
err收藏
Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulationsRAS-RAF复合物的动力学及与脂质膜的耦合关系通过多尺度模拟揭示
errBiophysical Journal
IF3.1
err2025-08-22
err0
errOAAI
errTimothy S. Carpenter; Fikret Aydin; Chris Neale; Que N. Van; Xiaohua Zhang; Harsh Bhatia; Jason W. Sidabras; Peter H. Frank; Konstantia Georgouli; Jeremy O.B. Tempkin; Violeta Burns Casamayor; Gulcin Gulten; Rebika Shrestha; Debanjan Goswami; Francesco Di Natale; Joseph R. Chavez; Adam Moody; Joseph Y. Moon; Tomas Oppelstrup; James N. Glosli; Gautham Dharuman; Sergio Wong; Shusen Liu; Nicolas W. Hengartner; Cesar A. López; Kien Nguyen; Christopher B. Stanley; Liam G. Stanton; Lara Patel; Tyler Reddy; Thomas J. Turbyville; Brian Van Essen; Peer-Timo Bremer; Felice C. Lightstone; Andrew G. Stephen; Sandrasegaram Gnanakaran; Frank McCormick; Dwight V. Nissley; Frederick H. Streitz; Helgi I. Ingólfsson
err分享
err收藏
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin促进RAS与PI3Kα结合的分子胶水可促进无胰岛素依赖的葡萄糖摄取
errScience
IF45.8
err2025-07-24
err0
PREAI
errKoji Terayama; Shinji Furuzono; Nicole Fer; Wupeng Yan; Lucy C. Young; Daniel J. Czyzyk; Ruby Goldstein de Salazar; Masato Sasaki; Akihiro Uozumi; Masahiro Konishi; Shoichi Kanda; Yoshitaka Sogawa; Mitsuhiro Yamaguchi; Takashi Tsuji; Junichi Kuroyanagi; Mayumi Hayashi; Yuji Ogura; Dhirendra K. Simanshu; Kazuishi Kubota; Jun Tanaka; Frank McCormick
err分享
err收藏
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interactionBBO-10203通过阻断RAS-PI3Kα相互作用抑制肿瘤生长，而不诱导高血糖症
errScience
IF45.8
err2025-06-12
err0
PREAI
errDhirendra K. Simanshu; Rui Xu; James P. Stice; Daniel J. Czyzyk; Siyu Feng; John-Paul Denson; Erin Riegler; Yue Yang; Cathy Zhang; Sofia Donovan; Brian P. Smith; Maria Abreu-Blanco; Ming Chen; Cindy Feng; Lijuan Fu; Dana Rabara; Lucy C. Young; Marcin Dyba; Wupeng Yan; Ken Lin; Samar Ghorbanpoorvalukolaie; Erik K. Larsen; Wafa Malik; Allison Champagne; Katie Parker; Jin Hyun Ju; Stevan Jeknic; Dominic Esposito; David M. Turner; Felice C. Lightstone; Bin Wang; Paul M. Wehn; Keshi Wang; Andrew G. Stephen; Anna E. Maciag; Aaron N. Hata; Kerstin W. Sinkevicius; Dwight V. Nissley; Eli M. Wallace; Frank McCormick; Pedro J. Beltran
err分享
err收藏
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine通过直接共价攻击CaaX盒半胱氨酸来阻断KRAS4b的C末端加工
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-09
err0
errOAAI
errMaciag, Anna E.; Yang, Yue; Sharma, Alok K.; Turner, David M.; Dehart, Caroline J.; Abdelkarim, Hazem; Fan, Lixin; Smith, Brian P.; Kumari, Vandana; Dyba, Marcin; Rigby, Megan; Badillo, Jean A. Castillo; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville, Thomas; Gillette, William; Messing, Simon; Agamasu, Constance; Wolfe, Andrew L.; Gysin, Stephan; Chan, Albert H.; Simanshu, Dhirendra K.; Esposito, Dominic; Chertov, Oleg; Stephen, Andrew G.; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L.; Gaponenko, Vadim; Lightstone, Felice C.; Nissley, Dwight, V; McCormick, Frank
err分享
err收藏
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation结构洞察：异构体特异性的RAS-PI3Kα相互作用及其RAS在PI3Kα激活中的作用
errNATURE COMMUNICATIONS
IF15.7
err2025-01-09
err0
errOAAI
errCzyzyk, Daniel; Yan, Wupeng; Messing, Simon; Gillette, William; Tsuji, Takashi; Yamaguchi, Mitsuhiro; Furuzono, Shinji; Turner, David M.; Esposito, Dominic; Nissley, Dwight V.; Mccormick, Frank; Simanshu, Dhirendra K.
err分享
err收藏
The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations
errSCIENTIFIC REPORTS
IF3.9
err2024-10-26
err0
errOAAI
errYi, Ming; Soppet, Daniel; Mccormick, Frank; Nissley, Dwight V.
err分享
err收藏
Inhibition and degradation of NRAS with a pan-NRAS monobodyPan-nras单体对NRAS的抑制和降解
errONCOGENE
IF7.3
err2024-10-08
err0
errOAAI
errWhaby, Michael; Ketavarapu, Gayatri; Koide, Akiko; Mazzei, Megan; Mintoo, Mubashir; Glasser, Eliezra; Patel, Unnatiben; Nasarre, Cecile; Sale, Matthew J.; McCormick, Frank; Koide, Shohei; O'Bryan, John P.
