未登录 Characterization of an anti-STEAP1 T-cell dependent bispecific antibody for the treatment of prostate cancer and associated toxicity in cynomolgus monkeys 抗STEAP1 T细胞依赖性双特异性抗体在前列腺癌治疗中的应用及其在食蟹猴中的相关性毒性表征 Tonkin, Elizabeth G.; Lepherd, Michelle; Davies, John; Gampa, Gautham; Hotzel, Isidro; Koeppen, Hartmut; Liu, Wenyu; Melnikov, Fjodor; Niu, Xiang; Nickles, Dorothee; Romero-Lopez, Monica; Shao, Lily; Totpal, Klara; Schaefer, Gabriele 分享 收藏
IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion Li, Ji; Clark, Robyn; Slaga, Dionysos; Avery, Kendra; Liu, Ke; Schubbert, Suzanne; Varma, Rajat; Chiang, Eugene; Totpal, Klara; Bernett, Matthew J.; Holder, Patrick G.; Junttila, Teemu T. 分享 收藏
T cell-dependent bispecific antibodies alter organ-specific endothelial cell-T cell interaction Himmels, Patricia; Nguyen, Thi Thu Thao; Mitzner, Maresa Caunt; Arrazate, Alfonso; Yeung, Stacey; Burton, Jeremy; Clark, Robyn; Totpal, Klara; Jesudason, Raj; Yang, Angela; Solon, Margaret; Eastham, Jeffrey; Modrusan, Zora; Webster, Joshua D.; Lo, Amy A.; Piskol, Robert; Ye, Weilan 分享 收藏
Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer Wang, Peiyin; Sun, Liping L.; Clark, Robyn; Hristopoulos, Maria; Chiu, Cecilia P. C.; Dillon, Michael; Lin, WeiYu; Lo, Amy A.; Chalsani, Sreedevi; Das Thakur, Meghna; Savill, Kristin M. Zimmerman; Rouge, Lionel; Lupardus, Patrick; Piskol, Robert; Husain, Bushra; Ellerman, Diego; Shivva, Vittal; Leong, Steven R.; Ovacik, Meric; Totpal, Klara; Wu, Yan; Spiess, Christoph; Lee, Genee; Leipold, Douglas D.; Polson, Andrew G. 分享 收藏
Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer Lo, Amy A.; Johnston, Jennifer; Li, Ji; Mandikian, Danielle; Hristopoulos, Maria; Clark, Robyn; Nickles, Dorothee; Liang, Wei-Ching; Hotzel, Kathy; Dunlap, Debra; Thinh Pham; Cai, Hao; Ovacik, Meric; Bravo-Perez, Daniel; Mai, Elaine; Slaga, Dionysos; Ellerman, Diego; Ziai, James; Totpal, Klara; Lee, Genee; Boswell, C. Andrew; Payandeh, Jian; Wu, Yan; Junttila, Teemu T. 分享 收藏
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PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer 树突状细胞的PD-L1表达是癌症中T细胞免疫的关键调节因子 Oh, Soyoung A.; Wu, Dai-Chen; Cheung, Jeanne; Navarro, Armando; Xiong, Huizhong; Cubas, Rafael; Totpal, Klara; Chiu, Henry; Wu, Yan; Comps-Agrar, Laetitia; Leader, Andrew M.; Merad, Miriam; Roose-Germa, Merone; Warming, Soren; Yan, Minhong; Kim, Jeong M.; Rutz, Sascha; Mellman, Ira 分享 收藏
IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment Harnoss, Jonathan M.; Le Thomas, Adrien; Reichelt, Mike; Guttman, Ofer; Wu, Thomas D.; Marsters, Scot A.; Shemorry, Anna; Lawrence, David A.; Kan, David; Segal, Ehud; Merchant, Mark; Totpal, Klara; Crocker, Lisa M.; Mesh, Kathryn; Dohse, Monika; Solon, Margaret; Modrusan, Zora; Rudolph, Joachim; Koeppen, Hartmut; Walter, Peter; Ashkenazi, Avi 分享 收藏
