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收藏Altered Inflammatory Signature in a C9ORF72-ALS iPSC-Derived Motor Neuron and Microglia Coculture ModelC9ORF72-ALS iPSC来源的运动神经元和微胶质细胞共培养模型中的炎症特征改变
Gao, Yujing; Brothwood, Jessica L.; Saini, Harpreet; O'Sullivan, Gregory A.; Bento, Carla F.; McCarthy, James M.; Wallis, Nicola G.; Di Daniel, Elena; Graham, Brent; Tams, Daniel M. 分享 收藏 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2) (vol 67, pg 4655, 2024)基于片段的SH2结构域蛋白酪氨酸磷酸酶-2（SHP2）别构抑制剂的发现（vol 67, pg 4655, 2024）Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; Denis, Jeffrey D. St; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N. 分享 收藏 Pulsatile induction of the p53 pathway by MDM2 antagonist ASTX295 shows an enhanced therapeutic index in vivoFazal, L.; Biondo, A.; Ahn, M.; Bevan, L.; Hearn, K.; Howard, S.; Jueliger, S.; Chessari, G.; Kucia-Tran, J.; Shah, A.; Sims, M.; Wilsher, N.; Keer, H.; Organesian, A.; Wedge, S.; Thomas, H.; Zhao, Y.; Newell, D.; Wallis, N.; Courtin, A. 分享 收藏 Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-GlucocerebrosidasePalmer, Nick; Agnew, Christopher; Benn, Caroline; Buffham, William J.; Castro, Joan N.; Chessari, Gianni; Clark, Mellissa; Cons, Benjamin D.; Coyle, Joseph E.; Dawson, Lee A.; Hamlett, Christopher C. F.; Hodson, Charlotte; Holding, Finn; Johnson, Christopher N.; Liebeschuetz, John W.; Mahajan, Pravin; McCarthy, James M.; Murray, Christopher W.; O'Reilly, Marc; Peakman, Torren; Price, Amanda; Rapti, Magdalini; Reeks, Judith; Schopf, Patrick; St-Denis, Jeffrey D.; Valenzano, Chiara; Wallis, Nicola G.; Walser, Reto; Weir, Heather; Wilsher, Nicola E.; Woodhead, Andrew; Bento, Carla F.; Tisi, Dominic 分享 收藏 Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic indexWillmore, Elaine; Ahn, Maria; Kyle, Suzanne; Zhao, Yan; Thomas, Huw; Rankin, Kenneth S.; Bevan, Luke; Fazal, Lynsey; Hearn, Keisha; Wilsher, Nicola; Kucia-Tran, Justyna; Ferrari, Nicola; Wallis, Nicola; Thompson, Neil; Lyons, John; Miller, Duncan; Cano, Celine; Noble, Martin E.; Hardcastle, Ian R.; Howard, Steven; Chessari, Gianni; Lunec, John; Newell, David R.; Wedge, Steve R. 分享 收藏 Integrating fragment-based crystallographic screening with dTAG-PROTAC degradation and genetic rescue to explore the function of eIF4EIntegrating fragment-based crystallographic screening with dTAG-PROTAC degradation and genetic rescue to explore the function of eIF4EClarke, Paul A.; Sharp, Swee Y.; Martella, Marianna; Milton, Christopher I.; East, Charlotte; Vinkovic, Mladen; Wallis, Nicola; Ward, George; Richardson, Caroline; Woodhead, Andrew 分享 收藏 Identification of biomarkers of response to MDM2 inhibition in solid tumours using computational, multi-omics approachesSaini, Harpreet Kaur; Ahn, Maria; Ward, George; Kucia-Tran, Justyna; Gewinner, Christina; Ferrari, Nicola; Brothwood, Jessica; Bevan, Luke; Davis, Matthew; Fazal, Lynsey; Sims, Martin; O'Reilly, Marc; Chessari, Gianni; Ferraldeschi, Roberta; Lyons, John; Wallis, Nicola; Thompson, Neil 分享 收藏 Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profileAhn, Maria; Bevan, Luke; Buck, Ildiko; Cano, Celine; Castro, Juan; Cons, Ben; Endicott, Jane; Fazal, Lynsey; Ferrari, Nicola; Hardcastle, Ian; Hearn, Keisha; Holvey, Rhian; Howard, Steven; Johnson, Chris; Jennings, Claire; Kucia-Tran, Justyna; Kyle, Suzanne; Lunec, John; Lyons, John; Miller, Duncan; Rees, David; Noble, Martin; Newell, David R.; Reeks, Judith; Saini, Harpreet; Denis, Jeffrey St.