err分享
err收藏
BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS- driven PI3Kalpha activity without affecting glucose metabolism
errCANCER RESEARCH
IF16.6
err2024-05-02
err1
PREAI
errBeltran, Pedro; Dhirendra, Simanshu; Xu, Rui; Chen, Ming; Czyzyk, Daniel; Donovan, Sofia; Feng, Siyu; Feng, Cindy; Fu, Lijuan; Lightstone, Felice; Lin, Ken; Maciag, Anna; Nissley, Dwight; Riegler, Erin; Sinkevicius, Kerstin; Stephen, Andrew; Stice, James; Turner, David; Wang, Bin; Wang, Keshi; Yang, Yue; Zhang, Cathy; McCormick, Frank; Wallace, Eli
err分享
err收藏
BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
errCANCER RESEARCH
IF16.6
err2024-04-05
err2
PREAI
errMaciag, Anna E.; Stice, James; Wang, Bin; Sharma, Alok; Chan, Albert; Lin, Ken; Singh, Devansh; Dyba, Marcin; Yang, Yue; Setoodeh, Saman; Smith, Brian P.; Rabara, Dana; Zhang, Zuhui; Larsen, Erik K.; Esposito, Dom; Denson, John Paul; Ranieri, Michela; Meynardie, Mary; Mehdizadeh, Sadaf; Alexander, Patrick; Blanco, Maria Abreu; Turner, David; Xu, Rui; Lightstone, Felice C.; Wong, Kwok Kin; Simanshu, Dhirendra; Wang, Keshi; Stephen, Andrew G.; Sinkevicius, Kerstin; Nissley, Dwight V.; Wallace, Eli; McCormick, Frank; Beltran, Pedro J.
err分享
err收藏
SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSale, Matthew J.; Mukherjee, Neal; Koch, Martin; Ruzicka, Regina; Jacob, Robin; Albrecht, Christoph; Zanin, Teresa; Madensky, Thomas; Schenk, Robyn L.; Baum, Anke; Kostyrko, Kaja; Gerlach, Daniel; Hofmann, Marco H.; McCormick, Frank
err分享
err收藏
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement
errANALYTICAL CHEMISTRY
IF6.7
err2024-03-18
err2
errOAAI
errD'Ippolito, Robert A.; Rabara, Dana; Blanco, Maria Abreu; Alberico, Emily; Drew, Matthew R.; Ramakrishnan, Nitya; Sontan, Dara; Widmeyer, Stephanie R. T.; Scheidemantle, Grace M.; Messing, Simon; Turner, David; Arkin, Michelle; Maciag, Anna E.; Stephen, Andrew G.; Esposito, Dominic; Mccormick, Frank; Nissley, Dwight V.; Dehart, Caroline J.
err分享
err收藏
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-03-02
err5
errOAAI
errFinci, Lorenzo I.; Chakrabarti, Mayukh; Gulten, Gulcin; Finney, Joseph; Grose, Carissa; Fox, Tara; Yang, Renbin; Nissley, Dwight V.; McCormick, Frank; Esposito, Dominic; Balius, Trent E.; Simanshu, Dhirendra K.
err分享
err收藏
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties
errSCIENCE ADVANCES
IF12.5
err2024-02-16
err5
errOAAI
errWhitley, Matthew J.; Tran, Timothy H.; Rigby, Megan; Yi, Ming; Dharmaiah, Srisathiyanarayanan; Waybright, Timothy J.; Ramakrishnan, Nitya; Perkins, Shelley; Taylor, Troy; Messing, Simon; Esposito, Dominic; Nissley, Dwight V.; McCormick, Frank; Stephen, Andrew G.; Turbyville, Thomas; Cornilescu, Gabriel; Simanshu, Dhirendra K.
err分享
err收藏
Revealing the mechanism of action of a fi rst-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31 P NMR通过31 p NMR揭示一类共价抑制剂KRASG12C (ON) 的作用机理和致癌KRAS的其他功能特性
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-02-01
err10
errOAAI
errSharma, Alok K.; Pei, Jun; Yang, Yue; Dyba, Marcin; Smith, Brian; Rabara, Dana; Larsen, Erik K.; Lightstone, Felice C.; Esposito, Dominic; Stephen, Andrew G.; Wang, Bin; Beltran, Pedro J.; Wallace, Eli; Nissley, Dwight V.; McCormick, Frank; Maciag, Anna E.
err分享
err收藏
Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance
errNATURE COMMUNICATIONS
IF15.7
err2024-01-12
err3
errOAAI
errVasudevan, Harish N.; Payne, Emily; Delley, Cyrille L.; Liu, S. John; Mirchia, Kanish; Sale, Matthew J.; Lastella, Sydney; Nunez, Maria Sacconi; Lucas, Calixto-Hope G.; Eaton, Charlotte D.; Casey-Clyde, Tim; Magill, Stephen T.; Chen, William C.; Braunstein, Steve E.; Perry, Arie; Jacques, Line; Reddy, Alyssa T.; Pekmezci, Melike; Abate, Adam R.; McCormick, Frank; Raleigh, David R.
err分享
err收藏
Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRASG12C inhibitors that bind in the switch II pocket
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errWang, Bin; Sharma, Alok; Stice, James; Smith, Brian; Dyba, Marcin; Singh, Devansh; Denson, John-Paul; Rabara, Dana; Larsen, Erik; Yang, Yue; Lightstone, Felice C.; Stephen, Andrew; Nissley, Dwight; McCormick, Frank; Wallace, Eli; Maciag, Anna E.; Beltran, Pedro J.
err分享
err收藏
RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights
errJOURNAL OF INVESTIGATIVE DERMATOLOGY
IF5.7
err2023-08-01
err2
errOAAI
errRhodes, Steven D.; McCormick, Frank; Cagan, Ross L.; Bakker, Annette; Staedtke, Verena; Ly, Ina; Steensma, Matthew R.; Lee, Sang Y.; Romo, Carlos G.; Blakeley, Jaishri O.; Sarin, Kavita Y.
err分享
err收藏

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