y The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma Lee, Ho-June; Trang Pham; Chang, Matthew T.; Barnes, Dwight; Cai, Allen G.; Noubade, Rajkumar; Totpal, Klara; Chen, Xu; Tran, Christopher; Hagenbeek, Thijs; Wu, Xiumin; Eastham-Anderson, Jeff; Tao, Janet; Lee, Wyne; Bastian, Boris C.; Carbone, Michele; Webster, Joshua D.; Dey, Anwesha 分享 收藏
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody Staflin, Karin; de Zafra, Christina L. Zuch; Schutt, Leah K.; Clark, Vanessa; Zhong, Fiona; Hristopoulos, Maria; Clark, Robyn; Li, Ji; Mathieu, Mary; Chen, Xiaocheng; Johnston, Jennifer; Low, Justin; Ybarra, Ryan; Slaga, Dionysos; Yang, Jihong; Ovacik, Meric; Dybdal, Noel O.; Totpal, Klara; Junttila, Melissa R.; Ellerman, Diego; Lee, Genee; Dennis, Mark S.; Prell, Rodney; Junttila, Teemu T. 分享 收藏
Disruption of IRE1α through its kinase domain attenuates multiple myeloma Harnoss, Jonathan M.; Le Thomas, Adrien; Shemorry, Anna; Marsters, Scot A.; Lawrence, David A.; Lu, Min; Chen, Yung-Chia Ariel; Qing, Jing; Totpal, Klara; Kan, David; Segal, Ehud; Merchant, Mark; Reichelt, Mike; Wallweber, Heidi Ackerly; Wang, Weiru; Clark, Kevin; Kaufman, Susan; Beresini, Maureen H.; Laing, Steven T.; Sandoval, Wendy; Lorenzo, Maria; Wu, Jiansheng; Lyh, Justin; De Bruyn, Tom; Heidersbach, Amy; Haley, Benjamin; Gogineni, Alvin; Weimer, Robby M.; Lee, Dong; Braun, Marie-Gabrielle; Rudolph, Joachim; VanWyngarden, Michael J.; Sherbenou, Daniel W.; Gomez-Bougie, Patricia; Amiot, Martine; Acosta-Alvear, Diego; Walter, Peter; Ashkenazi, Avi 分享 收藏
Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3 Slaga, Dionysos; Ellerman, Diego; Lombana, T. Noelle; Vij, Rajesh; Li, Ji; Hristopoulos, Maria; Clark, Robyn; Johnston, Jennifer; Shelton, Amy; Mai, Elaine; Gadkar, Kapil; Lo, Amy A.; Koerber, James T.; Totpal, Klara; Prell, Rodney; Lee, Genee; Spiess, Christoph; Junttila, Teemu T. 分享 收藏
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma 肿瘤抑制因子BAP1与BRAFV600E协同促进皮肤黑色素瘤的肿瘤形成 Webster, Joshua D.; Pham, Trang H.; Wu, Xiumin; Hughes, Nicolas W.; Li, Zhongwu; Totpal, Klara; Lee, Ho-June; Calses, Philamer C.; Chaurushiya, Mira S.; Stawiski, Eric W.; Modrusan, Zora; Chang, Matthew T.; Tran, Christopher; Lee, Wyne P.; Chalasani, Sreedevi; Hung, Jeffrey; Sharma, Neeraj; Chan, Sara; Hotzel, Kathy; Talevich, Eric; Shain, Alan; Xu, Mengshu; Lill, Jennie; Dixit, Vishva M.; Bastian, Boris C.; Dey, Anwesha 分享 收藏