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil; Vinkovic, Mladen; Ward, George; Wallis, Nicola; Walton, Hugh; Wedge, Stephen; Williams, Pamela; Willmore, Elaine; Wilshire, Nicola; Zhao, Yan; Chessari, Gianni 分享 收藏 Targeting MAPK-driven tumors via inhibition of MAP2K4Wade, Mark; Tamanini, Emiliano; Unbekandt, Mathieu; Wallis, Nicola; Lyons, John; Munck, Joanne; Woodhead, Andrew; Schopf, Patrick; Stow, Jessie; East, Charlotte; Clark, Mellissa; Denis, Jeffrey St.; Pathuri, Puja 分享 收藏 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2)Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; St. Denis, Jeffrey D.; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N. 分享 收藏 分享 收藏 分享 收藏 Identifying sensitive patient populations for CDK7 inhibitors using cell panel screens and bioinformatic approachesHearn, Keisha; Ahn, Maria; Bevan, Luke; Brothwood, Jessica; East, Charlotte; Esteve-Arneys, Anna; Fazal, Lynsey; Hindely, Christopher; James, Sabrina; Kucia-Tran, Justyna; Lyons, John; Munck, Joanne; Saini, Harpreet; Unbekandt, Mathieu; Varshney, Dhaval; Wagner, Steve; Woodhead, Andrew; Wallis, Nicola 分享 收藏 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2Heightman, Tom D.; Berdini, Valerio; Bevan, Luke; Buck, Ildiko M.; Carr, Maria G.; Courtin, Aurelie; Coyle, Joseph E.; Day, James E. H.; East, Charlotte; Fazal, Lynsey; Griffiths-Jones, Charlotte M.; Howard, Steven; Kucia-Tran, Justyna; Martins, Vanessa; Muench, Sandra; Munck, Joanne M.; Norton, David; O'Reilly, Marc; Palmer, Nicholas; Pathuri, Puja; Peakman, Torren M.; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Wallis, Nicola G.; Walton, Hugh; Wilsher, Nicola E.; Woolford, Alison J-A; Cooke, Michael; Cousin, David; Onions, Stuart; Shannon, Jonathan; Watts, John; Murray, Christopher W. 分享 收藏 ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERKMunck, Joanne M.; Berdini, Valerio; Bevan, Luke; Brothwood, Jessica L.; Castro, Juan; Courtin, Aurelie; East, Charlotte; Ferraldeschi, Roberta; Heightman, Tom D.; Hindley, Christopher J.; Kucia-Tran, Justyna; Lyons, John F.; Martins, Vanessa; Muench, Sandra; Murray, Christopher W.; Norton, David; O'Reilly, Marc; Reader, Michael; Rees, David C.; Rich, Sharna J.; Richardson, Caroline J.; Shah, Alpesh D.; Stanczuk, Lukas; Thompson, Neil T.; Wilsher, Nicola E.; Woolford, Alison J-A; Wallis, Nicola G. 分享 收藏 Different pharmacodynamic profiles of ERK1/2 inhibition can elicit comparable anti-tumor activityHindley, Christopher; Bevan, Luke; Braithwaite, Hannah; Courtin, Aurelie; Fazal, Lynsey; Ferraldeschi, Roberta; Martins, Vanessa; Muench, Sandra; Wallis, Nicola; Wilsher, Nicola; Lyons, John; Munck, Joanne 分享 收藏 Fragment-based drug discovery to identify small molecule allosteric inhibitors of SHP2Day, Philip J.; Berdini, Valerio; Castro, Juan; Chessari, Gianni; Davies, Thomas G.; Day, James E.; Fukaya, Satoshi; Hamlett, Chris; Hearn, Keisha; Hiscock, Steve; Holvey, Rhian; Ito, Satoru; Kodama, Yasuo; Matsuo, Kenichi; Nakatsuru, Yoko; Palmer, Nick; Price, Amanda; Shimamura, Tadashi; St Denis, Jeffrey D.; Wallis, Nicola G.; Williams, Glyn; Johnson, Christopher N. 分享 收藏 A novel ERK1/2 inhibitor has potent activity in KRAS-mutant non-small cell lung cancer modelsCourtin, Aurelie; Bevan, Luke; Heightman, Tom; Kidane, Birikiti; Kucia-Tran, Justyna; Lyons, John; Muench, Sandra; Shah, Alpesh; Stanczuk, Lukas; Thompson, Neil; Wallis, Nicola; Wilsher, Nicola; Munck, Joanne 分享 收藏 ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor GrowthWard, George A.; Lewis, Edward J.; Ahn, Jong Sook; Johnson, Christopher N.; Lyons, John F.; Martins, Vanessa; Munck, Joanne M.; Rich, Sharna J.; Smyth, Tomoko; Thompson, Neil T.; Williams, Pamela A.; Wilsher, Nicola E.; Wallis, Nicola G.; Chessari, Gianni 分享 收藏 
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