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors Hagenbeek, Thijs J.; Webster, Joshua D.; Kljavin, Noelyn M.; Chang, Matthew T.; Trang Pham; Lee, Ho-June; Klijn, Christiaan; Cai, Allen G.; Totpal, Klara; Ravishankar, Buvana; Yang, Naiying; Lee, Da-Hye; Walsh, Kevin B.; Hatzivassiliou, Georgia; de la Cruz, Cecile C.; Gould, Stephen E.; Wu, Xiumin; Lee, Wyne P.; Yang, Shuqun; Zhang, Zhixiang; Gu, Qingyang; Ji, Qunsheng; Jackson, Erica L.; Lim, Dae-Sik; Dey, Anwesha 分享 收藏
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model T细胞依赖性双特异性抗体的相对靶标亲和力决定了实体瘤小鼠模型中的生物分布 Mandikian, Danielle; Takahashi, Nene; Lo, Amy A.; Li, Ji; Eastham-Anderson, Jeffrey; Slaga, Dionysos; Ho, Jason; Hristopoulos, Maria; Clark, Robyn; Totpal, Klara; Lin, Kedan; Joseph, Sean B.; Dennis, Mark S.; Prabhu, Saileta; Junttila, Teemu T.; Boswell, C. Andrew 分享 收藏
T cell-dependent bispecific antibody anti-CD79b/CD3 as a potential therapy for B-cell malignancies Wang, Peiyin; Hristopoulos, Maria; Clark, Robyn; Chen, Yvonne; Ellerman, Diego; Mathieu, Mary; Spiess, Christoph; Li, Jessica; Chalouni, Cecile; Sukumaran, Siddharth; Stefanich, Eric; Wallin, Jeffrey; Li, Robert; Zabka, Tanja; Totpal, Klara; Dennis, Mark; Ebens, Allen; Gould, Stephen; Polson, Andrew; Sun, Liping Laura 分享 收藏
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice 介导小鼠抗肿瘤免疫抑制需要肿瘤和宿主细胞PD-L1 Lau, Janet; Cheung, Jeanne; Navarro, Armando; Lianoglou, Steve; Haley, Benjamin; Totpal, Klara; Sanders, Laura; Koeppen, Hartmut; Caplazi, Patrick; McBride, Jacqueline; Chiu, Henry; Hong, Rebecca; Grogan, Jane; Javinal, Vincent; Yauch, Robert; Irving, Bryan; Belvin, Marcia; Mellman, Ira; Kim, Jeong M.; Schmidt, Maike 分享 收藏
Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey 抗治疗性抗体介导的重组人Apo2L/TRAIL在食蟹猴中的肝毒性 de Zafra, Christina L. Zuch; Ashkenazi, Avi; Darbonne, Walter C.; Cheu, Melissa; Totpal, Klara; Ortega, Shirley; Flores, Heather; Walker, Mark D.; Kabakoff, Bruce; Lum, Bert L.; Mounho-Zamora, Barbara J.; Marsters, Scot A.; Dybdal, Noel O. 分享 收藏
Pharmacodynamic response to HER2/CD3 bispecific antibody (HER2-TDB): evidence of T-cell recruitment and further rationale for combination treatment with anti-PD-L1 Li, Ji; Hristopoulos, Maria; Clark, Robyn; Johnston, Jennifer; Slaga, Dion; Wang, Bu-Er; Cubas, Rafael; Totpal, Klara; Junttila, Melissa R.; Junttila, Teemu T. 分享 收藏
Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies Anti-CD20/cd3t细胞依赖性双特异性抗体治疗b细胞恶性肿瘤 Sun, Liping L.; Ellerman, Diego; Mathieu, Mary; Hristopoulos, Maria; Chen, Xiaocheng; Li, Yijin; Yan, Xiaojie; Clark, Robyn; Reyes, Arthur; Stefanich, Eric; Mai, Elaine; Young, Judy; Johnson, Clarissa; Huseni, Mahrukh; Wang, Xinhua; Chen, Yvonne; Wang, Peiyin; Wang, Hong; Dybdal, Noel; Chu, Yu-Waye; Chiorazzi, Nicholas; Scheer, Justin M.; Junttila, Teemu; Totpal, Klara; Dennis, Mark S.; Ebens, Allen J. 分享 收藏
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